Category: esters-buliding-blocks

Shrestha, Shyam Sharan published the artcileHimalayan nettle Girardinia diversifolia as a candidate ingredient for pharmaceutical and nutraceutical applications-phytochemical analysis and in vitro bioassays, Name: Methyl docosanoate, the main research area is Girardinia extract phytochem pharmaceutical nutraceutical cosmetics; LC-MS; LDLR; NMR; cytotoxicity; low-density lipoprotein receptor; phytosterols; polyphenols.

Girardinia diversifolia, also known as Himalayan nettle, is a perennial herb used in Nepal to make fiber as well as in traditional medicine for the treatment of several diseases. To date, phytochem. studies and biol. assays on this plant are scarce. Thus, in the present work, the G. diversifolia extracts have been evaluated for their potential pharmaceutical, cosmetic and nutraceutical uses. For this purpose, detailed phytochem. analyses were performed, evidencing the presence of phytosterols, fatty acids, carotenoids, polyphenols and saponins. The most abundant secondary metabolites were β- and γ-sitosterol (11 and 9% dw, resp.), and trans syringin (0.5 mg/g) was the most abundant phenolic. Fatty acids with an abundant portion of unsaturated derivatives (linoleic and linolenic acid at 22.0 and 9.7 mg/g resp.), vitamin C (2.9 mg/g) and vitamin B2 (0.12 mg/g) were also present. The antioxidant activity was moderate while a significant ability to inhibit acetylcholinesterase (AChE), butyrilcholinesterase (BuChE), tyrosinase, α-amylase and α-glucosidase was observed A cytotoxic effect was observed on human ovarian, pancreatic and hepatic cancer cell lines. The effect in hepatocarcinoma cells was associated to a downregulation of the low-d. lipoprotein receptor (LDLR), a pivotal regulator of cellular cholesterol homeostasis. These data show the potential usefulness of this species for possible applications in pharmaceuticals, nutraceuticals and cosmetics.

Molecules published new progress about Antioxidants. 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Name: Methyl docosanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mohammadi, Ghobad published the artcileChemical characterization and anti-breast cancer effects of silver nanoparticles using Phoenix dactylifera seed ethanolic extract on 7,12-Dimethylbenz[a] anthracene-induced mammary gland carcinogenesis in Sprague Dawley male rats, Formula: C11H22O2, the main research area is breast cancer silver nanoparticle Phoenix seed extract antitumor.

The aim of the recent research was to investigate the anti-breast cancer effects of silver nanoparticles using Phoenix dactylifera seed ethanolic extract (AgNPs). After preparation of Phoenix dactylifera seed extract, GC/MS was performed to detect the compounds The findings indicated that 9-Octadecenoic acid (Z)- Me ester (40.95%) and Dodecanoic acid Me ester (20%) were the most frequent constituents found in P. dactylifera. These nanoparticles were spherical with a size range of 17-19 nm and characterized using various anal. techniques including UV-Vis absorption spectroscopy to determine the presence of AgNPs in the solution We studied functional groups of P. dactylifera extract in the reduction and capping process of AgNPs by FT-IR, crystallinity and FCC planes by X-ray diffraction (XRD) pattern and surface morphol., shapes, and size of AgNPs by SEM and transmission electron microscopy (TEM). DPPH free radical scavenging test was used to test the antioxidant properties of P. dactylifera and AgNPs, which revealed high antioxidant potential similar to butylated hydroxy toluene (BHT) as the pos. control. The results of cytotoxicity anal. indicated that P. dactylifera and AgNPs were toxic for MCF-7 cells. In vivo design, induction of breast cancer was done by 7,12-Dimethylbenz[a] anthracene (DMBA) in 50 animals. After 10 days, the animals were randomly divided into six subgroups, including healthy control, untreated control, two groups receiving the P. dactylifera at 2 and 6 mg/kg and two groups receiving the AgNPs at 2 and 6 mg/kg concentrations Both doses of P. dactylifera and AgNPs (especially AgNPs6) significantly (p â‰?0.05) reduced the weight and volume of liver, mammary gland, kidney, spleen, ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, glucose, ferrous, ferritin, erythropoietin, GR, IL1, IL6, IL12, IL18, IFNY, and TNFα and increased HDL, total protein, albumin, WBC, lymphocyte, neutrophils, platelet, RBC, Hb, PCV, MCV, MCH, MCHC, SOD, CAT, GPx, IL4, IL5, IL10, IL13, and IFNα compared to the untreated group. Moreover, P. dactylifera and AgNPs (especially AgNPs6) significantly (p â‰?0.05) treated breast cancer with reduction of organs free of metastasis compared to the untreated group. Seemingly, the AgNPs can be used for the treatment of breast cancer.

Applied Organometallic Chemistry published new progress about Antioxidants. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Formula: C11H22O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mohammadi, Ghobad published the artcileChemical characterization and anti-breast cancer effects of silver nanoparticles using Phoenix dactylifera seed ethanolic extract on 7,12-Dimethylbenz[a] anthracene-induced mammary gland carcinogenesis in Sprague Dawley male rats, SDS of cas: 111-11-5, the main research area is breast cancer silver nanoparticle Phoenix seed extract antitumor.

The aim of the recent research was to investigate the anti-breast cancer effects of silver nanoparticles using Phoenix dactylifera seed ethanolic extract (AgNPs). After preparation of Phoenix dactylifera seed extract, GC/MS was performed to detect the compounds The findings indicated that 9-Octadecenoic acid (Z)- Me ester (40.95%) and Dodecanoic acid Me ester (20%) were the most frequent constituents found in P. dactylifera. These nanoparticles were spherical with a size range of 17-19 nm and characterized using various anal. techniques including UV-Vis absorption spectroscopy to determine the presence of AgNPs in the solution We studied functional groups of P. dactylifera extract in the reduction and capping process of AgNPs by FT-IR, crystallinity and FCC planes by X-ray diffraction (XRD) pattern and surface morphol., shapes, and size of AgNPs by SEM and transmission electron microscopy (TEM). DPPH free radical scavenging test was used to test the antioxidant properties of P. dactylifera and AgNPs, which revealed high antioxidant potential similar to butylated hydroxy toluene (BHT) as the pos. control. The results of cytotoxicity anal. indicated that P. dactylifera and AgNPs were toxic for MCF-7 cells. In vivo design, induction of breast cancer was done by 7,12-Dimethylbenz[a] anthracene (DMBA) in 50 animals. After 10 days, the animals were randomly divided into six subgroups, including healthy control, untreated control, two groups receiving the P. dactylifera at 2 and 6 mg/kg and two groups receiving the AgNPs at 2 and 6 mg/kg concentrations Both doses of P. dactylifera and AgNPs (especially AgNPs6) significantly (p â‰?0.05) reduced the weight and volume of liver, mammary gland, kidney, spleen, ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, creatinine, glucose, ferrous, ferritin, erythropoietin, GR, IL1, IL6, IL12, IL18, IFNY, and TNFα and increased HDL, total protein, albumin, WBC, lymphocyte, neutrophils, platelet, RBC, Hb, PCV, MCV, MCH, MCHC, SOD, CAT, GPx, IL4, IL5, IL10, IL13, and IFNα compared to the untreated group. Moreover, P. dactylifera and AgNPs (especially AgNPs6) significantly (p â‰?0.05) treated breast cancer with reduction of organs free of metastasis compared to the untreated group. Seemingly, the AgNPs can be used for the treatment of breast cancer.

Applied Organometallic Chemistry published new progress about Antioxidants. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, SDS of cas: 111-11-5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Leitemperger, Jossiele published the artcileBehavioural and biochemical parameters in guppy (Poecilia vivipara) following exposure to waterborne zinc in salt or hard water, COA of Formula: C24H14Cl2O7, the main research area is Poecilia behavior locomotion salt water lipid peroxidation acetylcholinesterase; Environmental risk; Estuarine fish; Hardness; IBR; Metal; Salinity.

Therefore, this study aimed investigate the influence of salinity, hardness on Zn toxicity on the behaviors and biochem. parameters of the estuarine guppy (Poecilia vivipara). The fish were exposed to waterborne zinc (500μg L-1) in salt water (25 ppt) or hard water (120 mg L-1 CaCO3). For behavioral anal., the locomotive and exploratory parameters of fish in novel environment and light-dark tests were evaluated. We observed that exposure to hard water decreased the distance covered by the fish, and when zinc also present the vertical exploratory behavior decreased. When zinc was tested alone, an increase in the maximum speed of fish was recorded. Activities of antioxidant enzymes, levels of lipid peroxidation, protein carbonylation, total peroxidation and, reactive oxygen species content, antioxidant capacity against peroxyl radicals, non-proteins thiols levels, acetylcholinesterase and Na+/K+-ATPase activities were evaluated in the whole fish body. The integrated biomarker response was calculated for each parameter to aid in the interpretation of the results and indicated that hard water containing zinc had the greatest effect on the biochem. parameters of the fish. In general, neither salinity nor hardness were totally effective in protecting the guppy from the biochem. damage caused by exposure to zinc.

Molecular Biology Reports published new progress about Antioxidants. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, COA of Formula: C24H14Cl2O7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xue-Hui published the artcileJejunal epithelial barrier disruption triggered by reactive oxygen species in early SIV infected rhesus macaques, SDS of cas: 2044-85-1, the main research area is jejunal epithelial barrier disruption reactive oxygen species; simian immunodeficiency virus infection rhesus macaques; Epithelial barrier disruption; Jejunum; Mitochondrial dysfunction; Reactive oxygen species; SIV infection.

Intestinal epithelial barrier destruction occurs earlier than mucosal immune dysfunction in the acute stage of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections. At present, however, the cause of compromised gastrointestinal integrity in early SIV infection remains unknown. In the current study, we investigated the effects of SIV infection on epithelial barrier integrity and explored oxidative stress-mediated DNA damage and apoptosis in epithelial cells from early acute SIVmac239-infected Chinese rhesus macaques (Macaca mulatta). Results showed that the sensitive mol. marker of small intestinal barrier dysfunction, i.e., intestinal fatty acid-binding protein (IFABP), was significantly increased in plasma at 14 days post-SIV infection. SIV infection induced a profound decrease in the expression of tight junction proteins, including claudin-1, claudin-3, and zonula occludens (ZO)-1, as well as a significant increase in the active form of caspase-3 level in epithelial cells. RNA sequencing (RNA-seq) anal. suggested that differentially expressed genes between pre- and post-SIV-infected jejuna were enriched in pathways involved in cell redox homeostasis, oxidoreductase activity, and mitochondria. Indeed, a SIV-mediated increase in reactive oxygen species (ROS) in the epithelium and macrophages, as well as an increase in hydrogen peroxide (H2O2) and decrease in glutathione (GSH)/glutathione disulfide (GSSG) antioxidant defense, were observed in SIV-infected jejuna. In addition, the accumulation of mitochondrial dysfunction and DNA oxidative damage led to an increase in senescence-associated β-galactosidase (SA-β-gal) and early apoptosis in intestinal epithelial cells. Furthermore, HIV-1 Tat protein-induced epithelial monolayer disruption in HT-29 cells was rescued by antioxidant N-acetylcysteine (NAC). These results indicate that mitochondrial dysfunction and oxidative stress in jejunal epithelial cells are primary contributors to gut epithelial barrier disruption in early SIV-infected rhesus macaques.

Free Radical Biology & Medicine published new progress about Antioxidants. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, SDS of cas: 2044-85-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shan, Kun published the artcileRNA-seq identifies long non-coding RNAs as potential therapeutic targets for human corneal endothelial dysfunction under oxidative stress, Safety of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, the main research area is long noncoding RNA therapeutic target human corneal endothelial dysfunction; Corneal endothelium; Epigenetics; Oxidative stress; lncRNAs.

Human corneal endothelial cells (CECs) have limited ability to regenerate in vivo. Oxidative stress has been proposed as one potential reason. Understanding the mechanism of oxidative stress-induced CEC dysfunction might provide novel targets for improving CEC regenerative capacity, and help develop non-surgical therapeutic strategies for CEC dysfunction. Long non-coding RNAs (lncRNAs) are non-coding transcripts with multiple biol. functions. The roles of lncRNAs in ocular cells under oxidative stress have been widely studied, such as lens epithelial cells, trabecular meshwork cells, and retinal ganglion cells. In the current study, we established oxidative stress-induced CEC dysfunction model in vitro. By RNA sequencing technol., we identified 824 differentially expressed lncRNAs in CEC dysfunction group, including 667 upregulated lncRNAs and 157 downregulated lncRNAs. We finally demonstrated that CEC functions under oxidative stress, including cellular proliferation, apoptosis, and anti-oxidative stress ability, could be regulated by different lncRNAs, including lncRNA-Z93241.1, lncRNA-XLOC_000818, and lncRNA-AC007952.4. Targeting these lncRNAs might be useful to further elucidate the pathol. of CEC dysfunction and develop novel therapeutic strategy.

Experimental Eye Research published new progress about Antioxidants. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Safety of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Slavova, Tatiana G. published the artcileEncapsulation of fragrances and oils by core-shell structures from silica nanoparticles, surfactant and polymer: Effect of particle size, SDS of cas: 140-11-4, the main research area is encapsulation fragrance oil silica nanoparticle surfactant polymer.

Oils and fragrances can be encapsulated by using composite shells of silica nanoparticles, polymer and surfactant (potassium oleate). The template for the creation of the core-shell structure is a particle stabilized (Pickering) emulsion. The surfactant adsorbs on the nanoparticles and leads to their reversible hydrophobization and adsorption on the oil/water interface. The outer layer of the self-assembled shell represents a layer from crosslinked polymer. The procedure of encapsulation is simple and includes single homogenization by ultrasound of the formulation that contains all ingredients together. The produced capsules have mean radius in the range between 2 and 11μ. By order of magnitude and trend, the capsule size follows the law of limited coalescence with respect to the dependence on nanoparticle size and concentration The composite structure of the shells leads also to dependence on the concentrations of added polymer and surfactant. The produced microcapsules are stable when rinsed with pure water of pH in the range 3 – 10. However, if dispersed in water of pH > 11, the microcapsules are destabilized and release their cargo, i.e., they are pH-responsive. Various fragrances and oils, such as limonene, citronellol, benzyl acetate, and sunflower seed oil were encapsulated. The developed methodol. could find applications in any field, in which reversible encapsulation of oily substances is needed.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about Encapsulation. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, SDS of cas: 140-11-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Corsini, Lara published the artcileCharacterization by gas chromatography-olfactometry of the most odour-active compounds in Italian balsamic vinegars with geographical indication, Category: esters-buliding-blocks, the main research area is balsamic vinegar odor compound geog GC olfactometry; Aroma; Balsamic vinegars from Modena; Gas chromatography-olfactometry; Geographical indication; Odour-active compounds.

Odor-active compounds in three traditional balsamic vinegars from Modena (TB) and seven balsamic vinegars from Modena (PGI) were determined by gas chromatog.-olfactometry (GC-O) using frequency of detection methodol. (modified frequency, MF, %). The main odor compounds (mean MF > 60%) were 2,3-butanedione (75%), acetic acid (70%), furan-2-carbaldehyde (62%), 1-(furan-2-yl)ethanone (62%), 2-methylpropanoic acid (66%), butanoic acid (78%), 3-methylbutanoic acid (83%), 2-phenylethyl acetate (65%), 2-hydroxy-3-methylcyclopent-2-en-1-one (61%), 2-phenylethan-1-ol (84%), 3-hydroxy-2-methylpyran-4-one (60%), (5-formylfuran-2-yl)methyl acetate (68%), 2-phenylacetic acid (69%) and 4-hydroxy-3-methoxybenzaldehyde (86%). All odor impact compounds were grouped into 7 categories according to their aromatic character: cheesy-butter-lactic, sweet, flower, empyreumatic, fruity, chem. and miscellaneous Balsamic vinegars from Modena showed lower values for the sweet category whereas for the miscellaneous and chem. categories they exhibited higher values than those found in traditional balsamic vinegars from Modena. A principal component anal. showed that both types of vinegars from Modena could be clearly differentiated based on olfactometric data.

Food Chemistry published new progress about Food analysis. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Issa-Issa, Hanan published the artcileAroma-active compounds, sensory profile, and phenolic composition of Fondilloń, Recommanded Product: Ethyl 3-hydroxybutanoate, the main research area is volatile grape aroma; Alicante wines; Aroma extract dilution analysis (AEDA); Gas chromatography-olfactometry (GC-O); Oxidized wines; Phenylethyl alcohol; Solvent-assisted flavor evaporation (SAFE).

The Fondilloń is a wine made from overripe grapes of the Monastrell variety, which is characterized by a high alc. content and a min. barrel ageing of 10 years. The objective of this study was to analyze the Fondilloń volatile composition, key aroma-active compounds, sensory profile and phenolic composition Fifty-four volatile compounds were identified, quantified and classified as alcs., esters, acids, aldehydes, lactones, phenols, hydrocarbons and ketone. From these compounds, 22 aroma-active compounds were identified, with phenylethyl alc., di-Et succinate and Et lactate having the highest flavor dilution factor. The Fondilloń wines were characterized by having high intensity of alc., fruity and toasted odor and flavor notes, and long aftertaste. Besides, 25 phenolic compounds were also identified and quantified; the phenolic acids (gallic, protocatechuic and syringic acids) were the predominant phenolic compounds

Food Chemistry published new progress about Food analysis. 5405-41-4 belongs to class esters-buliding-blocks, name is Ethyl 3-hydroxybutanoate, and the molecular formula is C6H12O3, Recommanded Product: Ethyl 3-hydroxybutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bi, Shuang published the artcileGas chromatography-mass spectrometry combined with multivariate data analysis as a tool for differentiating between processed orange juice samples on the basis of their volatile markers, Formula: C10H20O2, the main research area is GC MS multivariate analysis orange juice volatile marker; (E)-2-Heptenal (PubChem CID 5283316); (E)-2-nonenal (PubChem CID 5283335); Carveol (PubChem CID 7438); Discriminant volatile compound; Ethyl butanoate (PubChem CID 7762); Gas chromatography–mass spectrometry; Heptanal (PubChem CID 8130); High hydrostatic pressure; Nootkatone (PubChem CID 1268142); Orange juice; Partial least-squares analysis; Pasteurization; d-Carvone (PubChem CID 16724); d-Limonene (PubChem CID 440917); p-Mentha-1,5-dien-8-ol (PubChem CID 519323); β-Terpineol (PubChem CID 8748).

The contents of volatile aroma compounds in orange juice vary after high hydrostatic pressure (HHP) processing and pasteurization, and hence gas chromatog.-mass spectrometry has potential for discriminating between orange juice samples according to the processing method. Effects of HHP processing and pasteurization on orange juice were investigated immediately after processing and after storage for 28 days at 4°C. Processing decreased the contents of most terpenes and esters and increased those of alcs. and aldehydes. Volatile compounds that could serve as discriminant indicators of HHP processing and pasteurization were heptanal, (E)-2-heptenal, (E)-2-nonenal, and d-carvone and β-terpineol, p-mentha-1,5-dien-8-ol, carveol, and β-copaene, resp. The discrimination abilities of pH, ascorbic acid, total soluble solids, and color were compared with those of volatile compounds, which were found to be lower. The compounds d-carvone and β-terpineol could be used as discriminant indicators of HHP-treated and pasteurized orange juice, resp., throughout the storage period.

Food Chemistry published new progress about Food analysis. 106-32-1 belongs to class esters-buliding-blocks, name is Ethyl octanoate, and the molecular formula is C10H20O2, Formula: C10H20O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics