Category: esters-buliding-blocks

2-Pyrrolidinylideneureas, a new class of central nervous system agents was written by Rasmussen, C. R.;Gardocki, Joseph F.;Plampin, James N.;Twardzik, Barbara L.;Reynolds, Brian E.;Molinari, Albert J.;Schwartz, Norman;Bennetts, Walter W.;Price, Beth E.;Marakowski, Janis. And the article was included in Journal of Medicinal Chemistry in 1978.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:

Pyrrolidinylideneureas (I) were prepared and screened for pharmacol. activity. I (X = H, 4-NO₂, 3-Br, 3-F, 3-Cl, 3-Me) had anxiolytic activity. I 2,6-disubstituted with Me, Cl, and Br imparted potent muscle-relaxant properties which appear to be centrally mediated. A significant separation of the anxiolytic and muscle-relaxant properties fromother CNS activities, eg, anticonvulsant, sedative, and hypnotic, was achieved. I were prepared by treating 2-imino-1-methylpyrrolidines with aryl isocyanates. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Autoxidation in the presence of alcohols and protons. III. Autoxidation of cyclenes, hydroarenes, and hydroheterocycles was written by Treibs, Wilhelm;Schoellner, Roll. And the article was included in Chemische Berichte in 1961.Computed Properties of C11H14O3 This article mentions the following:

Cyclohexene (I) and Tetralin (II) yield by autoxidation in the presence of alcs. and protons 浼?ketones and also under cleavage of the C-C bond neighboring the place of the O attack (CH₂CH₂-CHO)₂ (III) and o-HOC₆H₄(CH₂)₃CHO (IV) which are stabilized as the acetals. The autoxidation of I yielded also as the result of a Prilesehayev-type reaction o-methoxycyclohexanol (V), 2-methoxy-1,3-cyclohexanediol (VI), and 3-methoxycyclohexene (VII). 1,2,3,4,10,11-Hexahydrodiphenylene oxide (VIII) yields similarly 1,2,3,4,11,12hexahydro-12-methoxydibenzodioxane (IX) and 1,2,3,4,10,11-hexahydro-10-methoxydiphenylene oxide (X). I (200 g.), 1500 cc. absolute MeOH, and 3 cc. concentrated H₂SO₄ irradiated 120 hrs. under O at 60鎺?with ultraviolet light, neutralized with NaHCO₃, decanted, and fractionated gave 7-8 g. VII, b. 135-6鎺? n¹_D² 1.463, 14 g. distillate, b₁₆ 67-9鎺?n¹_D⁰ 1.4700, which chromatographed yielded cyclohexen-3-one, n²_D⁰ 1.4798 (2,4-dinitrophenylhydrazone, m. 164-6鎺?, and V, n¹_D⁰ 1.4612, 3-4 g. cyclic di-Me acetal of III, b₁₅ 82-4鎺? n²_D⁰ 1.432 [bis(2,4-dinitrophenylhydrazone) of III, m. 216-17鎺砞, and 29 g. distillate, b₁₅ 98-118鎺? which chromatographed gave 50-5% bis(dimethyl acetal) of III, b₁₂ 103-8鎺?26-30% MeO₂C(CH₄)₄CH(OMe)₂ (2,4-dinitrophenylhydra zone m. 101鎺?, and 18-20% VI, n²_D⁰ 1.468. II (200 g.), 1500 cc. absolute MeOH, and 2.5 cc. concentrated H₂SO₄ irradiated 240 hrs. under O at 60鎺? and the crude product (30 g.) distilled gave 11 g. 浼?tetralone, b₁₂ 130鎺?(2,4-dinitrophenylhydrazone m. 257-8鎺?, 10 g. di-Me acetal of IV (2,4-dinitrophenylhydrazone of IV m. 148鎺?, and 15-20% o-HOC₆H₄(CH₂)₃CO₂Me. Diphenylene oxide in absolute EtOH hydrogenated at 120鎺?110 atm. gave 45-50% VIII, b_0.04 51-2鎺? n²_D⁰ 1.545, and some perhydrodiphenylene oxide, b₂₀ 130-4鎺? and 0-phenylcyclohexanol, b₂0 149-53鎺? VIII (150 g.) in 1500 cc. absolute MeOH and 2.5 cc. concn H₂SO₄ autoxidized under O during 96 hrs. at 60鎺? neutralized with NH₃, concentrated, and distilled gave a crude product, b_0.3 93-6鎺? n²_D⁰ 1.541, which chromatographed on Al₂O₃ yielded X, n²_D⁰ 1.5533, and IX. X (1 g.), 10 cc. 2N HCl, and 5 cc. MeOH refluxed 6 hrs., neutralized with NH₃, concentrated, and chromatographed gave the 10-OH analog of X, m. 102鎺? IX (1 g.), 20 cc. 0.1N HCl, and 5 cc. MeOH refluxed 6 hrs., and the crude product chromatographed on Al₂O₂ yielded 0.6 g. pure IX, m. 64-8鎺? n⁸_D⁰ 1.542, and an unidentified material. Cumene (150 g.) autoxidized under the usual conditions during 360 hrs. gave 10-12 g. product containing 12-15% AcPh (2,4-dinitrophenylhydrazone m. 247鎺?. Com. cumene hydroperoxide (60%) (20 g.) added dropwise to 0.5 cc. concentrated H₂SO₄ in 250 cc. absolute MeOH, cooled, neutralized with NaHCO₃, and fractionated yielded 6.7 g. cumene and 1.4 g. AcPh. In the experiment, the researchers used many compounds, for example, Methyl 4-(2-hydroxyphenyl)butanoate (cas: 93108-07-7Computed Properties of C11H14O3).

Methyl 4-(2-hydroxyphenyl)butanoate (cas: 93108-07-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C11H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of Inhibitors of Checkpoint Kinase 1 through Template Screening was written by Matthews, Thomas P.;Klair, Suki;Burns, Samantha;Boxall, Kathy;Cherry, Michael;Fisher, Martin;Westwood, Isaac M.;Walton, Michael I.;McHardy, Tatiana;Cheung, Kwai-Ming J.;Van Montfort, Rob;Williams, David;Aherne, G. Wynne;Garrett, Michelle D.;Reader, John;Collins, Ian. And the article was included in Journal of Medicinal Chemistry in 2009.SDS of cas: 173341-02-1 This article mentions the following:

Checkpoint kinase I (CHKI) is an oncol. target of significant current interest. Inhibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient cancer cells to genotoxic therapies. Using template screening, a fragment-based approach to small mol. hit generation, we have identified multiple CHK1 inhibitor scaffolds suitable for further optimization. The sequential combination of in silico low mol. weight template selection, a high concentration biochem. assay and hit validation through protein-ligand X-ray crystallog. provided 13 template hits from an initial in silico screening library of ca. 15000 compounds The use of appropriate counter-screening to rule out nonspecific aggregation by test compounds was essential for optimum performance of the high concentration bioassay. One low mol. weight, weakly active purine template hit was progressed by iterative structure-based design to give submicromolar pyrazolopyridines with good ligand efficiency and appropriate CHK1-mediated cellular activity in HT29 colon cancer cells. In the experiment, the researchers used many compounds, for example, tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1SDS of cas: 173341-02-1).

tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 173341-02-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cyclization of alk-5-ynyl ketones promoted by Tf₂NH and In(OTf)₃: selective synthesis of 5- and 7-membered carbocycles was written by Kinoshita, Hidenori;Miyama, Chika;Miura, Katsukiyo. And the article was included in Tetrahedron Letters in 2016.Computed Properties of C10H14O4 This article mentions the following:

Combined use of Tf₂NH and In(OTf)₃ effectively promotes the cyclization of alk-5-ynyl ketones to cyclopent-1-enyl ketones at 30 鎺矯 [e.g., I 閳?II (77%)]. Single use of Tf₂NH or In(OTf)₃ requires heating at 50 鎺矯 for efficient cyclization. The In(OTf)₃-promoted reaction of certain alk-5-ynyl ketones gives cyclohept-2-enones mainly. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Computed Properties of C10H14O4).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C10H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Influence of Freezing and Different Drying Methods on Volatile Profiles of Strawberry and Analysis of Volatile Compounds of Strawberry Commercial Jams was written by Abouelenein, Doaa;Mustafa, Ahmed M.;Angeloni, Simone;Borsetta, Germana;Vittori, Sauro;Maggi, Filippo;Sagratini, Gianni;Caprioli, Giovanni. And the article was included in Molecules in 2021.Recommanded Product: 868-57-5 This article mentions the following:

Strawberry is the most consumed berry fruit worldwide due to its unique aroma and flavor. Drying fruits to produce a powder represents one of the possible conservation methods to extend their shelf-life. The aim of the present study was to compare the influence of freezing and different drying methods on the volatile profile of strawberry using the HS-SPME/GC-MS method, in addition to anal. of strawberry jam volatiles. A total of 165 compounds were identified, accounting for 85.03-96.88% of the total volatile compositions Results and PCA showed that freezing and each drying process affected the volatile profile in a different way, and the most remarkable representative differential volatiles were Et hexanoate, hexyl acetate, (E)-2-hexenyl acetate, mesifurane, (E)-nerolidol, 绾?decalactone, 1-hexanol, and acetoin. Shade air-dried, frozen, freeze-dried, and oven-dried 45鎺矯 samples retained more of the fruity and sweet aromas of strawberry, representing more than 68% of the total aroma intensity according to the literature. In contrast, the microwave-drying method showed drastic loss of fruity esters. Strawberry jams demonstrated complete destruction of esters and alcs. in most jams, while terpenes were significantly increased. These findings help better understand the aroma of strawberry and provide a guide for the effects of drying, freezing, and jam processing. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Recommanded Product: 868-57-5).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 868-57-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deeper Insight into the Volatile Profile of Rosa willmottiae with Headspace Solid-Phase Microextraction and GC-MS Analysis was written by Jiao, Ruifang;Gao, Ping;Gao, Xinfen. And the article was included in Molecules in 2022.Reference of 105-87-3 This article mentions the following:

As the distribution center of Rosa in the world, China has abundant wild germplasm resources, which can contribute to the breeding of modern roses. To explore the potential value of wild roses distributed in the Sichuan-Tibet region, solid phase microextraction (SPME) and gas chromatog.-mass spectrometry (GC-MS) were used to determine the volatile organic compounds (VOCs) in Rosa willmottiae flowers at three flowering stages (bud stage, initial flowering stage, full flowering stage). Meanwhile, we compared the VOCs of R. willmottiae with different phenotypes (double flowers and single flowers). A total of 74 volatile compounds were identified. The results show that the essential substances belong to alcs. and terpenoids. The main volatile organic compounds are 2-Ph ethanol (20.49%), benzyl alc. (10.69%), 灏?maaliene (8.66%), geranyl acetate (8.47%), and (+)-浼?long pinene (6.127%). Different flowering stages had great influence on the volatile profile, from the bud stage to full flowering stage; the content of terpenoids released decreased by 6.17%, whereas alcs. and esters increased by 8.58% and 11.56%, resp. The chem. diversity and the content of the main components with a different phenotype were not significantly different. Our result will provide a theor. basis for the development and utilization of Rosa willmottiae in Sichuan and Tibet. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Reference of 105-87-3).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 105-87-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A metabolomics comparison of Lactobacillus communities isolated from breast milk and camel milk and Lactobacillus apis isolated from bee gut during cereals-based fermentation vs. Lactobacillus plantarum as a reference was written by Ghamry, Mohamed;Li, Li;Zhao, Wei. And the article was included in LWT–Food Science and Technology in 2021.HPLC of Formula: 706-14-9 This article mentions the following:

New and unconventional sources of probiotics may provide unique health efficacy by producing healthy, bioactive compounds The current study evaluates the fermentation efficiency and intrinsic effects on the bioactive substances produced by Lactobacillus apis (L. apis) as a novel strain isolated from the bumblebee gut, two different isolated Lactobacillus communities from breast milk (L.BM) and camel milk (L.CM). Lactobacillus plantarum (L. plantarum) was used as a reference during rice and oats fermentation The obtained results indicated that L.BM and L. CM treatments gave the highest production of phenolics and flavonoids values for different substrates and had the highest impact on the antioxidant capacity. All treatments demonstrated the ability to improve protein quality and properties significantly as compared to non-fermented flours. The best patterns were obtained with L.BM, followed by L. apis and L.CM compared with L. plantarum and non-fermented rice samples. The L.BM and L. apis showed a significant enhancement of volatile components in fermented rice, while L. CM displayed a pronounced effect on volatile production among oats treatments. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9HPLC of Formula: 706-14-9).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.HPLC of Formula: 706-14-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas was written by Temal, Taoues;Jary, Helene;Auberval, Marielle;Lively, Sarah;Guedin, Denis;Vevert, Jean-Paul;Deprez, Pierre. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Product Details of 16413-26-6 This article mentions the following:

Starting from Fendiline and R-568, a novel series of urea compounds, e.g. I [R¹ = H, i-Bu, t-BuO₂CCH₂, 2-(4-morpholinyl)ethyl, etc.; R² = 4-Me, 3-MeO₂C, 2-thiazolyl, etc.], was identified as pos. allosteric modulators of the calcium sensing receptor (CaSR), as part of a program to identify novel therapeutics for secondary hyperparathyroidism. Initially identified disubstituted ureas were converted to trisubstituted urea lead I [R¹ = 2-(4-morpholinyl)ethyl; R² = 3-MeO₂C], which was further modified to increase in vivo potency. Replacing a carbomethoxy substituent by various bioisosteres led to compound I [R¹ = 2-(4-morpholinyl)ethyl; R² = 5-oxazolyl] which exhibited potent in vitro and in vivo activity after oral administration. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Micro-Nanometer Particle Composition and Functional Design of Surface Nano-Structured Ammonium Polyphosphate and Its Application in Intumescent Flame-Retardant Polypropylene was written by Wu, Xiaolu;Qin, Zhaolu;Zhang, Xiang;Yu, Zhenfei;Zhang, Wenchao;Yang, Rongjie;Li, Dinghua. And the article was included in Nanomaterials in 2022.Application In Synthesis of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) This article mentions the following:

A novel composite and functional micro-nanometer particle is designed by the hydrolysis of aluminum isopropoxide on the surface of ammonium polyphosphate (APP) to prepare surface nanostructured ammonium polyphosphate (NSAPP). NSAPP is characterized by XPS, XRF, SEM, water solubility tests, and TGA. Results indicate that nanosized aluminum hydroxide is deposited on the surface of NSAPP, which enhanced its water resistance and thermostability. Then, APP and NSAPP coupled with dipentaerythritol (DPER) is used for the flame retardant of polypropylene (PP). The limiting oxygen index value of the PP/DPER/NSAPP composite is higher than that of PP/DPER/APP. Besides, the UL 94 vertical burning test of PP/DPER/NSAPP composites can reach the V-0 rating easily. According to the study of the combustion behavior of FR-PP composites, NSAPP contributes to form a dense and multi-layered char in the combustion process. Thus, such an intumescent char with a ceramic-like, continuous, and dense structure over the PP matrix protects the underlying matrix and enhances the thermal stability of the condensed phase, thereby improving the flame retardant performance of FR-PP. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Application In Synthesis of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Risk assessment of agricultural plastic films based on release kinetics of phthalate acid esters was written by Wang, Yu;Wang, Fang;Xiang, Leilei;Gu, Chenggang;Redmile-Gordon, Marc;Sheng, Hongjie;Wang, Ziquan;Fu, Yuhao;Bian, Yongrong;Jiang, Xin. And the article was included in Environmental Science & Technology in 2021.COA of Formula: C20H26O4 This article mentions the following:

Plastic films have become an integral part of fruit and vegetable production systems, but their release of phthalate acid esters (PAEs) is a threat to human health. The release kinetics of PAEs and measures of risk are still not well understood. We investigated 50 agricultural films, with concentrations ranging from 2.59 to 282,000 mg kg^-1. The seven com. available film types included were polyvinylchloride (PVC), metallocene polyethylene (mPE), ethylene vinyl acetate (EVA), polyolefin (PO), and three mulch films. Bis(2-ethylhexyl) phthalate (DEHP) was detected in most of films, and its release fitted well into the first-order kinetic model. The release rate of DEHP was neg. related to the film thickness. The potential carcinogenic risks of DEHP in the air of six kinds of plastic greenhouses to human health were estimated We found that the carcinogenic risks associated with PVC and mPE greenhouse films warrant greater attention. Though EVA, PO greenhouse, and mulch films were lower risk, we advise keeping plastic greenhouses well ventilated during the first month of use to reduce direct human exposure to volatile PAEs. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7COA of Formula: C20H26O4).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120掳 C鈥揅鈥揙 and O鈥揅鈥揙 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C鈥揙鈥揅 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C20H26O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics