Category: esters-buliding-blocks

Synthesis of 1,1-[1-Naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their Evaluation as Inhibitors of Serotonin, Norepinephrine, and Dopamine Transporters was written by White, James D.;Juniku, Rajan;Huang, Kun;Yang, Jongtae;Wong, David T.. And the article was included in Journal of Medicinal Chemistry in 2009.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

Stereodefined trisubstituted cyclopropanes I bearing naphthyloxy, thiophenyl, and (N-methylamino)methyl groups were synthesized in enantiopure form employing asym. cyclopropanation of (E)- and (Z)-allylic alcs. as the key step. In vitro assays of the synthesized cyclopropanes revealed that the K_i of one of the enantiomers as a dual inhibitor of serotonin and norepinephrine transporters is in the low nanomolar range and is comparable to that of duloxetine. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

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Modifications in Lemongrass (Cymbopogon spp.) in response to green synthesized nano-selenium complex was written by Tavallali, Vahid;Shabanpisheh, Zahra;Gholami, Hossein;Abarghuei, Faezeh Mirazimi. And the article was included in Scientia Horticulturae (Amsterdam, Netherlands) in 2022.Related Products of 105-87-3 This article mentions the following:

Selenium nanoparticles (Se-NPs) have different applications in various technologies due to their individual properties. In order to investigate the impacts of different concentrations of a green-synthesized selenium nano-complex (0, 20, 40, 60, and 80 mg L-1) on the chem. composition, antioxidant capacity and antimicrobial activity of lemongrass essential oil (EO), an experiment was designed as a completely randomized design (CRD) with four replications. The application of 40 mg L-1 selenium nano-complex caused the highest EO yield (3.96 鍗?0.09%). The dominant compounds in EO, geranial (44.12 鍗?1.22%) and neral (32.53 鍗?1.08%), were achieved by the application of 60 mg L-1 selenium nano-complex. HPLC anal. indicated that the extracts were rich in 5-o-cafeoylquinic acid, luteolin 6-c-pentosyl-8-c-pentoside, and luteolin 2-o-deoxyhexosyl-6-c-glucoside. The extracts of lemongrass plants treated with 40 and 60 mg L-1 selenium nano-complex achieved the highest amount of 5-o-cafeoylquinic acid (25.29鍗?.31 and 24.16鍗?.26 娓璯 mL-1, resp.). The highest antioxidant capacity was observed in the 40 mg L-1 selenium nano-complex treated plants. The min. inhibitory concentration (MIC) of EO derived from the 60 mg L-1 selenium nano-complex treated lemongrass for Salmonella typhimurium, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger and Candida albicans was 0.63鍗?.03, 1.84鍗?.1, 1.05鍗?.05, 0.008鍗?.01, 0.6鍗?.01 and 0.1鍗?.01 mg mL-1, resp. It is expected that the selenium nano-complex would find a wide range of applications in medicine for its antioxidant and antimicrobial properties. It may also be applied to medicinal plants to enhance the quality and quantity of EOs. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Related Products of 105-87-3).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 105-87-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Extraction, chemical composition, and anticancer potential of Origanum onites L. essential oil was written by Spyridopoulou, Katerina;Fitsiou, Eleni;Bouloukosta, Eleni;Tiptiri-Kourpeti, Angeliki;Vamvakias, Manolis;Oreopoulou, Antigoni;Papavassilopoulou, Eleni;Pappa, Aglaia;Chlichlia, Katerina. And the article was included in Molecules in 2019.Computed Properties of C6H12O2 This article mentions the following:

Origanum species are plants rich in volatile oils that are mainly used for culinary purposes. In recent years, there has been a growing interest in the biol. activities of their essential oils. Origanum onites L. is a plant mainly found in Greece, Turkey, and Sicily, whose oil is rich in carvacrol, a highly bioactive phytochem. The aim of this study was to analyze the chem. composition of Origanum onites essential oil (OOEO), and investigate its potential anticancer effects in vitro and in vivo. GC/MS anal. identified carvacrol as OOEO’s main constituent. In vitro antiproliferative activity was assayed with the sulforhodamine B (SRB) assay against human cancer cell lines from four tumor types. HT-29, a colorectal cancer cell line, was the most sensitive to the antiproliferative activity of OOEO. Wound-healing assay and Annexin V-PI staining were employed to investigate the antimigratory and the pro-apoptotic potential of OOEO, resp., against human (HT-29) and murine (CT26) colon cancer cells. Notably, OOEO attenuated migration and induced apoptosis-related morphol. changes in both cell lines. Prophylactic oral administration of the oil in a BALB/c exptl. mouse model inhibited the growth of syngeneic CT26 colon tumors. As far as we know, this is the first report on the antitumor potential of orally administered OOEO. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Computed Properties of C6H12O2).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C6H12O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reversible addition-fragmentation chain transfer copolymerization of methyl methacrylate and methyl acrylate was written by Ionychev, B. N.;Semchikov, Yu. D.;Kopylova, N. A.;Andreeva, E. S.;Zaitsev, S. D.. And the article was included in Russian Journal of Applied Chemistry in 2014.Quality Control of Benzyl benzodithioate This article mentions the following:

Pseudo-living radical copolymerization of Me methacrylate and Me acrylate under reversible addition-fragmentation chain transfer in a mass in the presence of reversible chain transfer agents of different nature was implemented. A comparison of phys. and mech. properties of narrowly dispersed copolymers was performed as well as copolymers obtained by uncontrolled radical polymerization In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Quality Control of Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of Benzyl benzodithioate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Artemisinin-Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation was written by La Pensee, Louise;Sabbani, Sunil;Sharma, Raman;Bhamra, Inder;Shore, Emma;Chadwick, Amy E.;Berry, Neil G.;Firman, James;Araujo, Nuna C.;Cabral, Lilia;Cristiano, Maria L. S.;Bateman, Cerys;Janneh, Omar;Gavrila, Adelina;Wu, Yi Hang;Hussain, Afthab;Ward, Stephen A.;Stocks, Paul A.;Cosstick, Rick;O’Neill, Paul M.. And the article was included in ChemMedChem in 2013.Electric Literature of C10H12O3 This article mentions the following:

Seven artemisinin-polypyrrole conjugates were prepared Conjugate I emerges as the most active mol. being twofold more active than DHA against HT-29 cells and exhibiting around five times the potency of DHA against HL-60 cells. Conjugate I also exhibits one of the strongest affinities for the DNA duplex d(CGCGAATTCGCG). Structurally, these results are not surprising as conjugate I has the longest flexible linker, allowing for the greatest steric freedom to both portions of the hybrid. Modeling studies have accurately predicted the exptl. 铻朤_m data, and decomposition of these calculated free energies of binding has shown that the binding affinity of these hybrid compounds depends on multiple factors, in particular electrostatic interactions and differential solvation of the ligand and DNA duplexes on complexation. Moreover, these factors are intrinsically linked to the varying degrees of conformational change the ligands and DNA duplex undergoes on binding. Further mechanistic studies are needed in HT-29 cells to clarify whether ART maintains mitochondrial membrane depolarization as a main mode of action or whether the presence of the DNA binding structure has in fact enhanced activity by causing a dual mode of action. In the experiment, the researchers used many compounds, for example, Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3Electric Literature of C10H12O3).

Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Electric Literature of C10H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Understanding the interactive effects of volatile compounds contributing to 閳ョ灚tone fruit閳?aroma nuances in white wines was written by Espinase Nandorfy, D.;Siebert, T.;Watson, F.;Keast, R.;Francis, I. L.. And the article was included in Australian Journal of Grape and Wine Research in 2022.SDS of cas: 706-14-9 This article mentions the following:

The sensory experience of wine aroma is challenging to study. Given the presence of numerous and trace level volatiles, the subtle aroma nuances involved, as well as the complexity of human odor processing, the contribution of individual compounds and mixtures can be difficult to determine In white wines, the volatile compounds eliciting stone fruit aromas are not well understood. Factorial designs were used with odorants added to model wine and assessed using sensory quant. descriptive anal. In model Viognier-like wines, several monoterpenes were confirmed to convey stone fruit attributes Apricot and Peach, which were strongly suppressed by aldehydes which imparted Cardboard-like odours. Importantly, lactones increased Apricot aroma when combined with the monoterpenes. For model unoaked Australian Chardonnay wine, sensory-directed screening followed by factorial studies showed that aliphatic Et esters, in particular Et octanoate, directed Peach aroma. Fatty acids were strong suppressors of the Peach attribute and gave Cheesy odours. Apricot and peach aromas in Viognier and Chardonnay, although perceptually similar, were caused by different chem. compound families: grape-derived monoterpenes with lactones and yeast-derived fatty acid Et esters, resp. Having confirmed the compounds responsible for apricot and peach white wine aromas, there is potential to modify their concentration through established viticultural and winemaking practices. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9SDS of cas: 706-14-9).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 706-14-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of various seasonings on the quality retention of dried mackerel (Scomber scombrus Linnaeus) was written by Kobayashi, Fumiyuki;Kimura, Ryusuke;Aoki, Ryoma;Tamura, Koji;Ozawa, Ryo;Odake, Sachiko. And the article was included in Journal of Food Processing and Preservation in 2022.Formula: C12H20O2 This article mentions the following:

The effect of seasonings on the quality retention of dried mackerel (Scomber scombrus Linnaeus) was investigated by analyzing the components of the seasonings and prepared dried mackerel. The pH, water content, salt concentration, and inosinic acid content of dried mackerel were influenced by the water content of seasoning liquid The free amino acid content of dried mackerel depended on the seasoning liquid The DPPH radical-scavenging activity of mirin seasoning liquid was significantly higher than that of salt and chorizo, and that of black seven spices (shichimi) and chorizo seasoning powders was extremely high. The content of some aldehydes, alkenes, and alkane of dried mackerel flavored with mirin, shichimi, and chorizo was significantly lower than that flavored with salt. Hexanal concentration further decreased in dried mackerel flavored with shichimi and chorizo. Therefore, the use of shichimi and chorizo as seasoning powders was effective for maintaining the quality of dried mackerel. The production and consumption of dried fish have decreased yearly in Japan. Recently, two types of seasonings flavored with shichimi and chorizo have been, therefore, developed for preparing dried mackerel. These seasonings consisted of liquid and powder. This is the first attempt to use seasoning powders in the production of dried mackerel. This study demonstrated that the generation of fishy volatile components from dried mackerel was inhibited by the shichimi and chorizo seasoning powders. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Formula: C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Asymmetric functionalization at a prochiral carbon center by the aid of sulfinyl chirality: a selective formation of 6-substituted (3R,S_S)- and (3S,S_S)-3-(hydroxymethyl)-3,4-dihydro-5-(p-tolyl)sulfinyl-2H-pyrans was written by Iwata, Chuzo;Fujita, Masahiro;Moritani, Yasunori;Sugiyama, Kenji;Hattori, Kohji;Imanishi, Takeshi. And the article was included in Tetrahedron Letters in 1987.Related Products of 82962-54-7 This article mentions the following:

Ring cleavage of dioxabicyclic compd I gave (3S)- and (3R)-pyran II. A successful asym functionalization of prochiral gem-bis(hydroxymethyl) groups has been achieved by the aid of a sulfinyl chirality. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7Related Products of 82962-54-7).

Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 82962-54-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Transition-metal peroxide reactions. Synthesis of 浼?hydroxycarbonyl compounds from enolates was written by Vedejs, E.;Engler, D. A.;Telschow, J. E.. And the article was included in Journal of Organic Chemistry in 1978.SDS of cas: 15399-05-0 This article mentions the following:

Enolates of ketones, esters, and lactones were oxidized by MoO₅.OP(NMe₂)₃.pyridine (I) to give 浼?hydroxy derivatives The reaction succeeds with carbonyl compounds having 浼?methylene or 浼?methine groups, but enolates from methyl ketones gave variable results. Thus, treatment of Me(CH₂)₅CO₂Me with (Me₂CH)₂NLi in THF-hexane at -70鎺?and subsequent addition of I gave 74% Me(CH₂)₄CH(OH)CO₂Me; similarly, 3灏?methoxypregna-5,16-dien-20-one gave 52% 21-hydroxy-3灏?methoxypregna-5,16-dien-20-one. The hydroxylation process did not give products of oxidative C-C cleavage, which formed from an 浼?hydroperoxycarbonyl intermediate. If the initial intermediate from an enolate and I was heated, further oxidation to an 浼?dicarbonyl compound occurred in poor yield. Hydroxylation of kinetic enolates derived from unsym. cyclic ketones, cyclohexenones, and certain methyl ketones was achieved. Acyloin regioisomers are not interconverted under the reaction conditions. Hydroxylation of nonhindered ketones is complicated by aldol condensation between unreacted enolate and the oxidation intermediate. This problem was minimized by reaction in dilute solution, or by using an inverse addition technique (enolate added to I). Oxidation of enolate analogs prepared from oximes or N,N-dimethylhydrazones has been demonstrated, although yields were low. Stabilized enolates of 1,3-dicarbonyl compounds were not hydroxylated and the related dianions afforded complex product mixtures In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0SDS of cas: 15399-05-0).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.SDS of cas: 15399-05-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Assessing the contribution of odor-active compounds in icewine considering odor mixture-induced interactions through gas chromatography-olfactometry and Olfactoscan was written by Ma, Yue;Beno, Noelle;Tang, Ke;Li, Yuanyi;Simon, Marie;Xu, Yan;Thomas-Danguin, Thierry. And the article was included in Food Chemistry in 2022.Name: 5-Hexyldihydrofuran-2(3H)-one This article mentions the following:

The sensory impact of odor-active compounds on icewine aroma could be influenced by perceptual interactions with other odor-active compounds The aim of this study was to establish an approach to evaluate the contribution of odor-active compounds found in icewine considering mixture-induced perceptual interactions. By comparing the impact of key odorants detected in icewine following a gas chromatog.-olfactometry approach with an Olfactoscan-based methodol. using a background odor of icewine, 69 odor zones were detected, and their related compounds were further identified. The results revealed that icewine background odor could exert odor masking or enhancement on key odorants when they are considered in the complex wine aroma buffer. Several compounds can induce qual. changes in the overall wine aroma. This study underlined the efficiency of Olfactoscan-like approaches to screen for the real impact of key odorants and to pinpoint specific compounds that could be highly influential once embedded in the aroma buffer. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Name: 5-Hexyldihydrofuran-2(3H)-one).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: 5-Hexyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics