Category: esters-buliding-blocks

Synthesis of Heterobiaryl 4-Aryl Furans through a Base-Promoted Decarboxylative Propargylation/Cycloisomerization Annulation was written by Wang, Sasa;Song, Meimei;Li, Xiuguang;Huang, Yunhong;Zhao, Tingxiang;Wei, Zhuoji;Lan, Yanyun;Tan, Haibo. And the article was included in Organic Letters in 2020.Safety of Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:

A transition-metal-free synthesis of heterobiaryl 4-aryl furans through a base-promoted decarboxylative propargylation/cycloisomerization annulation of ethynyl benzoxazinanones and readily accessible β-keto esters or 1,3-diketones has been developed. A series of novel heterobiaryl 4-aryl furans were accessed efficiently in the presence of base under mild reaction conditions. This protocol is significant for probing the reaction mechanism of ethynyl benzoxazinanones and even other propargylic compounds In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Safety of Ethyl 3-oxo-3-(m-tolyl)propanoate).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of Ethyl 3-oxo-3-(m-tolyl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Evaluation of anti-rheumatic activity of Piper betle L. (Betelvine) extract using in silico, in vitro and in vivo approaches was written by Murugesan, Selvakumar;Ravichandran, Devibala;Lakshmanan, Dinesh Kumar;Ravichandran, Guna;Arumugam, Velusamy;Raju, Karthik;Geetha, Karuppasamy;Thilagar, Sivasudha. And the article was included in Bioorganic Chemistry in 2020.Reference of 659-70-1 This article mentions the following:

Rheumatoid Arthritis is a chronic, inflammatory, and systemic autoimmune disease, it affects elders worldwide. Herbal medicines have been used for the treatment of various ailments from ancient times. Betelvine (Piper betle L.) leaves have long been used in Asian countries as a medicine to relieve pain and some metabolic diseases. The present study of methanolic extract of phytochem. anal. confirms the presence of alkaloids, tannins, terpenoids, saponins, steroids, total flavonoids and total phenols. GC-MS anal. of MeOH extract of Piper betle (PBME) revealed the presence of 40 bioactive compounds In vitro antioxidant and anti-inflammatory assays showed greater inhibitory effect. The anti-arthritic effects of PBME at 250 and 500 mg/kg concentration showed recovery from joint damage in in vivo rat model. Among the 40 GC-MS derived bioactives, 4-Allyl-1,2-Diacetoxybenzene exhibited the higher interactions with minimized binding energy to the RA targets of MMP 1 (-6.4 kcal/mol), TGF-β (-6.9 kcal/mol), IL-1β (-5.9 kcal/mol). Further, the effect of PBME extract against RA mol. disease targets (IL-1β, MMP1 and TGF- β) were studied using Real-time PCR. These results substantiate that P. betle leaves could be a source of therapeutics for the treatment of rheumatoid arthritis. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Reference of 659-70-1).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Reference of 659-70-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A Facile Method for Delaying the Migration of Antifogging Agents in Polyethylene Films was written by Yan, Ke;Chen, Dong;Wang, Li;Yang, Wantai. And the article was included in Industrial & Engineering Chemistry Research in 2022.Safety of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) This article mentions the following:

Antifog polyethylene (PE) films are widely used as covers for greenhouse structures because they can eliminate the multiple adverse effects of the fogging phenomenon. Herein, we propose a way to enhance the shelf life of antifog PE films by delaying the migration of antifogging agents using polymer microspheres. Crosslinked poly(maleic anhydride-styrene-divinylbenzene) microspheres (PMSD) were prepared by self-stabilized precipitation polymerization (2SP) and then converted into PMSD grafted with methoxy polyethylene glycol (mPEG) of different chain lengths (PMSD-g-mPEG). PMSD-g-mPEG microspheres were incorporated into PE films with an antifogging agent, and the properties of the prepared antifog PE films were investigated in detail. SEM displayed the good dispersion state of PMSD-g-mPEG at low loadings and its pos. correlation with mPEG chain length. Accelerated dripping experiments and contact angle tests showed that PMSD-g-mPEG2000 microspheres can exert the best effect in delaying the migration of antifogging agents, giving rise to a 36% improvement in dripping duration under optimized conditions. In addition, PMSD-g-mPEG2000 microspheres do not affect the optical, mech., and thermal properties of antifog PE films obviously. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Safety of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of disaccharide modified berberine derivatives and their anti-diabetic investigation in zebrafish using a fluorescence-based technology was written by Wang, Lizhen;Kong, Haotian;Jin, Meng;Li, Xiaobin;Stoika, Rostyslav;Lin, Houwen;Liu, Kechun. And the article was included in Organic & Biomolecular Chemistry in 2020.HPLC of Formula: 4163-60-4 This article mentions the following:

Berberine is a naturally occurring isoquinoline alkaloid and has been used as an important functional food additive in China due to its various pharmacol. activities. Berberine exhibits great potential for developing anti-diabetic agents against type 2 diabetes mellitus (T2DM), as it can reduce the blood glucose level in many animal models. However, the low anti-diabetic activity and poor bioavailability of berberine (below 5%) by oral administration significantly limit its practical applications. To solve these problems, this article focuses on the structural modification of berberine using some disaccharide groups, because the carbohydrate moiety has been proved to improve the bioavailability and enhance the receptor-binding affinity of drugs. Anti-diabetic investigation of the synthesized compounds was performed in a zebrafish model using a fluorescently labeled glucose analog 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose (2-NBDG) as a glucose tracker. The results indicated that the modification of berberine with carbohydrate groups could give derivatives with improved anti-diabetic activity, in particular the diglucose modified berberine derivative I which could dramatically promote the uptake of 2-NBDG in both zebrafish larvae and their eyes even at very low concentrations Furthermore, the fluorescence-based anti-diabetic investigation method in zebrafish shows great potential for anti-diabetic drug screening. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4HPLC of Formula: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Photochemistry of enolizable β-dicarbonyl compounds: study on the photoketonization of some esters of aroylacetic acids was written by Markov, P.;Petkov, I.;Eglova, D.. And the article was included in Journal of Photochemistry in 1978.HPLC of Formula: 33166-79-9 This article mentions the following:

Photolysis of RC₆H₄COCH₂CO₂Et (R = H, Me, MeO, NO₂, Cl, Br) results in a shift of the keto-enol equilibrium toward the keto form. Rate constants and quantum yields were determined Electron-releasing substituents in the para position favor ketonization. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9HPLC of Formula: 33166-79-9).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 33166-79-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An approach to pseudomonic acids from acetylenic precursors: synthesis of 2-(hydroxymethyl)-3-butyn-1-ol was written by Bates, Hans Aaron;Farina, James;Tong, Michael. And the article was included in Journal of Organic Chemistry in 1986.Computed Properties of C9H16O4 This article mentions the following:

The acetonide of 2-(hydroxymethyl)-3-butyn-1-ol (I) was prepared from (HOCH₂)₂C(CO₂Et)₂ or from (HOCH₂)₂CO. Alternative routes to I involving the highly unstable HOCH₂C(CHO)CCH or its acetate were unsuccessful. Condensation of the anion of I with 3-oxobutanal ethylene acetal followed by semihydrogenation and deprotection afforded MeCOCH₂CH(OH)CH:CHCH(CH₂OH)₂, which cyclized stereoselectivity to the dihydropyran II. Osmylation of II and functional group manipulation afforded the diol III, a precursor to pseudomonic acid C. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7Computed Properties of C9H16O4).

Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C9H16O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rh(III)-Catalyzed Domino [4 + 2] Annulation/Aza-Michael Addition of N-(Pivaloyloxy)benzamides with 1,5-Enynes via C-H Activation: Synthesis of Functionalized Aromathecins was written by Raji Reddy, Chada;Mallesh, Kathe;Bodasu, Srinivas;Donthiri, Ramachandra Reddy. And the article was included in Journal of Organic Chemistry in 2020.Category: esters-buliding-blocks This article mentions the following:

Reported herein is the Rh(III)-catalyzed cascade annulation reaction of N-(pivaloyloxy)benzamides with 1,5-enynes to access diversely substituted aromathecin derivatives, e.g., I (R = H, Br, Cl, NO₂, Me, OMe), involving C-H activation. The developed procedure offers an efficient synthetic tool for the reaction of a wide range of N-(pivaloyloxy)benzamides and 1,5-enynes with good atom-economy and functional group tolerance. The key reactions involved in this annulation are alkyne insertion and aza-Michael addition under oxidant-free mild reaction conditions. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Category: esters-buliding-blocks).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of malonic esters catalyzed by tin tetrachloride adsorbed with active carbon was written by Xue, Laiqi;Zhang, Zhihong;Qi, Hongjiang. And the article was included in Huaxue Shijie in 1998.Quality Control of malonic acid dibutyl ester This article mentions the following:

Malonic esters (di-Pr malonate, di-Bu malonate, diisobutyl malonate, diamyl malonate, dioctyl malonate) were synthesized through the reaction of malonic acid with corresponding alcs. under the catalysis of SnCl₄. 5H₂O adsorbed with activated C. The water produced in the synthesis reaction was carried off by benzene. The esterification rate for di-Bu malonate was 96.8%. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Quality Control of malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of malonic acid dibutyl ester

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Directed resolution of enantiomers by liquid chromatography of diastereomeric derivatives. 7. Syntheses of the stereoisomers of 17,21-dimethylheptatriacontane – sex recognition pheromone of the tsetse fly was written by Ade, Eugen;Helmchen, Guenter;Heiligenmann, Gudrun. And the article was included in Tetrahedron Letters in 1980.Safety of malonic acid dibutyl ester This article mentions the following:

(R,R)- And (S,S)-Me(CH₂)₁₅CHMe(CH₂)₃CHMe(CH₂)₁₅Me [(R,R)- and (S,S)-I] were both prepared in nine steps from (±)-Me(CH₂)₁₅CHMeCO₂H via diastereomeric amides and in eight steps in an asym. preparation from the ester II [R = Me for (S,S)-I; R = Me(CH₂)₁₅ for (R,R)-I]. (R,S)-I was also prepared In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Safety of malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of malonic acid dibutyl ester

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Microporous Formation Mechanism of Biaxial Stretching PA6/PP Membranes with High Porosity and Uniform Pore Size Distribution was written by Fang, Wenxiang;Liang, Guixue;Li, Jiang;Guo, Shaoyun. And the article was included in Polymers (Basel, Switzerland) in 2022.Application In Synthesis of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) This article mentions the following:

The low porosity and wide pore size distribution of biaxial stretching PP microporous membranes continue to be the primary impediments to their industrial application. To solve this problem, there is a critical and urgent need to study the micropore-forming mechanism of PP membranes. In this research, the interfacial micropore formation mechanism of PA6/PP membranes during biaxial stretching was investigated. PA6/PP membranes containing spherical PA6 and fibrillar PA6 were found to exhibit different interfacial micropore formation mechanisms. Numerous micropores were generated in the PA6/PP membranes, containing PA6 spherical particles via the interface separation between the PP matrix and PA6 spherical particles during longitudinal stretching. Subsequent transverse stretching further expanded the two-phase interface, promoting the breakdown and fibrosis of the PP matrix and forming a spider-web-like microporous structure centered on spherical PA6 particles. In PA6/PP membranes with PA6 fibers, fewer micropores were generated during longitudinal stretching, but the subsequent transverse stretching violently separated the PA6 fibers, resulting in a dense fiber network composed of PA6 fibers interwoven with PP fibers. Crucially, the PA6/PP biaxial stretching of microporous membranes presented an optimized pore structure, higher porosity, narrower pore size distribution, and better permeability than β-PP membranes. Furthermore, this study explored a new approach to the fabrication of high-performance PA6/PP microporous membranes, with good prospects for potential industrial application. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Application In Synthesis of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics