Category: esters-buliding-blocks

Desymmetrization of meso-Dicarbonatecyclohexene with β-Hydrazino Carboxylic Esters via a Pd-Catalyzed Allylic Substitution Cascade was written by Xu, Kai;Zheng, Yan;Ye, Yong;Liu, Delong;Zhang, Wanbin. And the article was included in Organic Letters in 2020.Electric Literature of C12H14O3 This article mentions the following:

The desymmetrization of meso-dicarbonatecyclohexene with β-hydrazino carboxylic esters has been achieved via a RuPHOX/Pd-catalyzed allylic substitution cascade for the construction of chiral hexahydrocinnoline derivatives with high performance. Mechanistic studies reveal that the reaction exploits a pathway different from that of our previous work and that the first nitrogen nucleophilic process is the rate-determining step. The protocol could be conducted on a gram scale without any loss of catalytic behavior, and the corresponding chiral hexahydrocinnolines can undergo diverse transformations. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Electric Literature of C12H14O3).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Electric Literature of C12H14O3

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Synthesis of densely functionalized pyrrolidinone templates by an intramolecular oxo-Diels-Alder reaction was written by Murray, William V.;Mishra, Pranab K.;Sun, Sengen;Maden, Amy. And the article was included in Tetrahedron Letters in 2002.Related Products of 87694-53-9 This article mentions the following:

Preparation of densely functionalized pyrrolidinone templates, is a challenge for synthetic chemists. These templates are important building blocks for novel conformationally constrained natural products or for library generation of highly functionalized bi or polycyclic compounds Trienes, e.g. I, undergo facile stereoselective intramol. Diels Alder reactions to generate densely functionalized cis fused pyrrolidinone templates, e.g. II. These reactions allow for directed remote hydroxylation with complete control of stereochem. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Related Products of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Homoleptic “Star” Ru(II) Polypyridyl Complexes: Shielded Chromophores to Study Charge-Transfer at the Sensitizer-TiO₂ Interface was written by Johansson, Patrik G.;Zhang, Yongyi;Meyer, Gerald J.;Galoppini, Elena. And the article was included in Inorganic Chemistry in 2013.Formula: C12H10O4 This article mentions the following:

Three homoleptic star-shaped Ru polypyridyl complexes, termed Star YZ1, Star YZ2, and Star YZ3, where the Ru(II) center is coordinated to three bipyridine ligands each carrying two oligo(phenylene ethynylene) (OPE) rigid linker units terminating with isophthalic ester (Ipa) groups for binding to metal-oxide surfaces were synthesized. In Star YZ3, each OPE linker was substituted with two n-butoxy (BuO) solubilizing groups. Star complex YZ4, which is homoleptic but lacks the octahedral symmetry, was synthesized as a reference compound The Star complexes were synthesized using two approaches: in the first, Ru(4,4′-(Br)₂-2,2′-bpy)₃ was reacted in a Sonogashira cross coupling reaction with the ethynyl-OPE-Ipa linkers; in the second, the 2,2′-bpy-OPE-Ipa ligands were reacted with Ru(DMSO)₄(PF₆)₂. The photophys. behavior of the Star complexes were studied in fluid solution and anchored to the surface of mesoporous nanocrystalline TiO₂ thin films (Star/TiO₂). To a first approximation the excited state behavior in MeCN was unchanged when the compounds were anchored to a TiO₂ thin film, indicating that the highly sym. (octahedral) and rigid mol. structure of the ligands shielded the chromophoric core from the TiO₂ semiconductor. Inefficient excited state injection, φ_inj < 0.05, occurs on a nanosecond time scale with slow recombination. The presence of BuO groups on the linker unit gave a large increase in the extinction coefficient of YZ3, which allows for enhanced harvesting of sunlight. Mol. design on the nanometer length scale can be used to control excited state relaxation pathways at semiconductor surfaces. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Formula: C12H10O4).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C12H10O4

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Synthesis and Structure-Activity Relationship Studies of Benzo[b][1,4]oxazin-3(4H)-one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X was written by Modranka, Jakub;Li, Jiahong;Parchina, Anastasia;Vanmeert, Michiel;Dumbre, Shrinivas;Salman, Mayla;Myllykallio, Hannu;Becker, Hubert F.;Vanhoutte, Roeland;Margamuljana, Lia;Nguyen, Hoai;Abu El-Asrar, Rania;Rozenski, Jef;Herdewijn, Piet;De Jonghe, Steven;Lescrinier, Eveline. And the article was included in ChemMedChem in 2019.Related Products of 16413-26-6 This article mentions the following:

Since the discovery of a flavin-dependent thymidylate synthase (ThyX or FDTS) that is absent in humans but crucial for DNA biosynthesis in a diverse group of pathogens, the enzyme has been pursued for the development of new antibacterial agents against Mycobacterium tuberculosis, the causative agent of the widespread infectious disease tuberculosis (TB). In response to a growing need for more effective anti-TB drugs, we have built upon our previous screening efforts and report herein an optimization campaign of a novel series of inhibitors with a unique inhibition profile. The inhibitors display competitive inhibition toward the methylene tetrahydrofolate cofactor of ThyX, enabling us to generate a model of the compounds bound to their target, thus offering insight into their structure-activity relationships. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 16413-26-6

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Unravelling microbial populations and volatile organic compounds of artisan fermented liver sausages manufactured in Central Italy was written by Belleggia, Luca;Ferrocino, Ilario;Reale, Anna;Haouet, M. Naceur;Corvaglia, Maria Rita;Milanovic, Vesna;Boscaino, Floriana;Di Renzo, Tiziana;Di Bella, Sara;Borghi, Monica;Farneti, Silvana;Cesaro, Cristiana;Garofalo, Cristiana;Cardinali, Federica;Aquilanti, Lucia;Musari, Evan;Cocolin, Luca;Osimani, Andrea. And the article was included in Food Research International in 2022.Computed Properties of C6H10O2 This article mentions the following:

The aim of the present study was to obtain information on the occurrence of bacteria and eumycetes in ready-to-eat fermented liver sausages manufactured by 20 artisan producers located in the Marche Region (Italy). To this end, culture-dependent analyses and metataxonomic sequencing were carried out. Physico-chem. parameters and volatilome of the fermented liver sausages were also studied. Finally, the presence of hepatitis E virus (HEV) was also assessed via real-time-RT-(q)PCR assays. Active microbial populations mainly represented by lactic acid bacteria, enterococci, coagulase-neg. cocci, and eumycetes were detected. Enterobacteriaceae, Pseudomonadaceae, and sulfite-reducing anaerobes were not detected in most of the samples. Latilactobacillus sakei dominated in all the analyzed samples, reaching abundances up to 80%. Staphylococcus xylosus and Staphylococcus equorum were also detected. Among minority bacterial taxa, Weissella spp., Leuconostoc spp., Macrococcus caseolyticus, Brochothrix thermosphacta, Staphylococcus succinus, Lactobacillus coryniformis, Lactiplantibacillus plantarum, Lactococcus garviae, Psychrobacter spp., and Carnobacterium viridans were detected. The mycobiota was mainly composed by Debaryomyces hansenii that was present in all samples at the highest frequency. Among minority fungal taxa, Aspergillus spp., Penicillium spp., Kurtzmaniella zeylanoides, Candida spp., Yamadazyma spp., Scopulariopsis spp., Yarrowia spp., and Starmerella spp. were detected. Interestingly, associations between some taxa and some physico-chem. parameters were also discovered. The absence of HEV in all the samples attested a high level of safety. Finally, most of the VOCs detected in the analyzed fermented liver sausages belonged to six classes as: terpenoids, aldehydes, ketones, alcs., esters, and acids. Nitrogen compounds, sulfur compounds, phenols, hydrocarbons, lactones, furans, and aromatic hydrocarbons were also identified. Several significant relationships were observed between mycobiota and VOCs. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Computed Properties of C6H10O2).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C6H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Multivalent Glycosheets for Double Light-Driven Therapy of Multidrug-Resistant Bacteria on Wounds was written by Hu, Xi-Le;Chu, Linyang;Dong, Xiaojing;Chen, Guo-Rong;Tang, Tingting;Chen, Daijie;He, Xiao-Peng;Tian, He. And the article was included in Advanced Functional Materials in 2019.Category: esters-buliding-blocks This article mentions the following:

With the evergrowing threat posed by multidrug resistance of bacteria, the development of effective antibacterial agents remains a global challenge. Infection with multidrug-resistant bacteria in hospitals significantly impairs the healing of wounds caused by deep-burn injuries or diabetic foot ulceration, leading to a high mortality rate among these patients. A multivalent glycosheet for the double light-driven therapy against multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) infection on wounds is developed here. Galactose- and fucose-based ligands are self-assembled to form a glyco-layer on the surface of thin-layer molybdenum disulfide, producing the glycosheets capable of selectively localizing P. aeruginosa through multivalent carbohydrate-lectin interactions. The glycosheets loaded with antibiotics have proven applicable for: (1) near-IR-light driven, in situ thermal release of antibiotics, increasing bacterial membrane permeability, and (2) white light-driven reactive-oxygen-species production to more thoroughly kill the bacteria. The targetability, together with the light sensibility, of the glycosheets enables a highly effective and optically controlled therapeutic regime for the healing of wounds infected by multidrug-resistant as well as clin. isolated P. aeruginosa. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Category: esters-buliding-blocks).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterization and Synergistic Effect of Antifungal Volatile Organic Compounds Emitted by the Geotrichum candidum PF005, an Endophytic Fungus from the Eggplant was written by Mookherjee, Abhirup;Bera, Paramita;Mitra, Adinpunya;Maiti, Mrinal K.. And the article was included in Microbial Ecology in 2018.Synthetic Route of C10H20O2 This article mentions the following:

Plant-associated endophytes are recognized as sources of novel bioactive mols. having diverse applications. In this study, an endophytic yeast-like fungal strain was isolated from the fruit of eggplant (Solanum melongena) and identified as Geotrichum candidum through phenotypic and genotypic characterizations. This endophytic G. candidum isolate PF005 was found to emit fruity scented volatiles. The compositional profiling of volatile organic compounds (VOCs) revealed the presence of 3-methyl-1-butanol, Et 3-methylbutanoate, 2-phenylethanol, isopentyl acetate, naphthalene, and iso-Bu acetate in significant proportion when analyzed on a time-course basis. The VOCs from G. candidum exhibited significant mycelial growth inhibition (54%) of phytopathogen Rhizoctonia solani, besides having mild antifungal activity against a few other fungi. The source of carbon as a nutrient was found to be an important factor for the enhanced biosynthesis of antifungal VOCs. The antifungal activity against phytopathogen R. solani was improved up to 91% by feeding the G. candidum with selective precursors of alc. and ester volatiles. Furthermore, the antifungal activity of VOCs was enhanced synergistically up to 92% upon the exogenous addition of naphthalene (1.0 mg/plate). This is the first report of G. candidum as an endophyte emitting antifungal VOCs, wherein 2-penylethanol, isopentyl acetate, and naphthalene were identified as important contributors to its antifungal activity. Possible utilization of G. candidum PF005 as a mycofumigant has been discussed based upon its antifungal activity and the qualified presumption of safety status. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Synthetic Route of C10H20O2).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C10H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Exploring anomeric glycosylation of phosphoric acid: Optimization and scope for non-native substrates was written by Beswick, Laura;Ahmadipour, Sanaz;Hofman, Gert-Jan;Wootton, Hannah;Dimitriou, Eleni;Reynisson, Johannes;Field, Robert A.;Linclau, Bruno;Miller, Gavin J.. And the article was included in Carbohydrate Research in 2020.Quality Control of (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate This article mentions the following:

An improved access to glycosyl 1-phosphates has been developed,formed using a melt of an acetylated precursor with H₃PO₄ under high vacuum. Through preparation of the reaction components in a glove box and reducing the reaction temperature and equivalent of H₃PO₄, small scale access to the preparation of native and non-native glycosyl 1-phosphates in good yields and with facile purification is enabled. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Quality Control of (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A novel method for the preparation of acid-sensitive epoxides from olefins with the combined use of molecular oxygen and an aldoacetal catalyzed by a cobalt(II) complex was written by Yorozu, Kiyotaka;Takai, Toshihiro;Yamada, Tohru;Mukaiyama, Teruaki. And the article was included in Bulletin of the Chemical Society of Japan in 1994.Related Products of 15399-05-0 This article mentions the following:

An efficient synthesis of acid-sensitive epoxides, such as chromene oxide or the epoxide of an γ,δ-unsaturated alc., was successfully achieved by the oxygenation of olefins with the combined use of 1 atm of O₂ and an aldehyde acetal catalyzed by a cobalt(II) complex containing a 1,3-diketone ligand. The reactions proceeded under mild and neutral conditions, and the desired epoxides were obtained in good yields. Neither overoxidn. nor decomposition of the epoxide was observed Furthermore, various silyl enol ethers and silyl ketene acetals, acid-sensitive compounds, were also smoothly monooxygenated to the corresponding α-hydroxy ketones and α-hydroxy carboxylic acid esters, resp. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Related Products of 15399-05-0).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 15399-05-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Contents and compositions of the aroma in “Wasanbon” sugar was written by Matsui, Toshiyuki;Kitaoka, Shozaburo. And the article was included in Journal of Nutritional Science and Vitaminology in 1981.Recommanded Product: 15399-05-0 This article mentions the following:

Wasanbon sugar which is handmade sugar manufactured traditionally in Japan by a unique refining procedure, is used in the making of Japanese traditional confectionery. The contents and compositions of the aroma in Wasanbon sugar and refinery final molasses were determined by column chromatog., gas chromatog., mass spectrometry, and sensory evaluation. The samples are the first press-off molasses (Ara-mitsu molasses), refinery final molasses, Shiroshita sugar (pre-refined sugar), and Wasanbon sugar. In the acidic fraction, the aroma of 3-phenylpropionic acid  [501-52-0] was similar to the stored aroma of Wasanbon sugar, whereas the aroma of its Me ester [103-25-3] was not. Aroma substance content of the weakly acidic fraction in Wasanbon sugar and refinery final molasses were 8.5 – 8.7% of those of the acidic fraction, and their main components were cyclotene  [80-71-7] and maltol,  [118-71-8] formed by thermal degradation of sugar. These components had higher aroma scores than other weakly acidic fraction aromas, by a paired preference test. Cyclotene and maltol increased about 3.7 and 1.5 times, resp., during heating of Shiroshita sugar. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Recommanded Product: 15399-05-0).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 15399-05-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics