Category: esters-buliding-blocks

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Computed Properties of 87-13-8.

El-Hadidya, Sherihan A.;Abu-Melhab, Sraa research published 《 Some studies in sulfadiazine incorporating pyridine, pyrimidine, oxadiazole, and azo moieties endowed with pharmaceutical potency》, the research content is summarized as follows. A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding sulfadiazines 2-18 and hydrozaones 19a-h which were evaluated for their in vitro cytotoxicity vs. four cancer cell lines. Compounds 3, 5, 19d and 19h were active against the tested cancer cells.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Computed Properties of 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 2495-37-6, formula is C11H12O2, Name is Benzyl methacrylate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Electric Literature of 2495-37-6.

El-saied, Hend Al-aidy;El-Fawal, Esraa M. research published 《 Green superabsorbent nanocomposite hydrogels for high-efficiency adsorption and photo-degradation/reduction of toxic pollutants from waste water》, the research content is summarized as follows. Developing renewable-based biomaterials is an important and sustainable solution to solve environmental and resource problems. Bio-super adsorbent treatment of contaminants is highly effective due to their minimal costs and environmental biocompatibility. Herein, superabsorbent nanocomposite hydrogels have been formed by grafting copolymerization of acrylic acid and acrylamide onto natural polysaccharide (green starch) with incorporation of NPs such as NiFe2O4 NPs and TiO2 NPs into the hydrogel matrix utilizing (MBA) N·N-methylene-bisacrylamide which acts as a crosslinker and (APS) ammonium persulfate as an initiator in aqueous medium. Starch-g-poly(acrylic acid-co-acrylamide)/NiFe2O4 (NiFe2O4/SANCH) and starch-g-poly (acrylic acid-co-acrylamide)/TiO2 (TiO2/SANCH) were identified by (TGA) thermal gravimetric anal., (SEM) scanning electron microscope, (EDX) energy dispersive X-ray, (TEM) transmission electron microscopy, (XRD) X-ray diffraction, and (FTIR) Fourier transform IR spectroscopy. The adsorption/photodegradation performance of the NiFe2O4/SANCH and TiO2/SANCH were also studied under visible light using Cr(VI) and Congo red dye as template of dyes for a photodegradation target, then comparing the results to the neat starch-g-poly(acrylic acid-co-acrylamide) superabsorbent hydrogel (SAH). The effect of irradiation time, pH, and catalyst dose photocatalytic reduction/degradation of Cr(VI) and CR on the prepared hydrogels was evaluated. The results show that, NiFe2O4/SANCH composite has effective photoefficiency towards Cr(VI) and CR than TiO2/SANCH and SAH polymers. The producibility of the reused NiFe2O4/SANCH and TiO2/SANCH composites were also investigated for five cycles with high efficiency. Therefore, these nanocomposite hydrogels possess high photocatalytic degradation/reduction efficiency and can be removed safely by direct filtration from the reaction. With such characteristics, NiFe2O4/SANCH and TiO2/SANCH hydrogels are mostly named green Polymers for usage in the adsorption/photodegradation technique to reduce many contaminants.

Electric Literature of 2495-37-6, Benzyl methacrylate, also known as Benzyl methacrylate, is a useful research compound. Its molecular formula is C11H12O2 and its molecular weight is 176.21 g/mol. The purity is usually 95%.
Benzyl methacrylate is a chemical compound that belongs to the group of benzyl compounds. It has a copolymer structure with methyl ethyl methacrylate (MEMA) and hydroxyl groups. Benzyl methacrylate is produced by polymerization of benzyl chloride with allyl carbonate in the presence of radiation, forming a polymeric matrix. The morphology of this copolymer depends on the length of the benzyl chains and the concentration of MEMA., 2495-37-6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Reference of 87-13-8.

El-Tunsi, Ashraf;Carter, Nicholas;Yeo, Song-Hee;Priest, Joshua D.;Choi, Anthony;Kobras, Carolin M.;Ndlovu, Soneni;Proietti Silvestri, Ilaria;Fenton, Andrew K.;Coldham, Iain research published 《 Kinetic Resolution by Lithiation: Highly Enantioselective Synthesis of Substituted Dihydrobenzoxazines and Tetrahydroquinoxalines》, the research content is summarized as follows. Kinetic resolution provided a highly enantioselective method to access a range of 3-aryl-3,4-dihydro-2H-1,4-benzoxazines using n-butyllithium and the chiral ligand sparteine. The enantioenrichment remained high on removing the tert-butoxycarbonyl (Boc) protecting group. The intermediate organolithium underwent opening to an enamine. The kinetic resolution was extended to give enantiomerically enriched substituted 1,2,3,4-tetrahydroquinoxalines and was applied to the synthesis of an analog of the antibiotic levofloxacin that was screened for its activity against the human pathogen Streptococcus pneumoniae.

Reference of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 2495-37-6, formula is C11H12O2, Name is Benzyl methacrylate. as in the substitution reaction of a carboxylic acid and an alcohol. Product Details of C11H12O2.

Escamilla, Maria;Pachuta, Kevin;Huang, Kuan;Klingseisen, Michael;Cao, Huaixuan;Zhang, Huichun;Sehirlioglu, Alp;Pentzer, Emily research published 《 Polymer particles armored with cobalt oxide nanosheets for the catalytic degradation of bisphenol A》, the research content is summarized as follows. 2D particle surfactants are attractive for the formation of highly stable emulsions and use as templates to prepare composite structures with performance properties dependent on the composition Cobalt oxide nanosheets (CONs) are a relatively understudied class of 2D particle surfactants that can be produced by the chem. exfoliation of lithium cobalt oxide, a transition metal oxide known for excellent gas-sensing, catalytic, and electrochem. properties. Here, we report a simple method to access CONs stabilized oil-in-water Pickering emulsions and use these as templates to prepare particles with a core of polymer and shell of CONs. Salt-flocculated CONs produce emulsions with droplets of hydrophobic monomer (e.g., styrene) in water that are stable for at least 24 h, and suspension free radical polymerization is used to produce CON-armored particles. Characterization by XPS, SEM (SEM), and thermal gravimetric anal. (TGA) confirmed the presence of CONs on the surface of the polymer core. We then demonstrated the CON-armored polymer particles can activate the oxidant peroxymonosulfate (PMS) for the degradation of bisphenol A (BPA). Freshly prepared and artificially aged CON-armored particles showed full degradation of BPA in less than an hour and no decrease in activity was observed after two uses. CON-armored particles combine high surface area of the nanosheets with the ease of recoverability of the particles.

2495-37-6, Benzyl methacrylate, also known as Benzyl methacrylate, is a useful research compound. Its molecular formula is C11H12O2 and its molecular weight is 176.21 g/mol. The purity is usually 95%.
Benzyl methacrylate is a chemical compound that belongs to the group of benzyl compounds. It has a copolymer structure with methyl ethyl methacrylate (MEMA) and hydroxyl groups. Benzyl methacrylate is produced by polymerization of benzyl chloride with allyl carbonate in the presence of radiation, forming a polymeric matrix. The morphology of this copolymer depends on the length of the benzyl chains and the concentration of MEMA., Product Details of C11H12O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 611-13-2, formula is C6H6O3, Name is Methyl furan-2-carboxylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Category: esters-buliding-blocks.

Fagbemi, Kehinde Oluwakemi;Aina, Daniel Ayandiran;Adeoye-Isijola, Morenike Olutunmbi;Naidoo, Kubendran Kista;Coopoosamy, Roger Murugas;Olajuyigbe, Olufunmiso Olusola research published 《 Bioactive compounds, antibacterial and antioxidant activities of methanol extract of Tamarindus indica Linn.》, the research content is summarized as follows. Tamarindus indica is one of the tropical medicinal plants that has been attributed curative potential of numerous diseases by many rural dwellers. This study was designed to evaluate the antioxidant, antibacterial activities and also to determine the various chem. constituents responsible for its pharmacol. activities. The methanol extract of Tamarindus indica fruit pulp was analyzed by Gas Chromatog./Mass Spectrometer to determine the volatile compounds present. The antioxidant activities were performed using DPPH and FRAP method and the antibacterial activity was tested against some common pathogens by macro broth dilution method. The GCMS anal. shows the presence of 37 compounds, out of which 14 had their peak area percentages ≥ 1% and only two compounds had no reported pharmacol. activities. Most of the bioactive compounds including 5-Hydroxymethylfurfural (31.06%)-3-O-Methyl-d-glucose (16.31%), 1,6-anhydro-β-D-Glucopyranose (9.95%), 5-methyl-Furancarboxaldehyde (3.2%), Triethylenediamine (1.17%), 1-(2-furanyl)-1-Propcanone (2.18%), Me 2-furoate (3.14%), Levoglucosenone (3.21%), Me ester-Hepta-2,4-dienoic acid, (8.85%), 2,3-dihydro-3,5-dihydrox-4H-Pyran-4-one (3.4%), O-α-D-glucopyranosyl-(1.fwdarw.3)-β-D-fructofuranosyl-α-D-Glucopyranoside (2.18%), n-Hexadecanoic acid (1.38%), 2-Heptanol, acetate (1.29%), 5-[(5-methyl-2-fur-2-Furancarboxaldehyde)] (1.08%), 3-Methyl-2-furoic acid (1.05%) and cis-Vaccenic acid (2.85%)have been reported with different activities such as antibacterial, antifungal, antitubercular, anticancer, antioxidant and other prophylactic activities. The extract demonstrated inhibitory potential against all tested pathogen. However, Plesiomonas shigellosis ATCC 15903 and Bacillus pumillus ATCC 14884 are more sensitive with the MIC of 0.22 and 0.44 mg/mL resp. The antioxidant activity was relatively low due to the low phenolic content of the extract This shows that there is a strong correlation between antioxidant activities and phenolic content. GC-MS anal. revealed the presence of bioactive phytoconstituents with various biol. activities and this justifies the rationale behind its usage as a curative therapy by many local dwellers.

Category: esters-buliding-blocks, Methyl 2-furoate has been identified as one of the volatile flavor compounds in tequila, okra, berrycactus and black currant juice.
Methyl 2-furoate, also known as fema 2703 or methyl pyromucate, belongs to the class of organic compounds known as furoic acid esters. These are ester derivatives of furoic acid. Methyl 2-furoate is soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Within the cell, methyl 2-furoate is primarily located in the cytoplasm. Methyl 2-furoate is a sweet, fruity, and fungal tasting compound that can be found in a number of food items such as cocoa and cocoa products, potato, tamarind, and fruits. This makes methyl 2-furoate a potential biomarker for the consumption of these food products.
Methyl 2-furoate is a reactive compound that belongs to the family of sesquiterpene lactones. It has been shown to have phosphotungstic acid and hydrochloric acid reactivity, as well as nitrous and water vapor sensitivity. Methyl 2-furoate also reacts with radiation, which can be used for structural analysis. The compound is an intermediate in the synthesis of pluronic p123, which is used in fabricating biomedical devices. Methyl 2-furoate has been shown to have anti-inflammatory properties through its inhibitory effect on prostaglandin synthesis., 611-13-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Name: 3-(Methoxycarbonyl)phenylboronic acid.

Chen, Xiao-Bing;Li, Li;Yang, Wan-Chun;Song, Kun-Long;Wu, Bin;Gan, Wan-Er;Cao, Jian;Xu, Li-Wen research published 《 Palladium-Catalyzed C-C Bond Activation/Suzuki Reaction of Methylenecyclobutanes》, the research content is summarized as follows. A novel palladium-catalyzed C-C bond activation manner of methylenecyclobutanes followed by subsequent Suzuki cross-coupling reaction afforded multisubstituted indanes. The tandem reaction process involved intramol. carbopalladation of double bond, β-carbon elimination and intermol. trapping of the transient σ-alkylpalladium complex with boronic acids. A new TADDOL-derived phosphoramidite ligand bearing fluorine and silicon-based bulky groups was found to be efficient for C-C bond activation of methylenecyclobutanes.

99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., Name: 3-(Methoxycarbonyl)phenylboronic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 2495-37-6, formula is C11H12O2, Name is Benzyl methacrylate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Name: Benzyl methacrylate.

Chen, Xiaomei;Guo, Zhian;Wei, Liulin;Liu, Qian;Zhao, Jingchan research published 《 Use of a temperature-responsive polymer micelle in microextraction method combined with gas chromatography-mass spectrometry for the determination of seven polycyclic aromatic hydrocarbons》, the research content is summarized as follows. In this study, a novel microextraction method based on temperature-responsive polymer micelle has been designed combined with gas chromatog.-mass spectrometry for the determination of seven polycyclic aromatic hydrocarbons (PAHs) in tea infusions. The method is based on the formation of micelles by poly (N-isopropylacrylamide)-block-poly (benzyl methacrylate) (PNIPAM-b-PBnMA) in aqueous samples at low temperatures and encapsulation of the targets due to the π-π and hydrophobic interaction between PBnMA with PAHs compounds, followed by the formation and insolubilization of agglomerates containing the preconcd. analytes by increasing the temperature Under the optimal conditions, good linearity was observed in the range of 0.1-100μg L^-1 with the coefficient of determination being above 0.9959. The limits of detection and limits of quantitation were in the range of 0.021-0.042μg L^-1 and 0.064-0.128μg L^-1, resp. The intra-day and inter-day precision were 3.4-9.1% and 5.9-13.7%, resp. The established method was applied successfully to analyze two tea infusions.

2495-37-6, Benzyl methacrylate, also known as Benzyl methacrylate, is a useful research compound. Its molecular formula is C11H12O2 and its molecular weight is 176.21 g/mol. The purity is usually 95%.
Benzyl methacrylate is a chemical compound that belongs to the group of benzyl compounds. It has a copolymer structure with methyl ethyl methacrylate (MEMA) and hydroxyl groups. Benzyl methacrylate is produced by polymerization of benzyl chloride with allyl carbonate in the presence of radiation, forming a polymeric matrix. The morphology of this copolymer depends on the length of the benzyl chains and the concentration of MEMA., Name: Benzyl methacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Electric Literature of 99769-19-4.

Chen, Xiao-Yue;Nie, Xiao-Xue;Wu, Yichen;Wang, Peng research published 《 para-Selective arylation and alkenylation of monosubstituted arenes using thianthrene S-oxide as a transient mediator》, the research content is summarized as follows. Using thianthrene S-oxide (TTSO) as a transient mediator, para-arylation and alkenylation of mono-substituted arenes was demonstrated to get biaryls via a para-selective thianthrenation/Pd-catalyzed thio-Suzuki-Miyaura coupling sequence under mild conditions. This reaction featured a broad substrate scope, and functional group and heterocycle tolerance. The versatility of this approach was further demonstrated by late-stage functionalization of complex bioactive scaffolds, and direct synthesis of some pharmaceuticals, including Tetriprofen, Ibuprofen, Bifonazole, and LJ570.

Electric Literature of 99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.

3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.

3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., 99769-19-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Quality Control of 870-50-8.

Cheng, Cheng;Li, Ying-Xian;Jia, Xue-Min;Zhang, Ji-Quan;Zhao, Yong-Long;Feng, Wei;Tang, Lei;Yang, Yuan-Yong research published 《 Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives》, the research content is summarized as follows. A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives was established, which was compatible with a broad range of substrates and delivered the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol%). The synthetic potential of this methodol. was also demonstrated in the gram scale level.

Quality Control of 870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., 870-50-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. as in the substitution reaction of a carboxylic acid and an alcohol. Application In Synthesis of 870-50-8.

Cheng, Peter T. W.;Kaltenbach, Robert F.;Zhang, Hao;Shi, Jun;Tao, Shiwei;Li, Jun;Kennedy, Lawrence J.;Walker, Steven J.;Shi, Yan;Wang, Ying;Dhanusu, Suresh;Reddigunta, Ramesh;Kumaravel, Selvakumar;Jusuf, Sutjano;Smith, Daniel;Krishnananthan, Subramaniam;Li, Jianqing;Wang, Tao;Heiry, Rebekah;Sum, Chi Shing;Kalinowski, Stephen S.;Hung, Chen-Pin;Chu, Ching-Hsuen;Azzara, Anthony V.;Ziegler, Milinda;Burns, Lisa;Zinker, Bradley A.;Boehm, Stephanie;Taylor, Joseph;Sapuppo, Julia;Mosure, Kathy;Everlof, Gerry;Guarino, Victor;Zhang, Lisa;Yang, Yanou;Ruan, Qian;Xu, Carrie;Apedo, Atsu;Traeger, Sarah C.;Cvijic, Mary Ellen;Lentz, Kimberley A.;Tirucherai, Giridhar;Sivaraman, Lakshmi;Robl, Jeffrey;Ellsworth, Bruce A.;Rosen, Glenn;Gordon, David A.;Soars, Matthew G.;Gill, Michael;Murphy, Brian J. research published 《 Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA₁) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases》, the research content is summarized as follows. The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1 (LPA₁) antagonist, with a human LPA₁K_b of 6.9 nM. The structure-activity relationship (SAR) studies starting from the LPA₁ antagonist clin. compound BMS-986020 (1), which culminated in the discovery of 33, are discussed. The detailed in vitro and in vivo preclin. pharmacol. profiles of 33, as well as its pharmacokinetics/metabolism profile, are described. On the basis of its in vivo efficacy in rodent chronic lung fibrosis models and excellent overall ADME (absorption, distribution, metabolism, excretion) properties in multiple preclin. species, 33 was advanced into clin. trials, including an ongoing Phase 2 clin. trial in patients with lung fibrosis (NCT04308681).

870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., Application In Synthesis of 870-50-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics