Category: esters-buliding-blocks

Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety was written by Xu, F. Z.;Wang, Y. Y.;Luo, D. X.;Yu, G.;Guo, S. X.;Fu, H.;Zhao, Y. H.;Wu, J.. And the article was included in RSC Advances in 2018.Name: Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

A series of trifluoromethyl pyridine derivatives containing 1,3,4-oxadiazole moiety I (R = H, 3-Cl-4-CH₃, 3-CH₃, etc.) was designed, synthesized and bio-assayed for their insecticidal activity. The result of bio-assays indicated the synthesized compounds exhibited good insecticidal activity against Mythimna separata and Plutella xylostella, most of the title compounds show 100% insecticidal activity at 500 mg L^-1 and >80% activity at 250 mg L^-1 against the two pests. Compounds I (R = 2-CF₃) and 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-(4-fluorobenzyl)-1,3,4-oxadiazole showed LC₅₀ values of 38.5 and 30.8 mg L^-1 against Mythimna separata, resp., which were close to that of avermectin (29.6 mg L^-1). Compounds I (R = 3,5-Cl₂, 4-C₂H₅, 2-Cl-5-Br, 4-I, 3,4-Cl₂, 2-I, 3-N(CH₃)₂) and 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-(4-fluorobenzyl)-1,3,4-oxadiazole showed 100% activity at 250 mg L^-1, which were better than chlorpyrifos (87%). CoMFA and CoMSIA models with good predictability were proposed, which revealed the electron-withdrawing groups with an appropriate bulk at 2- and 4-positions of benzene ring could enhance insecticidal activity. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Name: Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nanoporous well-defined reversible addition-fragmentation chain transfer polymer of N-acrylamido-L-tryptophan: synthesis and characterization was written by Singh, Pooja;Srivastava, Ambika;Kumar, Rajesh. And the article was included in Polymer International in 2014.Electric Literature of C14H12S2 This article mentions the following:

A nanoporous polymer with a chiral pendant chain of N-acrylamido-L-tryptophan was synthesized through a reversible addition-fragmentation chain transfer polymerization process using a dithiobenzoate derivative as chain transfer agent. The polymerization exhibited the usual characteristics of living processes, though slow polymerization rate and low percentage conversion for a chain extension experiment were observed Depending on the monomer/chain transfer agent ratio, poly(N-acrylamido-L-tryptophan) with number-average mol. weights between 640 and 4340 g mol^-1 and molar mass dispersities between 1.10 and 1.24 was obtained, as evidenced from gel permeation chromatog. SEM images indicated that the polymer was porous. Nitrogen adsorption anal. of the polymer evidenced the presence of mesopores (2-19 nm) associated with micropores (0.45-2 nm) according to the Barrett-Joyner-Halenda method with a specific Brunauer-Emmett-Teller surface area of 22.98 m2 g-1. 婕?2013 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Electric Literature of C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C14H12S2

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hydroxyindole Carboxylic Acid-Based Inhibitors for Receptor-Type Protein Tyrosine Protein Phosphatase Beta was written by Zeng, Li-Fan;Zhang, Ruo-Yu;Bai, Yunpeng;Wu, Li;Gunawan, Andrea M.;Zhang, Zhong-Yin. And the article was included in Antioxidants & Redox Signaling in 2014.Category: esters-buliding-blocks This article mentions the following:

Aims: Protein tyrosine phosphatases (PTPs) play an important role in regulating a wide range of cellular processes. Understanding the role of PTPs within these processes has been hampered by a lack of potent and selective PTP inhibitors. Generating potent and selective probes for PTPs remains a significant challenge because of the highly conserved and pos. charged PTP active site that also harbors a redox-sensitive Cys residue. Results: We describe a facile method that uses an appropriate hydroxyindole carboxylic acid to anchor the inhibitor to the PTP active site and relies on the secondary binding elements introduced through an amide-focused library to enhance binding affinity for the target PTP and to impart selectivity against off-target phosphatases. Here, we disclose a novel series of hydroxyindole carboxylic acid-based inhibitors for receptor-type tyrosine protein phosphatase beta (RPTP灏?, a potential target that is implicated in blood vessel development. The representative RPTP灏?inhibitor 8b-1 (L87B44) has an IC₅₀ of 0.38 娓璏 and at least 14-fold selectivity for RPTP灏?over a large panel of PTPs. Moreover, 8b-1 also exhibits excellent cellular activity and augments growth factor signaling in HEK293, MDA-MB-468, and human umbilical vein endothelial cells. Innovation: The bicyclic salicylic acid pharmacophore-based focused library approach may provide a potential solution to overcome the bioavailability issue that has plagued the PTP drug discovery field for many years. Conclusion: A novel method is described for the development of bioavailable PTP inhibitors that utilizes bicyclic salicylic acid to anchor the inhibitors to the active site and peripheral site interactions to enhance binding affinity and selectivity. Antioxid. Redox Signal. 20, 2130-2140. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Category: esters-buliding-blocks).

tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of Zinc Tetraphenylporphyrin Rigid Rods with a Built-In Dipole was written by Chitre, Keyur;Batarseh, Alberto;Kopecky, Andrew;Fan, Hao;Tang, Hao;Lalancette, Roger;Bartynski, Robert A.;Galoppini, Elena. And the article was included in Journal of Physical Chemistry B in 2015.SDS of cas: 313648-56-5 This article mentions the following:

Three Zn(II) tetraphenylporphyrins (ZnTPP) were synthesized to study the influence of a mol. dipole on the energy level alignment of a chromophore bound to a metal oxide semiconductor: ZnTPP-PE(DA)-IpaOMe (1), ZnTPP-PE-IpaOMe (2), and ZnTPP-PE(AD)-IpaOMe (3). Each contained a rigid-rod linker made of a p-phenylene ethynylene (PE) moiety terminated with the Me ester of an isophthalic acid unit (Ipa). Porphyrins 1 and 3 contained an intramol. dipole in the central Ph ring, which was built by introducing electron donor (D, NMe₂) and acceptor (A, NO₂) substituents in para position to each other. In 1 and 3, the relative position of the D and A substituents, and therefore the dipole direction, was reversed. Porphyrin 2, without substituents in the linker, was synthesized for a comparison. The structures of precursors to 1 and 3 and the structure of 1 were determined by single crystal x-ray anal. Solution UV-visible and steady-state fluorescence spectra of 1–3 were identical to each other and exhibited the spectral features typical of the ZnTPP chromophore and their electrochem. properties were also very similar. Me esters 1–3 were hydrolyzed to the corresponding carboxylic acids for binding to metal oxide semiconductors. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5SDS of cas: 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 313648-56-5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycan targeted polymeric antibiotic prodrugs for alveolar macrophage infections was written by Chen, Jasmin;Su, Fang-Yi;Das, Debobrato;Srinivasan, Selvi;Son, Hye-Nam;Lee, Brian;Radella, Frank II;Whittington, Dale;Monroe-Jones, Taylor;West, T. Eoin;Convertine, Anthony J.;Skerrett, Shawn J.;Stayton, Patrick S.;Ratner, Daniel M.. And the article was included in Biomaterials in 2019.Reference of 4163-60-4 This article mentions the following:

Alveolar macrophages resident in the lung are prominent phagocytic effector cells of the pulmonary innate immune response, and paradoxically, are attractive harbors for pathogens. Consequently, facultative intracellular bacteria, such as Francisella tularensis, can cause severe systemic disease and sepsis, with high morbidity and mortality associated with pulmonary infection. Current clin. treatment, which involves exhaustive oral or i.v. antibiotic therapy, has limitations such as systemic toxicity and off-target effects. Pulmonary administration represents a promising alternative to systemic dosing for delivering antibiotics directly to the lung. Here, we present synthesized mannosylated ciprofloxacin polymeric prodrugs for efficient pulmonary delivery, targeting, and subsequent internalization by alveolar macrophages. We demonstrate significant improvement in efficacy against intracellular infections in an otherwise uniformly lethal airborne Francisella murine model (F. novicida). When administered to the lungs of mice in a prophylactic regimen, the mannosylated ciprofloxacin polymeric prodrugs led to 50% survival. In a treatment regimen that was concurrent with infection, the survival of mice increased to 87.5%. Free ciprofloxacin antibiotic was ineffective in both cases. This significant difference in antibacterial efficacy demonstrates the impact of this delivery platform based on improved physiochem., pharmacokinetic, and pharmacodynamic properties of ciprofloxacin administered via our glycan polymeric prodrug. This modular platform provides a route for overcoming the limitations of free drug and increasing efficacy in treatment of intracellular infection. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Reference of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quantitative analysis of Phthalate Esters by in-situ thermal desorption atmospheric pressure photoionization mass spectrometry using a dopant as the internal standard was written by Wang, Weimin;Jiang, Dandan;Jin, Liuyu;Wang, Pingping;Xu, Fuxing;Li, Haiyang;Ding, Chuan-Fan. And the article was included in International Journal of Mass Spectrometry in 2022.Formula: C20H26O4 This article mentions the following:

Phthalate Esters (PAEs) are a group of chems. widely used in plastic products, and they are also known as endocrine disruptors that can adversely affect the hormonal balance in humans. Since many food-contacting items, such as lunch boxes, fresh keeping film, disposable cups, are made of plastic, the PAEs can easily enter the human body through the polluted foods or drinks. Traditional anal. techniques involve laborious sample pretreatment and low-throughput anal., so it is necessary to develop techniques that can rapidly and quant. detect these compounds In this article, a miniaturized ion trap mass spectrometer (ITMS) was established firstly, then, an in-situ thermal desorption atm. pressure photoionization (in-situ TD-APPI) was designed, and the dopant was explored using for improving the sensitivity and as internal standard (IS) simultaneously in the anal. process. The in-situ TD-APPI presents good performance: (1) More than 20 times improvement in sensitivity compared with Nano-ESI for PAEs; (2) 12 kinds of phthalates were quantified with using acetone as the IS, and the LODs and LOQs ranges were found to be 0.02-1 娓璯/mL and 0.02-100 娓璯/mL, resp. The technique was also applied to the quantification of mixed solutions, and the results were validated by LC/MS. Finally, six categories of food-contacting items containing PAEs were analyzed with superficial content (ng/cm²) ranging from 0 to 6.20 ng/cm². These results demonstrate the potential of rapid quantification of anal. of PAEs in practical plastic food-contacting items by in-situ TD-APPI. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Formula: C20H26O4).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C20H26O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and calpain inhibitory activity of 浼?ketoamides with 2,3-methanoleucine stereoisomers at the P₂ position was written by Donkor, Isaac O.;Zheng, Xiaozhang;Miller, Duane D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Related Products of 87694-53-9 This article mentions the following:

A series of novel ketoamides I, (Ph = phenyl) incorporating all four 2,3-methanoleucine stereoisomers at the P₂ position, was synthesized. The compounds displayed a wide variation in K_i values for inhibition of calpain I depending on the configuration of the P₂ methanoleucine residue. However, similar variation in cathepsin B inhibition was not observed suggesting that the S₂ pocket of calpain I is more stereosensitive than that of cathepsin B. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Related Products of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemical Composition of the Unexplored Volatile Fraction of Betula glandulosa, a Prevalent Shrub in Nunavik, Quebec was written by Seguin, Jean-Christophe;Fernandez, Xavier;Boudreau, Stephane;Voyer, Normand. And the article was included in Chemistry & Biodiversity in 2022.Recommanded Product: 118-61-6 This article mentions the following:

The volatile fraction of the leaves of Betula glandulosaICHX. has been investigated for its secondary metabolite composition by GC/MS and GC/FID. The rapid expansion of this shrub species in subarctic landscapes, like the ones found in Nunavik (Northern Quebec, Canada), highly impacts ecosystem dynamics. Yet, despite its abundance, few phytochem. investigations have yet been conducted on this species. In this study, we present the first phytochem. investigation of the volatile metabolites of B. glandulosa leaves. Although no essential oil was isolated, volatile compounds were extracted from the hydrosol by steam distillation The main metabolites observed were linalool (14.6-19.0 %), C6 oxylipins (known as green leaf volatiles, GLV; total of 18.2-40.2 %), eugenol (1.6-8.6 %) and 浼?terpineol (3.3-4.8 %). Dwarf birch is an important food source for insects and herbivores, so knowledge of its metabolite composition could help understand parts of its functional role in subarctic ecosystems. The composition of the volatile fraction could serve as marker for differentiating B. glandulosa from other dwarf birch species like Betula nana L. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Recommanded Product: 118-61-6).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Recommanded Product: 118-61-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of rac-bisabola-3(15),10-dien-7-ol was written by Weyerstahl, Peter;Schlicht, Volker. And the article was included in Liebigs Annalen/Recueil in 1997.Recommanded Product: Ethyl 4-methylenecyclohexanecarboxylate This article mentions the following:

1-Acetyl-4-methylenecyclohexane was obtained from 4-methylenecyclohexanecarboxylate, by DIBAH reduction, Grignard reaction, and oxidation A further Grignard reaction furnished rac-bisabola-3(15),10-dien-7-ol, which was isolated recently from vetiver oil. Its odor is mainly aldehydic (fatty, floral). In the experiment, the researchers used many compounds, for example, Ethyl 4-methylenecyclohexanecarboxylate (cas: 145576-28-9Recommanded Product: Ethyl 4-methylenecyclohexanecarboxylate).

Ethyl 4-methylenecyclohexanecarboxylate (cas: 145576-28-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Ethyl 4-methylenecyclohexanecarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Applicability of pea ingredients in baked products: Links between formulation, reactivity potential and physicochemical properties was written by Krause, Svenja;Asamoah, Eugenia Ayebea;Huc-Mathis, Delphine;Moulin, Gabrielle;Jakobi, Ralf;Rega, Barbara;Bonazzi, Catherine. And the article was included in Food Chemistry in 2022.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one This article mentions the following:

This study aimed to evaluate the applicability of purified pea ingredients (starch and protein isolate) by assessing their potential to form volatile compounds during the different steps of sponge cake development compared to pea flour and wheat flour. While pea flour was highly susceptible to lipid oxidation during batter beating, the combination of purified pea starch and pea protein yielded significantly fewer oxidation markers with known green-beany off-odors. This was due more to the inactivation of lipoxygenase during flour fractionation than to differences in batter structure. However, fractionated ingredients were highly prone to participating in the Maillard reaction and caramelization during baking, leading to a more complex mixture of pyrazines, Strecker aldehydes and furanic compounds with potential malty and roasted notes compared to cakes based on pea flour or wheat flour. These findings confirm that using purified pea fractions can create high-quality products with an attractive composition In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics