Category: esters-buliding-blocks

Zou, Wenjing published the artcileImproving cure performance of Si₃N₄ suspension with a high refractive index resin for stereolithography-based additive manufacturing, COA of Formula: C15H20O6, the publication is Ceramics International (2022), 48(9), 12569-12577, database is CAplus.

Silicon nitride (Si₃N₄) slurries with high solid loading, low viscosity and good stability is difficulty prepared, due to low intrinsic surface charge and a large refractive index (RI) difference between Si₃N₄ powder and resin. In this paper, the curing behavior of Si₃N₄ slurry with different functional group and RI of resin monomer were systematically researched, and then the kind and optimum content of dispersant were investigated. Subsequently, a high solid loading Si₃N₄ slurry (44 vol%) with good curing behavior, low viscosity and favorable stability was successfully prepared Lastly, the dense Si₃N₄ ceramic parts were fabricated by the suitable Si₃N₄ slurry (44 vol%) via stereolithog. After debinding and sintering process, the relative d. and flexural strength of Si₃N₄ ceramic were 98.28% and 800 ± 27.28 Mpa, resp.

Ceramics International published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C10H10O6, COA of Formula: C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Lishou published the artcileSynthesis of novel 1-phenyl-benzopyrrolizidin-3-one derivatives and evaluation of their cytoneuroprotective effects against NMDA-induced injury in PC12 cells, HPLC of Formula: 103-26-4, the publication is Bioorganic & Medicinal Chemistry (2022), 116675, database is CAplus and MEDLINE.

A range of novel 1-phenyl-benzopyrrolizidin-3-one derivatives I (R¹ = Ph, 2-MeOC₆H₄, 3-BnOC₆H₄, etc.; R² = H, 8-F, 7-OBn) were synthesized and evaluated for neuroprotective effects against N-methyl-D-aspartate (NMDA)-induced injury in PC12 cells. Interestingly, derivatives that 1-Ph moiety bearing electron-donating group, especially benzyloxy, and the trans-forms exhibited better protective activity against NMDA-induced neurotoxicity. Compound I (R¹ = 3-BnOC₆H₄; R² = 8-F) demonstrated the best neuroprotective potency and shown a dose-dependent prevention. The increased intracellular calcium (Ca²⁺) influx caused by NMDA in PC12 cells was reversed in the case of compound I (R¹ = 3-BnOC₆H₄; R² = 8-F) pretreatment at 15μM. These results suggested that the synthesized 1-phenyl-benzopyrrolizidin-3-one derivatives exerted neuroprotective effect on NMDA-induced excitotoxicity in PC12 cells associated with inhibition of Ca²⁺ overload and can be further optimized for the development of neuroprotective agents.

Bioorganic & Medicinal Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C4H6O3, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shen, Yanjia published the artcileThe histone deacetylase inhibitor belinostat ameliorates experimental autoimmune encephalomyelitis in mice by inhibiting TLR2/MyD88 and HDAC3/ NF-κB p65-mediated neuroinflammation, Quality Control of 624-49-7, the publication is Pharmacological Research (2022), 105969, database is CAplus and MEDLINE.

Multiple sclerosis (MS) is a Th cell-mediated inflammatory demyelinating autoimmune disease. MS cannot be cured, and long-term drug treatment is still needed for MS patients. In this study, we examined the effect of belinostat, a pan-histone deacetylase inhibitor (HDACi), on exptl. autoimmune encephalomyelitis (EAE) and elucidated its mechanism of action. We found that belinostat alleviates the clin. symptoms, histopathol. central nervous system (CNS) inflammation and demyelination outcomes in EAE mice. Compared to the MS oral drug di-Me fumarate (DMF) (100 mg/kg), belinostat (30 mg/kg) treatment exhibited better efficacy in improving the clin. symptoms of EAE mice. Belinostat treatment significantly suppressed the activation of M1 microglia and the proinflammatory cytokine expression; but it had no effects on the M2 microglial polarization. Belinostat also decreased both NO and iNOS levels in LPS-stimulated BV2 microglia. Accordingly, belinostat treatment of EAE mice significantly inhibited activation of the TLR2/MyD88 signaling pathway and downregulated the expression of HDAC3 while upregulating the acetylated NF-κB p65 levels. Taken together, these data demonstrate for the first time that belinostat ameliorates EAE in mice through inhibiting neuroinflammation via suppressing M1 microglial polarization, and implicating belinostat as a potential candidate for the treatment of multiple sclerosis.

Pharmacological Research published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C9H7NO4, Quality Control of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hu, Jin published the artcileRobust, transparent, and self-healable polyurethane elastomer via dynamic crosslinking of phenol-carbamate bonds, Safety of Propyl 3,4,5-trihydroxybenzoate, the publication is Polymer (2021), 123674, database is CAplus.

Intrinsic self-healing materials designed through the incorporation of noncovalent interactions or dynamic covalent bonds are prized for their ability to recover from mech. damages. However, they often suffer from deteriorated mech. property due to the increased chain mobility. In this work, we reported a high-strength, colorless transparent self-healing polyurethane elastomer through dynamic crosslinking of reversible phenol-carbamate bonds. Tetrabromobisphenol A (TBBPA) and Pr gallate (PG) were used as the dynamic chain extender and dynamic crosslinking agent, resp. They both can be effectively deblocked at mild temperatures ensuring that the self-healing efficiency is not affected by the material formulation. The mech. properties can be tailored in a wide range by varying the crosslink d. and hard segment content, and their combination uniquely determines the material formulation. The phenol-carbamate based polyurethane (PPU) with a hard segment of 60% and a crosslink d. ν of 0.5 mmol cm^-3 exhibited a tensile strength up to 46.4 MPa at the break strain of 615% and displayed high elastic resilience. In the meantime, it could be fully healed (ησ = 93%) with 2 h of heating at 100°C after completely cut off. After recycled three times, it still maintained 80% of its original tensile strength. The structural rigidity of the crosslinker PG and the highly reversible phenol-carbamate bond play a crucial role in strengthening the mech. strength while maintaining the self-healing efficiencies at elevated temperatures This work provides a feasible strategy to prepare mech. robust crosslinked polyurethane elastomer with high self-healing efficiency in a cost-effective manner.

Polymer published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Safety of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cai, Jiawen published the artcileA Physical-chemical Synergetic Inhibitor for Coal Spontaneous Combustion and Its Fire Prevention Performance, Quality Control of 31570-04-4, the publication is Combustion Science and Technology (2022), 194(6), 1155-1167, database is CAplus.

A single phys. or chem. inhibitor can hardly meet the uttermost requirements for coal spontaneous combustion prevention. Therefore, it has become essential to develop an efficient inhibitor with multiple inhibitory properties. In light of studies on the properties of the super absorbent polymer (SAP), the main antioxidant pentaerythritol tetrakys 3-(3,5-ditert-butyl-4-hydroxyphenyl) propionate and auxiliary antioxidant tris (2,4-di-tert-butyl-pheny) phosphite, a synergistic antioxidant with both phys. and chem. inhibitory properties was prepared According to the determination of volatile matter and calorific value of coal, the optimum molar ratio of the compound antioxidant (main antioxidant: auxiliary antioxidant = 2:1) was selected. Furthermore, the optimum formulation ratio (SAP: antioxidant = 1:3) and the optimum mass ratio (12%) were determined, taking the low-temperature oxygen consumption and cross-point temperature (CPT) of coal as indexes. Three grades of metamorphic coal were selected to obtain the gaseous product, oxygen consumption at 70°C, CPTs and inhibition rate. The addition inhibitor reduced the release of CO and C₂H₄ gas and oxygen consumption, while it raised CPTs and inhibition rate of coal oxidation The inhibiting capacity of MgCl₂ is mainly at low-temperature stage, while the synergistic inhibitor has excellent congenerous phys. and chem. effect in the whole coal oxidation process.

Combustion Science and Technology published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C42H63O3P, Quality Control of 31570-04-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Entin-Meer, Michal published the artcileIn vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas, Safety of (Pivaloyloxy)methyl butyrate, the publication is Neuro-Oncology (Durham, NC, United States) (2007), 9(2), 82-88, database is CAplus and MEDLINE.

Histone modification has emerged as a promising approach to cancer therapy. We explored the in vivo efficacy of a butyric acid derivative, pivaloyloxymethyl butyrate (AN-9), for the treatment of gliomas. Relative to control and single-modality treatments, the combination of AN-9 and radiation significantly inhibited tumor growth and prolonged time to failure in mice bearing glioma xenografts. The enhanced response to radiation was accompanied by inhibition of cellular proliferation and by increased phosphorylation of H2AX, implicating DNA double-strand breaks in the antineoplastic effects of AN-9 and radiation. The data suggest that AN-9 in combination with radiation may be an effective therapy for malignant gliomas.

Neuro-Oncology (Durham, NC, United States) published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Safety of (Pivaloyloxy)methyl butyrate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cao, Jilei published the artcileMetal-free hydrogen evolution cross-coupling enabled by synergistic photoredox and polarity reversal catalysis, Application of Ethyl 2-mercaptopropanoate, the publication is Green Chemistry (2021), 23(22), 8988-8994, database is CAplus.

A synergistic combination of photoredox and polarity reversal catalysis enabled a hydrogen evolution cross-coupling of silanes with H₂O, alcs., phenols, and silanols, which afforded the corresponding silanols, monosilyl ethers, and disilyl ethers, resp., in moderate to excellent yields. The dehydrogenative cross-coupling of Si-H and O-H proceeded smoothly with broad substrate scope and good functional group compatibility in the presence of only an organophotocatalyst 4-CzIPN and a thiol HAT catalyst, without the requirement of any metals, external oxidants and proton reductants, which is distinct from the previously reported photocatalytic hydrogen evolution cross-coupling reactions where a proton reduction cocatalyst such as a cobalt complex is generally required. Mechanistically, a silyl cation intermediate is generated to facilitate the cross-coupling reaction, which therefore represents an unprecedented approach for the generation of silyl cation via visible-light photoredox catalysis.

Green Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Application of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ren, Shi-Chao published the artcileCarbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones, Safety of 3-(Methoxycarbonyl)benzoic acid, the publication is Nature Communications (2022), 13(1), 2846, database is CAplus and MEDLINE.

The carbene and photocatalyst co-catalyzed radical coupling of acyl electrophile and a radical precursor is emerging as attractive method for ketone synthesis. However, previous reports mainly limited to prefunctionalized radical precursors and two-component coupling. Herein, an N-heterocyclic carbene and photocatalyst catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles is disclosed, in which the carboxylic acids are directly used as radical precursors. The acyl imidazoles could also be generated in situ by reaction of a carboxylic acid with CDI thus furnishing a formally decarboxylative coupling of two carboxylic acids. In addition, the reaction is successfully extended to three-component coupling by using alkene as a third coupling partner via a radical relay process. The mild conditions, operational simplicity, and use of carboxylic acids as the reacting partners make our method a powerful strategy for construction of complex ketones from readily available starting materials, and late-stage modification of natural products and medicines.

Nature Communications published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Safety of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Mengdan published the artcileSelective Synthesis of Pyrano[3,2-b]indoles or Cyclopenta[b]indoles Tethered with Medium-Sized Rings via Cascade C-C σ-Bond Cleavage and C-H Functionalization, Application of 3-Acetyldihydrofuran-2(3H)-one, the publication is Journal of Organic Chemistry (2021), 86(1), 683-692, database is CAplus and MEDLINE.

Highly atom-economical tandem reactions have been developed for the synthesis of pyrano[3,2-b]indoles or cyclopenta[b]indoles tethered with 7-, 8-, or 9-membered rings. These reactions first undergo a carbon-carbon σ-bond cleavage reaction of cyclic β-ketoesters. Next, in the presence of CuCl₂ and Ag₂CO₃, intramol. O-H/C-H coupling occurs to give pyrano[3,2-b]indoles. This is the first example for capture of the enoloxyl radical of the intramol. C-O bond formation reaction, whereas C3 nucleophilic addition afforded cyclopenta[b]indoles using TsOH·H₂O.

Journal of Organic Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C8H6ClN, Application of 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Jing published the artcileDesign, Synthesis, and Structure-Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase, Product Details of C6H10O3, the publication is ChemMedChem (2021), 16(10), 1600-1604, database is CAplus and MEDLINE.

In this study, a series of pyrazolones was synthesized, and their inhibitory effects against pancreatic lipase (PL) were assayed by using 4-methylumbelliferyl oleate (4-MUO) as optical substrate for PL. Comprehensive structure-activity relationship anal. of these pyrazolones led us to design and synthesize a novel compound I as a potent mixed-competitive inhibitor of PL (IC₅₀=0.30μM). In addition, compound I displayed some selectivity over other known serine hydrolases. A mol. docking study for compound I demonstrated that the inhibitory activity of compound I towards PL could be attributed to the π-π interactions of 2-naphthyl unit and hydrophobic interactions of Ph moiety with the active site of PL. Thus, compound I could serve as promising lead compound for the development of more efficacious and selective pyrazolones-type PL inhibitors for biomedical applications.

ChemMedChem published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C11H21BF4N2O2, Product Details of C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics