Category: esters-buliding-blocks

Design and synthesis of a new fluorescent probe for cascade detection of Zn²⁺ and H₂PO₄^– in water and targeted imaging of living cells was written by Du, Kui;Liu, Jian;Shen, Runpu;Zhang, Pengfei. And the article was included in Luminescence in 2019.SDS of cas: 4163-60-4 This article mentions the following:

Design and synthesis of new fluorescence probes with good water-solubility is of great importance to better understanding the significant role of ions which are related to biol. and the environment. As important ions, zinc ion (Zn2+) and dihydrogen phosphate ion (H2PO4-) display essential roles in living systems, and quant. detection of these ions in water is still a challenge. In order to consider the significant role of the galactose moiety in the design of a water-soluble fluorescence sensor, herein, we have developed a novel probe, Gal-AQTF, for the cascade detection of Zn2+ and H2PO4- with excellent selectivity in water. Through the introduction of the galactose moiety onto the sensor AQTF, which has been reported earlier by us, the water-solubility, cell compatibility and targeting ability were enhanced. Gal-AQTF has been successfully applied in the imaging of the living cells of HepG2 and A549, and illustrated good selectivity for the HepG2 cells which overly express the asialoglycoprotein (ASGP) receptor. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4SDS of cas: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.SDS of cas: 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Organogelators with dual β- and α-nucleating ability in isotactic polypropylene was written by Horvath, Flora;Bodrogi, Dominika;Hilt, Bendeguz;Pregi, Emese;Menyhard, Alfred. And the article was included in Journal of Thermal Analysis and Calorimetry in 2022.Recommanded Product: 6683-19-8 This article mentions the following:

Nucleation efficiency and the special supermol. structure formed in the presence of novel nucleating agents, N,N’-dicyclohexylsuberoylamide and N,N’-dicyclohexylsebacoylamide are presented in this work. The nucleation effect is studied in isotactic polypropylene (iPP). The melting and crystallization processes as well as the polymorphic composition are studied using calorimetric and thermo-optical techniques, while the solubility of the nucleating agents is studied by rheol. The properties of the iPP products nucleated by the novel compounds are characterized by conventional tensile and impact tests and the optical properties are measured by standardized haze measurements. The results indicated clearly that the studied nucleating agents are partially soluble in the iPP melt and possess dual nucleating ability. The formation of β-phase is evidenced by the calorimetric and thermo-optical measurements. The morphol. of the nucleated samples shows similarity to iPP nucleated by well-known soluble “organogelators”; however, the nucleating agents introduced in this work are the first “organogelators” with β-nucleating efficiency. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Recommanded Product: 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltage-gated sodium channels (VGSCs) as promising anticonvulsant drug candidates was written by Kapron, Barbara;Luszczki, Jarogniew J.;Siwek, Agata;Karcz, Tadeusz;Nowak, Gabriel;Zagaja, Miroslaw;Andres-Mach, Marta;Stasilowicz, Anna;Cielecka-Piontek, Judyta;Kocki, Janusz;Plech, Tomasz. And the article was included in Bioorganic Chemistry in 2020.Name: Ethyl 2-hydroxybenzoate This article mentions the following:

Epilepsy is a chronic neurol. disorder affecting nearly 65-70 million people worldwide. Despite the observed advances in the development of new antiepileptic drugs (AEDs), still about 30-40% of patients cannot achieve a satisfactory seizure control. In our current research, we aimed at using the combined results of radioligand binding experiments, PAMPA-BBB assay and animal experimentations in order to design a group of compounds that exhibit broad spectrum of anticonvulsant activity. The synthesized 4-alkyl-5-substituted-1,2,4-triazole-3-thione derivatives were primarily screened in the maximal electroshock-induced seizure (MES) test in mice. Next, the most promising compounds (17, 22) were investigated in 6 Hz (32 mA) psychomotor seizure model. Protective effect of compound 22 was almost similar to that of levetiracetam. Moreover, these compounds did not induce genotoxic and hemolytic changes in human cells as well as they were characterized by low cellular toxicity. Taking into account the structural requirements for good anticonvulsant activity of 4-alkyl-5-aryl-1,2,4-triazole-3-thiones, it is visible that small electron-withdrawing substituents attached to Ph ring have beneficial effects both on affinity towards VGSCs and protective activity in the animal models of epilepsy. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Name: Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: Ethyl 2-hydroxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tryptophan-Containing Block Copolymers Prepared by RAFT Polymerization: Synthesis, Self-Assembly, and Chiroptical and Sensing Properties was written by Mori, Hideharu;Takahashi, Eri;Ishizuki, Ai;Nakabayashi, Kazuhiro. And the article was included in Macromolecules (Washington, DC, United States) in 2013.Name: Benzyl benzodithioate This article mentions the following:

Novel tryptophan-based block copolymers with unique self-assembled structures, chiroptical properties, and sensing functionality were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of a tryptophan-containing acrylamide, N-acryloyl-L-tryptophan (A-Trp-OH). Polymerization of A-Trp-OH using a suitable chain transfer agent (CTA) proceeded in a controlled fashion, as confirmed by the relatively narrow polydispersity of the products and a mol. weight that could be controlled by the monomer-to-CTA molar ratio. Hydrophilic polymers obtained by RAFT polymerization of N,N-dimethylacrylamide, poly(ethylene glycol) Me ester methacrylate, and N-acryloyl-4-trans-hydroxy-L-proline were used as macro-CTAs. Chain extension of these hydrophilic macro-CTAs with A-Trp-OH was well controlled under the appropriate conditions to afford block copolymers with “as-designed” chain structures and relatively low polydispersities. The formation of micelles consisting of a hydrophobic core of poly(A-Trp-OH) and a hydrophilic shell was observed in aqueous solution and affected the optoelectronic properties of the polymer. We further investigated the chiroptical and sensing properties of the block copolymers by dynamic light scattering, UV-vis and fluorescence spectroscopy, and CD measurements. We present a new example of amino acid-based polymeric fluoride ion (F^–) probes in which micelles self-assembled from these block copolymers serve as enhanced ratiometric fluorescent and chiroptical F^– sensors, possessing characteristic detection capabilities in aqueous and organic media. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Name: Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Poly(3,4-propylenedioxypyrrole) Nanofibers with Branched Alkyl Chains by Electropolymerization to Obtain Sticky Surfaces with High Contact Angles was written by Diouf, Djibril;Diouf, Alioune;Mortier, Claudio;Darmanin, Thierry;Dieng, Samba Yande;Guittard, Frederic. And the article was included in ChemistrySelect in 2017.Name: Diethyl isobutylmalonate This article mentions the following:

Inspired by natural species such as rose petals or Echeveria pulvinata leaves with both high water contact angle θ_w and high water adhesion (also called parahydrophobic), we have prepared poly(3,4-propylenedioxypyrrole) with branched alkyl chains on the 3-position by electropolymerization The grafting at the 3-position keeps the NH group free, which is an important condition to obtain nanofibers. Different lengths of branched alkyl chains are studied. Here, using extremely long branched alkyl chains (ProDOP-br-C₁₀), it is possible to obtain extremely long and well defined nanofibers leading to porous surfaces (fiber mats) favoring the trapping of air between the surface and water droplets. Using a deposition charge of 200 mC cm^-2, extremely high θ_w up to ~140° while water droplets placed on this surface remained stuck even for a sliding angle of 90°, revealing extremely strong adhesion. These materials could be used in the future in water harvesting systems. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Name: Diethyl isobutylmalonate).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: Diethyl isobutylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 2-methoxydibenzo[b,f](1,4)-thiazepin-11(10H)-one 5,5-dioxide was written by Bennett, O. Francis;Johnson, James;Tramondozzi, John. And the article was included in Organic Preparations and Procedures International in 1974.Related Products of 2327-45-9 This article mentions the following:

The title compound (I, n = 2) was prepared from the nitrobenzoate II (R = Me, R1 = NO2) in 8 steps. Thus II (R = Me, R1 = NO2) was reduced to II (R = Me, R1 = NH2), hydrolyzed to II (R = H, R1 = NH2), deaminated and treated with Na2S to give II (R = H, R1 = SH), which was esterified and treated with 2-O2NC6H4I and hydrolyzed to give II (R = H, R1 = 2.O2NC6H4S). FeSO4-NH4OH reduction gave II (R = H, R1 = 2-H2NC6H4S), which was cyclized to I (n = 0) and oxidized to I (n = 2). In the experiment, the researchers used many compounds, for example, Methyl 5-methoxy-2-nitrobenzoate (cas: 2327-45-9Related Products of 2327-45-9).

Methyl 5-methoxy-2-nitrobenzoate (cas: 2327-45-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 2327-45-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalytic Asymmetric Synthesis of Quaternary Barbituric Acids was written by del Pozo, Sandra;Vera, Silvia;Oiarbide, Mikel;Palomo, Claudio. And the article was included in Journal of the American Chemical Society in 2017.Recommanded Product: Diethyl isobutylmalonate This article mentions the following:

The catalytic asym. α-functionalization of prochiral barbituric acids, a subtype of pseudosym. 1,3-diamides, to yield the corresponding 5,5-disubstituted (quaternary) derivatives remains essentially unsolved. In this study 2-alkylthio-4,6-dioxopirimidines are designed as key 1,3-diamide surrogates that perform exceedingly in amine-squaramide catalyzed C-C bond forming reactions with vinyl ketones or Morita-Baylis-Hillmann-type allyl bromides as electrophiles. Mild acid hydrolysis of adducts affords barbituric acid derivatives with an in ring quaternary carbon in unprecedented enantioselectivity, offering valuable materials for biol. evaluations. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: Diethyl isobutylmalonate).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Diethyl isobutylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Neryl acetate synthesis from nerol esterification with acetic anhydride by heterogeneous catalysis using ion exchange resin was written by Zeferino, Rubieli Carla Frezza;Piaia, Vinicius Aleixo Angonese;Orso, Vinicius Tres;Pinheiro, Vitor Machado;Zanetti, Micheli;Colpani, Gustavo Lopes;Padoin, Natan;Soares, Cintia;Fiori, Marcio Antonio;Riella, Humberto Gracher. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2022.COA of Formula: C12H20O2 This article mentions the following:

This work aims to synthesize neryl acetate from the nerol esterification reaction with acetic anhydride through heterogeneous catalysis using the ion exchange resin Lewatit GF 101. The reaction was monitored by gas chromatog. and the neryl acetate chem. structure was confirmed by mass spectrometry and NMR spectroscopy. The variables effect on the neryl acetate synthesis was evaluated from an exptl. design anal. The reaction showed the highest combined values for nerol conversion (98.11%) and neryl acetate selectivity (86.10%) at 30 min within optimal exptl. conditions of temperature at 40°C, catalyst content at 7% wt, molar ratio at 1:4 (nerol: acetic anhydride), agitation speed at 250 rpm and nerol content at 3 mmol. The complete nerol conversion was achieved at 40 min with 82.34% selectivity. The reaction rate was controlled only by the nerol decay, an expected behavior due to the excess of acetic anhydride used. In addition, the value obtained for the main reaction kinetic constant found by a pseudo-homogeneous model was 6 times greater than that of the parallel reaction. The catalyst reuse was investigated and after 3 cycles a high conversion (96.68%) and selectivity (83.78%) were observed indicating a low loss of the catalytic activity. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3COA of Formula: C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and Preliminary Screening of O-β-D-Galactopyranosides as Potential Mimic of UDP-Galp against Mycobacterium tuberculosis was written by Mugunthan, G.;Sriram, Dharmarajan;Yogeeswari, Perumal;Kartha, K. P. Ravindranathan. And the article was included in Journal of Carbohydrate Chemistry in 2012.Computed Properties of C8H4N2O This article mentions the following:

O-Galactopyranosides, e.g. I, were synthesized as potential mimics of uridine diphosphate galactopyranose (UDP-Galp), which is the substrate of the mutase enzyme involved in the mycobacterial cell wall biosynthesis by converting UDP-Galp to UDP-Galf. In vitro assay against the Mycobacterium tuberculosis H₃₇Rv strain gave promising results with min. inhibitory concentration (MIC) values in the range of 3.13 to 25 μg/mL. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Computed Properties of C8H4N2O).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C8H4N2O

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases was written by Goetz, Marion G.;Caffrey, Conor R.;Hansell, Elizabeth;McKerrow, James H.;Powers, James C.. And the article was included in Bioorganic & Medicinal Chemistry in 2004.Application of 87694-53-9 This article mentions the following:

A new series of peptidyl allyl sulfone inhibitors was discovered while trying to synthesize epoxy sulfone inhibitors from vinyl sulfones using basic oxidizing conditions. The various dipeptidyl allyl sulfones were evaluated with calpain I, papain, cathepsins B and L, cruzain and rhodesain and found to be potent inhibitors. In comparison to the previously developed class of vinyl sulfone inhibitors, the novel dipeptidyl allyl sulfones were more potent inhibitors than the corresponding dipeptidyl vinyl sulfones. It was observed that the stereochem. of the vinyl sulfone precursor played a role in the potency of the dipeptidyl allyl sulfone inhibitor. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Application of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics