Esters-buliding-blocks

Synthesis, antioxidant, antimicrobial, and molecular docking studies of some N-cinnamyl phenylacetamide and N-(3,7-dimethylocta-2,6-dien-1-yl)phenylacetamide derivatives was written by El-Zemity, Saad R.;Badawy, Mohamed E. I.;Esmaiel, Kareem E. E.;Badr, Mai M.. And the article was included in Journal of Molecular Structure in 2022.Category: esters-buliding-blocks This article mentions the following:

A series of N-cinnamyl phenylacetamides I [R = 2-OH, 4-Cl, 4-SO₂NH₂, etc.] and N-(3,7-dimethylocta-2,6-dien-1-yl)phenylacetamide derivatives II [R¹ = 3,5-di-MeC₆H₃, 2,6-di-MeC₆H₃, 2-Me,6-EtC₆H₃, 1-naphthyl] with different active moieties have been designed, synthesized and tested for antioxidant and antimicrobial activity. The synthetic protocol was based on the formation of Schiff bases followed by chloroacetylation of imines. The chem. structures of the compounds were recognized by 1H-NMR, ¹³C-NMR and MS spectral techniques. Compounds I and II exhibited superior antioxidant activity (IC₅₀ = 9.92-19.06μM) compared to α-tocopherol (IC₅₀ = 26μM). Derivatives II showed excellent antibacterial activities against all the tested strains with MIC values in the range of 10-230μM comparable to those of amoxicillin (80-275μM) against Bacillus cereus (G+), Staphylococcus aureus (G+), Escherichia coli (G-), and Pseudomonas aeruginosa (G-). Besides, the compounds also exhibited candidacidal activity against Candida albicans and Compound II [R¹ = 2-Me,6-EtC₆H₃] was the most active compound (EC₅₀ = 423.62μM). Mol. docking, drug-likeness data, physicochem. properties, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) parameters of the compounds were in silico computed. The derivatives presented good properties for Lipinski’s parameters, poor solubility in the aqueous medium (Log S of -4.06 to -5.97), and PSA <140, indicating good permeability in biol. membranes and gastrointestinal absorption. Mol. docking to the active sites of NADPH oxidase (PDB: 1W6X), penicillin-binding protein 2a (PDB: 1VQQ), and lanosterol 14-alpha demethylase (PDB 1EA1) revealed that most compounds displayed minimal binding energy and have a good affinity toward the active pocket of each enzyme. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Category: esters-buliding-blocks).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis was written by Guo, Tao;Shao, Yuefei;Qian, Gang;Rokosz, Laura L.;Stauffer, Tara M.;Hunter, Rachael C.;Babu, Suresh D.;Gu, Huizhong;Hobbs, Doug W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Application In Synthesis of 3-Cyanophenylisocyanate This article mentions the following:

An encoded combinatorial library based on aryl- and biarylpiperidine scaffolds was designed and synthesized. Screening of this library resulted in the discovery of high-nanomolar biarylpiperidine-based MCH1 receptor antagonists. Follow-up optimization using a parallel synthesis provided potent, single digit nanomolar antagonists. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Application In Synthesis of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mechanochemical synthesis of coumarins via Pechmann condensation under solvent-free conditions: an easy access to coumarins and annulated pyrano[2,3-f] and [3,2-f]indoles was written by Sharapov, Ainur D.;Fatykhov, Ramil F.;Khalymbadzha, Igor A.;Sharutin, Vladimir V.;Santra, Sougata;Zyryanov, Grigory V.;Chupakhin, Oleg N.;Ranu, Brindaban C.. And the article was included in Green Chemistry in 2022.Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

A green protocol has been developed for the synthesis of simple coumarins, e.g., I linear pyrano[2,3-f] and [3,2-f]indoles by the reaction of phenol derivatives ROH (R = 3,5-(OH)₂C₆H₃, 4-Br-3-OHC₆H₃, 3-OMeC₆H₄) with β-ketoesters, e.g., cyclohexanecarboxylic acid, 2-oxo-, Et ester under ball milling at ambient temperature in the presence of methanesulfonic acid as a mild acid catalyst. The significant advantages of this procedure are high yields, scalability, no use of hazardous acids or solvents, shorter reaction time, ambient temperature, low cost, and straightforward purification without column chromatog. This procedure is associated with high EcoScale metrics and a low E-factor. In contrast to traditional Pechmann condensation procedures, the mechanochem. protocol leads to the synthesis of pyranoindoles with excellent regioselectivity and high yields. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pd-catalyzed decarboxylative cross-couplings of potassium malonate monoesters with aryl halides was written by Feng, Yi-Si;Wu, Wei;Xu, Zhong-Qiu;Li, Yan;Li, Ming;Xu, Hua-Jian. And the article was included in Tetrahedron in 2012.Application of 1190-39-2 This article mentions the following:

An efficient catalytic protocol for Pd-catalyzed decarboxylative cross-coupling of potassium malonate monoesters and derivatives with aryl bromides and chlorides are described. E.g., in presence of Pd₂(allyl)₂Cl₂ and BINAP, decarboxylative cross-coupling of EtO₂CCH₂CO₂K with PhBr gave 85% PhCH₂CO₂Et. Because of its broad applicability, this new catalytic system provides an alternative method for the preparation of diverse aryl acetic acids and derivatives In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Application of 1190-39-2).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application of 1190-39-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Copper-catalyzed, silver-mediated formal [3+2] cycloaddition of simple alkynes with β-ketoesters through propargylic C(sp³)-H functionalization was written by Liu, Zhen-Ting;Hu, Xiang-Ping. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Recommanded Product: 13669-10-8 This article mentions the following:

A copper-catalyzed propargylic [3+2] cycloaddition of simple alkynes with β-ketoesters through the propargylic C(sp³)-H functionalization has been realized. Under catalysis by CuI in combination with 1,10-phenanthroline hydrate as the ligand and Ag₂CO₃ as a bifunctional reagent (oxidant and base), the reaction proceeds smoothly with a broad substrate scope, thus providing a variety of highly functionalized furans I (R¹ = C₆H₅, 2-ClC₆H₄, 4-FC₆H₄, etc.; R² = Me, Et) in moderate to high yields. This represents the first successful example of the catalytic propargylic cycloaddition of simple alkynes with bisnucleophiles based on the propargylic C(sp³)-H functionalization strategy. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Unusual Tethering Effects in the Schmidt Reaction of Hydroxyalkyl Azides with Ketones: Cation-π and Steric Stabilization of a Pseudoaxial Phenyl Group was written by Katz, Christopher E.;Aube, Jeffrey. And the article was included in Journal of the American Chemical Society in 2003.Name: Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

The Lewis acid-promoted reactions of chiral 2-aryl-3-azido-1-propanols with 4-substituted cyclohexanones lead to iminium ethers and ultimately caprolactams (following a hydrolysis step). In this study, it is shown that these reactions afford variable ratios of products, depending on the electronic nature of the Ph group. These results are interpreted in the context of a cation-π stabilizing effect in the product-determining reaction intermediate. Remarkably, the best selectivity was obtained when an azidopropanol reagent containing a quaternary center was used; a control experiment showed that the high selectivity observed in this result depended upon the free rotation of the pseudoaxial aromatic group in the intermediate that affords the major product. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Name: Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sequential Hydrozirconation/Cyclization of Dienes, a New Route toward Trans 2-Substituted Vinylcyclopentanes was written by Clergue, Sebastien;Vasse, Jean-Luc. And the article was included in Organic Letters in 2014.Product Details of 19432-68-9 This article mentions the following:

Trans-2-substituted vinylcyclopentanes such as I (R = Ph, 2-BrC₆H₄, 4-MeOC₆H₄, 2-thienyl, PhCH₂, PhCH₂OCH₂CH₂CH₂) were prepared in 25-72% yields and in 2.8:1->19:1 diastereoselectivities by diastereoselective reductive cyclizations of 7-methoxy-1,5-heptadienes such as (E)-H₂C:CHCH₂CHRCH:CHCH₂OMe (R = Ph, 2-BrC₆H₄, 4-MeOC₆H₄, 2-thienyl, PhCH₂, PhCH₂OCH₂CH₂CH₂) mediated by (chloro)(hydrido)zirconocene (Schwartz’s reagent) and Me₃SiOTf. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Product Details of 19432-68-9).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 19432-68-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Towards Gram-positive antivirulence drugs: New inhibitors of Streptococcus agalactiae Stk1 was written by Oxoby, Mayalen;Moreau, Francois;Durant, Lionel;Denis, Alexis;Genevard, Jean-Marie;Vongsouthi, Vanida;Escaich, Sonia;Gerusz, Vincent. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Related Products of 16413-26-6 This article mentions the following:

A structure-activity relationship study from a screening hit and structure-based design strategy has led to the identification of bisarylureas as potent inhibitors of Streptococcus agalactiae Stk1. As this target has been directly linked to bacterial virulence, these inhibitors can be considered as a promising step towards antivirulence drugs. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Primary Alcohols via Nickel Pentacarboxycyclopentadienyl Diamide Catalyzed Hydrosilylation of Terminal Epoxides was written by Steiniger, Keri A.;Lambert, Tristan H.. And the article was included in Organic Letters in 2021.Quality Control of Ethyl 2-hydroxy-3-phenylpropanoate This article mentions the following:

The efficient and regioselective hydrosilylation of epoxides co-catalyzed by a pentacarboxycyclopentadienyl (PCCP) diamide Ni complex and Lewis acid is reported. This method allows for the reductive opening of terminal, monosubstituted epoxides to form unbranched, primary alcs. A range of substrates including both terminal and nonterminal epoxides work, and a mechanistic rationale is provided. This work represents the 1st use of a PCCP derivative as a ligand for transition-metal catalysis. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Quality Control of Ethyl 2-hydroxy-3-phenylpropanoate).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Ethyl 2-hydroxy-3-phenylpropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Degradation and Stabilization of Poly(Butylene Adipate-co-Terephthalate)/Polyhydroxyalkanoate Biodegradable Mulch Films Under Different Aging Tests was written by Wang, James H.;Tian, Yuchuan;Zhou, Bing. And the article was included in Journal of Polymers and the Environment in 2022.Recommanded Product: 6683-19-8 This article mentions the following:

The degradation and stability of biodegradable films determine the service length of mulch films in actual use. Most biodegradable polymers degrade too fast to meet the required durability of mulch films. The objective of this work is to investigate the degradation behaviors of poly(butylene adipate-co-terephthalate) (PBAT)/polyhydroxyalkanoate (PHA) blend mulch films. Several different types of stabilizers were incorporated in the biodegradable blends to provide protection for the PHA/PBAT films during thermal processing and aging on agricultural fields. The degradation process of the films was systematically studied under an Accelerated aging test (AAT) and a Soil aging test (SAT). Adding a UV stabilizer, or antioxidant to the mulch films led to significant improvement in the retention of mech. properties of the films under both AAT and SAT. Morphol. evolution of the films with or without a UV stabilizer as a function of aging times was studied by SEM. The results of thermal properties and crystallinity revealed damage of crystalline structure of the films during AAT. Spectrocopic results indicated that the films underwent both hydrolysis and photodegradative chain scissions (Norrish Type I/II reactions and photo-oxidation). Two degradation mechanisms of the PBAT/PHA biodegradable mulch films were proposed. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Recommanded Product: 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics