Category: esters-buliding-blocks

Schweighuber, Andrea published the artcileInvestigations on the influence of multiple extrusion on the degradation of polyolefins, Category: esters-buliding-blocks, the publication is Polymer Degradation and Stability (2021), 109689, database is CAplus.

The importance of mech. recycling of polymers has increased within the last decades, especially due to numerous regulations of governments all over the world. Hereby recycling quotas are enforced to pave the way towards a closed loop recycling. During its lifetime, polymers are exposed to multiple environmental factors, which can already induce degradation However, a major factor that needs to be taken into account is the increased thermo-mech. stress during the recycling process, which may have significant impact on the quality of recyclates as well. In the present work, polyolefins (high-d. polyethylene and polypropylene) were artificially exposed to stress by continuous extrusion at varying speeds and absence or presence of stabilizers to analyze the extent to which the recycling contributes to degradation processes. These samples were analyzed for low-mol.-weight stress markers by thermodesorption gas chromatog. and by high-performance liquid chromatog. (both coupled to mass spectrometric detection). Depending on the extent of stress, the occurrence of odd-numbered linear alkane chains was revealed in polyethylene samples, and of oxidized branched alkanes in polypropylene samples. Correlations with mol. weight (determined by high temperature gel permeation chromatog.) and with decreasing concentrations of stabilizers could be demonstrated.

Polymer Degradation and Stability published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C12H13NO3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Guoping published the artcileNon-fullerene acceptors with direct and indirect hexa-fluorination afford >17% efficiency in polymer solar cells, Category: esters-buliding-blocks, the publication is Energy & Environmental Science (2022), 15(2), 645-659, database is CAplus.

The rational mol. design of non-fullerene acceptors (NFAs) in organic solar cells (OSCs) can profoundly influence the photovoltaic (OPV) performance. To date, NFA fluorination has proven beneficial to cell performance. However, there is a lack of comprehensive understanding of how various fluorination modalities influence film morphol., carrier mobility, mol. packing, other structural properties, electronic structure, exciton separation, and charge transport, that determine ultimate cell efficiency. Here, we compare two types of end group (EG) fluorination patterns on Y6-based A-DAD-A cores, resulting in highly efficient NFAs: direct skeletal fluorination (BTF) and indirect trifluoromethyl fluorination (BTFM). These two patterns induce distinctive behaviors in the active layer blends with a chlorinated donor polymer D18-Cl and the additive, 1-chloronaphthalene, affording high PCE values of 17.30% (BTF + additive) and 17.10% (BTFM, no-additive). The BTFvs. BTFM OSC performance trends can be correlated with diffraction-derived differences in mol. packing. D. functional theory (DFT) reveals remarkably low internal reorganization energies and high electronic coupling between NFA dimers, greater and more numerous than in other NFAs reported to date, thus providing extended 3D charge transport networks in the thin film crystalline domains. Transient absorption spectroscopy reveals that hole transfer from the acceptor to the donor occurs in <300 fs and that photoexcited carriers persist for hundreds of ns in each blend film. The contrasting role of the additive in BTF and BTFM cells is further clarified by recombination dynamics anal. using in situ photocurrent and impedance spectroscopy. Overall, this work provides guidance for developing new NFAs via direct and indirect fluorination strategies for high efficiency OSCs.

Energy & Environmental Science published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Malosse, Christian published the artcileNitric oxide chemical-ionization mass spectrometry of long-chain unsaturated alcohols, acetates, and aldehydes, Application of (Z)-Dodec-9-en-1-yl acetate, the publication is Analytical Chemistry (1990), 62(3), 287-93, database is CAplus.

NO⁺ chem.-ionization mass spectrometry is a highly efficient tool for locating the C:C double bond in long-chain monounsaturated alcs., acetates, and aldehydes Me(CH₂)_xCH:CH(CH₂)_yR (R = CH₂OH, CH₂OAc, CHO). The double bond assignment is mostly provided by the presence of an acylium ion C_x+2H_2x+3O⁺ formed from the alkyl side of the mol. When the double bond is close to the terminal oxygen function (y ≤ 2), a C_y+3H_2y+4NO⁺ ion may also be used as a complementary diagnostic ion. In the case of di- or triethylenic compounds, an acylium ion is also formed which characterizes the external (unconjugated) double-bond position. From the observed strong influence of the sample pressure on the formation of the acylium ion and results of MS/MS experiments, two mechanisms are proposed to explain the origin of this diagnostic ion. Although some instrument dependence may not be excluded, the method is optimally applicable to moderate sample loads (20-200 ng).

Analytical Chemistry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Application of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Abadleh, Mohammed M. published the artcileSynthesis and Biological Activity of Some New N1-(6-fluoro-4-oxoquinolin-8-yl)amidrazones, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is Letters in Organic Chemistry (2014), 11(9), 664-670, database is CAplus.

A selected set of five N1-(6-fluoro-4-oxoquinolin-8-yl)amidrazone-3-carboxylates incorporating piperazines and related congeners has been synthesized by reacting the hydrazonoyl chloride, derived from 8-amino-6-fluoro-4-oxoquinline-3-carboxylate, with the appropriate sec-cyclic amines. Their suggested structures are supported by elemental anal., 1H NMR, 13C NMR and ESI-HRMS spectral data. These novel compounds were screened for their antitumor and antibacterial activity. While no significant antitumor activity was observed, three compounds, e.g. I, have shown moderate in vitro antibacterial activity against Gram pos. bacteria cells. Unlike the others, compound I has also shown to moderately inhibit the growth of Gram neg. bacteria.

Letters in Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Safety of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Huniti, Mohammed H. published the artcileHeterocycles [h]fused onto 4-oxoquinoline-3-carboxylic acid, Part IV. Convenient synthesis of substituted hexahydro[1,4]thiazepino[2,3-h]quinoline-9-carboxylic acid and its tetrahydroquino[7,8-b]benzothiazepine homolog, Computed Properties of 924-99-2, the publication is Molecules (2007), 12(8), 1558-1568, database is CAplus and MEDLINE.

Substituted [1,4]thiazepino[2,3-h]quinolinecarboxylate I is prepared by PPA-catalyzed thermal lactamization of the resp. 8-amino-7-[(2-carboxyethyl)thio]-1,4-dihydroquinoline-3-carboxylate. The latter synthon is obtained by reduction of the 8-nitro-1,4-dihydroquinoline precursor 8 which, in turn, is made accessible via interaction of 3-mercaptopropionate with 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-1,4-dihydroquinoline-3-carboxylate (II) in the presence of Et₃N. A benzo-homolog of I, namely tetrahydroquino[7,8-b]benzothiazepine-3-carboxylate, is analogously prepared via the reaction of 2-mercaptobenzoate with II, followed by reduction of the resulting 7-[(2-carboxyphenyl)thio]-8-nitro product into the corresponding 8-amino derivative, and subsequent lactamization.

Molecules published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Sinjilawi, Hadeel T. published the artcileSynthesis and antibacterial activity of some novel 4-oxopyrido[2,3-a]phenothiazines, SDS of cas: 924-99-2, the publication is Archiv der Pharmazie (Weinheim, Germany) (2014), 347(11), 861-872, database is CAplus and MEDLINE.

A series of substituted 4-oxopyrido[2,3-a]phenothiazine-3-carboxylic acids I [R = H ; X = H, CH₃, OCH₃, Cl] was prepared via cyclization of 4-oxoquinoline-3-carboxylates II, followed by hydrolysis of the resultant esters I [R = C₂H₅]. Synthesized carboxylic acids I [R = H] were evaluated for their antibacterial activity. Among the tested carboxylic acids, I [R = H ; X = H] was most active against representative Gram-pos. and Gram-neg. bacterial strains and these compounds were also active against Methicillin-resistant Staphylococcus aureus (MRSA) with very low toxicity to the normal cells. Virtual screening using ligand-protein docking modeling predicted that the compounds I [R = H] were potential inhibitors of the topoisomerase IV enzyme and that hydrophobic interactions and hydrogen bonds were the major mol. interactions between these compounds and the residues of the active site of topoisomerase IV.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Trawneh, Salah A. published the artcileA new efficient route to 7-aryl-6-fluoro-8-nitroquinolones as potent antibacterial agents, Product Details of C7H13NO2, the publication is European Journal of Medicinal Chemistry (2014), 364-367, database is CAplus and MEDLINE.

A series of 7-aryl-6-fluoro-8-nitroquinolones were synthesized through a novel, simple and clean synthetic procedure, through a Suzuki-Miyaura reaction. The target compounds were evaluated in vitro for their antimicrobial properties against bacterial and fungal strains. All of them showed antibacterial activity higher than the activity of ciprofloxacin, both towards Gram pos. Bacillus subtilis and Staphylococcus aureus, and Gram neg. Haemophilus influenzae strains. Compound 1-Cyclopropyl-6-fluoro-7-(4-methoxy-3,5-dimethylphenyl)8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, containing the trisubstituted 7-aryl moiety, emerged as the most active quinolone derivative with MIC values ranging from 0.00007 μg/mL to 0.015 μg/mL.

European Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Product Details of C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fathy, Samah M. published the artcileNeuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson′s disease, Name: Propyl 3,4,5-trihydroxybenzoate, the publication is BMC Complementary Medicine and Therapies (2021), 21(1), 130, database is CAplus and MEDLINE.

Paraquat, (PQ), an herbicide that can induce Parkinsonian-like symptoms in rodents and humans. The consumption of phytochem.-rich plants can reduce the risk of chronic illnesses such as inflammation and neurodegenerative diseases. The present study aimed to investigate the protective effects of pomegranate seed extract (PSE) and juice (PJ) against PQ-induced neurotoxicity in mice. Mice were assigned into 4 groups; three groups received PQ (10 mg/kg, i.p.) twice a week for 3 wk. Two of the PQ-induced groups pretreated with either PSE or PJ. Detection of phytochems., total phenolics, and total flavonoids in PSE and PJ was performed. Tyrosine hydroxylase (TH) level was measured in the substantia nigra (SN) by Western blotting technique. Striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were detected using high-performance liquid chromatog. (HPLC). The levels of ATP (ATP), malondialdehyde (MDA), and the activity of the antioxidant enzymes were estimated in the striatum by colorimetric anal. Striatal pro-inflammatory and anti-inflammatory markers using ELISA (ELISA) as well as DNA fragmentation degree by qual. DNA fragmentation assay, were evaluated. Real-time polymerase chain reaction (qPCR) assay was performed for the detection of nuclear factor kappa B (NF-kB) gene expression. Moreover, Western blotting anal. was used for the estimation of the cluster of differentiation 11b (CD11b), transforming growth factor β (TGF-β), and glial cell-derived neurotrophic factor (GDNF) levels in the striatum. Pretreatment with PSE or PJ increased the levels of TH in the SN as well as DA and its metabolite in the striatum that were reduced by PQ injection. PSE and PJ preadministration improved the PQ-induced oxidative stress via a significant reduction of the MDA level and the augmentation of antioxidant enzyme activities. PSE and PJ also significantly downregulated the striatal NF-kB gene expression, reduced the PQ-enhanced apoptosis, decreased the levels of; pro-inflammatory cytokines, CD11b, and TGF-β coupled with a significant increase of; interleukin-10 (IL-10), GDNF, and ATP levels as compared with PQ-treated mice. The current study indicated that PSE and PJ consumption may exhibit protective effects against PQ-induced neurotoxicity in mice.

BMC Complementary Medicine and Therapies published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Name: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

D′Arcy, Tom D. published the artcileOrganocatalytic Enantioselective Synthesis of Bicyclo[2.2.2]octenones via Oxaziridinium Catalysed ortho-Hydroxylative Phenol Dearomatization, HPLC of Formula: 126613-06-7, the publication is Angewandte Chemie, International Edition (2022), 61(30), e202205278, database is CAplus and MEDLINE.

Hydroxylative dearomatization reactions of phenols (HPD) offer an efficient way to assemble complex, biol. relevant scaffolds. Despite this, enantioselective hydroxylative phenol dearomatizations for the construction of bicyclo[2.2.2]octenones are classically limited to stoichiometric chiral reagents, and a practical, enantioselective catalytic method has remained elusive. Herein, authors describe a highly enantioselective, organocatalytic tandem o-HPD-[4+2] reaction. Authors methodol. utilizes a chiral oxaziridinium organocatalyst, that is available in both enantiomeric forms, to afford dearomatized products in high enantioselectivity over a range of phenol substitution patterns. This approach was applied to the highly enantioselective synthesis of (+)-biscarvacrol (99 : 1 e.r.) and (-)-bis(2,6-xylenol) (94 : 6 e.r.). The practicality of authors conditions was demonstrated at gram-scale, using an amine precatalyst, accessible in a single synthetic step.

Angewandte Chemie, International Edition published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, HPLC of Formula: 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Parker, Seth J. published the artcileSpontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters, Recommanded Product: Dimethyl itaconate, the publication is Nature Communications (2021), 12(1), 4905, database is CAplus and MEDLINE.

α-ketoglutarate (KG), also referred to as 2-oxoglutarate, is a key intermediate of cellular metabolism with pleiotropic functions. Cell-permeable esterified analogs are widely used to study how KG fuels bioenergetic and amino acid metabolism and DNA, RNA, and protein hydroxylation reactions, as cellular membranes are thought to be impermeable to KG. Here we show that esterified KG analogs rapidly hydrolyze in aqueous media, yielding KG that, in contrast to prevailing assumptions, imports into many cell lines. Esterified KG analogs exhibit spurious KG-independent effects on cellular metabolism, including extracellular acidification, arising from rapid hydrolysis and de-protonation of α-ketoesters, and significant analog-specific inhibitory effects on glycolysis or mitochondrial respiration. We observe that imported KG decarboxylates to succinate in the cytosol and contributes minimally to mitochondrial metabolism in many cell lines cultured in normal conditions. These findings demonstrate that nuclear and cytosolic KG-dependent reactions may derive KG from functionally distinct subcellular pools and sources.

Nature Communications published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics