Category: esters-buliding-blocks

Chemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts was written by Haida, S.;Kribii, A.. And the article was included in South African Journal of Botany in 2020.Application In Synthesis of malonic acid dibutyl ester This article mentions the following:

This work is part of the valorization of the Haloxylon scoparium plant, belonging to the Chenopodiaceae family and native to southeastern of Morocco. The aim of the present work is to study the chem. composition of this plant, to estimate the phenolic compounds contents of its extracts and to evaluate their antioxidant powers. After extraction by maceration of the aerial and root part of Haloxylon scoparium, the extracts obtained are fractionated by liquid-liquid extraction using solvents of different polarities. The best extraction yield is obtained in the aerial part 23.54% against 10.99% for the root part. The anal. carried out by the coupling of gas chromatog. with mass spectrometry (GC-MS) shows that the root part contains mainly carbohydrates, however the aerial part consists mainly of alkaloids. The total polyphenol content obtained in the root part 69.86 mg/gEAG (mg/g of gallic acid) is significantly higher than that in the aerial part 56.79 mg/g EAG. The hydrolysable tannins are the predominant polyphenols of the root part of Haloxylon scoparium corresponding to 83.87 mg/g EAT (mg/g of tannic acid). The antioxidant activity of the various extracts obtained is evaluated by two methods: the DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical scavenging test and the ferric reducing antioxidant power (FRAP). The examination of the inhibitory concentration values shows that the butanolic extract of the root part is the most active with values of IC₅₀ = 0.06 mg/mL and IC_0.5 = 0.19 mg/mL resp. for the DPPH and FRAP tests. The other extracts also showed a very interesting potential as antioxidants. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Application In Synthesis of malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of malonic acid dibutyl ester

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Characterisation of the chocolate aroma in roast jackfruit seeds was written by Spada, Fernanda Papa;Balagiannis, Dimitrios P.;Purgatto, Eduardo;do Alencar, Severino Matias;Canniatti-Brazaca, Solange Guidolin;Parker, Jane K.. And the article was included in Food Chemistry in 2021.Name: Isopentyl 3-methylbutanoate This article mentions the following:

The seeds of the jackfruit (Artocarpus heterophyllus Lam.) are an abundant waste-stream in Brazil and a potential source of chocolate aroma. The aim of the study was to characterize the aroma compounds in flours prepared from the roasted jackfruit seeds and compare them with a typical Brazilian cocoa powder. Jackfruits seeds were either left untreated, acidified or fermented before drying and roasting. The volatiles were extracted using solid phase micro extraction or solid phase extraction and analyzed by gas chromatog. mass spectrometry. The most odor-active volatiles were identified by GC-Olfactometry. Most of the compounds known to be odor-active character impact compounds in cocoa products were also found in the jackfruit seed flours, however, the jackfruit seeds produced many addnl. pyrazines, some of which were responsible for the characteristic earthy “roasted jackfruit seed” aroma. The fermented sample had the most similar aroma profile to cocoa powder. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Name: Isopentyl 3-methylbutanoate).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: Isopentyl 3-methylbutanoate

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Ester – Wikipedia,
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A Unified and Desymmetric Approach to Chiral Tertiary Alkyl Halides was written by Zheng, Yin;Zhang, Suihan;Low, Kam-Hung;Zi, Weiwei;Huang, Zhongxing. And the article was included in Journal of the American Chemical Society in 2022.Computed Properties of C10H11FO2 This article mentions the following:

A suite of dinuclear zinc catalysts with a prolinol- or pipecolinol-derived tetradentate ligand reductively desymmetrized a large collection of easily available halomalonic esters to α-halo-β-hydroxyesters were reported. These polyfunctionalized tertiary alkyl fluorides, chlorides, and bromides proved to be useful intermediates toward fluorinated drug analogs and polyhalogenated monoterpenes. The facile intramol. epoxidation of the chiral chloride and bromide products was enabled an expeditious access to natural products containing tertiary alc. motifs. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Computed Properties of C10H11FO2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C10H11FO2

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Ester – Wikipedia,
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Inter-Tree Variation in the Chemical Composition of Boswellia papyrifera Oleo-Gum-Resin was written by DeCarlo, Anjanette;Agieb, Salah;Johnson, Stephen;Satyal, Prabodh;Setzer, William N.. And the article was included in Natural Product Communications in 2022.COA of Formula: C12H20O2 This article mentions the following:

Frankincense is a fragrant resin produced by Boswellia species, and has been used for centuries as a perfume, medicine, and incense, and is an important cosmetic and therapeutic product today. A number of studies have been conducted on the resin essential oils, but many have used com. sources outside of the country of origin, leading to potential taxonomic confusion or misidentification. Individual Boswellia papyrifera resin samples were each obtained directly from 11 individual trees in Sudan, hydrodistd., the volatile phytochems. determined by gas chromatog. methods, and the chem. compositions subjected to cluster anal. All samples were very similar, with high levels of octyl acetate (49.5%-81.0%) and octanol (6.5%-13.7%), and varying levels of diterpenoids (6.6%-32.7%). The cluster anal. indicated 3 highly similar groups, defined by (1) relatively higher levels of octyl acetate (58.9%-81.0%), but with low levels of diterpenoids (6.6%-18.6%); (2) relatively lower levels of octyl acetate (49.5%-61.3%), but with a higher proportion of diterpenoids (19.0%-22.8%); and (3) with octyl acetate (51.6%) and diterpenoids (32.7%). In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3COA of Formula: C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C12H20O2

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An Inexpensive Air-Stable Titanium-Based System for the Conversion of Esters to Primary Alcohols was written by Reding, Matthew T.;Buchwald, Stephen L.. And the article was included in Journal of Organic Chemistry in 1995.Quality Control of Methyl 2-thienylacetate This article mentions the following:

Polymethylhydrosiloxane, when combined with titanium(IV) isopropoxide, provides a convenient system for the conversion of esters to the corresponding primary alcs. in the presence of a wide range of functional groups. Reactions are carried out as mixtures of the neat reaction components; workup with aqueous alk. THF affords primary alcs. in good to excellent yields. The system tolerates primary alkyl bromides and iodides, olefins, epoxides, and alkynes. Steric differentiation of Me and tert-Bu esters is also possible. The results observed in the parent and related reactions argue against pathways involving Lewis-acid catalysis and anionic hydridosilicate-mediated reductions, and instead support a neutral titanium hydride complex or strongly associated titanium/silane complex as the active reducing agent. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Quality Control of Methyl 2-thienylacetate).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Methyl 2-thienylacetate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

RAFT Polymerization of S-Vinyl Sulfide Derivatives and Synthesis of Block Copolymers Having Two Distinct Optoelectronic Functionalities was written by Nakabayashi, Kazuhiro;Abiko, Yohei;Mori, Hideharu. And the article was included in Macromolecules (Washington, DC, United States) in 2013.Formula: C14H12S2 This article mentions the following:

Well-defined sulfur-containing polymers and block copolymers were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of S-vinyl sulfide derivatives, in which the thioether moiety is directly connected to the vinyl group. We initially investigated RAFT polymerization of four different S-vinyl sulfide derivatives, Ph vinyl sulfide (PVS), 4-chlorophenyl vinyl sulfide (CPVS), 2,4-dichlorophenyl vinyl sulfide (DCPVS), and 4-bromophenyl vinyl sulfide (BPVS). Three xanthate-type chain transfer agents (CTAs), a dithiocarbamate-type CTA, and a dithioester-type CTA were compared for these RAFT polymerizations Reasonable control of the polymerization of PVS was confirmed by an observed linear increase in the mol. weight with the conversion, feasibility to control mol. weight based on the ratio of monomer consumed to the amount of CTA used, chain end structure determined by ¹H NMR, and chain extension experiment The RAFT polymerization of the bromo-substituted monomer (BPVS) also proceeded in the controlled fashion under the same conditions. Incorporation of optoelectronic groups, including anthracene, fluorene, diphenylamine, and phenothiazine on the bromophenyl pendant group of poly(BPVS) were accomplished by palladium-catalyzed postmodifications. We also investigated characteristic optoelectronic properties of modified polymers and block copolymers with two distinct electronic functionalities. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Formula: C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C14H12S2

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hydroxamic Acids as Potent Inhibitors of Endothelin-Converting Enzyme from Human Bronchiolar Smooth Muscle was written by Bihovsky, Ron;Levinson, Barry L.;Loewi, Rivka C.;Erhardt, Paul W.;Polokoff, Mark A.. And the article was included in Journal of Medicinal Chemistry in 1995.COA of Formula: C11H20O4 This article mentions the following:

Hydroxamic acids HONHCOCHRCO-X-R¹ (I; R = H. CHMe₂, CH₂CHMe₂; X = β-Ala, Asn, Trp, Gly; R¹ = OH. NH₂), derived from malonyl amino acids, and HONHCHCH₂CH(CHMe₂)CO-X-R¹ (X = Asn, β-Ala, Trp, R¹ = OH, NH₂), derived from succinyl amino acids, were synthesized as inhibitors of human bronchiolar smooth muscle endothelin-converting enzyme (HBSM ECE). Several unexpected side reactions were discovered, particularly in the synthesis of hydroxamates derived from succinates. In vitro evaluation against human bronchiolar ECE revealed that in all cases hydroxamates derived from malonate were more potent than hydroxamates derived from succinate. P₁‘ side chains R = CHMe₂, CH₂CHMe₂ were suitable; omission of the P₁‘ side chain (R = H) seriously diminished potency. In the P₂‘ position, several amino acids gave potent malonate-derived hydroxamate inhibitors (IC₅₀ = 0.2-6.8 nM), and I (R = CHMe₂, X = β-Ala, R¹ = OH) (II) provided an extremely potent inhibitor (IC₅₀ = 0.01 nM). C-terminus carboxylates are much more potent ECE inhibitors than the corresponding amides. Most of the hydroxamates were also potent inhibitors of thermolysin and neutral endopeptidase (NEP); however, the P₂‘ β-Ala derivative II uniquely inhibited HBSM ECE much more potently than NEP. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4COA of Formula: C11H20O4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C11H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hazardous compounds in recreational and urban recycled surfaces made from crumb rubber. Compliance with current regulation and future perspectives was written by Celeiro, Maria;Armada, Daniel;Dagnac, Thierry;de Boer, Jacob;Llompart, Maria. And the article was included in Science of the Total Environment in 2021.Electric Literature of C20H26O4 This article mentions the following:

Crumb rubber obtained from scrap tires is greatly employed for the construction of different facilities for sport, recreational and other uses. However, in recent years the concern about their safety and the related adult and children exposure to these surfaces is growing. This study aims a thorough chem. characterization encompassing 42 hazardous compounds, including polycyclic aromatic hydrocarbons (PAHs), phthalates, adipates, antioxidants and vulcanization agents in a wide range of crumb rubber from different surfaces. For the extraction of the target compounds, a method based on ultrasound-assisted extraction followed by gas chromatog.-tandem mass spectrometry (UAE-GC-MS/MS) was validated. Forty crumb rubber samples coming from synthetic turf football pitches, outdoor and indoor playgrounds, urban pavements, com. tiles and granulates, and scrap tires, were analyzed. In addition, green alternative materials, such as sand and artificial turf based on cork granulate infill were included to compare the levels of the target compounds with those of crumb rubber. Most of the analyzed recycled surfaces meet the recent limits proposed by the European Commission for rubber granulates and mulches, although they exceed in several cases the maximum levels allowed for rubber consumer products. Besides, most of the other target compounds, including several of them considered as endocrine disruptors, were detected in the analyzed samples, reaching ppm concentrations In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Electric Literature of C20H26O4).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C20H26O4

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors was written by Vats, Lalit;Sharma, Vikas;Angeli, Andrea;Kumar, Rajiv;Supuran, Claudiu T.;Sharma, Pawan K.. And the article was included in European Journal of Medicinal Chemistry in 2018.Recommanded Product: 13669-10-8 This article mentions the following:

The design, synthesis and biol. evaluation of a library of 1,2,3-triazole carboxylates incorporating carboxylic acid, hydroxymethyl, carboxylic acid hydrazide, carboxamide and benzenesulfonamide moieties was disclosed. All the compounds were investigated for their inhibition potential against carbonic anhydrase (CA, EC 4.2.1.1) human (h) isoforms hCA 1, 2, 4 and 9, well established drug targets. The cytosolic isoform hCA 1 was inhibited with Ki’s ranging between 53.2 nM and 7.616 μM whereas the glaucoma associated cytosolic isoform hCA 2 was inhibited with Ki’s in the range 21.8 nM-0.807 μM. The membrane bound isoform hCA 4, involved in glaucoma and retinitis pigmentosa among others, was effectively inhibited by some of these compounds with Ki < 60 nM, better than the reference drug acetazolamide (AAZ). The tumor associated isoform hCA 9, a recently validated antitumor/antimetastatic drug target, was also effectively inhibited by some of the new sulfonamides, which possessed the potential to be used as tools for exploring in more details the selective inhibition of hCAs involved in various pathologies. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 13669-10-8

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Ester – Wikipedia,
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Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis was written by Madaiah, Malavalli;Prashanth, Maralekere K.;Revanasiddappa, Hosakere D.;Veeresh, Bantal. And the article was included in New Journal of Chemistry in 2016.Related Products of 16413-26-6 This article mentions the following:

The current study involves the synthesis of novel imidazo[4,5-c]pyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacol. activities were determined by the objective to better understand their structure-activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened, compounds 21, 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model, 21, 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg^-1 body weight In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics