Category: esters-buliding-blocks

Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities was written by Keles Atici, Rueveyde;Dogan, Senguel Dilem;Guenduez, Miyase Gozde;Krishna, Vagolu Siva;Chebaiki, Melina;Homberset, Haavard;Lherbet, Christian;Mourey, Lionel;Toenjum, Tone. And the article was included in Drug Development Research in 2022.Formula: C8H4N2O This article mentions the following:

The recent emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) has complicated and significantly slowed efforts to eradicate and/or reduce the worldwide incidence of life-threatening acute and chronic cases of tuberculosis. To overcome this setback, researchers have increased the intensity of their work to identify new small-mol. compounds that are expected to remain efficacious antimicrobials against Mtb. Here, we describe our effort to apply the principles of mol. hybridization to synthesize 16 compounds carrying thiophene and thiazole rings beside the core urea functionality (TTU1-TTU16). Following extensive structural characterization, the obtained compounds were initially evaluated for their antimycobacterial activity against Mtb H37Rv. Subsequently, three derivatives standing out with their anti-Mtb activity profiles and low cytotoxicity (TTU5, TTU6, and TTU12) were tested on isoniazid-resistant clin. isolates carrying katG and inhA mutations. Addnl., due to their pharmacophore similarities to the well-known InhA inhibitors, the mols. were screened for their enoyl acyl carrier protein reductase (InhA) inhibitory potentials. Mol. docking studies were performed to support the exptl. enzyme inhibition data. Finally, drug-likeness of the selected compounds was established by theor. calculations of physicochem. descriptors. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Formula: C8H4N2O).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C8H4N2O

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

RAFT synthesis of triply responsive poly[N-[2-(dialkylamino)ethyl]acrylamide]s and their N-substitute determined response was written by Wang, Ke;Song, Zefeng;Liu, Chonggao;Zhang, Wangqing. And the article was included in Polymer Chemistry in 2016.Name: Benzyl benzodithioate This article mentions the following:

The thermo- and pH/CO₂-responsive poly[N-[2-(dialkylamino)ethyl]acrylamide]s containing a polyacrylamide backbone but different N-substitutes of dialkylamine were synthesized and their solution properties were comparatively checked. A controllable RAFT synthesis of poly[N-[2-(dialkylamino)ethyl]acrylamide]s was achieved when a typical trithiocarbonate containing an easily cleavable R group was employed. The RAFT polymerization rate decreases with the increasing C-number in the N-substitutes. The thermo- and pH/CO₂-responsive property of poly[N-[2-(dialkylamino)ethyl]acrylamide]s is firmly correlative to the N-substitutes. With the C-number in the R-substitute increasing, the solution properties of poly(N-[2-(dialkylamino)ethyl]acrylamide)s undergo a soluble-to-thermoresponsive-to-insoluble evolution, and the critical pH of poly[N-[2-(dialkylamino)ethyl]acrylamide]s gradually decreases. The dialkylamine moieties in the poly[N-[2-(dialkylamino)ethyl]acrylamide]s lead to a characteristic CO₂-response during CO₂/N₂ bubbling. The present study reveals the structure-dependent solution properties of the thermo- and pH/CO₂-responsive poly[N-[2-(dialkylamino)ethyl]acrylamide]s, and these multistimuli-responsive polymers are believed to be useful due to the controllable RAFT synthesis and tunable solution properties. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Name: Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Influence of post-harvest moisture on roasted almond shelf life and consumer acceptance was written by Luo, Kathleen K.;Chapman, Dawn M.;Lerno, Larry A.;Huang, Guangwei;Mitchell, Alyson E.. And the article was included in Journal of the Science of Food and Agriculture in 2021.Synthetic Route of C6H10O2 This article mentions the following:

BACKGROUND : The harvest weights of sweet almonds (Prunus dulcis) have significantly increased to meet consumer demand and now exceed processing facility capabilities. Crops are stockpiled for longer periods, increasing the probability of moisture exposure. Wet almonds can be mech. dried prior to processing; however, it is unclear how this practice influences lipid oxidation, shelf-life, and consumer acceptance. To address this, almonds were exposed to 8% moisture and dried with low heat (ME). Almonds were roasted and stored under accelerated conditions for 12 mo and markers of lipid oxidation, headspace volatiles, sensory attributes, and consumer liking were evaluated. RESULTS : At 7 mo of storage, light roast ME almonds had higher levels of volatiles related to lipid oxidation than non-moisture exposed almonds (NME) and were significantly higher in oxidized, cardboard and painty / solvent flavors. Although untrained consumers did not show significant preferences between the light roast ME and NME almonds, there were quality losses related to lipid oxidation that trained panelists could detect. Dark roast ME almonds demonstrated significant lipid oxidation by 5 mo of storage, indicating they will have a compromised shelf life. Findings also indicate that octanal, nonanal, 2-octenal, and hexanoic acid are good indicators of consumer acceptability. CONCLUSION : The results of this research illustrate that post-harvest moisture exposure with mech. drying has a significant effect on the storage quality of roasted almonds and is most pronounced in dark roast products. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Synthetic Route of C6H10O2).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C6H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

CuO-Catalyzed oxidation of aryl acetates with aqueous tert-butyl hydroperoxide for the synthesis of α-ketoesters was written by Jiang, Jin. And the article was included in Journal of Chemical Research in 2019.Application of 19432-68-9 This article mentions the following:

A practical method to access α-ketoesters ArC(O)C(O)OR [Ar = Ph, 4-BrC₆H₄, 2-thienyl, etc.; R = Me, iPr, Bn, etc.] via CuO catalyzed oxidation of aryl acetates using aqueous tert-Bu hydroperoxide was developed. No addnl. solvents were required in this method and it was found the peroxide side products in the reaction could be decomposed to products by using pyridine. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Application of 19432-68-9).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 19432-68-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

2-Oxo-1,8-naphthyridine-3-carboxylic acid derivatives with potent gastric antisecretory properties was written by Santilli, Arthur A.;Scotese, Anthony C.;Bauer, Raymond F.;Bell, Stanley C.. And the article was included in Journal of Medicinal Chemistry in 1987.Category: esters-buliding-blocks This article mentions the following:

The syntheses of 2-oxo-1,8-naphthyridine-3-carboxylic acid derivatives, e.g., I (R = H, Me, Et, Pr, allyl, etc.; R¹ = NH₂, 4-methylpiperazinyl, etc.; R² = H, Me), having potent gastric antisecretory properties in the Shay rat model are described. Two of the more potent compounds tested that were selected for more detailed dose-response evaluation were I (R = Et, R¹ = NH₂, R² = H; II) and I (R = Et, R¹ = 4-methylpiperazinyl, R² = Me; III). II and III lowered total acid output in a dose-related fashion, were more potent than cimetidine, and showed inhibitory activity in food-stimulated acid secretion in the Pavlov dog. The mechanism of action for this series is not known. Details of structure-activity relationships are described. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Category: esters-buliding-blocks).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effects of Exposure Conditions on Antioxidant Depletion, Tensile Strength, and Creep Modulus of Corrugated HDPE Pipes Made With or Without Recycled Resins was written by Nguyen, Khanh Q.;Cousin, Patrice;Mohamed, Khaled;Robert, Mathieu;Benmokrane, Brahim. And the article was included in Journal of Polymers and the Environment in 2022.Reference of 6683-19-8 This article mentions the following:

The service lifetime of corrugated high-d. polyethylene (HDPE) pipes used in transportation infrastructure applications has been the subject of several studies over the years. How factors specific to North American climate conditions-such as freeze/thaw cycles, deicing salts, and abrasion-affect pipe service life have not been addressed. In this study, laboratory accelerated-aging tests were conducted to examine the thermo-oxidative degradation as well as tensile strength and creep modulus of HDPE pipes made with or without recycled resins. Specimens were immersed in saline solution (NaCl), acidic solution (H₂SO₄), alk. solution (NaOH) at 60°C, or in water and exposed to freeze/thaw cycles ranging from – 40 to + 40°C. Measuring the oxidative induction time (OIT) at various time intervals quantified the amounts of antioxidants present in the pipes, revealing that the rate of antioxidant depletion depended on the surrounding environment. The depletion rate was faster in the saline solution and slower in the freeze/thaw cycles. For specimens exposed to freeze/thaw cycles, the depletion was 1.12 to 1.91 lower than in the acidic solution, 1.25 to 2.64 times lower than in the alk. solution, and 1.43 to 3.25 times lower than in saline solution Nevertheless, the HDPE pipes all met the OIT requirements of a min. of 20 min. Furthermore, the one-way anal. of variance (ANOVA) and Tukey’s HSD test indicate that the tensile strength and creep modulus values of the recycled and virgin HDPE pipes were unchanged before and after immersion in the different solutions In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Reference of 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The hydrolysis of carboxylic anhydrides. IV. Succinic and tetramethylsuccinic anhydrides was written by Bunton, C. A.;Fendler, J. H.;Fuller, N. A.;Perry, S.;Rocek, J.. And the article was included in Journal of the Chemical Society in 1963.Related Products of 584-74-7 This article mentions the following:

Hydrolysis of succinic and tetramethylsuccinic anhydride is retarded by aqueous mineral acids (except for dilute H₂SO₄ and HCl). It is acid-catalyzed in aqueous dioxane. Hydrolysis of succinic anhydride in water is accelerated by bivalent electrolytes, but retarded by univalent electrolytes (except for NaHSO₄). In water the feeble catalysis by protons is opposed by a sp. neg. salt effect, but the rate in aqueous acid is always greater than that in solutions of the alkali-metal salts. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Related Products of 584-74-7).

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 584-74-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Biodegradation of dibenzothiophene by efficient Pseudomonas sp. LKY-5 with the production of a biosurfactant was written by Li, Lin;Shen, Xianwei;Zhao, Chaocheng;Liu, Qiyou;Liu, Xuwei;Wu, Yanan. And the article was included in Ecotoxicology and Environmental Safety in 2019.Quality Control of Ethyl 2-hydroxybenzoate This article mentions the following:

A potent bacterial strain capable of degrading dibenzothiophene (DBT) was isolated and evaluated for its characteristics. The strain, designated as LKY-5, is rod-shaped, gram-neg., and occurs mainly in clusters. It was identified as belonging to the Pseudomonas genus based on the 16S rDNA sequence and phylogenic anal. Determination of its DBT depletion efficiency by gas chromatog. revealed that the isolate was able to completely degrade up to 100 mg L^-1 DBT within 144 h. The pH values, DBT concentrations, and biomasses in the medium varied significantly in the initial 24 h. A biosurfactant produced by LKY-5 was extracted and identified as a di-rhamnolipid with the formula Rha-Rha-C₈-C_8:1 by HPLC-ESI-MS/MS. There were 26 metabolites in the DBT degradation process. Pseudomonas sp. LKY-5 exhibited unusually high DBT degradation efficiency via multiple metabolic pathways. Compared with the reported 4S and Kodama pathways, two more expanded metabolic pathways for the degradation of DBT are proposed. The polycyclic aromatic sulfur heterocycles (PASHs) in diesel, such as C₁-DBT, C₂-DBT, C₃-DBT, 4,6-DMDBT, and 2,4,6-TMDBT, can also be degraded with 28.2-42.3% efficiency. The results showed that LKY-5 is an excellent bacterial candidate for the bioremediation of PASH-contaminated sites and sediments. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Quality Control of Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Ethyl 2-hydroxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pd-Catalyzed Divergent C(sp²)-H Activation/Cycloimidoylation of 2-Isocyano-2,3-diarylpropanoates was written by Tang, Shi;Yang, Sheng-Wen;Sun, Hongwei;Zhou, Yali;Li, Juan;Zhu, Qiang. And the article was included in Organic Letters in 2018.Computed Properties of C10H11FO2 This article mentions the following:

A Pd-catalyzed site-selective C(sp²)-H activation/cycloimidoylation of 2-isocyano-2,3-diarylpropanoates to construct diverse cyclic imine products has been developed. Six-membered 3,4-dihydroisoquinolines containing a C3 quaternary carbon center were generated dominantly by using bulky Ad₂Pn-Bu as a ligand, while five-membered 1,1-disubstituted 1H-isoindoles were formed preferentially in the presence of bidentate phosphine ligand DPPB. The selectivity for 1H-isoindole formation was enhanced by using steric hindered aryl iodides. DFT calculations suggested that the exptl. observed ligand-controlled selectivity was a result of trans effect. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Computed Properties of C10H11FO2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C10H11FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models was written by Shimizu, Hiroki;Yamasaki, Tomonori;Yoneda, Yoshiyuki;Muro, Fumihito;Hamada, Tomoaki;Yasukochi, Takanori;Tanaka, Shinji;Toki, Tadashi;Yokoyama, Mika;Morishita, Kaoru;Iimura, Shin. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.HPLC of Formula: 525362-07-6 This article mentions the following:

We have discovered imidazo[1,2-b]pyridazine derivatives that show suppressive activity of inflammation in arthritis models. We optimized the substructures of imidazo[1,2-b]pyridazine derivatives to combine potent IKKβ inhibitory activity, TNFα inhibitory activity in vivo and excellent pharmacokinetics. The compound we have acquired, which had both potent activities and good pharmacokinetic profiles based on improved physicochem. properties, demonstrated efficacy on collagen-induced arthritis models in mice and rats. In the experiment, the researchers used many compounds, for example, Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6HPLC of Formula: 525362-07-6).

Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 525362-07-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics