Category: esters-buliding-blocks

Curran, Dennis P.; Ko, Sung-Bo published the artcile< Synthesis of Optically Active α-Hydroxy Lactones by Sharpless Asymmetric Dihydroxylations of Ketene Acetals, Enol Ethers, and Ene Lactones>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Sharpless asym dihydroxylation hydroxy lactone synthesis; ketene acetal Sharpless asym dihydroxylation; enol ether Sharpless asym dihydroxylation; unsaturated lactone Sharpless asym dihydroxylation.

Three different AD routes to optically active α-hydroxy lactones of good to excellent optical purity are reported. The substrates for the AD reaction are endocyclic ketene acetals, endocyclic enol ethers, and exocyclic α,β-unsaturated lactones.

Journal of Organic Chemistry published new progress about Acetals, ketene Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peixoto, Andreia F.; Soliman, Mohamed M. A.; Pinto, Tania V.; Silva, Sonia M.; Costa, Paula; Alegria, Elisabete C. B. A.; Freire, Cristina published the artcile< Highly active organosulfonic aryl-silica nanoparticles as efficient catalysts for biomass derived biodiesel and fuel additives>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is organosulfonic aryl silica nanoparticle catalyst biodiesel aldol condensation.

Post-grafting methodologies were used to prepare aryl-organosulfonic acid functionalized silica nanoparticles (SO3H-aryl-SiO2NPs) as highly active heterogeneous acid catalysts for catalytic esterification of free fatty acids (FFA) and levulinic acid (LA), and aldol condensation of furfural with 3-methylfuran, well known renewable feedstocks for biodiesel and fuel additives production The chem. and structural characterization of the SO3H-aryl-SiO2NPs confirmed the success of the functionalization. Complete conversion for all FFA was observed using SO3H-aryl-SiO2NPs after 2 h of reaction. SiO2NPs_CSPTMS showed to be the most active and stable catalyst with no significant loss of activity in the first 5 cycles. In the LA esterification in the presence of an alc., complete conversion and selectivity and high reusability were observed (e.g., 83.2% yield after 10 cycles in the presence of 1-propanol, SiO2NPs 10_CSPTMS, at 120°C and 2h reaction). Finally, aldol condensation of furfural and 3-methylfuran had been performed using SiO2NPs_CSPTMS catalysts with almost 100% yield after 10 min at 65°C, high stability and reusability for 7 catalytic cycles. In general, the prepared SO3H-aryl-SiO2NPs have demonstrated promising catalytic performance for transformation of biomass-derived feedstocks into biodiesel and fuel additives.

Biomass and Bioenergy published new progress about Aldol condensation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Attiku, Keren; Bonney, Joseph; Agbosu, Esinam; Bonney, Evelyn; Puplampu, Peter; Ganu, Vincent; Odoom, John; Aboagye, James; Mensah, John; Agyemang, Seth; Awuku-Larbi, Yaw; Arjarquah, Augustina; Mawuli, Gifty; Quaye, Osbourne published the artcile< Circulation of hepatitis delta virus and occult hepatitis B virus infection amongst HIV/HBV co-infected patients in Korle-Bu, Ghana>, COA of Formula: C19H34O2, the main research area is human HIV HDV hepatitis B virus infection circulation.

Within HIV/HBV infected patients, an increase in HDV infection has been observed; there is inadequate information on HDV prevalence as well as virol. profile in Ghana. This study sought to determine the presence of HDV in HIV/HBV co-infected patients in Ghana. This was a longitudinal purposive study which enrolled 113 HIV/HBV co-infected patients attending clinic at Korle-Bu Teaching Hospital (KBTH) in Accra, Ghana. After consenting, 5 mL whole blood was collected at two-time points (baseline and 4-6 mo afterwards). The sera obtained were tested to confirm the presence of HIV, HBV antibodies and/or antigens, and HBV DNA. Antibodies and viral RNA were also determined for HDV. Amplified HBV DNA and HDV RNA were sequenced and phylogenetic anal. carried out with reference sequences from the GenBank to establish the genotypes. Of the 113 samples tested 63 (55.7%) were females and 50 (44.25%) were males with a median age of 45 years. A total of 100 (88.5%) samples had detectable HBV surface antigen (HBsAg), and 32 out of the 113 had detectable HBV DNA. Nucleotide sequences were obtained for 15 and 2 samples of HBV and HDV, resp. Phylogenetic anal. was predominantly genotype E for the HBVs and genotype 1 for the HDVs. Of the 13 samples that were HBsAg unreactive, 4 (30.8%) had detectable HBV DNA suggesting the incidence of occult HBV infections. The percentage occurrence of HDV in this study was observed to be 3.54. Our data suggest the presence and circulation of HDV and incidence of occult HBV infection in HIV/HBV co-infected patients in Ghana. This informs health staff and makes it imperative to look out for the presence of HDV and occult HBV in HIV/HBV co-infected patients presenting with potential risk of liver cancers and HBV transmission through hemodialysis and blood transfusions.

PLoS One published new progress about Antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Huafang; Tong, Zongbo; Ren, Zhaoyang; Mishra, Kanchan; Morita, Shunya; Edouarzin, Edruce; Gorla, Lingaraju; Averkiev, Boris; Day, Victor W.; Hua, Duy H. published the artcile< Synthesis and Characterization of Bimetallic Nanoclusters Stabilized by Chiral and Achiral Polyvinylpyrrolidinones. Catalytic C(sp3)-H Oxidation>, Application In Synthesis of 112-63-0, the main research area is polyvinylpyrrolidinone stabilizer bimetallic nanocluster catalytic carbon hydrogen bond oxidation.

Second-generation chiral-substituted poly-N-vinylpyrrolidinones (CSPVPs) (-)-1R and (+)-1S were synthesized by free-radical polymerization of (3aR,6aR)- and (3aS,6aS)-5-ethenyl-tetrahydro-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyrrol-4-one, (I and II, resp.), using thermal and photochem. reactions. They were produced from resp. D-isoascorbic acid and D-ribose. In addition, chiral polymer (-)-2 was also synthesized from the polymerization of (S)-3-(methoxymethoxy)-1-vinylpyrrolidin-2-one (III). Mol. weights of these chiral polymers were measured using HRMS, and the polymer chain tacticity was studied using 13C NMR spectroscopy. Chiral polymers (-)-1R, (+)-1S, and (-)-2 along with poly-N-vinylpyrrolidinone (PVP, MW 40K) were sep. used in the stabilization of Cu/Au or Pd/Au nanoclusters. CD spectra of the bimetallic nanoclusters stabilized by (-)-1R and (+)-1S showed close to mirror-imaged CD absorption bands at wavelengths 200-300 nm, revealing that bimetallic nanoclusters’ chiroptical responses are derived from chiral polymer-encapsulated nanomaterials. Chemo-, regio-, and stereo-selectivity was found in the catalytic C-H group oxidation reactions of complex bioactive natural products, such as ambroxide, menthofuran, boldine, estrone, dehydroabietylamine, 9-allogibberic acid, and sclareolide, and substituted adamantane mols., when catalyst Cu/Au (3:1) or Pd/Au (3:1) stabilized by CSPVPs or PVP and oxidant H2O2 or t-BuOOH were applied. Oxidation of (+)-boldine N-oxide 23 using NMO as an oxidant yielded 4,5-dehydroboldine 27, and oxidation of (-)-9-allogibberic acid yielded C6,15 lactone 47 and C6-ketone 48.

Journal of Organic Chemistry published new progress about Amine oxides, heterocyclic Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (N-oxide group as oxygen source for C-H oxidation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Xin; Hu, Shaoqi; Yang, Qiao; Sang, Xianan; Tang, Dongxin; Cao, Gang published the artcile< Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy>, Category: esters-buliding-blocks, the main research area is paeoniflorin airway inflammation immune response asthma oxidative stress; Asthma; Immune; Inflammatory; Paeoniflorin; Pulmonary injury.

Asthma characterized by airway remodeling is a multiple pulmonary disease, which is associated with various physiol. processes including inflammation reaction, immune response, oxidative stress and autophagy. This study aimed to investigate whether these processes are modulated by the total glucosides of Paeonia lactiflora Pall (TGP), and its active compound paeoniflorin (PF) with anti-inflammatory and immune-regulatory effects could alleviate ovalbumin (OVA)-induced mouse asthma. In vivo, models of mouse asthma were established by i.p. with a mixture of OVA and aluminum hydroxide, plus a single nasal injected with OVA to female C57BL/6 mice. The results were observed with PET imaging, TEM, RT-PCR, western blotting. In vitro, CD4+ T cells were isolated and detected with flow cytometry. TGP, either in its crude or processed form, and PF effectively ameliorated lung injury in mice induced by OVA, regulated immune/inflammatory response by inhibiting the release of pro-inflammatory cytokines, thereby decreasing Th2 cell proportion, inhibited oxidative stress by recovering mitochondrial membrane potential and regulating metabolic activity in dose-dependent manner. Moreover, PF could inhibit autophagy by regulating mitochondrial function. In addition, the therapeutic effects of TGP and PF on pulmonary injury in asthmatic mice were not affected by processing. PF may be a valuable agent in ameliorating inflammation and immune response in asthmatic mice, and the possible mechanism involved in this response rang may from oxidative stress to autophagy.

Phytomedicine published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Furukawa, Takayuki; Tobisu, Mamoru; Chatani, Naoto published the artcile< C-H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is platinum carbene complex preparation catalyst borylation arene heteroarene; phenylboronic ester preparation.

Despite significant progress in the area of C-H bond functionalization of arenes, no general method is reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, the authors report the development of the 1st Pt-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Youchi; Zhang, Jingli; Yuan, Ye; Liu, Liran; Chen, Bifeng; Sun, Taolei published the artcile< Synthesis of Polysubstituted 2H-Pyran-2-ones or Phenols via One-Pot Reaction of (E)-β-Chlorovinyl Ketones and Electron-Withdrawing Group Substituted Acetates or β-Diketones>, COA of Formula: C11H12O3, the main research area is pyranone polysubstituted phenol preparation chlorovinyl ketone acetate beta diketone.

This paper describes a facile one-pot synthesis of highly functionalized 2H-pyran-2-ones and phenols through a base-promoted annulation of readily available β-chlorovinyl ketones with various active methylene compounds Conjugate addition of electron-withdrawing group substituted acetates to allenone intermediates and direct conjugate addition of β-diketones to β-chlorovinyl ketones reveal versatile electrophilic pathways of β-chlorovinyl ketones under different reaction conditions. In particular, cyclocondensation is regiospecific for 3,5-disubstituted phenols. Moreover, the utility of [3+3] cyclocondensation is further illustrated by the concise synthesis of benzofuran derivative and penta- or hexa-substituted phenol construction.

European Journal of Organic Chemistry published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, COA of Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Belanger, Katherine; Ung, Timothy H.; Damek, Denise; Lillehei, Kevin O.; Ormond, D. Ryan published the artcile< Concomitant Temozolomide plus radiotherapy for high-grade and recurrent meningioma: a retrospective chart review>, HPLC of Formula: 112-63-0, the main research area is temozolomide radiotherapy anticancer recurrent meningioma; Chemotherapy; Local Recurrence; Meningioma; Radiation Therapy; Temozolomide.

High-grade and recurrent meningiomas are often treatment resistant and pose a therapeutic challenge after surgical and radiation therapy (RT) failure. Temozolomide (TMZ) is a DNA alkylating agent that appears to have a radiosensitizing effect when used in combination with RT and may be worthwhile in meningioma treatment. Thus, we investigated the potential efficacy of concomitant RT plus TMZ compared to historical controls of just RT used in the treatment of high-grade and recurrent meningiomas. We performed a retrospective anal. of patients with meningioma treated at the University of Colorado with TMZ chemoradiation. Progression free survival (PFS) and overall survival (OS) were calculated from the start of chemoradiation to local recurrence or death, resp. Eleven patients (12 tumors) were treated with chemoradiation with a median follow-up of 41.5 mo. There were two WHO grade 1, eight grade 2 and two grade 3 meningiomas. Three patients died during the follow-up period-one being disease related (11.1%). Two patients had meningioma recurrence-at 2.3 mo (WHO grade 3), and 5.4 years (WHO grade 2). Three-year OS and PFS for grade 2 meningiomas were each 88%. Historical controls demonstrate a 3-yr median OS and PFS of 83% and 75.8%, resp. Treatment options are limited for meningiomas after local failure. In this study, TMZ chemoradiation demonstrated no significant difference in PFS and OS in the treatment of grade 2 meningiomas compared to historic controls. Further study is warranted to find novel methods for the treatment of malignant and recurrent meningiomas.

BMC Cancer published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Daisy Precilla, S.; Kuduvalli, Shreyas S.; Angeline Praveena, E.; Thangavel, Saravanabhavan; Anitha, T. S. published the artcile< Integration of synthetic and natural derivatives revives the therapeutic potential of temozolomide against glioma- an in vitro and in vivo perspective>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioma therapeutic temozolomide chloroquine naringenin phloroglucinol antitumor apoptosis BCL2; Apoptosis; Chloroquine; Glioblastoma; Naringenin; Repurposing drugs; Temozolomide.

Malignant gliomas constitute one of the deadly brain tumors with high degeneration rate. Though temozolomide (TMZ) is the first-line drug for glioma, its efficacy has decreased due to chemo-resistance. Repurposing synthetic and natural compounds have gained increasing interest in glioma. Hence, we combined chloroquine (CHL) a synthetic drug, naringenin (NAR) and phloroglucinol (PGL) (natural derivatives), to investigate whether the apoptotic effect of these drugs both alone and in combination, enhances the anti-tumor effects of TMZ in an in vitro and in vivo orthotopic xenograft glioma model. The cytotoxic effect of the drugs was assessed in C6 (murine) glioma cells, U-87 MG and LN229 (human) glioblastoma cells, primary astrocytes (isolated from rat brain tissues) and HEK-293 T cells. Mitochondrial depolarization and alterations in the cell cycle was determined by confocal imaging and flow cytometry. The expression of angiogenic and apoptotic markers was evaluated using qRT-PCR and ELISA. The efficacy of the combinatorial treatment was assessed in an orthotopic xenograft model using U-87 MG cells. The combinatorial treatment inhibited cell proliferation, induced apoptosis and contributed to cell cycle arrest in glioma cells. The quadruple combinatorial cocktail down-regulated BCL-2 with a concomitant decrease in VEGF. As observed in vitro, the quadruple combinatorial treatment enhanced the median survival of glioma-induced rats with lower cellularity rate. The combination of CHL, NAR and PGL synergistically potentiated the efficacy of TMZ on glioma in vitro and in vivo. Hence, this combination may characterize an advanced strategy for glioma treatment, thereby providing a possible translation to clin. trial.

Life Sciences published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Knauer, Nadezhda; Arkhipova, Valeria; Li, Guanzhang; Hewera, Michael; Pashkina, Ekaterina; Nguyen, Phuong-Hien; Meschaninova, Maria; Kozlov, Vladimir; Zhang, Wei; Croner, Roland S.; Caminade, Anne-Marie; Majoral, Jean-Pierre; Apartsin, Evgeny K.; Kahlert, Ulf D. published the artcile< In Vitro Validation of the Therapeutic Potential of Dendrimer-Based Nanoformulations against Tumor Stem Cells>, Electric Literature of 112-63-0, the main research area is dendrimer nanoformulation tumor stem cell therapeutic target; 3D tumor models; Lyn; dendrimers; nanomedicine; nucleic acid therapeutics; phosphorus; polyelectrolyte complexes; tumor stem cells.

Tumor cells with stem cell properties are considered to play major roles in promoting the development and malignant behavior of aggressive cancers. Therapeutic strategies that efficiently eradicate such tumor stem cells are of highest clin. need. Herein, we performed the validation of the polycationic phosphorus dendrimer-based approach for small interfering RNAs delivery in in vitro stem-like cells as models. As a therapeutic target, we chose Lyn, a member of the Src family kinases as an example of a prominent enzyme class widely discussed as a potent anti-cancer intervention point. Our selection is guided by our discovery that Lyn mRNA expression level in glioma, a class of brain tumors, possesses significant neg. clin. predictive value, promoting its potential as a therapeutic target for future mol.-targeted treatments. We then showed that anti-Lyn siRNA, delivered into Lyn-expressing glioma cell model reduces the cell viability, a fact that was not observed in a cell model that lacks Lyn-expression. Furthermore, we have found that the dendrimer itself influences various parameters of the cells such as the expression of surface markers PD-L1, TIM-3 and CD47, targets for immune recognition and other biol. processes suggested to be regulating glioblastoma cell invasion. Our findings prove the potential of dendrimer-based platforms for therapeutic applications, which might help to eradicate the population of cancer cells with augmented chemotherapy resistance. Moreover, the results further promote our functional stem cell technol. as suitable component in early stage drug development.

International Journal of Molecular Sciences published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics