Category: esters-buliding-blocks

Experiments on the Walden Inversion. VII. Action of Phosphorus Pentachloride and of Thionyl Chloride on Optically Active Hydroxy Acids and Esters was written by McKenzie, Alex;Barrow, Fred. And the article was included in Journal of the Chemical Society, Transactions in 1911.Recommanded Product: 15399-05-0 This article mentions the following:

Phenylchloroacetic acid and benzylidene chloride are formed from SOCl₂ and dl-mandelic acid. l-Mandelic acid gives l-phenylchloroacetic acid, which, with Ag₂CO₃ and H₂O, forms d-mandelic acid. Me l-mandelate gives methyl l-phenylchloroacetate, PhCHClCO₂Me; b₁₁ 123-6鎺? d₄¹⁵ 1.213; [浼猐_D¹⁵ -86.7鎺? It gave l-phenylchloroacetic acid. From the ester and MeONa was obtained dl-phenylmethoxyacetic acid. Et l-mandelate gave ethyl l-phenylchloroacetate; b₁₃ 132-3鎺? d₄^16.4 1.162; [浼猐_D^16.4 -64.00. It gave l-phenylchloroacetic acid. The ester and EtONa gave dl-phenylethoxyacetic acid. l-Malie acid and SOCl₂ form d-chlorosuccinic acid. Et l-malate produced ethyl d-chlorosuccinate, EtO₂CCH₂CHClCO₂Et; b₁₆ 124鎺? d₄^19.5 1.152; [浼猐_D^19.8 32.7鎺? Et d-tartrate and SOCl₂ give from which d-tartaric acid was produced. Ethyl d,浼?hydroxy-灏?phenzylpropionate. PhCH₂OH(OH)CO₂Et, b₂ 152-4鎺? d₄¹⁷ 1.105; [浼猐_D¹⁷ 7.6鎺?m. 46-7鎺? in alc.[浼猐_D^18.6 -4.8鎺? in C₆H₆, [浼猐_D^17.5 22.5鎺? in acetone, [浼猐_D^17.5 13.6鎺? Ethyl l,浼?hydroxy-灏?phenvlpropionate b₂₀ 159-60鎺? m. 46-7鎺? in C₆H₆ [浼猐_D¹³ -22.6鎺? With PCl₃ the product is l-rotatory and the resulting Ca salt d-rotatory, in H₂O. The d-ester gave a similar result. The l-acid and PCl, gave a product l-rotatory in alc. Et l,浼?hydroxy-灏?phenylpropionate and SOCl₂ gave a d-rotatory product which formed a Ca salt that was l-rotatory in H₂O. d,灏?Hydroxy-灏?phenylpropionic acid and concentrate HCl gave a chloro acid having [浼猐_D -4.6鎺? in alc. With H₂O a hydroxy acid had 浼?sub>D 0.29鎺? in alc. With the l,灏?hydroxy-灏?phenylpropionic acid and HCl the products had [浼猐_D 6.5-21.8鎺? d,灏?Hydroxy-灏?phenylproplonic acid and PCl₃ gave a l-rotatory chloro acid, which, with moist Et₂O gave a l-rotatory compound With SOCl₂, instead of PCl₃, the products are cinnamic and dl- and d,灏?chloro-灏?phenylpropionic acids. B. H₂O converts these latter into dl- and l,灏?hydroxy-灏?phenylpropionic acids. l,灏?Hydroxy-灏?phenylpropionic acid and SOCl₂ formed cinnamic and dl- and l,灏?chloro-灏?phenylpropionic acids, from which, with H₂O, some d-hydroxy acid was produced. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Recommanded Product: 15399-05-0).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 15399-05-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rhenium-Catalyzed Construction of Polycyclic Hydrocarbon Frameworks by a Unique Cyclization of 1,n-Diynes Initiated by 1,1-Difunctionalization with Carbon Nucleophiles was written by Murai, Masahito;Uemura, Erika;Hori, Shunsuke;Takai, Kazuhiko. And the article was included in Angewandte Chemie, International Edition in 2017.COA of Formula: C10H14O4 This article mentions the following:

A regioselective cyclization of 1,n-diynes under rhenium catalysis was developed on the basis of a rare type of 1,1-difunctionalization of terminal alkynes with carbon nucleophiles, followed by sequential addition reactions of the resulting alkenylrhenium species. The reaction provides an efficient approach to the synthesis of complex cyclopentane-fused bi- and tricycles and spirocycles, which are useful building blocks for the construction of essential frameworks of biol. active compounds as well as functional materials, from simple starting materials by the formation of up to six new carbon-carbon bonds in a single step. The reaction proceeds under neutral conditions and does not require external ligands or additives. The key to this reactivity is the unique activation mode of the rhenium carbonyl complex, which prefers to interact with heteroatoms in polar carbon-heteroatom bonds as well as nonpolar carbon-carbon unsaturated 锜?bonds. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9COA of Formula: C10H14O4).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C10H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Properties and structure of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) filaments for fused deposition modelling was written by Kovalcik, Adriana;Smilek, Jiri;Machovsky, Michal;Kalina, Michal;Enev, Vojtech;Dugova, Hana;Cernekova, Nicole;Kovacova, Maria;Spitalsky, Zdenko. And the article was included in International Journal of Biological Macromolecules in 2021.Category: esters-buliding-blocks This article mentions the following:

Fused deposition modeling (FDM) is a process of additive manufacturing allowing creating of highly precise complex three-dimensional objects for a large range of applications. The principle of FDM is an extrusion of the molten filament and gradual deposition of layers and their solidification. Potential applications in pharmaceutical and medical fields require the development of biodegradable and biocompatible thermoplastics for the processing of filaments. In this work, the potential of production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) filaments for FDM was investigated in respect to its thermal stability. Copolymer P(3HB-co-4HB) was biosynthesised by Cupriavidus malaysiensis. Rheol. and mech. properties of the copolymer were modified by the addition of plasticizers or blending with poly(lactic acid). Thermal stability of mixtures was studied employing thermogravimetric anal. and rheol. analyses by monitoring the time-dependent changes in the complex viscosity of melt samples. The plasticization of P(3HB-co-4HB) slightly hindered its thermal degradation but the best stabilization effect was found in case of the copolymer blended with poly(lactic acid). Overall, rheol., thermal and mech. properties demonstrated that the plasticized P(3HB-co-4HB) is a potential candidate of biodegradable polymer for FDM processes. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Category: esters-buliding-blocks).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 浼? 灏?unsaturated 绾?amino esters with unprecedented high (E)-stereoselectivity and their conformational analysis in peptides was written by Mali, Sachitanand M.;Bandyopadhyay, Anupam;Jadhav, Sandip V.;Kumar, Mothukuri Ganesh;Gopi, Hosahudya N.. And the article was included in Organic & Biomolecular Chemistry in 2011.HPLC of Formula: 87694-53-9 This article mentions the following:

Mild, efficient and racemization-free synthesis of N-protected 浼? 灏?unsaturated 绾?amino esters with unprecedented high E- stereoselectivity is described. This method is found to be compatible with Boc- (Boc = tert-butoxycarbonyl), Fmoc- (Fmoc = 9-fluorenylmethoxycarbonyl) and other side chain protecting groups. The crystal conformations of the vinylogous 绾?amino esters in monomers and in homo- and mixed dipeptides are studied. Further, the vinylogous homo-dipeptide showed a 灏?sheet conformation, while mixed 浼? and 浼?灏?unsaturated 绾?hybrid dipeptide adapted an irregular structure in single crystals. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9HPLC of Formula: 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of novel tripeptide propylene oxide proteasome inhibitors for the treatment of multiple myeloma was written by Zhang, Wen;Wang, Xueyuan;Zhang, Haoyang;Wen, Tiantian;Yang, Lin;Miao, Hang;Wang, Jia;Liu, Hailong;Yang, Xu;Lei, Meng;Zhu, Yongqiang. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Related Products of 87694-53-9 This article mentions the following:

The ubiquitin proteasome pathway (UPP) plays a critical role in the maintenance of cell homeostasis and the development of diseases, such as cancer and neurodegenerative disease. A series of novel tripeptide propylene oxide compounds as proteasome inhibitors were designed, synthesized and biol. investigated in this manuscript. The enzymic activities of final compounds against 20S human proteasome were investigated and structure-activity relationship (SAR) was summarized. Some potent compounds were further evaluated to inhibit the proliferation of multiple myeloma (MM) cancer cell lines RPMI8226 and U266B. The results showed that some compounds were active against MM cancer cell lines with IC₅₀ values of less than 50 nM. The microsomal metabolic stabilities in human, rat and mice species were carried out and the results showed that compounds (I) (R¹ = iso-Bu, Bn) were stable enough to be in vivo investigated. The in vivo pharmacokinetic results showed that compounds I (R¹ = iso-Bu, Bn) had acceptable biol. parameters for both ig and iv administrations. In vivo antitumor activities of compounds I (R¹ = iso-Bu, Bn) with the doses of 100 mg/kg and 50 mg/kg BIW were performed by using RPMI8226 xenograft nude mouse model. Toxicities of compounds I (R¹ = iso-Bu, Bn) were not observed during the experiment and dose dependent effect was obvious and the tumor volume was greatly inhibited. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Related Products of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of bioactive components in the hydroalcoholic extract of Syringodium Isoetifolium and assessment of its biological activity by gas chromatography – masspectrometry was written by Kalaivani, P.;Amudha, P.. And the article was included in International Journal of Research in Pharmaceutical Sciences (Madurai, India) in 2021.HPLC of Formula: 84-61-7 This article mentions the following:

Herbal plants show a growing interest in natural antioxidant, also play an important role in the treatment of muscle pain, stomach problems, wounds etc. About 75 to 80% of the world population uses herbal medicine. One such herb (Marine Plants) used in the treatment of cancer is Syringodium isoetifolium. In a previous study, Syringodium isoetifolium with three different extracts (Aqueous, ethanol and 70% hydroalc.) proves the presence of phytocompound such as Tannin, Saponin, Flavonoids, Stroids, Terpenoids, coumarin etc and also has high antioxidant activity. The current study aims to identify the bioactive compounds from the hydroalcoholic extract of Syringodium isoetifolium. The photo components present in the hydroalcoholic extract was determined by GC-MS Anal. and the mass spectra of compounds present in the extract were matched with the National Institute of Standards and Technol. library. 20 different phytocompounds were found to be present in the hydroalcoholic extract of Syringodium isoetifolium using GC-MS anal. Some of the important phytocompounds are Hexanoic acid, Me ester, Octadecanoic acid, 1,2-Benzenedicarboxylic acid, bis(2-methylpropyl) ester, 1-Isopropylidene-3-methyl-3-vinylcyclobutane. The study reveals that the identified phytocompounds from the hydroalcoholic extract of Syringodium isoetifolium has essential biol. activities such as Antibacterial, Antifungal, Antimicrobial, Antifouling and Anticancer properties. Further depth of the study will deal with the exact mode of action of the phytocompounds. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7HPLC of Formula: 84-61-7).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 84-61-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An efficient protocol for multicomponent synthesis of 1H-chromeno[4,3-b]pyridin-5(4H)-ones derivatives was written by Chen, Zhiwei;Gu, Jinying;Su, Weike. And the article was included in Journal of Chemical Research in 2013.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:

A series of 1H-chromeno[4,3-b]pyridin-5(4H)-one derivatives, e.g., I, were synthesized via a three-component condensation of 4-aminocoumarin, aldehydes and Et benzoylacetates, under simple mild reaction conditions. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts was written by Brnardic, Edward J.;Fraley, Mark E.;Garbaccio, Robert M.;Layton, Mark E.;Sanders, John M.;Culberson, Chris;Jacobson, Marlene A.;Magliaro, Brian C.;Hutson, Pete H.;O’Brien, Julie A.;Huszar, Sarah L.;Uslaner, Jason M.;Fillgrove, Kerry L.;Tang, Cuyue;Kuo, Yuhsin;Sur, Sylvie M.;Hartman, George D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Recommanded Product: 16413-26-6 This article mentions the following:

Hit to lead optimization of (5R)-5-hexyl-3-phenyl-1,3-oxazolidin-2-one as a pos. allosteric modulator of mGluR2 is described. Improvements in potency and metabolic stability were achieved through SAR on both ends of the oxazolidinone. The optimized lead compound 34 (I) was found to be brain penetrant and active in a rat ketamine-induced hyperlocomotion model for antipsychotic activity. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterization of odor-active volatiles and odor contribution based on binary interaction effects in mango and vodka cocktail was written by Niu, Yunwei;Wang, Pinpin;Xiao, Qing;Xiao, Zuobing;Mao, Haifang;Zhang, Jun. And the article was included in Molecules in 2020.Quality Control of Methyl2-methylbutyrate This article mentions the following:

Thirty-six volatile compounds, composed of 18 esters, 10 terpenes, and 8 others, were detected by headspace-solid phase microextraction (HS-SPME) equipped with gas chromatog.-mass spectrometry (GC-MS) in mango and vodka cocktail. Moreover, these compounds were detected by olfactometry using aroma intensities. Comparing these compounds revealed that the aroma intensities (AIs) of limonene, 3-carene, myrcene, 灏?caryophyllene, and citronellyl propanoate were higher than others (AIs 閳?4). In this context, limonene was selected as the reference compound on the basis of the strongest component model. The aim of this study was to determine the perceptual interaction between limonene and 3-carene, myrcene, 灏?caryophyllene, citronellyl propanoate, resp., in a binary mixture In addition, feller’s addition model revealed that limonene presented an addition effect when combined with 3-carene, myrcene, 灏?caryophyllene, and citronellyl propanoate. It could be stated that these compounds played an important role in the aroma of mango and vodka cocktail. The results demonstrated that mol. structure and the ratio between compounds affected the synergistic effect, and compounds with similar structure and aroma were more prone to undergo addition and synergy. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Quality Control of Methyl2-methylbutyrate).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of Methyl2-methylbutyrate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anodic oxidation potentials of substituted pyrroles: derivation and analysis of substituent partial potentials was written by Tabba, Hani D.;Smith, Kevin M.. And the article was included in Journal of Organic Chemistry in 1984.Application In Synthesis of Ethyl 4-methyl-1H-pyrrole-3-carboxylate This article mentions the following:

The anodic oxidation potentials of 117 pyrroles, determined by cyclic voltammetry, were used to estimate substituent partial potentials; the substituent constants accurately predicted the oxidation potentials of any common substituted pyrrole. Calculated and observed oxidation potentials differed when 2 strongly electron-withdrawing substituents (EWS) were located at C(2) and C(5) and when the pyrrole was unsubstituted at C(2) and had a strong EWS at C(5). LFER of the substituent partial potentials with 锜?sub>p and 锜?sub>m were not good; a good LFER of substituent partial potentials and the pK_a of 5-pyrrolecarboxylic acids was observed In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Application In Synthesis of Ethyl 4-methyl-1H-pyrrole-3-carboxylate).

Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Application In Synthesis of Ethyl 4-methyl-1H-pyrrole-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics