Category: esters-buliding-blocks

Zhang, Jianxu published the artcileGender and individual information coded by insect pheromone analogs in preputial glands in male brandt’s voles Lasiopodomys brandtii, Computed Properties of 16974-11-1, the publication is Dongwu Xuebao (2007), 53(4), 616-624, database is CAplus.

The volatile composition of dichloromethane extracts of preputial glandular secretions (PGS) from intact and castrated male Brandt’s voles Lasiopodomys brandtii were analyzed by using gas chromatog.-mass spectrometry (GC-MS). Thirty-three volatile compounds were detected and were present in nearly all scent donors, and 27 had previously been reported as insect pheromone components. Castration did not eliminate any compounds; however, it significantly suppressed the relative quantity of ten early-eluting, low mol. weight components. These included seven saturated and unsaturated acetates, one hexanoate, and two saturated octanoates. In particular, E,E-farnesyl acetate (FA) was the most abundant compound in the PGS. FA and other components might be candidates for male-produced pheromones. Two-choice behavioral assays of females revealed that low concentrations of raw PGS (0.056%) and FA (5 ppm in water v/w) were attractive, whereas high concentrations (0.56% and 50 ppm, resp.) were repellent. This suggested that FA might act as a male pheromone in a dosage-dependent manner. Extremely high variability of the relative quantities of almost all detected compounds among individuals indicated the inter-individual dissimilarities of PGS and consequent possibilities to communicate individuality to other conspecific members.

Dongwu Xuebao published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C4H7BrO2, Computed Properties of 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhu, Jian published the artcileSuperb Ni-foam-structured nano-intermetallic InNi₃C_0.5 catalyst for hydrogenation of dimethyl oxalate to ethylene glycol, Category: esters-buliding-blocks, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2021), 130857, database is CAplus.

A high-performance Ni-foam-structured nano-intermetallic InNi₃C_0.5 catalyst is developed for the gas-phase hydrogenation of di-Me oxalate (DMO) to ethylene glycol (EG). The InNi₃C_0.5/Ni-foam catalyst is obtainable by hydrothermal growth of NiC₂O₄ onto the Ni-foam, impregnation with In₂O₃ precursor, subsequent calcination and carburization in a syngas. Despite DMO cascade hydrogenation to MG, then to EG, and finally to EtOH, such catalyst hydrogenates DMO dexterously until to EG with a high turnover frequency of 636 h^-1, because the 3Ni-In and 3Ni-C sites on InNi₃C_0.5(1 1 1) effectively activate DMO but hinder EG over-hydrogenation to EtOH. Favorable reaction pathway on the InNi₃C_0.5(1 1 1) surface predicted theor. is DMO* → CH₃OCOCO* → CH₃OCOCHO* → CH₃OCOCHOH* → MG* → CH₃OCHOCH₂OH* → CHOCH₂OH* → HOCHCH₂OH* → EG*. Moreover, the neutral Ni-foam diminishes the formation of ethers and diols. The catalyst achieves full DMO conversion with 96-98% EG selectivity and is stable for at least 2500 h under industrial-relevant conditions, and can also hydrogenate a broad scope of carbonyl compounds to corresponding alcs. with high yields.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C2H2N4O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liang, Kuan published the artcileBio-based cross-linked polyitaconamides synthesized through a Michael ene-amine addition and bulk polycondensation, Product Details of C7H10O4, the publication is Journal of Polymer Research (2020), 27(3), 56, database is CAplus.

A simple method is established to synthesize bio-based cross-linked polyitaconamides (cPITAs) through a Michael ene-amine addition and bulk polycondensation. A tetraester, i.e. tetra-Me piperazine-N,N’-bis(2-methylene butanedioate) (TMPB), was synthesized through a Michael addition of di-Me itaconate and piperazine at 90°C. Bulk polycondensation of TMPB with butanediamine or hexamethylenediamine was conducted at 130-170°C under atm. pressure, and several cPITAs with tunable properties were prepared The Michael addition and the polycondensation were monitored by FT-IR and ¹H NMR spectra. The cPITA films were characterized by DSC, WAXS, TGA, dynamic mech. anal., and tensile test. cPITAs exhibited Tg ranging from 58 to 72°C, tensile strength up to 85 MPa, and strain at break from 9% to 17%.

Journal of Polymer Research published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Product Details of C7H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ma, Shuai published the artcileSynthesis of elvitegravir, SDS of cas: 924-99-2, the publication is Zhongguo Yiyao Gongye Zazhi (2014), 45(1), 5-8, database is CAplus.

Elvitegravir was synthesized from 2,4-difluorobenzoic acid via iodization, acylation and condensation to give Et 2-(2,4-difluoro-5-iodobenzoyl)-3-dimethylaminoacrylate, which was subjected to addition-elimination with L-valinol, cyclization, protection with tert-butyldimethylsilyl chloride and Negishi coupling reaction with 3-chloro-2-fluorobenzylzinc bromide, followed by one-pot synthesis including deprotection, hydrolysis and methoxylation with an overall yield of about 42%.

Zhongguo Yiyao Gongye Zazhi published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Song, Qiuyan published the artcileNondiffusion-Controlled Photoelectron Transfer Induced by Host-Guest Complexes to Initiate Cationic Photopolymerization, Product Details of C11H15NO2, the publication is Macromolecules (Washington, DC, United States) (2021), 54(18), 8314-8320, database is CAplus.

Two novel supramol. photoinitiators (supra-photoinitiators) based on the host-guest complexation of macrocycles (pillar[6]arene, P6; prism[5]arene, NP5) and diphenyl-iodonium salt (Iod) were fabricated. Under light irradiation, macrocycle P6 or NP5 could donate electrons to the guest mol. Iod, which generated highly active free radicals and cationic fragments to achieve efficient polymerization Compared to a com. activator, the electron transfer between macrocycles and Iod were under nondiffusion control, endowing a much higher photopolymerization rate and epoxy resin final conversion. In addition, the host-guest complexation of NP5 extended the initiating wavelength of Iod from ultrashort UV to near-UV, which could better match the environment-friendly LED light source. It is anticipated that a supra-photoinitiator may open a new route for designing novel photoinitiators with high performance.

Macromolecules (Washington, DC, United States) published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C9H7NO4, Product Details of C11H15NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Ao published the artcileAntioxidant effects of gallic acid alkyl esters of various chain lengths in oyster during frying process, Category: esters-buliding-blocks, the publication is International Journal of Food Science and Technology (2021), 56(6), 2938-2945, database is CAplus.

Summary : The antioxidant effects of gallic acid (GA) and its alkyl esters including Me gallate, Et gallate, Pr gallate, Bu gallate (GA-C4), octyl gallate, lauryl gallate, hexadecyl gallate and octadecyl gallate in frying oil (soybean oil) and oyster during frying were investigated. Rancimat induction period (RIP) assay indicated GA and its alkyl esters effectively improved the oxidative stability of soybean oil according to the ‘polar paradox’; i.e., the antioxidant effects of the polyphenols decreased in lipid system with the increasing of hydrophobicity. Results also indicated that GA and its alkyl esters all effectively retarded lipid oxidation in oyster tissue according to parameters including RIP, peroxide value and ESR assays. Moreover, the antioxidant efficiency in oyster increased with the alkyl chain length until GA-C4, and thereafter, the antioxidant effects decreased, similar to the ‘cut-off effect’. This study provides basic data for improving the oxidative stability of seafood during frying.

International Journal of Food Science and Technology published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cao, Jiangying published the artcileDevelopment of a bestatin-SAHA hybrid with dual inhibitory activity against APN and HDAC, Product Details of C9H8O4, the publication is Molecules (2020), 25(21), 4991, database is CAplus and MEDLINE.

With five histone deacetylase (HDAC) inhibitors approved for cancer treatment, proteolysis-targeting chimeras (PROTACs) for degradation of HDAC are emerging as an alternative strategy for HDAC-targeted therapeutic intervention. Herein, three bestatin-based hydroxamic acids (P1, P2 and P3) were designed, synthesized and biol. evaluated to see if they could work as HDAC degrader by recruiting cellular inhibitor of apoptosis protein 1 (cIAP1) E3 ubiquitin ligase. Among the three compounds, the bestatin-SAHA hybrid P1 exhibited comparable even more potent inhibitory activity against HDAC1, HDAC6 and HDAC8 relative to the approved HDAC inhibitor SAHA. It is worth noting that although P1 could not lead to intracellular HDAC degradation after 6 h of treatment, it could dramatically decrease the intracellular levels of HDAC1, HDAC6 and HDAC8 after 24 h of treatment. Intriguingly, the similar phenomenon was also observed in the HDAC inhibitor SAHA. Cotreatment with proteasome inhibitor bortezomib could not reverse the HDAC decreasing effects of P1 and SAHA, confirming that their HDAC decreasing effects were not due to protein degradation Moreover, all three bestatin-based hydroxamic acids P1, P2 and P3 exhibited more potent aminopeptidase N (APN, CD13) inhibitory activities than the approved APN inhibitor bestatin, which translated to their superior anti-angiogenic activities. Taken together, a novel bestatin-SAHA hybrid was developed, which worked as a potent APN and HDAC dual inhibitor instead of a PROTAC.

Molecules published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Product Details of C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cai, Yanyao published the artcileAccess to Functionalized E-Allylsilanes and E-Alkenylsilanes through Visible-Light-Driven Radical Hydrosilylation of Mono- and Disubstituted Allenes, Quality Control of 19788-49-9, the publication is Organic Letters (2019), 21(24), 9836-9840, database is CAplus and MEDLINE.

A visible-light-driven radical hydrosilylation of allene was achieved by using eosin Y as the photocatalyst, with thiol and base as additives. Depending on allenes, two types of adducts with E-selectivity were obtained. Monosubstituted nonarylated allenes reacted to give linear E-allylsilanes, while 1,3-disubstituted electron-deficient allenes afforded E-alkenylsilanes. A radical mechanism is proposed to account for the chemo-, regio-, and stereoselective formation of these functionalized Si-containing compounds

Organic Letters published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Quality Control of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhuo, Jin-Cong published the artcile¹⁷O NMR spectra of α,β-unsaturated carbonyl compounds RCH=CHCOX: the influence of group X on the δ(¹⁷O) value of the carbonyl oxygen and on the shielding effect of group R, Formula: C7H13NO2, the publication is Molecules [Electronic Publication] (1999), 4(11), 320-328, database is CAplus.

¹⁷O NMR spectra of 26 X (R = Me, Ph), 40 RCH:CHCOX (I; R = H, Ph, Me, EtO₂C) and 4 Me₂C:CHCOX (X = H, Me, Et, CHMe₂, CMe₃, Ph, CH:CHPh, OMe, OEt, Cl, cyano, CF₃, CO₂Et) are reported. The ¹⁷O shift values of these carbonyl compounds depend mainly on the electron-donating power of X and correlate well with the resonance consts, σ_R⁺ of X. This suggests that the δ(¹⁷O) values can be used to reflect qual. the electrophilicity of the carbonyl group. The shielding effect of the substituent R in I is diminished with increasing electron-donating power of X and correlates with σ⁺ values of X.

Molecules [Electronic Publication] published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H17NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Guo-Quan published the artcileNickel-catalyzed electrochemical carboxylation of unactivated aryl and alkyl halides with CO₂, Formula: C9H8O4, the publication is Nature Communications (2021), 12(1), 7086, database is CAplus and MEDLINE.

A general and practical electro-reductive Ni-catalytic system, realizing the electrocatalytic carboxylation of unactivated aryl chlorides and alkyl bromides with CO₂ were reported. A variety of unactivated aryl bromides, iodides and sulfonates can also undergo such a reaction smoothly. Notably, realized the catalytic electrochem. carboxylation of aryl (pseudo)halides with CO₂ avoiding the use of sacrificial electrodes. Moreover, this sustainable and economic strategy with electron as the clean reductant features mild conditions, inexpensive catalyst, safe and cheap electrodes, good functional group tolerance and broad substrate scope. Mechanistic investigations indicated that the reaction might proceed via oxidative addition of aryl halides to Ni(0) complex, the reduction of aryl-Ni(II) adduct to the Ni(I) species and following carboxylation with CO₂.

Nature Communications published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C10H20O2, Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics