Category: esters-buliding-blocks

Using dilatometry in the reversible addition fragmentation transfer polymerization of N-(S)-(-)-浼?methylbenzyl methacryloylamine was written by Soriano-Moro, J. Guillermo;Percino, M. Judith;Chapela, Victor M.;Guerrero-Santos, Ramiro. And the article was included in Journal of Polymer Research in 2011.Recommanded Product: Benzyl benzodithioate This article mentions the following:

Optically active polymers were prepared using reversible addition-fragmentation chain transfer polymerization (RAFT) of N-(S)-浼?methylbenzylmethacryloylamine (N-(S)-浼?MBMA), a functional optically active monomer. RAFT polymerizations were carried out at 70 鎺矯 in ethanol using AIBN as a thermal initiator and benzyl or (1-phenyl)ethyl dithiobenzoate (BDB and PEDB, resp.) as the RAFT agents. The kinetic study was performed by dilatometry. Plots of conversion vs time indicated that the polymerizations followed first order kinetics. ¹H NMR, IR, and UV-vis spectrophotometric studies confirmed the presence of thiocarbonylthio moieties (-SCS-) in the polymer chains. The mol. weight distributions (MWDs) were moderately narrow with polydispersity indexes between 1.3 and 1.6, which indicated that the control of the reaction was not completely achievement using BDB or PEDB as RAFT agents. The optical activity [浼猐 measurements of synthesized polymers by RAFT did not show a noticeably linear increase dependence with respect to mol. weight, as was previously reported for another controlled free radical polymerization (CRP) system. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Recommanded Product: Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation of Orthogonal 锜?Conjugated Aryl Alkynes and Cyclophanes was written by Crisp, G. T.;Turner, P. D.. And the article was included in Tetrahedron in 2000.Application of 313648-56-5 This article mentions the following:

A series of anthracene based orthogonal 锜?conjugated aryl alkynes was prepared using palladium-catalyzed couplings. Thia- and azacyclophanes were prepared from anthracene based orthogonal 锜?conjugated aryl alkynes. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Application of 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 313648-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rapid identification of fatty acids from Leptadenia reticulata areal parts by GC-MS was written by Dhalani, Jayesh;Parmar, Rahul;Rajpara, Raj;Nariya, Pankajkumar. And the article was included in Journal of Scientific & Industrial Research in 2020.Category: esters-buliding-blocks This article mentions the following:

The investigation was carried out to identify the various fatty acids present in the areal parts of Leptadenia reticulata, one of the important medicinal plants of India. Non-polar (Petroleum Ether) extract of areal parts was used for this study. Saponification was carried out using dried extract to obtain fatty acids. Further esterification of saponifiable fraction was performed to obtain fatty acid Me ester. Extracted fatty acid Me esters were analyzed by gas chromatog. and mass spectrometry (GC-MS) technique using NIST library. From GC-MS anal., 14 components were identified in areal parts of Leptadenia reticulata. This study reveals that L. reticulata is a good source of fatty acids with medicinal properties. This methodol. has the advantage of excellent identification of Non polar moiety of medicinal plant. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Category: esters-buliding-blocks).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Organotin-catalyzed synthesis of hydroxyalkylamides from lactones via a ring-opening process was written by Liang, Xiayu;Yu, Peng;Fu, Chen;Shen, Yongcun. And the article was included in Tetrahedron Letters in 2021.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one This article mentions the following:

A new strategy for the facile synthesis of hydroxyalkylamides through the ring-opening reaction of lactones with amine promoted by dibutyltin acetate was developed. A series of hydroxyalkylamide compounds were obtained and the method was successfully applied to the synthesis of pharmaceutically active mols. tyrosinase inhibitor V and HDAC inhibitor VI via a three-step synthetic pathway. The broad substrate scope, mild reaction conditions and practical application proved the effectiveness, compatibility and practicality of this method. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design was written by Yeh, Teng-Kuang;Song, Jen-Shin;Chang, Po-Wei;Yu, Jin-Chen;Chang, Chia-Hwa;Liao, Fang-Yu;Tien, Ya-Wen;Kuppusamy, Ramajayam;Li, An-Siou;Chen, Chi-Han;Chen, Chieh-Wen;Lin, Li-Mei;Chang, Hsin-Huei;Huang, Chih-Hsiang;Yao, Jau-Ying;Wu, Mine-Hsine;Peng, Yi-Hui;Hsueh, Ching-Cheng;Hsiao, Wen-Chi;Chen, Pei-Husan;Lin, Chin-Yu;Hsieh, Su-Huei;Shih, Chuan;Hung, Ming-Shiu;Wu, Su-Ying;Kuo, Ching-Chuan;Ueng, Shau-Hua. And the article was included in European Journal of Medicinal Chemistry in 2022.Product Details of 16413-26-6 This article mentions the following:

Indoleamine 2,3-dioxygenase-1 (IDO1) is a potential target for the next generation of cancer immunotherapies. We describe the development of two series of IDO1 inhibitors incorporating a N-hydroxy-thiophene-carboximidamide core generated by knowledge-based drug design. Structural modifications to improve the cellular activity and pharmacokinetic (PK) properties of the compounds synthesized, including extension of the side chain of the N-hydroxythiophene-2-carboximidamide core, resulted in compound 27a, a potent IDO1 inhibitor which demonstrated significant (51%) in vivo target inhibition on IDO1 in a human SK-OV-3 ovarian xenograft tumor mouse model. This strategy is expected to be applicable to the discovery of addnl. IDO1 inhibitors for the treatment of other diseases susceptible to modulation of IDO1. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts was written by Haida, S.;Kribii, A.. And the article was included in South African Journal of Botany in 2020.Reference of 106-79-6 This article mentions the following:

This work is part of the valorization of the Haloxylon scoparium plant, belonging to the Chenopodiaceae family and native to southeastern of Morocco. The aim of the present work is to study the chem. composition of this plant, to estimate the phenolic compounds contents of its extracts and to evaluate their antioxidant powers. After extraction by maceration of the aerial and root part of Haloxylon scoparium, the extracts obtained are fractionated by liquid-liquid extraction using solvents of different polarities. The best extraction yield is obtained in the aerial part 23.54% against 10.99% for the root part. The anal. carried out by the coupling of gas chromatog. with mass spectrometry (GC-MS) shows that the root part contains mainly carbohydrates, however the aerial part consists mainly of alkaloids. The total polyphenol content obtained in the root part 69.86 mg/gEAG (mg/g of gallic acid) is significantly higher than that in the aerial part 56.79 mg/g EAG. The hydrolysable tannins are the predominant polyphenols of the root part of Haloxylon scoparium corresponding to 83.87 mg/g EAT (mg/g of tannic acid). The antioxidant activity of the various extracts obtained is evaluated by two methods: the DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical scavenging test and the ferric reducing antioxidant power (FRAP). The examination of the inhibitory concentration values shows that the butanolic extract of the root part is the most active with values of IC₅₀ = 0.06 mg/mL and IC_0.5 = 0.19 mg/mL resp. for the DPPH and FRAP tests. The other extracts also showed a very interesting potential as antioxidants. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Reference of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aminopyrazine Pathway to the Moco Metabolite Dephospho Form A was written by Klewe, Anne;Kruse, Tobias;Lindel, Thomas. And the article was included in Chemistry – A European Journal in 2017.Category: esters-buliding-blocks This article mentions the following:

An efficient synthesis of the molybdopterin/molybdenum cofactor (Moco) oxidation product dephospho Form A I is described that assembles the pteridinone system starting from an iodinated aminopyrazine. The sodium salt of dephospho Form A could be purified by precipitation from methanol, which paved the way to the title compound in the 100 mg range. By HPLC, the synthetic material was compared with a sample isolated from a recombinant Moco containing protein. Anal. of dephospho Form A is the only method that allows the quantification of the Moco content of crude cell extracts and recombinant protein preparations In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Category: esters-buliding-blocks).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine was written by Huang, Wei;Ma, Jing-Yi;Yuan, Mu;Xu, Long-Fei;Wei, Bang-Guo. And the article was included in Tetrahedron in 2011.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

An efficient approach to trans-4-hydroxylpyrrolidine lactams, e.g. I [R¹ = t-Bu, PhCH₂; R² = H, Me; Me₂CH, etc.; R³ = H, TBSO], starting from an amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride and antiangiogenic streptopyrrolidine. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phenyl bioisosteres in medicinal chemistry: discovery of novel 绾?secretase modulators as a potential treatment for Alzheimer閳ョ灚 disease was written by Ratni, H.;Baumann, K.;Bellotti, P.;Cook, X. A.;Green, L. G.;Luebbers, T.;Reutlinger, M.;Stepan, A. F.;Vifian, W.. And the article was included in RSC Medicinal Chemistry in 2021.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate This article mentions the following:

Ph rings are one of the most prevalent structural moieties in active pharmaceutical ingredients, even if they often contribute to poor physico-chem. properties. Herein, we propose the use of a bridged piperidine (BP) moiety as a Ph bioisostere, which could also be seen as a superior Ph alternative as it led to strongly improved drug like properties, in terms of solubility and lipophilicity. Addnl., this BP moiety compares favorably to the recently reported saturated Ph bioisosteres. We applied this concept to our 绾?secretase modulator (GSM) project for the potential treatment of Alzheimer閳ョ灚 disease delivering clin. candidates. In the experiment, the researchers used many compounds, for example, Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate).

Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Janus glycosides of next generation: Synthesis of 4-(3-chloropropoxy)phenyl and 4-(3-azidopropoxy)phenyl glycosides was written by Stepanova, Elena V.;Abronina, Polina I.;Zinin, Alexander I.;Chizhov, Alexander O.;Kononov, Leonid O.. And the article was included in Carbohydrate Research in 2019.Product Details of 4163-60-4 This article mentions the following:

Efficient procedures for the preparative synthesis of per-O-acyl derivatives of 4-(3-chloropropoxy)phenyl (CPP) glycosides of a series of common mono- and disaccharides (D-glucose, D-galactose, D-mannose, L-rhamnose, D-arabinofuranose, D-glucosamine, lactose) are described. The CPP glycosides obtained were transformed in almost quant. yields to the corresponding unprotected 4-(3-azidopropoxy)phenyl (APP) glycosides, which could become next-generation Janus glycosides with cleavable spacer aglycon, ready for conjugation or further transformation. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Product Details of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics