Category: esters-buliding-blocks

Electric Literature of 1105187-36-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1105187-36-7, name is Methyl 3-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of 3-Bromo-4-(4-trifluoromethyl-benzyl)-4H-thieno[3,2-b]pyrrole-S-carboxylic acid methyl ester (2.3 g), 4-trifluoromethybenzyl bromide (2.4 g) and Cs2CO3 (4 g) was stirred for 14 h at room temperature. The reaction mixture was then diluted with 100 ml of 1:1 hexane/EtOAc and filtered through a pad of silica gel. The filtrate was concentrated to give 4.0 g of the crude title compound which was used for the next step without further purification.

The synthetic route of Methyl 3-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beta Pharma Canada Inc.; YUAN, Wei, W.; (58 pag.)EP2320906; (2016); B1;,
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Synthetic Route of 56741-34-5, A common heterocyclic compound, 56741-34-5, name is Methyl 5-amino-2-fluorobenzoate, molecular formula is C8H8FNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 11a (500 mg, 1.85 mmol) in acetone (10 mL) was added 12 (380 mg, 1.85 mmol) and pyridine (0.45 mL, 5.54 mmol).The mixture was stirred at 55 C for 1 h. The mixture was concentrated,diluted with ethyl acetate and washed with 1M HCl and brine twice.Then, the ethyl acetate layer was dried over anhydrous sodium sulfate andconcentrated to give the crude product. The crude product was purified bysilica column eluting with petroleum ether/ethyl acetate (5/1-2/1) to givethe desired product (0.33 g, yield 44.3%) as grey solid

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; He, Yulong; Dou, Huixia; Gao, Dingding; Wang, Ting; Zhang, Mingming; Wang, Heyao; Li, Yingxia; Bioorganic and Medicinal Chemistry; vol. 27; 19; (2019);,
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Reference of 6091-64-1, The chemical industry reduces the impact on the environment during synthesis 6091-64-1, name is Ethyl 2-bromobenzoate, I believe this compound will play a more active role in future production and life.

General procedure: 5mL of hydrazine monohydrate (80%) was added to a solution of intermediate 3 (5mmol) in ethanol (5mL). The reaction mixture was maintained under reflux for 5h. was then concentrated under reduced pressure and the resulting solid was collected by filtration, washed with cold water and dried to give the desired intermediate 4 as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-bromobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5652 – 5661;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55666-42-7, name is tert-Butyl 2-bromobenzoate, A new synthetic method of this compound is introduced below., Application In Synthesis of tert-Butyl 2-bromobenzoate

tert-Butyl 2-bromobenzoate (51 mg, 0.20 mmol) and anhydrous THF (3 mL) were put into a dried flask inside of which was substituted with argon. The mixture was cooled to -78 C., and then added with 1M sec¡¤BuLi (0.30 mmol), and the mixture was stirred for 20 minutes. The mixture was slowly added with 4,5-difluoro-3,6-diOTBDMS-Si-xanthone (5.4 mg, 0.010 mmol) dissolved in anhydrous THF (3 mL) at the same temperature, and the mixture was returned to room temperature. The mixture was stirred at room temperature for 1 hour, and then added with 2 N HCl (10 mL), and the mixture was stirred for 20 minutes. The mixture was extracted with dichloromethane, and the organic layer was washed with brine, and dried over Na2SO4. The solvent was removed, then the residue was added with TFA (3 mL), and the mixture was stirred at room temperature for 2 hours. The solvent was removed, and then the residue was purified by HPLC to obtain 2-COOH DFTM (2.2 mg, 0.054 mmol, yield 54%). 1H-NMR (300 MHz, CD3OD): delta 0.68 (s, 3H), 0.79 (s, 3H), 6.66 (d, 2H, J=8.8 Hz), 6.87 (t, 2H, J=9.2 Hz), 7.13 (d, 1H, J=7.3 Hz), 7.57-7.68 (m, 2H), 7.92 (d, 1H, J=8.1 Hz) HRMS m/z Found 411.0902, calculated 411.0864 for [M+H]+ (3.8 mmu)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THE UNIVERSITY OF TOKYO; Nagano, Tetsuo; Hanaoka, Kenjiro; Koide, Yuichiro; Egawa, Takahiro; Hirabayashi, Kazuhisa; US2013/289256; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 13831-03-3, name is tert-Butyl propiolate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13831-03-3, Product Details of 13831-03-3

General procedure: To a stirred solution of the acetylenic ester (2 mmol) and the 1,3-diketones (2 mmol) in 10 mL of CH2Cl2 was added 0.26 g of isoquinoline (2 mmol) at r.t. After completion of the reaction (2-3 h), as indicated by TLC (AcOEt/hexane, 1:2), the solvent was removed under reduced pressure and the viscous residue was purified by column chromatography on silica gel (Merck 230-400 mesh) using hexane-AcOEt (2:1) as eluent to afford pure title compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl propiolate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Piltan, Mohammad; Yavari, Issa; Moradi, Loghman; Journal of the Iranian Chemical Society; vol. 13; 4; (2016); p. 605 – 608;,
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Reference of 2216-92-4, A common heterocyclic compound, 2216-92-4, name is N-Phenylglycine Ethyl Ester, molecular formula is C10H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Prepared in the manner of Example 16 except 4- (trifluoromethyl) benzyl bromide was substituted for 4-chlorobenyl chloride. Purification by flash chromatography (10: 1 to 5: 1 hexanes/EtOAc) afforded the title compound as a yellow oil (30%). 1H NMR [(CDCI3)] [8] 7.62 (d, 2H), 7.52 (d, 2H), 7.43 (d, 2H), 6.68 (d, 2H), 4.73 (s, 2H), 4.25 (q, 2H), 4.14 (s, 2H), 1.30 (t, 3H). Anal. Calc. [FOR C21H18NO3FS] : C, 50.11 ; H, 3.60 ; N, 2.78. Found: C, 50.01 ; H, 3.98 ; N, 2.61. HRMS (MH+). Calc. : 504.1221. Found: 504.1227.

The synthetic route of 2216-92-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5159-59-1, name is Methyl 6-amino-2-naphthoate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C12H11NO2

To a solution of methyl 6-amino-2-naphthoate (1.2 g, 6.0 mmol, 1.0 eq) and 4-(trifluoromethyl)cyclohexanone (2.0 g, 12.0 mmol, 2.0 eq) in DCM (20 mL) were added NaBH(OAc)3 (2.6 mg, 12.0 mmol, 2.0 eq) and HO Ac (360 mg, 6.0 mmol, 1.0 eq). The mixture was stirred at rt for 16 h and washed with sat. aq. NaHC03 (30 mL). The aqueous layer was extracted with EtOAc (30 mLx2). The combined organic layers were combined and concentrated. The residue was washed with MeOH to give the title compound as a yellow solid (700 mg, yield: 30%) with cis isomer only. 1H NMR (400 MHz, CDC13) delta 8.42 (s, 1H), 7.93 (dd, /= 1.6 Hz, 9.2 Hz, 1H), 7.72 (d, /= 9.2 Hz, 1H), 7.59 (d, /= 8.0 Hz, 1H), 6.92 (d, / = 8.0 Hz, 1H), 6.78 (s, 1H), 3.94 (s, 3H), 3.83 (s, 1H), 2.22-2.05 (m, 3H), 1.85-1.60 (m, 6H); ESI-MS (M+H) +: 352.2.

According to the analysis of related databases, 5159-59-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOGEN IDEC MA INC.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam; MA, Bin; MI, Sha; SHAO, Zhaohui; SUN, Lihong; TAVERAS, Arthur; WANG, Deping; XIN, Zhili; ZHANG, Lei; WO2014/18887; (2014); A1;,
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Electric Literature of 69812-51-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69812-51-7, name is Methyl 4-chlorosulfonylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.

Methyl 4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)-N-methyl-methylaminosulfonyl]phenyl-4-carboxylate (compound5(0086) Compound 4 (2.77 g, 10 mmol) and methyl-4-chlorosulfonylbenzenecarboxylate (2.46 g, 10.5 mmol) were dissolved in 30 mL DMF. TEA (3.03 g, 3 eq) was added and the solution was stirred for 12 hours at room temperature. The solvent was removed and silica gel plaque was made. Column separation offered a purified white powder compound 5 in 80% yields, Rf0.25 (CHCl3/CH3OH, 10/1); 1H NMR (DMSO-d6) delta 1.26 (s, 9H), 2.60 (2, 3H), 4.21 (s, 2H, 6.25 (s, 1H), 7.94 (d, 2H), 8.06 (d, 2H), 10.91 (br, 1H), 11.63 (br, 1H), 11.91 (br, 1H).

The chemical industry reduces the impact on the environment during synthesis Methyl 4-chlorosulfonylbenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Duquesne University of The Holy Ghost; GANGJEE, ALEEM; MATHERLY, LARRY H.; (12 pag.)US2016/229857; (2016); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6279-86-3, name is Triethyl methanetricarboxylate, A new synthetic method of this compound is introduced below., name: Triethyl methanetricarboxylate

1,2,3,4-tetrahydroquinoline (1.78 g, 13.4 mmol) and triethyl methane tricarboxylate (3.1 g, 13.4 mmol) were heated at 230 C. for 30 minutes. The resulting compound is cooled to room temperature, filtered using ethyl acetate (50 mL) and MeOH (30 mL),The organics were concentrated and purified by column chromatography (ethylacetate: methanol = 49: 1) to ethyl 1-hydroxy-3-oxo-3,5,6,7-tetrahydropyrido [3,2,1-ij]quinoline-2-carboxylate (0.96 g, 3.5 mmol) was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Korea Research Institute of Chemical Technology; Park Cheol-min; Lee Seon-gyeong; Song Jong-hwan; (39 pag.)KR2019/67546; (2019); A;,
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Related Products of 23426-63-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23426-63-3, name is Methyl 2-bromo-2-methylpropanoate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Toa solution of 1a (770 mg, 3.24 mmol) in DMF (20 mL) was added potassium carbonate (2.69g, 19.5 mmol).Thereaction mixture was stirred at ambient temperature for 30minutes. After addition of ethyl bromoacetate (1.08mL), the mixture was heated at 70oC for 2 hours. The mixture was cooled to ambient temperature andwater (60 mL) was added. The solution was extractedwith ethyl acetate (3 30 mL). The organic phase was washed withsaturated aqueous sodium chloride solution (2 ¡Á 15mL), dried over sodium sulfate, filtered and concentrated. The residue waspurified by column chromatography (silica gel, petroleum ether/ethyl acetate 5:1)to give the title compound (464 mg, 44% yield) as white solid.

The chemical industry reduces the impact on the environment during synthesis Methyl 2-bromo-2-methylpropanoate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Huang, Yaping; Sun, Geng; Wang, Pengfei; Shi, Rui; Zhang, Yanchun; Wen, Xiaoan; Sun, Hongbin; Chen, Caiping; Bioorganic and Medicinal Chemistry Letters; vol. 28; 17; (2018); p. 2957 – 2960;,
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