Category: esters-buliding-blocks

Matic, Tamara published the artcileSr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes, Product Details of C11H15NO2, the publication is Ceramics International (2022), 48(8), 11155-11165, database is CAplus.

The aim of this study was to investigate the influence of binary Sr, Mg ion-doping compared to the single-ion doping effects on the phase composition and morphol. of hydrothermally obtained calcium hydroxyapatite (HAP) powders and on the phase composition, microstructure, and mech. properties of the sintered materials. Addnl., the focus of this study was to investigate the possible utilization of the binary doped Sr,Mg-HAP compacts as dentin substitutes in restorative dentistry by evaluating their bonding ability with com. available restorative materials using the shear bond strength test (SBS). The hydrothermally obtained mono-doped Mg5 and Sr5 showed the monophasic apatite structure, while in all co-doped samples β-TCP phase was formed, resulting in biphasic calcium phosphate (BCP) powders. It was confirmed that co-doping with Sr and Mg ions led to the thermal stabilization of the β-TCP phase by suppressing the phase transition into α-TCP when sintered at 1200 βC. Moreover, the co-presence of Mg ions significantly improved the hardness of Sr-doped HAP from 3.74 to 5.02 GPa. Sr,Mg-HAP dental inserts were found to achieve sufficient bonding (13.53 MPa) through the micromech. interlocking with Z250 dental composite and Single Bond Universal dental adhesive applied with a total etch approach. The SBS values obtained for the SrMg-HAP insert were similar to the literature data on bonding ability with human dentin, indicating that binary doped Sr,Mg-HAP ceramics present a promising material for application in restorative dentistry as dentin substitutes.

Ceramics International published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Product Details of C11H15NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bovin, N. V. published the artcileIsomerization of (trifluoroacetamido)propyl 2-acetamido-2-deoxy-β-D-galactopyranoside into an α-anomer. A facile synthesis of artificial T-antigen, Safety of (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, the publication is Bioorganicheskaya Khimiya (1986), 12(4), 533-8, database is CAplus and MEDLINE.

β-Glycoside I [R = O(CH₂)₃NHAc, R¹ = H], prepared by glycosidation of I (R = H, R¹ = Cl) with HO(CH₂)₃NHAc in the presence of Hg(CN)₂, was isomerized by BF₃.Et₂O to give 50-60% α-anomer I [R = H, R¹ = O(CH₂)₃NHAc] (II) and oxazoline III. α-Anomer II was converted to benzylidene derivative IV (R = H) which was glycosidated by acetobromogalactose to give 50% IV (R = 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl), followed by deacetylation to give bioside V, the precursor for artificial T-antigen.

Bioorganicheskaya Khimiya published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Safety of (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Shihai published the artcileStudy on chemical constituents of the soft coral Sinularia inexplicita. I. Elucidation of structure of hydroxyl compound, Computed Properties of 110-34-9, the publication is Jinan Daxue Xuebao, Ziran Kexue Yu Yixueban (1997), 18(5), 63-67, database is CAplus.

The soft coral Sinularia inexplicita collected from the South China Sea was studied chromatog., and 3 secondary metabolites were found. The spectral data and elemental anal. showed that the structures of the metabolites were gorgosterol, batylalc., and iso-Bu palmitate.

Jinan Daxue Xuebao, Ziran Kexue Yu Yixueban published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C6H12Br2, Computed Properties of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Xiaotu published the artcilePlastic additives in ambient fine particulate matter in the Pearl River Delta, China: High-throughput characterization and health implications, COA of Formula: C10H12O5, the publication is Environmental Science & Technology (2021), 55(8), 4474-4482, database is CAplus and MEDLINE.

Elucidation of the chem. components of airborne fine particulate matter (PM_2.5) facilitates the characterization of atm. contamination sources and associated human exposure risks. In the present study, we employed a high-throughput anal. approach to investigate the abundance and distribution of 163 plastic additives in ambient PM_2.5 collected from 94 different sites across the Pearl River Delta region, China. These chems. are from six categories, including organophosphate esters (OPEs), phthalate esters (PAEs), PAE replacements, bisphenol analogs, UV stabilizers, and antioxidants. Ninety-three of them exhibited a detection frequency greater than 50% in PM_2.5, while the combined concentrations of target plastic additives ranged from 610 to 49,400μg/g (median: 3500μg/g) across sites. By category, concentrations of PAEs (median: 2710μg/g) were one to three orders of magnitude greater than those of other groups, followed by PAE replacements (540μg/g) and OPEs (76.2μg/g). Chem.-dependent exposure risks to PM_2.5-bound plastic additives were characterized via the estimated daily intake and hazard quotient (HQ) approaches, which resulted in two different risk prioritization systems. Although the HQ approach suggested no or very low health concerns when considering individual chems., the complexity of co-concurrent chems. in PM_2.5 raises the concern on potential health risks from exposure to airborne particles and a cocktail of chem. components.

Environmental Science & Technology published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, COA of Formula: C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xiao, Zhi-qiang published the artcileStudy on synthesis process of p-hydroxyphenyl acetic acid-N,N-dimethylformamide, dimethyl carbamyl, HPLC of Formula: 59721-16-3, the publication is Yingyong Huagong (2014), 43(12), 2237-2238, database is CAplus.

Using N,N-dimethyl-2-chloro-acetamide, 4-hydroxyphenyl acetic acid, triethylamine, etc. as raw materials, the reaction in acetonitrile, HPLC was used to detect hydroxyphenyl acetic acid for synthesis of N,N-dimethylformamide, carbamoyl ester (compound B). The result showed that the optimal synthesis parameters were: reaction time 12 h, the reaction temperature 60 degree C, the amount of solvent 2200 m L, and material ratio of n(4-hydroxyphenyl acetic acid):n(N, N-dimethyl-2-chloroacetamide) = 1:1.10. Under the optimal conditions the yield was 86%, with a purity of over 98%.

Yingyong Huagong published new progress about 59721-16-3. 59721-16-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Phenol,Ester,Amide, name is 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate, and the molecular formula is C16H11Cl2N3O2, HPLC of Formula: 59721-16-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Lei published the artcileCatalyst-Free 1,2-Dibromination of Alkenes Using 1,3-Dibromo-5,5-dimethylhydantoin (DBDMH) as a Bromine Source, Quality Control of 103-26-4, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

A direct 1,2-dibromination method of alkenes is realized using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as bromine source. This reaction proceeds under mild reaction conditions without the use of catalyst and external oxidant. Various sorts of alkene substrates are transformed into the corresponding 1,2-dibrominated products in good to excellent yields with broad substrate scope and exclusive diastereoselectivity. This method offers a green and practical approach to synthesize vicinal dibromide compounds

Journal of Organic Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C6H13I, Quality Control of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ni, Zihao published the artcileReaction kinetics analysis of branched-chain alkyl esters of palmitic acid and cold flow properties, Recommanded Product: Isobutyl palmitate, the publication is Renewable Energy (2020), 147(Part_1), 719-729, database is CAplus.

Preparation of Me palmitate, iso-Pr palmitate, iso-Bu palmitate, and isoamyl palmitate was carried out using pyridine Bu bisulfate ionic liquid as catalyst in a self-designed reactor to catalyze esterification reaction of palmitic acid with methanol, isopropanol, isobutanol, and isoamyl alc., resp. According to the single-factor exptl. results, an orthogonal test of four factors and three levels was carried out for branched-chain alkyl esters of palmitic acid under different reaction time, reaction temperature, and catalyst dosage. Verification test was conducted under the optimal conditions, and the conversion in all the cases was up to 97%. Anal. of the reaction kinetics of Me palmitate, iso-Pr palmitate, iso-Bu palmitate, and isoamyl palmitate was carried out by the integral method. Reaction order, frequency factor, activation energy, and reaction kinetic model were determined Compared to Me palmitate, the kinematic viscosity of the branched-chain alkyl esters of palmitic acid was slightly higher; however, the solidifying point (SP) and cold filter plugging point (CFPP) decreased with increasing degree of branched-chain. The CFPP reduced by up to 15°C. Therefore, the use of branched-chain alc. instead of methanol ester exchange descaling method can effectively reduce the SP and CFPP of biodiesel to improve its cold flow properties.

Renewable Energy published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gao, Tianfeng published the artcileTargeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents, Related Products of esters-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2019), 329-340, database is CAplus and MEDLINE.

A novel series of 6-substituted pyrrolo[2,3-d]pyrimidines with reversed amide moieties from the lead compound I (R = 4-pyridyl) were designed and synthesized as nonclassical antifolates and as potential antitumor agents. Target compounds II were successfully obtained through two sequential condensation reactions from the key intermediate 2-amino-6-(2-aminoethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one. In preliminary antiproliferation assay, all compounds demonstrated submicromolar to nanomolar inhibitory effects against KB tumor cells, whereas compounds I (R = 2-, 3-, 4-pyridyl) also exhibited nanomolar antiproliferative activities toward SW620 and A549 cells. In particular, compounds I (R = 2-, 3-, 4-pyridyl) were significantly more potent than the pos. control methotrexate (MTX) and pemetrexed (PMX) to A549 cells. The growth inhibition induced cell cycle arrest at G1-phase with S-phase suppression. Along with the results of nucleoside protection assays, inhibition assays of dihydrofolate reductase (DHFR) clearly elucidated that the intracellular target of the designed compounds was DHFR. Mol. modeling studies suggested two binding modes of the target compounds with DHFR.

European Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Huang, Qi published the artcileSystematic investigation of the pharmacological mechanism for renal protection by the leaves of Eucommia ulmoides Oliver using UPLC-Q-TOF/MS combined with network pharmacology analysis, Quality Control of 103-26-4, the publication is Biomedicine & Pharmacotherapy (2021), 111735, database is CAplus and MEDLINE.

Bark is the traditional medicinal component of Eucommia ulmoides Oliver (E. ulmoides). However, the demand for E. ulmoides medicinal materials seriously limits their sustainability. To alleviate resource constraints, the bioactivity of E. ulmoides leaves and its pharmacodynamic basis were investigated. In the present study, extracts of E. ulmoides leaves were found to display potential renal protective properties in rat glomerular mesangial (HBZY-1) cells treated with high levels of glucose, suggesting that they possess potential factors capable of treating diabetic nephropathy. Ultra-performance liquid chromatog. tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was used to comprehensively characterize the chem. components of E. ulmoides leaves. A total of 83 possible chem. components, including 12 iridoids, 13 flavonoids, 14 lignans, 20 phenylpropanoids, 14 phenolic acids, and 10 addnl. components, were identified in E. ulmoides leaves. Network pharmacol. was used for a preliminary exploration of the potential mechanism of action of renal protection afforded by E. ulmoides leaves towards diabetic nephropathy. The network pharmacol. results were verified using a series of biol. experiments The present study provided the basis for the comprehensive development and utilization of E. ulmoides leaves and the discovery of potential drugs.

Biomedicine & Pharmacotherapy published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Quality Control of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kodama, Susumu published the artcileAssociation between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats, SDS of cas: 517-23-7, the publication is Journal of Toxicological Sciences (2021), 46(12), 569-587, database is CAplus.

The liver plays critical roles to maintain homeostasis of living organisms and is also a major target organ of chem. toxicity. Meanwhile, nuclear receptors (NRs) are known to regulate major liver functions and also as a critical target for hepatotoxic compounds In this study, we established mammalian one-hybrid assay systems for five rat-derived NRs, namely PXR, PPARα, LXRα, FXR and RXRα, and evaluated a total of 326 compounds for their NR-activating profiles. Then, we assessed the association between their NR-activating profile and hepatotoxic endpoints in repeated-dose toxicity data of male rats from Hazard Evaluation Support System. In the in vitro cell-based assays, 68, 38, 20, 17 and 17 compounds were identified as positives for PXR, PPARα, LXRα, FXR and RXRα, resp. The association analyses demonstrated that the PXR-pos. compounds showed high frequency of endpoints related to liver hypertrophy, such as centrilobular hepatocellular hypertrophy, suggesting that PXR activation is involved in chem.-induced liver hypertrophy in rats. It is intriguing to note that the PXR-pos. compounds also showed statistically significant associations with both prolonged activated partial thromboplastin time and prolonged prothrombin time, suggesting a possible involvement of PXR in the regulation of blood clotting factors. Collectively, our approach may be useful for discovering new functions of NRs as well as understanding the complex mechanism for hepatotoxicity caused by chem. compounds

Journal of Toxicological Sciences published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, SDS of cas: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics