Category: esters-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3196-15-4, name is Methyl 2-bromobutyrate, A new synthetic method of this compound is introduced below., Formula: C5H9BrO2

Weighed 2,4-dichlorophenol (815mg, 5mmol) in 100mL round bottom flask was added anhydrous potassium carbonate (1.38g, 10.0mmol, 2eq), acetone (30 mL) and 2-bromo-butyric acid methyl ester ( 995.6mg, 5.5mmol, 1.1eq), was heated under reflux for 12 hours.The reaction was cooled to room temperature, the solid was removed by suction filtration, and the filtrate was evaporated to dryness after the addition of water (30 mL), extracted with ethyl acetate (50mL × 3), combined extracts were washed with water (20mL × 2) and saturated brine (20 mL ) was washed, dried over anhydrous sodium sulfate, filtered and concentrated, the crude product was purified by silica gel column chromatography [V (ethyl acetate) :V (petroleum ether) = 1: 8] to give 1.22g, 93% yield.1HNMR (400MHz, CDCl3)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Changzhou University; Chen, Xi; Liang, Cuirong; Yang, Qinghong; Ren, Jie; Jin, Guihua; Huang, Qianhui; Xu, Yuanyuan; Hu, Kun; (32 pag.)CN105440020; (2016); A;,
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These common heterocyclic compound, 2033-24-1, name is 2,2-Dimethyl-1,3-dioxane-4,6-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: esters-buliding-blocks

General procedure: Method A: Adapted from the procedure of Srensen et al.14 To a solution of Meldrum?s acid (1equiv) in dichloromethane at 0C was added pyridine (2equiv) drop wise, and the resulting solution was stirred for 15min. The corresponding acid chloride (1equiv) was added to this reaction mixture. Thereafter, the reaction was stirred for 1.5h at 0C, and for an additional 1.5h at room temperature. The reaction was quenched with 2M hydrochloric acid, and extracted with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography using a gradient from 5% to 10% ethyl acetate in hexane, 1% acetic acid to yield acyl Meldrum?s acids (11a-e, j, l, p).

The synthetic route of 2,2-Dimethyl-1,3-dioxane-4,6-dione has been constantly updated, and we look forward to future research findings.

Reference:
Article; Verma, Astha; Wong, Dawn M.; Islam, Rafique; Tong, Fan; Ghavami, Maryam; Mutunga, James M.; Slebodnick, Carla; Li, Jianyong; Viayna, Elisabet; Lam, Polo C.-H.; Totrov, Maxim M.; Bloomquist, Jeffrey R.; Carlier, Paul R.; Bioorganic and Medicinal Chemistry; vol. 23; 6; (2015); p. 1321 – 1340;,
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141-12-8, name is (Z)-3,7-Dimethylocta-2,6-dien-1-yl acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of (Z)-3,7-Dimethylocta-2,6-dien-1-yl acetate

General procedure: To a solution of the geranyl derivative (1.0 equiv) in acetonitrile(0.07 M) cooled to 0 C, PIFA (1.1 equiv) was added. Asolution of tetra-n-butylammonium bromide (1.1 equiv) inacetonitrile (0.07 M) was then added dropwise over 5 min.After stirring for 10 min, the reaction mixture was diluted withEtOAc, saturated aqueous Na2S2O3 solution was added and thelayers were separated. The aqueous layer was extracted twicewith EtOAc. The combined organic extracts were washed withbrine, dried over MgSO4, filtered and concentrated underreduced pressure before purification by flash chromatography.

The synthetic route of 141-12-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Peilleron, Laure; Grayfer, Tatyana D.; Dubois, Joelle; Dodd, Robert H.; Cariou, Kevin; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1103 – 1111;,
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Related Products of 120-51-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 120-51-4 name is Benzyl benzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 13Hydrogenation of Benzyl Benzoate Benzyl benzoate (8 mmol), a ruthenium complex 1 (0.008 mmol), and tetrahydrofuran (3.2 mL) were charged into a 100-mL autoclave equipped with a stirrer. Then, the mixture was subjected to hydrogenation at a hydrogen pressure of 5 MPa at 80 C. for 16 hours. The reaction liquid was analyzed by gas chromatography. As a result, benzyl alcohol was obtained at a conversion rate of 23% and a selectivity of 98%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Benzyl benzoate, and friends who are interested can also refer to it.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; US2010/63294; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40876-98-0, name is Sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 40876-98-0

(a) 6-Hydroxy-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid ethyl ester 5-Aminopyrazole (25 g) and diethyl oxalacetate sodium salt (74.4 g) were dissolved under cooling in 1N hydrochloric acid. 68.75 mL of glacial acetic acid were added and the mixture was stirred at 80 C. for 14 h. The mixture was cooled to room temperature and the formed precipite was filtered off and titurated in ethyl acetate to give 16.06 g (26%) of the desired product. LC/MS (Method LC1): Rt=0.86 min: m/z=208.07 [M+H]+.

The synthetic route of 40876-98-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI; PLETTENBURG, Oliver; LOEHN, Matthias; MENDEZ-PEREZ, Maria; HACHTEL, Stephanie; PODESCHWA, Michael; KANNT, Aimo; IVASHCHENKO, Yuri; BJERGARDE, Kirsten; US2013/150340; (2013); A1;,
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Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35179-98-7, name is Chloromethyl ethyl carbonate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

J. (R)-3-[N-(5′-Chloro-2′-fluorobiphenyl-4-methyl)-N’-oxalylhydrazino]-2-hydroxy-propionic Acid Ethoxycarbonyloxymethyl Ester A mixture of (R)-3-[N’-t-butoxyoxalyl-N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)hydrazino]-2-hydroxypropionic acid (270 mg, 580 mumol), chloromethyl ethyl carbonate (160 mg, 1.16 mmol), NaI (174 mg, 1.2 mmol) and 2,6-dimethylpyridine (620 mg, 5.8 mmol) in DMF (10 mL) was stirred at room temperature overnight. The mixture was poured into water (30 mL) and the mixture was then extracted with EtOAc (3*30 mL). The combined organic layers were washed with saturated aqueous NaCl (2*30 mL), dried over anhydrous Na2SO4, and concentrated in vacuo. The crude Compound 1 (300 mg) was used without purification. LC-MS: 569 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; HUGHES, Adam D.; FENSTER, Erik; FLEURY, Melissa; GENDRON, Roland; US2013/109639; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 89-91-8,Some common heterocyclic compound, 89-91-8, name is Methyl 2,2-dimethoxyacetate, molecular formula is C5H10O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step F; 5-Bromo-6-ethyl-N*2*-isopropyl-pyridine-2, 3-diamine (1 g) is dissolved in diethoxymethylacetate (4 mL) and is heated at 120 C for 90 min. After cooling to RT the mixture is directly purified by flash column chromatography on silica gel to give 6-bromo-5- ETHYL-3-ISOPROPYL-3H-IMIDAZO [4,5-b] pyridine as colorless oil. Rf (hexane: EtOAc = 2: 1) = 0.32

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2,2-dimethoxyacetate, its application will become more common.

Reference:
Patent; NEUROGEN CORPORATION; AVENTIS PHARMACEUTICALS INC.; WO2005/23806; (2005); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 3196-15-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3196-15-4, name is Methyl 2-bromobutyrate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 4: methyl 2-[2-(4-methylbenzoylimino)-6-(phenylcarbamoyl)benzo[d]thiazol-3(2H)-yl]butanoate To a solution of 2-(4-methylbenzamido)-N-phenylbenzo[d]thiazol-6-carboxamide (200 mg, 0.52 mmol) prepared in Step 3 in N,N-dimethylformamide (2.0 mL) was added dropwise potassium carbonate (216 mg, 1.56 mmol) and methyl 2-bromobutyrate (90 uL, 0.78 mmol). The reaction mixture was refluxed under stirring at 80 C. overnight. The reaction mixture was quenched with water and then extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered, and then evaporated. The residue was purified with silica gel column chromatography (n-hexaneethyl acetate=2/1, v/v) to give 200 mg of the titled compound as a white solid (Yield: 79%). 1H NMR (CDCl3, 400 MHz) delta 8.23 (s, 1H), 8.17 (d, 2H), 7.97 (d, 1H), 7.88 (s, 1H), 7.65 (d, 2H), 7.34-7.41 (m, 3H), 7.28 (d, 2H), 7.18 (t, 1H), 5.63 (m, 1H), 3.68 (s, 3H), 2.46-2.57 (m, 2H), 2.42 (s, 3H), 0.92 (t, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromobutyrate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; YUHAN CORPORATION; Hur, Youn; Kim, Dong-Hyun; Kim, Eun-Kyung; Park, Jin-Hwi; Joo, Jae-Eun; Kang, Ho-Woong; Oh, Se-Woong; Kim, Dong-Kyun; Ahn, Kyoung-Kyu; US2015/11528; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 150726-89-9, name is Dimethyl 2-(2-methoxyphenoxy)malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 150726-89-9

d) Na (2.3 g) was dissolved in methanol (40 ml) and 2-(3-methoxy-phenyl)-acetamidine hydrochloride (10 g) and (2-methoxyphenoxy)-malonic acid dimethyl ester (12.67 g) were added in succession at room temperature. The mixture was stirred for 5 hours at room temperature, concentrated in a rotary evaporator and the crude product was added to water. The aqueous phase was washed with ethyl acetate, adjusted to pH 1 and the precipitated crystals were sucked off and dried under a high vacuum. There was thus obtained 2-(3-methoxy-benzyl)-5-(2-methoxy-phenoxy)-pyrimidine-4,6-diol as beige crystals. MS: 354 (M)

The synthetic route of 150726-89-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; US5837708; (1998); A;,
Ester – Wikipedia,
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Electric Literature of 23062-51-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23062-51-3, name is Methyl 4-bromobicyclo[2.2.2]octane-1-carboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of XVIII-2 (6 g, 24.2 mmol) in anhydrous benzene (60.15 g) was added dropwise to an ice-water cooled suspension of AlCl3 (5.95 g, 45.1 mmol) in benzene (60.15 g) under nitrogen. The resulting reaction mixture was allowed to stirred in the ice bath for 30 min and then at rt overnight. The mixture was heated to 60 C. for 4 h and then allowed to cool to rt and poured into ice and concentrated HCl. The mixture was extracted with EtOAc, washed with brine, separated, and dried over Na2SO4 to leave an orange-brown solid, which was purified by column chromatography (PE:EA=10:1) to afford XVIII-3 (2.3 g, yield: 38.6%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-bromobicyclo[2.2.2]octane-1-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/200215; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics