Category: esters-buliding-blocks

de Farias Marques, Antonia Dayane Jenyffer published the artcileOxidative stability of chicken burgers using organic coffee husk extract, Recommanded Product: Methyl octanoate, the main research area is Coffee husk extract chicken burger oxidative stability; Lipid oxidation; Meat products; Natural antioxidant; Protein oxidation.

The antioxidant capacity of organic coffee husk extract (Coffee arabica L.) added to chicken burgers was evaluated. Two formulations were prepared: with addition of the extract (100 and 200 ppm CAE/kg), in addition to control formulations without the addition of antioxidant, and with the addition of synthetic antioxidant. The products were characterized by phys. and chem. anal. and analyzed for oxidative stability during 45 days of storage under freezing. The addition of extract in the proportion of 200 ppm CAE/kg of hamburger revealed efficacy against lipid oxidation equivalent to treatment with a synthetic antioxidant. As for protein oxidation, there was no pro or antioxidant influence in the treatments. The addition of organic coffee husk extract to chicken hamburgers is thus indicated, being considered as a potential natural additive. In addition, the use of coffee husks helps to minimize the lager amounts of agro-industrial byproducts generated by the coffee industry.

Food Chemistry published new progress about Antioxidants. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, Recommanded Product: Methyl octanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jugreet, Bibi Sharmeen published the artcileChemical variability, pharmacological potential, multivariate and molecular docking analyses of essential oils obtained from four medicinal plants, Quality Control of 111-11-5, the main research area is essential oil medicinal plant bioactive compound mol docking.

Essential oils (EOs) hold tremendous medicinal attributes and are greatly exploited industrially worldwide. In the present study, the chem. composition of five EOs prepared from four aromatic plants were revealed together with their inhibitory activities against five key clin. enzymes (α-amylase, α-glucosidase, tyrosinase, acetyl- and butyryl-cholinesterase). Limonene (84.3%) and sabinene (38.1%) were the most dominant constituents present in Citrus aurantium fruit peel and leaf EOs resp. Turmerone (31.4%), ar-turmerone (16.1%), and turmerol (14.6%) were the principal components identified in Curcuma longa rhizome EO. Addnl., Morinda citrifolia fruit EO was abundant in octanoic acid (78.9%), while carvacrol (17.9%), δ-3-carene (15.2%), and camphor (12.9%) were predominant in Plectranthus amboinicus EO. The investigated EOs were all active inhibitors of acetylcholinesterase, amylase, and tyrosinase. Morinda citrifolia and P. amboinicus EOs inhibited butyrylcholinesterase exclusively, while M. citrifolia and C. aurantium fruit peel EOs displayed inhibition against glucosidase as well. Due to strong interactions with their active sites, mol. docking showed turmerone followed by carvacrol to have the highest binding affinities with target enzymes. Moderate to strong antioxidant potential was also demonstrated by all EOs. However, P. amboinicus EO presented the most potent antioxidant capacity and contained the highest amount of phenolics, while M. citrifolia EO was the weakest among all. Besides, a strong pos. correlation was noted between EOs’ antioxidant capacities and total phenolic content. With the exception of C. aurantium leaf and C. longa EOs which showed similar bioactivities and were grouped together, the other EOs were subdivided into distinct groups by principal component anal. Altogether, this study highlighted interesting pharmacol. properties of the investigated EOs that could serve as sources of bioactive ingredients with potential industrial applications.

Industrial Crops and Products published new progress about Antioxidants. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, Quality Control of 111-11-5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brahmi-Chendouh, Nabila published the artcileA nutraceutical extract from Inula viscosa leaves: UHPLC-HR-MS/MS based polyphenol profile, and antioxidant and cytotoxic activities, Safety of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, the main research area is Inula viscosa leaf polyphenol antioxidant nutraceutical cytotoxicity UHPLC HRMS; Chromatography; Depsides; High pressure liquid; Inula; Polyphenols; Tandem mass spectrometry.

Nowadays, advanced extraction techniques and highly sensitive metabolic profiling methods are effectively employed to get new information on plant chem. constituents. Among them wild medicinal plants or their parts, with large and ancient use in folk medicine, are investigated for their potential functional use and cultivation. In this context, Inula viscosa leaves engaged our attention. A simple exptl. design, based on Soxhlet extraction and chromatog. fractionation, allowed us to obtain the investigated polyphenol fraction (IvE). UHPLC-HRMS analyses revealed shikimoyl depsides of caffeic acid and unusual dihydrobenzofuran lignans as main secondary metabolites. These compounds, together with cinchonain-type phenols, and hydroxycinnamoyl flavonol glycosides, are reported for the first time in inula. Overall, forty-three secondary metabolites were identified. The extract exerted a remarkable antiradical activity towards DPPH· and ABTS+·. Furthermore, it was able to inhibit cell viability and mitochondrial redox activity of neuroblastoma, hepatoblastoma and colon carcinoma cells, whereas it did not affect cell d. of HaCaT cells immortalized human keratinocytes. As detected by the oxidant-sensing probe 2′,7′-dichlorodihydrofluorescein diacetate, the inhibitory responses seemed to be related to IvE-induced increase of intracellular reactive oxygen species (ROS). The obtained results highlighted that inula leaves, nowadays even undervalued and unexplored, could be considered a renewable source of nutraceutical compounds

Journal of Food and Drug Analysis published new progress about Antioxidants. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Safety of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Rong-Fu published the artcileSuppression of Oxygen Radicals Protects Diabetic Endothelium Damage and Tissue Perfusion in a Streptozotocin-Induced Diabetes Rodent Model, Computed Properties of 2044-85-1, the main research area is diabetic endothelium damage tissue perfusion streptozotocin.

Oxygen free radicals play a central role in diabetic angiopathy. This study investigated whether suppression of oxygen radicals could decrease endothelial damage and increase peripheral tissue circulation in a diabetic rodent model. Sprague-Dawley rats were treated using streptozotocin to induce diabetes. The experiments were performed 4 wk after diabetes induction: group 1: control, consisted of normal rats; group 2: diabetes, did not receive treatment; groups III (SOD10) and IV (SOD50): diabetes, received polyethylene glycol-conjugated superoxide dismutase (SOD), an antioxidant, 10 and 50 U/kg per day i.p. for 4 wk. Each subgroup consisted of 10 rats. Oxygen radicals in blood mononuclear cells were detected by flow cytometry. The blood lipid peroxidation byproduct malondialdehyde was measured. Tissue perfusion of hind limb was examined by laser Doppler. The expressions of oxygen radicals, as demonstrated by 8-hydroxyguanosine (8-OG), and constitutive endothelial nitric oxide synthase in distal femoral vessels were examined by immunohistochem. staining. Oxygen radicals, as demonstrated by H2O2 with 2′,7′-dichlorofluorescin diacetate-conjugated expression, were significantly increased in diabetic rats. However, the SOD treatment groups significantly suppressed the H2O2 reaction. Diabetic-induced high malondialdehyde levels were significantly suppressed in the SOD50 group. The topical tissue blood perfusion was significantly increased as detected by laser Doppler in SOD10 and SOD50 groups, as compared with that in diabetes without treatment group (P < 0.05). The expression of 8-OG was markedly increased in the diabetic endothelium and subintima compared with that in normal vessels. Polyethylene glycol-conjugated SOD significantly suppressed 8-OG expression and protected endothelial nitric oxide synthase expression. Suppression of oxygen radicals, particularly with the higher dosage of polyethylene glycol-conjugated SOD at 50 U/kg per day, could have a pos. effect to protect against endothelial damage and enhance peripheral perfusion in diabetes. Annals of Plastic Surgery published new progress about Antioxidants. 2044-85-1 belongs to class esters-buliding-blocks, name is 2',7'-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate, and the molecular formula is C24H14Cl2O7, Computed Properties of 2044-85-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tandee, Kanokwan published the artcileAntioxidant activities and volatile compounds in longan (Dimocarpus longan Lour.) wine produced by incorporating longan seeds, Synthetic Route of 5405-41-4, the main research area is Dimocarpus Saccharomyces antioxidant volatile compound wine seed fermentation temperature; 2,3-Butylene glycol (PubChem CID: 262); 4-Hydroxyphenethyl alcohol (PubChem CID: 10393); 5-Hydroxymethyl-2-furaldehyde (PubChem CID: 237332); Antioxidant; Ethyl hydrogen succinate (PubChem CID: 70610); Longan wine; Phenethyl alcohol (PubChem CID: 6054); Seed; Volatile compound.

The seeds of dried longan, one of the major processed fruits in Thailand, contain several bioactive compounds In this study, we developed longan wine by incorporating its seeds during juice preparation and evaluated the antioxidant activities and volatile compounds in different conditions. The results suggested that Saccharomyces cerevisiae EC-1118 was suitable for fermentation of longan juice supplemented with 50% seed and 20% initial soluble solids at an optimal temperature of 30°C. Different yeast strains showed various extents of antioxidant activities; however, the fermentation temperature and initial soluble solids of longan juice had little effect on the inhibition of reactive species. Antioxidant activities were significantly increased with increasing seed content. Dominant volatile compounds, which were independent of the winemaking conditions, were found to be phenethyl alc., 2,3-butylene glycol, 5-hydroxymethyl-2-furaldehyde, Et hydrogen succinate, and 4-hydroxyphenethyl alc. These compounds highly influenced the antioxidant activities of longan wine produced by incorporating the seeds.

Food Chemistry published new progress about Antioxidants. 5405-41-4 belongs to class esters-buliding-blocks, name is Ethyl 3-hydroxybutanoate, and the molecular formula is C6H12O3, Synthetic Route of 5405-41-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mostofa, Mohammad Golam published the artcileStrigolactones regulate arsenate uptake, vacuolar-sequestration and antioxidant defense responses to resist arsenic toxicity in rice roots, Recommanded Product: 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, the main research area is strigolactone antioxidant defense response arsenic toxicity rice root; Arsenic toxicity; Glutathione metabolism; Oxidative stress; Phosphate transporters; Rice; Strigolactones.

We explored genetic evidence for strigolactonesâ€?role in rice tolerance to arsenate-stress. Comparative analyses of roots of wild-type (WT) and strigolactone-deficient mutants d10 and d17 in response to sodium arsenate (Na2AsO4) revealed differential growth inhibition [WT (11.28%) vs. d10 (19.76%) and d17 (18.03%)], biomass reduction [(WT (33.65%) vs. d10 (74.86%) and d17 (60.65%)] and membrane damage (WT < d10 and d17) at 250 μM Na2AsO4. Microscopic and biochem. analyses showed that roots of WT accumulated lower levels of arsenic and oxidative stress indicators like reactive oxygen species and malondialdehyde than those of strigolactone-deficient mutants. qRT-PCR data indicated lower expression levels of genes (OsPT1, OsPT2, OsPT4 and OsPT8) encoding phosphate-transporters in WT roots than mutant roots, explaining the decreased arsenate and phosphate uptake by WT roots. Increased levels of glutathione and OsPCS1 and OsABCC1 transcripts indicated an efficient vacuolar-sequestration of arsenic in WT roots. Furthermore, higher activities (transcript levels) of SOD (OsCuZnSOD1 and OsCuZnSOD2), APX (OsAPX1 and OsAPX2) and CAT (OsCATA) corresponded to lower oxidative damage in WT roots compared with strigolactone-mutant roots. Collectively, these results highlight that strigolactones are involved in arsenic-stress mitigation by regulating arsenate-uptake, glutathione-biosynthesis, vacuolar-sequestration of arsenic and antioxidant defense responses in rice roots. Journal of Hazardous Materials published new progress about Antioxidants. 2044-85-1 belongs to class esters-buliding-blocks, name is 2',7'-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate, and the molecular formula is C24H14Cl2O7, Recommanded Product: 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cho, Suk Ju published the artcile7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress, Quality Control of 2044-85-1, the main research area is dihydroxyflavone glucose neuronal cell damage oxidative stress; Diabetic neuropathy; High glucose; Oxidative stress.

Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent complications of diabetes, affect sensory, motor, and autonomic nerves. This study aimed to investigate whether 7,8-dihydroxyflavone (7,8-DHF) protects SH-SY5Y neuronal cells against high glucose-induced toxicity. In the current study, we found that diabetic patients exhibited higher lipid peroxidation caused by oxidative stress than healthy subjects. 7,8-DHF exhibits superoxide anion and hydroxyl radical scavenging activities. High glucose-induced toxicity severely damaged SH-SY5Y neuronal cells, causing mitochondrial depolarization; however, 7,8-DHF recovered mitochondrial polarization. Furthermore, 7,8-DHF effectively modulated the expression of pro-apoptotic protein (Bax) and anti-apoptotic protein (Bcl-2) under high glucose, thus inhibiting the activation of caspase signaling pathways. These results indicate that 7,8-DHF has antioxidant effects and protects cells from apoptotic cell death induced by high glucose. Thus, 7,8-DHF may be developed into a promising candidate for the treatment of diabetic neuropathy.

Biomolecules & Therapeutics published new progress about Antioxidants. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Quality Control of 2044-85-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Yaxi published the artcilePhotoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties, Category: esters-buliding-blocks, the main research area is cerium oxide nanoparticle UV A irradiation antioxidant skin fibroblasts.

UV irradiation, particularly UV A (UVA), stimulates reactive oxygen species (ROS) production in the epidermis and dermis, which plays a major part in the photoageing of human skin. Several studies have demonstrated that cerium oxide nanoparticles (CeO2 NP) can exhibit an antioxidant effect and free radical scavenging activity. However, the protective role of CeO2 NP in skin photoageing and the underlying mechanisms are unclear. In this study, we investigated the effects of CeO2 NP on UVA-irradiated human skin fibroblasts (HSFs) and explored the potential signalling pathway. CeO2 NP had no apparent cytotoxicity, and could reduce the production of proinflammatory cytokines, intracellular ROS, senescence-associated β-galactosidase activity, and downregulate phosphorylation of c-Jun N-terminal kinases (JNKs) after exposure to UVA radiation. Based on our findings, CeO2 NPs have great potential against UVA radiation-induced photoageing in HSFs via regulating the JNK signal-transduction pathway to inhibit oxidative stress and DNA damage.

Scientific Reports published new progress about Antioxidants. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhen, Ao Xuan published the artcileNiacinamide protects skin cells from oxidative stress induced by particulate matter, COA of Formula: C24H14Cl2O7, the main research area is niacinamide skin cells oxidative stress particulate matter; Human HaCaT keratinocyte; Niacinamide; Oxidative stress; Particulate matter 2.5.

Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that particulate matter 2.5 (PM2.5) induced reactive oxygen species (ROS), causing disruption of DNA, lipids, and protein, mitochondrial depolarization, and apoptosis of skin keratinocytes. Here, we investigated the protective effects of NIA on PM2.5-induced oxidative stress in human HaCaT keratinocytes. We found that NIA could inhibit the ROS generation induced by PM2.5, as well block the PM2.5-induced oxidation of mols., such as lipids, proteins, and DNA. Furthermore, NIA alleviated PM2.5-induced accumulation of cellular Ca2+, which caused cell membrane depolarization and apoptosis, and reduced the number of apoptotic cells. Collectively, the findings show that NIA can protect keratinocytes from PM2.5-induced oxidative stress and cell damage.

Biomolecules & Therapeutics published new progress about Antioxidants. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, COA of Formula: C24H14Cl2O7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yadav, Khushbu published the artcileEffect of synthetic and aromatic amine antioxidants on oxidation stability, performance, and emission analysis of waste cooking oil biodiesel, Safety of Methyl docosanoate, the main research area is aromatic amine antioxidant waste cooking oil biodiesel oxidation stability; Additives; Biodiesel; DPA antioxidant; Diesel engine; Induction time; NO reduction; Rancimat method.

In the present study, an attempt was made to improve the oxidation stability of biodiesel by adding antioxidants to waste cooking oil biodiesel, and their impact on performance and emissions was analyzed. Two types of antioxidants were chosen for the anal.: an aromatic amine antioxidant, diphenylamine (DPA), and synthetic oxidants, tert-butylhydroxyquinone (TBHQ) and pyrogallol (PY). All the antioxidants were added to the biodiesel at doses of 200 ppm and 500 ppm to evaluate their effect. The oxidation stability was found as per the ASTM standard by mixing 500 ppm antioxidants for all three antioxidant-treated biodiesel blends. DPA yielded similar results as TBHQ, although PY had a better oxidation stability according to the Rancimat test. Gas chromatog. and mass chromatog. were also performed on the neat biodiesel. Performance and emission tests were performed on the antioxidant-treated biodiesel blends and diesel. The brake thermal efficiency of the tested fuel increased by 9.8%, 6.9%, and 15.88% when the DPA, TBHQ, and PY antioxidants were added to the test fuel compared to that of the test fuel without added antioxidant. The brake specific energy consumption of the test fuel decreased by 9.05% with DPA, 7.03% with TBHQ, and 14.08% with PY compared to that of the test fuel without antioxidant. The NOx emissions of the antioxidant-treated test fuels were reduced by 14.65% with DPA, 11.22% with TBHQ, and 23.10% with PY compared to those of the test fuel without antioxidants. Addnl., the aromatic amine antioxidant (DPA) was found to be effective in enhancing the performance and lowering the exhaust emissions compared to diesel for unmodified diesel engines.

Environmental Science and Pollution Research published new progress about Antioxidants. 929-77-1 belongs to class esters-buliding-blocks, name is Methyl docosanoate, and the molecular formula is C23H46O2, Safety of Methyl docosanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics