Category: esters-buliding-blocks

Organizing Nanoparticles in Semicrystalline Polymers by Modifying Particle Diffusivity was written by Mendez, Nicholas F.;Altorbaq, Abdullah S.;Muller, Alejandro J.;Kumar, Sanat K.. And the article was included in ACS Macro Letters in 2022.Product Details of 6683-19-8 This article mentions the following:

We have previously shown that semicrystalline polymers can be reinforced by adding nanoparticles (NPs) and then ordering them into specific motifs using the crystallization process. A key result we have found is that when the spherulite growth rate is slowed below a critical value, then, NPs can order into the amorphous interlamellar regions of the semicrystalline structure. The effects of spherulite growth rate in this context have previously been examined, and here we focus on the role of NP diffusivity. We achieve this goal by changing the poly(ethylene oxide) (PEO) mol. weight as a route to altering the matrix viscosity. In particular, four mol. weights of PEO were employed ranging from 5.4-46 kDa. Each sample was loaded with 10 vol % of bare 14 nm diameter silica NPs. After initially studying spherulite growth rates, experiments were designed to fix the spherulite growth rate across sample mol. weights to study particle ordering, induced by polymer crystallization We find that, at the fastest growth rate studied (12μm/s), the lowest mol. weight sample showed the highest order, presumably due to enhanced particle mobility. However, as the spherulite growth rate is slowed, the maximum ordering behavior is observed at intermediate mol. weights The trend observed at slow growth rates is explained by the large-scale segregation of NPs (presumably into the grain boundaries, i.e., the interspherulitic regions); evidence for this is the observed transition of spherulite growth to diffusion-control at slow growth rates in the lowest mol. weight PEO sample studied. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Product Details of 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterization and comparison of predominant aroma compounds in microwave-treated wheat germ and evaluation of microwave radiation on stability was written by Zhang, Yukun;Tang, Ning;Shi, Lin;Miao, Yuxin;Liu, Xu;Ge, Xinhui;Cheng, Yongqiang;Zhang, Xiuqing. And the article was included in Journal of Cereal Science in 2020.Electric Literature of C6H10O2 This article mentions the following:

The present study was performed to evaluate the effects of microwave (MW) output power and treatment time on moisture content, lipase and lipoxygenase activities as well as color changes of wheat germ (WG). In addition, the key aroma compounds in different MW-power-treated WG, which is of importance to the flavor of WG products, were also investigated. The obtained results showed that MW treatment maintained the inherent color of WG and significantly reduced the moisture content (maximum reduction of 95%) and the activities of lipase and lipoxygenase (maximum reduction of 65% and 99%, resp.). In terms of aroma compounds, with the increase of the MW output power, the content of esters, alkanes, alcs. and acids decreased, while the content of heterocyclic compounds, nitrogen-containing compounds, aldehydes and ketones increased, providing more compounds with roasted flavor and less volatiles with grass-like flavor. Therefore, MW treatment was an effective stabilization method for WG utilization. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Electric Literature of C6H10O2).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Electric Literature of C6H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deciphering Structure-Activity Relationships in a Series of 2,2-Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants was written by Pirotte, Bernard;Florence, Xavier;Goffin, Eric;Lebrun, Philippe. And the article was included in ChemMedChem in 2017.HPLC of Formula: 16413-26-6 This article mentions the following:

4,6-Disubstituted 2,2-dimethylchromans are reported as pharmacol. active compounds that mainly target the ATP-sensitive potassium channels. The present study is an attempt to characterize the impact of the nature of substituents introduced at the 4- and 6-positions of 2,2-dimethylchromans on their capacities to inhibit insulin release from pancreatic β-cells or to relax vascular smooth muscle cells, both biol. responses that are supposed to reflect interaction with specific ion channels. From the core structure 4-amino-2,2-dimethylchroman, a progressive increase in the steric hindrance of the chem. functionalities introduced at the 4-position (amino, formamido, acetamido, arylureido/thioureido) and at the 6-position (amino, formamido, acetamido, alkoxycarbonylamino) led to a progressive magnification of the inhibitory effect on the insulin release process and, to a lesser extent, of the vasorelaxant activity. Moreover, the dextrorotatory enantiomer of 2,2-dimethylchroman compound 29 was more potent than its levorotatory counterpart for inhibiting the insulin secretory process. Addnl. pharmacol. investigations suggested, however, that the myorelaxant activity of 11 and 15 resulted from a direct Ca²⁺ entry blockade. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6HPLC of Formula: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of a Potent Thieno[2,3-d]pyrimidine-2,4-dione-Based Protoporphyrinogen IX Oxidase Inhibitor through an In Silico Structure-Guided Optimization Approach was written by Wang, Da-Wei;Zhang, Hang;Yu, Shu-Yi;Zhang, Rui-Bo;Liang, Lu;Wang, Xia;Yang, Huang-Ze;Xi, Zhen. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Recommanded Product: Methyl 2-aminonicotinate This article mentions the following:

A key objective for herbicide research is to develop new compounds with improved bioactivity. Protoporphyrinogen IX oxidase (PPO) is an essential target for herbicide discovery. Here, we report using an in silico structure-guided optimization approach of our previous lead compound I and designed and synthesized a new series of compounds Systematic bioassays led to the discovery of a highly potent compound II, 1-methyl-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, which exhibited an excellent and wide spectrum of weed control at the rates of 30-75 g ai/ha by the postemergence application and is relatively safe on maize at 75 g ai/ha. Addnl., the K_i value of II to Nicotiana tabacum PPO (NtPPO) was found to be 2.5 nM, showing 3-, 12-, and 18-fold higher potency relative to compound 1 (K_i = 7.4 nM), trifludimoxazin (K_i = 31 nM), and flumioxazin (K_i = 46 nM), resp. Furthermore, mol. simulations further suggested that the thieno[2,3-d]pyrimidine-2,4-dione moiety of 6g could form a more favorable π-π stacking interaction with the Phe392 of NtPPO than the heterocyclic moiety of compound I. This study provides an effective strategy to obtain enzyme inhibitors with improved performance through mol. simulation and structure-guided optimization. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Recommanded Product: Methyl 2-aminonicotinate).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Methyl 2-aminonicotinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors α/γ Dual Agonists with Improved Potency and Reduced Adverse Effects on Skeletal Muscle Function was written by Fracchiolla, Giuseppe;Laghezza, Antonio;Piemontese, Luca;Tortorella, Paolo;Mazza, Fernando;Montanari, Roberta;Pochetti, Giorgio;Lavecchia, Antonio;Novellino, Ettore;Pierno, Sabata;Conte Camerino, Diana;Loiodice, Fulvio. And the article was included in Journal of Medicinal Chemistry in 2009.Name: Ethyl 2-hydroxy-3-phenylpropanoate This article mentions the following:

The preparation of a new series of 2-aryloxy-3-phenyl-propanoic acids, resulting from the introduction of a linker into the di-Ph system of the previously reported PPARα/γ dual agonist 1, allowed the identification of new ligands with improved potency on PPARα and unchanged activity on PPARγ. For the most interesting stereoisomers I [X = CH₂, CH₂CH₂], X-ray studies in PPARγ and docking experiments in PPARα provided a mol. explanation for their different behavior as full and partial agonists of PPARα and PPARγ, resp. Due to the adverse effects provoked by hypolipidemic drugs on skeletal muscle function, we also investigated the blocking activity of I on skeletal muscle membrane chloride channel conductance and found that these ligands have a pharmacol. profile more beneficial compared to fibrates currently used in therapy. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Name: Ethyl 2-hydroxy-3-phenylpropanoate).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Ethyl 2-hydroxy-3-phenylpropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Donor-Acceptor Complex Enables Alkoxyl Radical Generation for Metal-Free C(sp³)-C(sp³) Cleavage and Allylation/Alkenylation was written by Zhang, Jing;Li, Yang;Xu, Ruoyu;Chen, Yiyun. And the article was included in Angewandte Chemie, International Edition in 2017.Synthetic Route of C7H8O2S This article mentions the following:

The alkoxyl radical is an essential and prevalent reactive intermediate for chem. and biol. studies. Here we report the first donor-acceptor complex-enabled alkoxyl radical generation under metal-free reaction conditions induced by visible light. Hantzsch ester forms the key donor-acceptor complex with N-alkoxyl derivatives, which is elucidated by a series of spectrometry and mechanistic experiments Selective C(sp³)-C(sp³) bond cleavage and allylation/alkenylation is demonstrated for the first time using this photocatalyst-free approach with linear primary, secondary, and tertiary alkoxyl radicals. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Synthetic Route of C7H8O2S).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C7H8O2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pd-Catalyzed Regioselective Branched Hydrocarboxylation of Terminal Olefins with Formic Acid was written by Ren, Wenlong;Wang, Mingzhou;Guo, Jianqiong;Zhou, Jintao;Chu, Jianxiao;Shi, Yuan;Shi, Yian. And the article was included in Organic Letters in 2022.HPLC of Formula: 3903-40-0 This article mentions the following:

A regioselective Pd-catalyzed hydrocarboxylation of terminal olefins with HCOOH was described. A wide variety of branched carboxylic acids can readily be obtained with high regioselectivities under mild reaction conditions. The reaction is operationally simple and requires no handling of toxic CO. The ligand and LiCl are important factors for reaction reactivity and selectivity. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0HPLC of Formula: 3903-40-0).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 3903-40-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of a C-2 Stapled Bis-Lexitropsin was written by Al-Said, Naim H.;Klaib, Sami. And the article was included in Monatshefte fuer Chemie in 2007.Electric Literature of C7H8N2O4 This article mentions the following:

A convenient synthesis method was developed for the preparation of C-stapled homodimeric bis-lexitropsins connected through the nitrogen atoms of the central pyrrole ring with a bis-methylene linker. This lexitropsin is designed as a standard for other bis-lexitropsins with longer chains in biol. evaluation and NMR studies. The key step in this method is the treatment of Et 4-nitropyrrole-2-carboxylate with flame-dried K₂CO₃ in DMF followed by the addition of 1,2-dibromoethane to form the 1,2-dipyrroloethane derivative In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Electric Literature of C7H8N2O4).

Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C7H8N2O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Migration of (non-) intentionally added substances and microplastics from microwavable plastic food containers was written by He, Ying-Jie;Qin, Yan;Zhang, Tie-Li;Zhu, Yan-Yan;Wang, Zhao-Jie;Zhou, Zhong-Shun;Xie, Tian-Zhen;Luo, Xiao-Dong. And the article was included in Journal of Hazardous Materials in 2021.HPLC of Formula: 6683-19-8 This article mentions the following:

Microwavable plastic food containers (MPFCs) are extensively used for food storage, cooking, rapid heating and as take-out containers. There is an urgent need to investigate whether MPFCs pose potential health risks, as a result of the migration of chems. into foods. Herein, 42 intentionally added substances (IAS) and > 100 non-IAS (NIAS) migrating from MPFCs were identified in food simulants according to Regulation (EU). The migration of major IAS and NIAS was higher in 95% ethanol compared to other simulants, and gradually decreased following repeated use. NIAS, including Cramer class III toxic compounds, such as PEG oligomers of N,N-bis(2-hydroxyethyl) alkyl(C8-C18)amines, isomers of hexadecanamide and oleamide, and Irgafos 168 OXO were detected and exceeded the recommended limits in some MPFCs. Furthermore, microplastics (MPs) were detected with high values of over one million particles/L in some MPFCs in a single test, and migration behaviors of MPs in different MPFCs were diverse. Surprisingly, this rigorous migration might result in an annual intake of IAS/NIAS up to 55.15 mg and 150 million MPs particles if take-out food was consumed once a day. Multi-safety evaluation studies on the migration of various chems. from MPFCs to foodstuffs during food preparation should be assessed. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8HPLC of Formula: 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Modular preparation of diverse dipyrrolemethanes was written by Pham, Cindy C.;Park, Michelle H.;Pham, Jenny Y.;Martin, Sadie G.;Schramm, Michael P.. And the article was included in Synthesis in 2013.Quality Control of Ethyl 4-nitro-1H-pyrrole-2-carboxylate This article mentions the following:

A modular synthesis of polyfunctional dipyrrolemethanes is presented. Diverse side chains are introduced to 2-carboxypyrrole building blocks in two to four steps, resulting in a collection of substituted pyrroles that, when condensed in one step, give rise to diverse structural features. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Quality Control of Ethyl 4-nitro-1H-pyrrole-2-carboxylate).

Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of Ethyl 4-nitro-1H-pyrrole-2-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics