Category: esters-buliding-blocks

Roztocki, Kornel; Formalik, Filip; Bon, Volodymyr; Krawczuk, Anna; Goszczycki, Piotr; Kuchta, Bogdan; Kaskel, Stefan; Matoga, Dariusz published the artcile< Tuning Adsorption-Induced Responsiveness of a Flexible Metal-Organic Framework JUK-8 by Linker Halogenation>, Reference of 112-63-0, the main research area is pyridyl benzenedicarbohalohydrazide zinc oxydibenzoic carboxylate MOF preparation crystal structure; gas adsorption responsiveness flexible zinc metal organic framework; crystal mol structure pyridyl benzenedicarbohalohydrazide zinc oxydibenzoic carboxylate MOF.

Flexible stimuli-responsive metal-organic frameworks have become promising candidates for numerous applications in gas-related technologies; however, the methods of fine tuning their responses are still limited and sought after. In this work, authors demonstrate control over the adsorption properties of a flexible platform by incorporating halogen substituents (X = F, Cl, Br, I) into an eightfold interpenetrated isoreticular series [Zn(oba)(X-pip)]n (JUK-8X; X-pip = 4-pyridyl-functionalized benzene-1,3-dicarbo-5-halogenohydrazide; oba2- = 4,4′-oxydibenzoic carboxylate). The introduced halogen atoms allow for precise tuning of CO2 gate-opening pressures from p/p0 = 0.08 for the parental JUK-8 to 0.78 for the chlorine-functionalized JUK-8Cl. The presence of fluorine or chlorine substituent in the X-pip linker practically does not influence the maximum molar CO2 uptake as compared to JUK-8, whereas larger bromine or iodine atoms increase this uptake by 59 and 48%, resp. Utilizing in situ powder x-ray diffraction (PXRD) during CO2 adsorption for a model JUK-8F, they propose a detailed mechanism of phase transitions including positions of the adsorbed gas mols. for the two loaded phases. D. functional theory calculations supported by in situ PXRD measurements at a saturation pressure shed light on the unusual CO2 adsorption properties of JUK-8Br and JUK-8I. Overall, their report demonstrates the use of halogen interactions for the control of a gas-responsive system and provides insightful guidance for the further development of flexible, adaptable materials.

Chemistry of Materials published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seo, Chang-Seob; Lee, Mee-Young published the artcile< Simultaneous Determination of Fourteen Marker Compounds in the Traditional Herbal Prescription, Geumgwesingihwan, Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry>, Formula: C19H34O2, the main research area is geumgwesingihwan traditional herbal prescription UPLCMS; Geumgwesingihwan; UPLC–MS/MS; simultaneous determination; traditional herbal prescription.

Geumgwesingihwan (GSH) is a traditional herbal prescription composed of eight medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Dioscorea japonica Thunb., Cornus officinalis Siebold and Zucc., Poria cocos Wolf, Paeonia suffruticosa Andrews, Alisma plantago-aquatica subsp. orientale (Sam.) Sam., Achyranthes bidentate Blume, and Plantago asiatica L. This study developed and validated an ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) method in the multiple reaction monitoring (MRM) mode for simultaneous determination of 14 compounds (allantoin, gallic acid, 5-(hydroxymethyl)furfural, geniposidic acid, oxypaeoniflorin, loganin, geniposide, paeoniflorin, ecdysterone, verbascoside, cornuside, benzoylpaeoniflorin, paeonol, and alisol B acetate) in GSH. The chromatog. separation of all marker analytes was carried out on an Acquity UPLC BEH C18 column (100 mm × 2.1 mm, 1.7μm) using gradient elution of a mobile phase of distilled water-acetonitrile containing 0.1% acetic acid. The newly established UPLC-MS/MS MRM method was validated by evaluating the linearity, the limits of detection and quantification, recovery, and precision. All markers were detected at concentrations of 6.94-4126.28 mg/kg. In addition, the recovery was 76.65-119.49% and the relative standard deviation value of the precision was 0.19-9.91%. The newly developed and validated UPLC-MS/MS assay will provide useful information for quality assessment of GSH.

Molecules published new progress about Achyranthes bidentata. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Lan-xiang; Zhang, Bao-hua; Zhang, Xing-chen published the artcile< Synthesis of 4-bromo-N,N-dimethylaniline>, Quality Control of 112-63-0, the main research area is bromo dimethylaniline preparation pyridinium tribromide.

A method for the synthesis of the title compound is reported here. In presence of pyridine, 4-bromo-N,N-dimethylaniline was synthesized by a substitution reaction starting from N,N-dimethylaniline and bromine. In this reaction, the easy-to-handle bromination agent pyridinium tribromide was formed and the regioselectivity of the substitution reaction was enhanced. The optimal molar ratio was n(C8H11N):n(Br2):n(C5H5N) = 1:1.1:1.1, the reaction was at 10-15° for 6 h (product yield 68%).

Hebei Shifan Daxue Xuebao, Ziran Kexueban published new progress about Bromination, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sghaier, Randa; Nury, Thomas; Leoni, Valerio; Caccia, Claudio; Pais De Barros, Jean-Paul; Cherif, Ameur; Vejux, Anne; Moreau, Thibault; Limem, Khalifa; Samadi, Mohammad; Mackrill, John J.; Masmoudi, Ahmed Slaheddine; Lizard, Gerard; Zarrouk, Amira published the artcile< Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol>, Category: esters-buliding-blocks, the main research area is oligodendrocyte oxiapoptophagy dimethyl monomethyl fumarate oxidative stress mitochondrial dysfunction; 158N cells; 7β-hydroxycholesterol; Apoptosis; Autophagy; Dimethyl fumarate; Lipid profile; Mitochondria; Monomethyl fumarate; Oxiapoptophagy; Oxidative stress; Peroxisome.

The cytoprotective effects of dimethylfumarate, used in the treatment of relapsing remitting multiple sclerosis and of MMF, its main metabolite, were evaluated on murine oligodendrocytes 158 N exposed to 7β-OHC (50μM, 24 h) with or without DMF or MMF (25μM). The activity of 7β-OHC in the presence or absence DMF or MMF was evaluated on several parameters: cell adhesion; plasma membrane integrity measured with PI, trypan blue and FDA assays; LDH activity; antioxidant enzyme activities ; generation of lipid peroxidation products (MDA, CDs) and CPs; ROS overproduction conducted with DHE and DHR123. Apoptosis and autophagy were characterized by staining with Hoechst 33,342, Giemsa and acridine orange, and with antibodies raised against caspase-3 and LC3. DMF and MMF attenuate 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction (decrease of succinate dehydrogenase activity, loss of ΔΨm, increase of mitochondrial O·-2 production, alteration of the TCA cycle, and cardiolipins content); oxidative stress induction; changes in fatty acid and cholesterol metabolism; and cell death induction (caspase-3 cleavage, activation of LC3-I in LC3-II). Ultrastructural alterations of mitochondria and peroxisomes were prevented. These results demonstrate that DMF and MMF prevent major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.

Journal of Steroid Biochemistry and Molecular Biology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rahman, Masum; Olson, Ian; Mansour, Moustafa; Carlstrom, Lucas P.; Sutiwisesak, Rujapope; Saber, Rehan; Rajani, Karishma; Warrington, Arthur E.; Howard, Adam; Schroeder, Mark; Chen, Sisi; Decker, Paul A.; Sananikone, Eliot F.; Zhu, Yi; Tchkonia, Tamar; Parney, Ian F.; Burma, Sandeep; Brown, Desmond; Rodriguez, Moses; Sarkaria, Jann N.; Kirkland, James L.; Burns, Terry C. published the artcile< Selective vulnerability of senescent glioblastoma cells to BCL-XL inhibition>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Glioblastoma (GBM) is a rapidly fatal malignancy typically treated with radiation and temozolomide (TMZ), an alkylating chemotherapeutic. These cytotoxic therapies cause oxidative stress and DNA damage, yielding a senescent-like state of replicative arrest in surviving tumor cells. Unfortunately, recurrence is inevitable and may be driven by surviving tumor cells eventually escaping senescence. A growing number of so-called “”senolytic”” drugs have been recently identified that are defined by their ability to selectively eliminate senescent cells. A growing inventory of senolytic drugs is under consideration for several diseases associated with aging, inflammation, DNA damage, as well as cancer. Ablation of senescent tumor cells after radiation and chemotherapy could help mitigate recurrence by decreasing the burden of residual tumor cells at risk of recurrence. This strategy has not been previously explored for GBM. We evaluated a panel of 10 previously described senolytic drugs to determine whether any could exhibit selective activity against human GBM persisting after exposure to radiation or TMZ. Three of the 10 drugs have known activity against BCL-XL and preferentially induced apoptosis in radiated or TMZ-treated glioma. This senolytic activity was observed in 12 of 12 human GBM cell lines. Efficacy could not be replicated with BCL-2 inhibition or senolytic agents acting against other putative senolytic targets. Knockdown of BCL-XL decreased survival of radiated GBM cells, whereas knockdown of BCL-2 or BCL-W yielded no senolytic effect. Implications: These findings imply that molecularly heterogeneous GBM lines share selective senescence-induced BCL-XL dependency increase the significance and translational relevance of the senolytic therapy for latent glioma.

Molecular Cancer Research published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meyhoff, Ulrich; Riber, Ulla; Boas, Ulrik published the artcile< Convergent synthesis of degradable dendrons based on L-malic acid>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is polyester dendrimer degradable dendron malic acid convergent preparation.

New degradable polyester dendrons based on the cellular tricarboxylic acid cycle component L-malic acid were synthesized up to the third generation by convergent synthesis. The dendron wedges could be introduced in a stepwise, highly regioselective fashion. HMBC-NMR revealed that the C1-carbonyl on malic acid was exclusively esterified, before the reaction of the second dendron wedge at C4 took place. Degradation studies on a first generation dendron analyzed by HPLC showed that hydrolytic degradation of the dendron most profoundly takes place at pH 4 and pH 9 with the highest degradation rate at alk. pH. NMR shows that the dendron degrades to malic acid and fumaric acid derivatives Preliminary studies performed in the cell culture show low toxicity of the dendrons in concentrations of up to 50 μg mL-1.

New Journal of Chemistry published new progress about Biodegradable medical goods. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xiaoyang; Hou, Yaqin; Peng, Cheng; Wang, Chu; Wang, Xiang; Liang, Zhigang; Lu, Jing; Chen, Baian; Dai, Jiapei; Liu, Boli; Cui, Mengchao published the artcile< Oligoethyleneoxy-Modified 99mTc-Labeled β-Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is technetium oligoethyleneoxy amyloid SPECT imaging brain pharmacokinetics.

An oligoethyleneoxy linker was introduced for conjugation between 99mTc/Re-bis(aminoethanethiol) (BAT) and β-amyloid (Aβ) binding scaffolds. Rhenium complexes exhibited high to moderate binding affinity to Aβ1-42 aggregates and efficient fluorescent staining to Aβ plaques in brain tissue. After radiolabeling, the 99mTc-labeled probes revealed improved brain pharmacokinetics in normal ICR mice. Probe [99mTc]15 with potent binding affinity (Ki = 13.4 nM) and the highest initial brain uptake (2.10% ID/g at 2 min) in normal ICR mice was evaluated further. In vitro autoradiog. showed specific labeling of Aβ plaques by [99mTc]15 in transgenic (Tg) mouse brain tissue. Ex vivo autoradiog. further demonstrated its efficient labeling of Aβ plaques in a living Tg mouse. In vivo single photon emission computed tomog. (SPECT)/CT imaging in six rhesus monkeys revealed remarkably improved brain uptakes (1.94-2.63% ID within 20 min) of [99mTc]15, making it highly potential to be used in humans for Aβ plaques imaging in the brain.

Journal of Medicinal Chemistry published new progress about Brain. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Chang-Xia; Guo, Yu-Ting; Wu, Yu-Huan; Li, Zhao-Yue; Wang, Yao-Zong; Du, Fu-Sheng; Li, Zi-Chen published the artcile< Synthesis and Controlled Organobase-Catalyzed Ring-Opening Polymerization of Morpholine-2,5-Dione Derivatives and Monomer Recovery by Acid-Catalyzed Degradation of the Polymers>, HPLC of Formula: 2743-40-0, the main research area is acid catalyzed degradation polymer morpholine dione ring opening polymerization.

Polydepsipeptides (PDPs) are strictly alternating copolymers of α-hydroxy acids and α-amino acids produced via the ring-opening polymerization (ROP) of morpholino-2,5-dione derivatives (MDs). They have been used as promising biomaterials for their combined high thermal stability and good mech. properties of polyamides as well as the inherent degradability of polyesters. ROP of MDs is usually carried out at high temperatures with metal catalysts or enzymes, with less control over the polymer mol. weights and dispersities. In this work, we developed a simple and efficient synthetic strategy of a new platform MD via the Passerini-type reaction between an isocyano derivative of the amino acid and an aldehyde, followed by intramol. esterification. Nine new MDs were synthesized by using this method, and the organobase-catalyzed ROP of these MDs was investigated. When the ROPs of these MDs were catalyzed by either triazabicyclo[4.4.0]dec-5-ene (TBD) or diazabicyclo[5.4.0]undec-7-ene (DBU) in the presence of benzyl alc. as an initiator, the polymerizations were uncontrolled with the formation of both linear PDPs and cyclic PDPs. By using binary catalytic systems of 1-(3,5-bis(trifluoromethyl)-phenyl-3-cyclohexyl-2-thiourea) (TU) with DBU or TBD ([TU]/[TBD] or [DBU] > 3), the polymerizations became well-controlled, allowing the synthesis of PDPs with controlled mol. weights, low dispersities, as well as block copolymers. Furthermore, cyclic PDPs were obtained when the ROP of these MDs was catalyzed with TBD in the absence of both TU and an initiator. Finally, we used two methods to recover the monomer precursors or pure MD monomers: the TBD-catalyzed alcoholysis of PDPs was very fast and generated the monomer precursors quant., while the acid-catalyzed depolymerization of PDPs led to pure and quant. monomer recovery.

Macromolecules (Washington, DC, United States) published new progress about Crystal structure. 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, HPLC of Formula: 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wadsworth, D. H.; Schupp, III O. E.; Sous, E. J.; Ford, Jr. J. A. published the artcile< The stereochemistry of the phosphonate modification of the Wittig reaction>, COA of Formula: C19H34O2, the main research area is .

A number of olefins prepared by the phosphonate carbanion modification of the Wittig reaction were shown to have trans configurations.. Vapor phase chromatography of the intact reaction mixtures showed, at most, only trace amounts of cis isomers. To determine the degree of stereospecificity of the reaction under adverse circumstances, several experiments were devised with systems which, based on the generally accepted reaction mechanism, should be more favorable for the preparation of cis olefins. In only one case, however, was a significant amount of a cis isomer formed [6.4% cis-1,2-(1,1′-dinaphthyl)ethylene in a 1:10 cis-trans mixture], demonstrating the great stereospecific tendency of the reaction. Possible interpretations of the observed differences in stereospecificity of olefin formation from phosphonate carbanions and phosphorus ylides are discussed.

Journal of Organic Chemistry published new progress about NMR (nuclear magnetic resonance). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bai, Zhang-Zhen; Ni, Jing; Tang, Jun-Man; Sun, Dao-Yang; Yan, Zhen-Guo; Zhang, Jing; Niu, Li-Xin; Zhang, Yan-Long published the artcile< Bioactive components, antioxidant and antimicrobial activities of Paeonia rockii fruit during development>, COA of Formula: C19H34O2, the main research area is transresveratrol benzoic acid paeoniflorin luteolin Paeonia antioxidant antimicrobial activity; Albiflorin (PubChem CID: 24868421); Antibacterial activity; Antioxidant activity; Benzoic acid (PubChem CID: 243); LC-ESI-QqQ-MS; Luteolin (PubChem CID: 5280445); Methyl gallate (PubChem CID: 7428); Monoterpene glycosides; OPLS-DA; PCA; Paeonia rockii fruit; Paeoniflorin (PubChem CID: 442534); Phenolic compounds; Trans-resveratrol (PubChem CID: 445154).

In last ten years, much attention focused on tree peony fruit (TPF) for edible oil production despite other potential utilization. The present study identified and quantified 29 bioactive components by liquid chromatog.-electrospray ionization-triple quadrupole-mass spectrometry (LC-ESI-QqQ-MS) targeted approach during the development of TPF. Trans-resveratrol, benzoic acid, luteolin, and Me gallate were selected as predominant chem. markers between seeds and pods through principal component anal. (PCA) and orthogonal partial least square-discriminant anal. (OPLS-DA). Extremely high levels of paeoniflorin (1893 mg/100 g) and trans-resveratrol (1793 mg/100 g) were observed at stage 2 (S2) and S6 in seeds, resp. Antioxidant activities determined by ABTS+·, DPPH·, and FRAP assays showed significant correlations with total phenolic content (TPC) and total flavonoid content (TFC). The strongest antibacterial effects of pod and seed against Staphylococcus aureus and Proteus vulgaris occurred at initial stages and maturation stages. TPF could be a potential source of bioactive compounds with functional properties.

Food Chemistry published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics