Category: esters-buliding-blocks

Amphiphilic mPEG-block-poly (profen amide-co-esters) copolymers: One pot biocatalytic synthesis, self-assembly in water and drug release was written by Qian, Xueqi;Wu, Qi;Xu, Fangli;Lin, Xianfu. And the article was included in Polymer in 2011.Reference of 106-79-6 This article mentions the following:

We developed a three-component, one pot biocatalytic polymerization to prepare amphiphilic diblock methoxy poly(ethylene glycol)-b-poly(profen amide-co-esters) (mPEG-PPAE) copolymers under the catalysis of Novozym-435 performed in di-Ph ether at 85° in vacuum for 48 h. 13 mPEG-PPAE copolymers with different profens, dicarboxylates, or PEG were designed and prepared as carriers for the sustained release of the ketoprofen, naproxen and ibuprofen amides. Their structure was characterized by FT-IR, ¹H NMR, and GPC measurements. These copolymers can readily self-assemble into nanosized micelles with the well dispersed sphere in aqueous solution, which were confirmed by DLS and TEM. The size of the micelles was influenced by the copolymer concentrations, and the higher copolymer concentration lead to the smaller size. The in vitro ibuprofen amide sustained release behavior indicated that the copolymer is highly sensitive to acid environment, and the release of ibuprofen amide can be effectively controlled. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Reference of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Metabolism-Guided Design of Short-Acting Calcium-Sensing Receptor Antagonists was written by Southers, James A.;Bauman, Jonathan N.;Price, David A.;Humphries, Paul S.;Balan, Gayatri;Sagal, John F.;Maurer, Tristan S.;Zhang, Yan;Oliver, Robert;Herr, Michael;Healy, David R.;Li, Mei;Kapinos, Brendon;Fate, Gwendolyn D.;Riccardi, Keith A.;Paralkar, Vishwas M.;Brown, Thomas A.;Kalgutkar, Amit S.. And the article was included in ACS Medicinal Chemistry Letters in 2010.COA of Formula: C15H21BO4 This article mentions the following:

As part of a strategy to deliver short-acting calcium-sensing receptor (CaSR) antagonists, the metabolically labile thiomethyl functionality was incorporated into the zwitterionic amino alc. derivative I with the hope of increasing human clearance through oxidative metabolism, while delivering a pharmacol. inactive sulfoxide metabolite. The effort led to the identification of thioanisoles II (R = H, F) as potent and orally active CaSR antagonists with a rapid onset of action and short pharmacokinetic half-lives, which led to a rapid and transient stimulation of parathyroid hormone in a dose-dependent fashion following oral administration to rats. On the basis of the balance between target pharmacol., safety, and human disposition profiles, compounds II were advanced as clin. candidates for the treatment of osteoporosis. In the experiment, the researchers used many compounds, for example, Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6COA of Formula: C15H21BO4).

Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C15H21BO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and conformational preferences of short analogs of antifreeze glycopeptides (AFGP) was written by Urbanczyk, Malgorzata;Jewginski, Michal;Krzciuk-Gula, Joanna;Gora, Jerzy;Latajka, Rafal;Sewald, Norbert. And the article was included in Beilstein Journal of Organic Chemistry in 2019.Recommanded Product: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate This article mentions the following:

Antifreeze glycoproteins are a class of biol. agents which enable living at temperatures below the f.p. of the body fluids. Antifreeze glycopeptides usually consist of repeating tripeptide unit (-Ala-Ala-Thr*-), glycosylated at the threonine side chain. However, on the microscopic level, the mechanism of action of these compounds remains unclear. As previous research has shown, antifreeze activity of antifreeze glycopeptides strongly relies on the overall conformation of the mol. as well an on the stereochem. of amino acid residues. The desired monoglycosylated analogs with acetylated amino termini and the carboxy termini in form of N-methylamide have been synthesized. Conformational NMR (NMR) studies of the designed analogs have shown a strong influence of the stereochem. of amino acid residues on the peptide chain stability, which could be connected to the antifreeze activity of these compounds A better understanding of the mechanism of action of antifreeze glycopeptides would allow applying these materials, e.g., in food industry and biomedicine. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Recommanded Product: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterization of Key Aroma Compounds in Pellets of Different Hop Varieties (Humulus lupulus L.) by Means of the Sensomics Approach was written by Brendel, Sabrina;Hofmann, Thomas;Granvogl, Michael. And the article was included in Journal of Agricultural and Food Chemistry in 2019.Application of 868-57-5 This article mentions the following:

The use of hops in beer brewing is mainly based on its content of bitter acids and aroma compounds Due to the loss of volatile odorants during wort boiling, the so-called dry hopping is a possibility to intensify the hoppy aroma in the final beer. To clarify the potential of different hop varieties for aroma modulation of beer via dry hopping, key aroma compounds of three different hop varieties were characterized using the sensomics approach. Aroma extract dilution anal. revealed 41 aroma-active compounds, of which 39 were identified via gas chromatog.-olfactometry and gas chromatog.-mass spectrometry. The highest flavor dilution factor was determined for myrcene with a geranium-like odor. Fourteen substances were quantitated by stable isotope dilution anal. and further two odorants via the internal standard method; all of them revealed odor activity values (OAVs; ratio of concentration to odor threshold) �. Linalool, 3-methylbutanoic acid, myrcene, and di-Me trisulfide showed the highest OAVs (>1000) in all analyzed hop varieties. For validation of the anal. data, reconstitution models were prepared by adding all quantitated aroma compounds with OAVs �1 in their naturally occurring concentrations to cellulose as matrix. All three recombinates showed a very high similarity to the aroma profile of the resp. hop sample, confirming the correct identification and quantitation of all key aroma compounds In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Application of 868-57-5).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 868-57-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of Copper-Based Fungicide Treatments on the Quality of Hop Produced in the Northeastern United States was written by Chrisfield, Benjamin J.;Gugino, Beth K.;Hopfer, Helene;Elias, Ryan J.. And the article was included in Journal of the American Society of Brewing Chemists in 2022.Electric Literature of C12H20O2 This article mentions the following:

The quality of hops is dictated in large part by the content of flavor and aroma compounds These compounds vary in concentration and are affected by agricultural practises. Previous research has found that the application of Bordeaux Mixture may impact the aroma quality of hops by altering concentrations of varietal thiols. The impact of copper fungicides other than Bordeaux Mixture and in hop production areas outside of the Pacific Northwest in the United States has yet to be evaluated. Herein we study the effects of application frequency of a copper (II) hydroxide fungicide on markers of hop quality in hops grown in the Northeastern United States. Copper fungicide application was found to significantly increase the total copper content of hop cones, regardless of application frequency; however, traditional markers of hop quality, including yield, essential oil composition, and acid content, were not affected. Beer consumers were unable to discriminate between beers dry-hopped with conventional or copper-treated hops based on aroma but were able to discriminate based on in-mouth perception. These findings suggest that the use of copper (II) hydroxide for the mitigation of fungal pathogens in hops grown in the Northeastern United States is unlikely to adversely affect final hop yield, acid content, or thiol quality. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Electric Literature of C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The synthesis and herbicidal activity of 1-alkyl-3-(α-hydroxybenzylidene)pyrrolidine-2,4-diones was written by Zhu, You-Quan;Yao, Chang-Sheng;Zou, Xiao-Mao;Hu, Fang-Zhong;Liu, Bin;Li, Yong-Hong;Yang, Hua-Zheng. And the article was included in Molecules in 2005.Product Details of 33166-79-9 This article mentions the following:

Title compounds I (R¹ = 3-NO₂, 4-NO₂, 2-Me, 3-Me, 4-Me, 2-MeO, 4-MeO, 2-Cl, 4-Cl; R² = Me, CHMe₂, CMe₃) were prepared by cyclocondensation of R¹C₆H₄COCH₂COOEt with R²NHCH₂COOEt. Preliminary bioassay results indicated that some of products have high herbicidal activity against annual dicotyledonous and monocotyledonous plants. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Product Details of 33166-79-9).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 33166-79-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterization of aroma compounds of four brandies by aroma extract dilution analysis was written by Zhao, Yuping;Li, Jiming;Xu, Yan;Fan, Wenlai;Jiang, Wenguang. And the article was included in American Journal of Enology and Viticulture in 2009.Application In Synthesis of Ethyl 2-hydroxy-3-phenylpropanoate This article mentions the following:

Aroma compounds in two VSOP and two XO brandies were identified by gas chromatog.-mass spectrometry (GC-MS) and gas chromatog.-olfactometry (GC-O) after fractionation. A total of 109 aroma compounds were detected by GC-O in the four brandy samples on DB-wax and HP-5 columns. Aroma extract dilution anal. (AEDA) was further used to identify the most important aroma compounds Results showed that esters could be the most important aroma compounds, particularly Et esters. Various alcs., aldehydes, acetals, furan derivatives, lactones, and phenolic compounds were also identified. According to flavor dilution (FD) factors, the most significant aroma compounds were 2-methylpropanol, 3-methylbutanol, Et hexanoate, Et heptanoate, Et octanoate, β-damascenone, and trans-β-methyl-γ-octalactone (FD â‰?024). These compounds contributed to fruity, sweet, and coconut-like aromas, with the exception of 2-methylpropanol and 3-methylbutanol, which imparted a fusel note. 1,1-Diethoxyethane and cis-β-methyl-γ-octalactone, with cream- and coconut-like aromas, were the important aroma compounds (FD 1024) in two of the brandies. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Application In Synthesis of Ethyl 2-hydroxy-3-phenylpropanoate).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of Ethyl 2-hydroxy-3-phenylpropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Time-resolved electron spin resonance observations of the initial stages of conventional and controlled radical polymerization processes was written by Kajiwara, Atsushi. And the article was included in ACS Symposium Series in 2018.Recommanded Product: 27249-90-7 This article mentions the following:

Structural and kinetic investigations of radicals formed in the early stage of polymerizations have been conducted by the ESR technique with various time resolutions Time-resolved ESR observations of water-soluble (meth)acrylate radicals formed in aqueous phase free-radical polymerization and controlled radical polymerization systems were conducted. These measurements had not been examined previously in spite of their fundamental importance in understanding the initiation procedures in radical polymerizations Clear and well-resolved TR ESR spectra of sodium (meth)acrylates in water were observed and the structures and mol. dynamics of the radicals formation and reactions were discussed. TR ESR spectroscopy was also applied to the RAFT controlled radical polymerization and the sequential radical addition reactions in the initial stage of the RAFT polymerizations were observed In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Recommanded Product: 27249-90-7).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 27249-90-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One-Pot Synthesis of Substituted 2-Amino Isonicotinic Acids: Reminiscent of the Guareschi-Thorpe Condensation was written by Jin, Xiangle;Xing, Lidong;Deng, Daniel Da;Yan, Jun;Fu, Yan;Dong, Weitong. And the article was included in Journal of Organic Chemistry in 2022.Application In Synthesis of Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate This article mentions the following:

This work describes a concise manner to make a wide variety of mono- or disubstituted 2-amino isonicotinic acids via the corresponding 2,4-dioxo-carboxylic acid Et esters and Et 3-amino-3-iminopropionate hydrochloride. The reaction likely proceeds through an in situ decarboxylation process and is reminiscent to the Guareschi-Thorpe Condensation. In the experiment, the researchers used many compounds, for example, Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate (cas: 39163-39-8Application In Synthesis of Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate).

Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate (cas: 39163-39-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Exchange of Substituents between (Macro)Alkoxyamines and (Macro)RAFT Agents (ESARA): A Bridge between Nitroxide-Mediated and RAFT Controlled Radical Polymerization Techniques was written by Favier, Arnaud;Luneau, Benoit;Vinas, Jerome;Laissaoui, Nasrine;Gigmes, Didier;Bertin, Denis. And the article was included in Macromolecules (Washington, DC, United States) in 2009.Related Products of 27249-90-7 This article mentions the following:

Developing new tools to combine different polymerization techniques significantly extends the possibilities in terms of polymer design. Here, we report on a radical process abbreviated ESARA that creates a bridge between two controlled radical polymerization (CRP) techniques, nitroxide-mediated polymerization (NMP) and reversible addition-fragmentation chain transfer polymerization (RAFT). Proof of concept was first obtained with low mol. weight compounds Alkoxyamine and thiocarbonylthio control agents were shown to exchange their resp. substituents in selected exptl. conditions, opening the way for the synthesis of new original control agents. The ESARA process was then implemented at the macromol. level. Polystyryl macroalkoxyamines were converted to the corresponding polystyryl macroRAFT agents using thiocarbonylthio compounds In addition, polystyryl macroRAFT agents were converted back to polystyryl macroalkoxyamine after reaction with an alkoxyamine. The bridge created between the two CRP techniques offers an access to a large number of well-defined polymer architectures such as block copolymers that would be difficult to obtain by only one technique. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Related Products of 27249-90-7).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 27249-90-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics