Category: esters-buliding-blocks

Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists was written by Fracchiolla, Giuseppe;Laghezza, Antonio;Piemontese, Luca;Parente, Mariagiovanna;Lavecchia, Antonio;Pochetti, Giorgio;Montanari, Roberta;Di Giovanni, Carmen;Carbonara, Giuseppe;Tortorella, Paolo;Novellino, Ettore;Loiodice, Fulvio. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Category: esters-buliding-blocks This article mentions the following:

PPARs are transcription factors that govern lipid and glucose homeostasis and play a central role in cardiovascular disease, obesity, and diabetes. Thus, there is significant interest in developing new agonists for these receptors. Given that the introduction of fluorine generally has a profound effect on the phys. and/or biol. properties of the target mol., we synthesized a series of fluorinated analogs of the previously reported compound 2 (I), some of which turned out to be remarkable PPARα and PPARγ dual agonists. Docking experiments were also carried out to gain insight into the interactions of the most active derivatives with both receptors. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Category: esters-buliding-blocks).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A highly porous NbO type metal-organic framework constructed from an expanded tetracarboxylate was written by Cai, Jianfeng;Rao, Xingtang;He, Yabing;Yu, Jancan;Wu, Chuande;Zhou, Wei;Yildirim, Taner;Chen, Banglin;Qian, Guodong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Name: Dimethyl 5-ethynylisophthalate This article mentions the following:

A novel NbO type microporous metal-organic framework Cu₂L (ZJU-32 (5); H₄L (4) = 5′-((3,5-dicarboxyphenyl)ethynyl)-[1,1′:3′,1”-terphenyl]-4,4”-dicarboxylic acid) constructed from an elaborately designed tetratopic ligand was solvothermally synthesized and structurally characterized. The activated ZJU-32a exhibits high permanent porosity with the Brunauer-Emmett-Teller (BET) surface area of 3831 m² g^-1 and the pore volume of 1.482 cm³ g^-1, enabling it to be a promising material for both methane storage and carbon dioxide capture at room temperature In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Name: Dimethyl 5-ethynylisophthalate).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Dimethyl 5-ethynylisophthalate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shifting Sol-Gel Phase Diagram of a Doubly Thermosensitive Hydrophilic Diblock Copolymer Poly(methoxytri(ethylene glycol) acrylate-co-acrylic acid)-b-poly(ethoxydi(ethylene glycol) acrylate-co-acrylic acid) in Aqueous Solution was written by Jin, Naixiong;Zhang, Hao;Jin, Shi;Dadmun, Mark D.;Zhao, Bin. And the article was included in Macromolecules (Washington, DC, United States) in 2012.Formula: C14H12S2 This article mentions the following:

This article reports that the C-shaped sol-gel phase diagram of a doubly thermosensitive hydrophilic diblock copolymer with each block containing a small amount of weak acid groups in aqueous solution in the moderate concentration range can be readily and reversibly shifted by changing the solution pH. The diblock copolymer, poly(methoxytri(ethylene glycol) acrylate-co-acrylic acid)-b-poly(ethoxydi(ethylene glycol) acrylate-co-acrylic acid) (P(TEGMA-co-AA)-b-P(DEGEA-co-AA)), was synthesized by reversible addition-fragmentation chain transfer polymerization and postpolymn. modification. A 20 wt % aqueous solution of P(TEGMA-co-AA)-b-P(DEGEA-co-AA) with pH of 3.29 underwent sol-to-gel, gel-to-sol, and clear sol-to-cloudy sol transitions at 17° (T_sol-gel), 38° (T_gel-sol), and 55° (T_clouding), resp., upon heating. With the increase of pH, all transition temperatures shifted to high values; for instance, the T_sol-gel, T_gel-sol, and T_clouding were 20, 45, and 63°, resp., at pH = 5.10, and 28, 52, and 77°, resp., at pH = 5.79. Using vial inversion tests, we mapped out sol-gel phase diagrams of the diblock copolymer in aqueous solutions at three pH values (3.29, 5.10, and 5.79, measured at ∼0°); the whole sol-gel phase diagram shifted upward with the increase of pH. When the pH was lowered from 5.79 to 5.10, the diagram shifted back, though there was a 1° difference at each selected concentration, compared with the original curve of pH = 5.10. The tunability of sol-gel-sol-clouding transitions stemmed from the pH dependences of thermosensitive properties of two blocks, which were confirmed by a dynamic light scattering study. The results from small-angle X-ray scattering experiments indicated that spherical micelles of P(TEGMA-co-AA)-b-P(DEGEA-co-AA) in 20 wt % aqueous solutions at selected pH and temperatures were packed into crystalline structures, either body-centered cubic or face-centered cubic, in the gel states. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Formula: C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Large pores generated by the combination of different inorganic units in a zinc hydroxide ethynylene diisophthalate MOF was written by Hausdorf, Steffen;Seichter, Wilhelm;Weber, Edwin;Mertens, Florian O. R. L.. And the article was included in Dalton Transactions in 2009.Safety of Dimethyl 5-ethynylisophthalate This article mentions the following:

A 5,5′-ethynylenediisophthalic acid linker mol. was synthesized and used to form a zinc carboxylate-based metal organic framework (MOF) with very large pores and unit cell volume resulting from the unusual combination of structurally different inorganic units forming the secondary building blocks (SBUs). The structure is the first zinc hydroxide carboxylate structure where the inorganic units do not form layers or ribbons but isolated islands. The structure forms true pores with a significantly narrowed pore entry similar to zeolites. The pores are, thus, not created simply by intersecting channels as in most other MOF structures. Although the pore shape is highly asym. the spherical free volume is with 10.8 Å still large. The stability of the SBUs in respect to exchange and removal of coordinated solvent mols. was studied. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Safety of Dimethyl 5-ethynylisophthalate).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Dimethyl 5-ethynylisophthalate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Combined effects of tangerine oil vapour mixed with banana flavor to enhance the quality and flavor of ‘Hom Thong’ bananas and evaluating consumer acceptance and responses using electroencephalography (EEG) was written by Saengwong-Ngam, Ravinun;Koomhin, Phanit;Songsamoe, Sumethee;Matan, Nirundorn;Matan, Narumol. And the article was included in Journal of Food Science and Technology (New Delhi, India) in 2022.SDS of cas: 659-70-1 This article mentions the following:

The objectives of this study were to investigate the effect of tangerine oil (TO) at 25, 50 and 75μL mixed with banana flavor (BF) at 25, 50 and 75μL to protect the quality and enhance the flavor of bananas. Then, 25μL TO + BF 50μL were selected for studying the quality of bananas stored at 13°C ± 2°C for 7 days, and was used to test consumer brain responses using an electroencephalog. (EEG). Results showed that mold grew and decomposition occurred in 10 and 50% of the 25μL TO + 50μL BF mixture and control, resp., after 7 days. Furthermore, this ratio increased ripening by having higher L*, b*, firmness and total soluble solid than the control (p < 0.05), whereas titratable acidity and pH were maintained (p > 0.05). The EEG demonstrated that consumption of TO-treated banana could increase brain alertness using stimulating the beta wave activity on banana stimulations for human brain. Limonene, one of the main components of TO, was found in the flesh of treated banana after storage for 4 wk and possibly interacted with other components to improve antifungal activity and brain response. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1SDS of cas: 659-70-1).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.SDS of cas: 659-70-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemistry of nitro esters. XVII. Production of mesoxalic acid esters was written by Kochergin, P. M.;Titkova, R. M.. And the article was included in Zhurnal Organicheskoi Khimii in 1994.Name: malonic acid dibutyl ester This article mentions the following:

The preparation of mesoxalic acid esters from monobromomalonates and silver nitrate is described. Thus, bromination of di-Et malonate gave 85% di-Et bromomalonate (I) and 4% di-Et dibromomalonate. I with AgNO₃ in anhydrous EtOH gave AgBr and 77% di-Et mesoxalate via intermediate O₂NOCH(CO₂Et)₂. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Name: malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: malonic acid dibutyl ester

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Genetic and physical mapping of the Rhodobacter sphaeroides photosynthetic gene cluster from R-prime pWS2 was written by Wu, Yongqiang;MacGregor, Barbara J.;Donohue, Timothy J.;Kaplan, Samuel;Yen, Bill. And the article was included in Plasmid in 1991.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate This article mentions the following:

Plasmid pWS2 is an R68.45 chimera originally isolated as an R-prime which complemented the R. sphaeroides bch-420 allele. PWS2 is also able to complement a wide range of R. sphaeroides pigment and photosynthetic mutants employing nitrosoguanidine, transposon or insertion-generated mutations effecting puhA, puc, puf, cycA, bch, and crt genes. A combination of orthogonal-field-alternation gel electrophoresis, transverse alternating field gel electrophoresis, and conventional electrophoresis have been used to estimate the size of pWS2 at ≃168.3 ± 3.5 kb. A restriction map of the ≃109 kb of R. sphaeroides insert DNA was generated by partial and complete restriction endonuclease digestion coupled with Southern hybridization anal. using either gene-specific or junction fragment probes. Genes encoding bacteriochlorophyll (Bchl)-binding proteins (pufBALMX, PucBA, and puhA), cytochrome c₂ (cycA), and enzymes involved in Bchl (bch) and carotenoid (crt) biosynthesis have been shown to reside within a contiguous 53-kb region of the R. sphaeroides DNA present on pWS2. The puf operon lies at one end of the 53-kb segment, while the genes puhA, cycA, and pucBA, the latter 2 of which are located within ≃12.0 kb of each other, define the other end of this 53-kb region. The genetic and phys. mapping data provided in this paper are discussed in terms of the similarities and differences in the organization of the photosynthetic gene cluster between R. sphaeroides and other photosynthetic bacteria as well as highlighting the use of pWS2 in studies of photosynthetic gene structure and function. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Migration of Irganox 1010, Irganox 1076, and Titanium dioxide into Doogh and corresponding food simulant from laminated packaging was written by Forooghi, Elaheh;Ahmadi, Shervin;Farhoodi, Mehdi;Mortazavian, Amir M.. And the article was included in Journal of Environmental Health Science and Engineering in 2022.Synthetic Route of C73H108O12 This article mentions the following:

Doogh is a famous Iranian drink based on fermented milk. Laminated film is one of the most common packaging for this beverage in Iran. So, chem. substances of the packaging may migrate to the Doogh and endanger human health. In this research, High-Performance Liquid Chromatog. (HPLC) was used to determine the migration of Irganox 1010 and Irganox 1076 from the contact layer and inductively coupled plasma for Titanium dioxide (TiO₂) from the second layer of three-layer laminate films into Doogh and acetic acid 3% (w/v). The influence of different storage temperatures and times was investigated by evaluating the samples stored in various conditions. The morphol., thermal and mech. properties of the film, before and after contact with food simulant were further studied. The highest amount of Irganox 1010 concentration of the tested samples were 0.8 ± 0.04 mg/l in acetic acid 3% (w/v), and 0.62 ± 0.04 mg/l in Doogh. The highest amount of TiO₂ concentration were 0.25 ± 0.04 mg/l in acetic acid 3% (w/v), and 0.12 ± 0.02 mg/l in Doogh. The migration of Irganox 1076 was determined, but it was not detected. The results indicated that the food simulant had no significant effect on the microstructure and thermal properties of the polymer, but it reduced the mech. properties. The results indicate the possible migrating of Irganox 1010 and TiO₂ through laminate packaging into Doogh in some storage conditions. Since the migration value was low, the mentioned film was proven safe for Doogh packaging, imposing no hazards on human health. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Synthetic Route of C73H108O12).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C73H108O12

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Expedient Synthesis of Substituted Benzoheterocycles using 2-Butoxy-2,3-dihydrofurans as [4+2] Benzannulation Reagents was written by Liu, Changhui;Huang, Wenbo;Wang, Man;Pan, Bin;Gu, Yanlong. And the article was included in Advanced Synthesis & Catalysis in 2016.Category: esters-buliding-blocks This article mentions the following:

2-Alkoxy-2,3-dihydrofurans were found to be versatile benzannulation reagents. Indoles can be synthesized in good to excellent yields via the [4+2] annulation of 2-butoxy-2,3-dihydrofuran with pyrroles catalyzed by copper bromide. With the same protocol, carbazoles can also be obtained when indoles are used as starting material with the aid of p-toluenesulfonic acid. This type of benzannulation reagent can also be used to synthesize benzofuran, benzothiophene and naphthalene derivatives in the presence of a catalytic amount of triflic acid in moderate yields. This benzannulation protocol features wide substrate scope and mild reaction condition. Moreover, most of examples have a good regioselectivity. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Category: esters-buliding-blocks).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition was written by Capela, Rita;Oliveira, Rudi;Goncalves, Lidia M.;Domingos, Ana;Gut, Jiri;Rosenthal, Philip J.;Lopes, Francisca;Moreira, Rui. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

A series of artemisinin-vinyl sulfone hybrid mols. with the potential to act in the parasite food vacuole via endoperoxide activation and falcipain inhibition was synthesized and screened for antiplasmodial activity and falcipain-2 inhibition. All conjugates were active against the Plasmodium falciparum W2 strain in the low nanomolar range and those containing the Leu-hPhe core inhibited falcipain-2 in low micromolar range. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics