Category: esters-buliding-blocks

Chemical composition and acetylcholinesterase inhibition activity of volatile oil from leaves of Arbutus unedo L. from Croatia was written by Politeo, O.;Ercegovic, I.. And the article was included in Asian Journal of Chemistry in 2019.Reference of 118-61-6 This article mentions the following:

The volatile oil from leaves of Arbutus unedo L. from Croatia was subjected to chem. composition and acetylcholinesterase inhibition activity. The tested volatile oil was dominated by nonterpene compounds, with (E)-2-decenal, nonanal, nonanoic acid and octanol as main compounds Terpene compounds were identified in lower quantity, with linalool and α-terpineol as main ones. Results showed low to moderate acetylcholinesterase (AChE) inhibition potential of tested oil, for tested concentration of 1 mg/mL. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Reference of 118-61-6).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 118-61-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of phthalic acid esters and di(2-ethylhexyl) adipate in coffee obtained from capsules was written by Dominguez-Hernandez, Cristopher;Ortega-Zamora, Cecilia;Gonzalez-Salamo, Javier;Hernandez-Borges, Javier. And the article was included in Food Chemistry in 2022.Category: esters-buliding-blocks This article mentions the following:

In this work, the ammonium formate version of the QuEChERS method has been applied for the first time to the extraction of a group of nine phthalic acid esters and one adipate from three types of coffee (maximum intensity, intermediate intensity and decaffeinated) prepared from coffee capsules, using gas chromatog. coupled to mass spectrometry for analytes separation and determination Matrix-matched calibration showed good linearity with determination coefficients (R2) higher than 0.9983 for all analytes and matrixes. In general, matrix effect assessment revealed a medium effect of signal suppression, while mean relative recovery values were in the range 70-120% with relative standard deviation values ≤19% for most analytes. Several samples of each type of coffee obtained from capsules made of different materials were also analyzed, finding concentrations of DBP, DEHA and DEHP in the range 29.3-734 ng/capsule, below the tolerable daily intake established for some of them. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Category: esters-buliding-blocks).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis, in-vitro, in-vivo anti-inflammatory activities and molecular docking studies of acyl and salicylic acid hydrazide derivatives was written by Munir, Abida;Khushal, Adil;Saeed, Kiran;Sadiq, Abdul;Ullah, Rahim;Ali, Gowhar;Ashraf, Zaman;Ullah Mughal, Ehsan;Saeed Jan, Muhammad;Rashid, Umer;Hussain, Izhar;Mumtaz, Amara. And the article was included in Bioorganic Chemistry in 2020.Product Details of 81245-24-1 This article mentions the following:

To cure the inflammation effectively and associated with side effects ,1,3,4-oxadiazole II [R= 4-Me, 4-Me-2-MeO, n=0,1] , 1,2,4-triazole III [R= 4-Me, 4-Me-2-MeO, n=0,1] , Schiff base IV [R= F, Me,MeO… n=0,1; R’ = 2-HO-4-MeO, 2-HO, -4-F, 4-HO, etc.] and 3,5-disubstituted pyrazole V derivatives were synthesized starting from salicylic acid and acyl acid hydrazides I[R = 4-Me, 3-MeO, 4-Me-2-MeO, etc., n = 0,1] as COX-1 and COX-2 inhibitors. In-vivo anti-inflammatory activities were also tested by carrageenan-induced mice paw edema against albino mice of any sex. Structures of all the synthesized compounds were confirmed by FT-IR and ¹H NMR anal. Schiff base derivative of 4-aminotriazole (24) with IC₅₀ value of 1.76 ± 0.05 (COX-2) and 117.8 ± 2.59 emerged as potent COX-2 inhibitor. Furthermore, this also performed in-vivo anti-inflammatory investigations by using carrageenan induced paw edema test. From in-vivo anti-inflammatory activities, it was found that after 1 h the maximum percentage inhibition 15.8% was observed by compound I [R= 3-OMe, n=1] which was comparable with that of the standard drug followed by the compound III[R= 4-Me, n=1] with percentage inhibition of 10.5%. After 3 h, the maximum percentage inhibition was observed by compound III [R= 4-Me, n=1] with 22.2% and compound 14 with 16.7%. After 5 h the maximum percentage inhibition was observed by compound III [R= 4-Me, n=1] with 29.4% followed by compound 16 with 23.5%. The mechanism of the inhibition by using docking simulations was also explored. Docking studies revealed that the selective COX-2 inhibitors established interactions with addnl. COX-2 enzyme pocket residues. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Product Details of 81245-24-1).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 81245-24-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification, quantitation and sensorial contribution of lactones in brandies between China and France was written by Li, Yuanyi;Li, Qianqian;Zhang, Baochun;Shen, Chunhua;Xu, Yan;Tang, Ke. And the article was included in Food Chemistry in 2021.Product Details of 695-06-7 This article mentions the following:

Lactones are important flavor compounds in lots of foodstuffs. They also play an important role in brandy, but have not been studied at large. In this study, solid-phase extraction (SPE) and stir bar sorptive extraction (SBSE) combined with comprehensive two-dimensional gas chromatog. and time-of-flight mass spectrometry (GC x GC-TOFMS) were applied to identify and quantify lactones in brandies between China and France. Totally 17 lactones were identified, four of which were detected only in SBSE. Among them, γ-valerolactone, γ-heptalactone, δ-octalactone, γ-undecanolactone and δ-dodecalactone were detected in brandy for the first time. The results of partial least squares-discriminant anal. (PLS-DA) revealed that lactones distinguished regional characteristics among different brandies. The omission test showed that four lactones (OAV > 1) had direct impact on the aroma of brandy, and other seven lactones at sub-threshold (0.1 < OAV < 1) provided peach and apricot aroma characteristics through synergistic effects. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Product Details of 695-06-7).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 695-06-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of butyl 4-[4-hydroxy(alkanoyloxy, aroyloxy)benzylideneamino]benzoates was written by Dikusar, E. A.;Kozlov, N. G.;Potkin, V. I.. And the article was included in Russian Journal of Organic Chemistry in 2008.Application of 20665-85-4 This article mentions the following:

A series of Schiff bases containing ether and ester groups, e.g., I (R¹ = Me, Et; R² = H, Ac, etc), were synthesized by reactions of Bu 4-aminobenzoate with vanillin and 3-ethoxy-4-hydroxybenzaldehyde and their esters. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Application of 20665-85-4).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 20665-85-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aroma Composition of Vitis vinifera Cv. Tannat: the Typical Red Wine from Uruguay was written by Boido, Eduardo;Lloret, Adriana;Medina, Karina;Farina, Laura;Carrau, Francisco;Versini, Giuseppe;Dellacassa, Eduardo. And the article was included in Journal of Agricultural and Food Chemistry in 2003.Application In Synthesis of Ethyl 2-hydroxy-3-phenylpropanoate This article mentions the following:

The free volatiles, as well as those released from the glycosidically bound forms by enzyme hydrolysis, were analyzed to characterize young Tannat wines from 2 successive vintages. The Tannat wine showed some aroma profile peculiarities detected in the free forms but, above all, in the bound fraction for the level and profile of the norisoprenoidic fraction. Among the free volatile compounds, a rather low content of C₆ alcs. with a prevalence of cis-3-hexen-1-ol on the trans form and sometimes a remarkable level of trans-2-hexen-1-ol seem to be typical for the variety. C₁₃-norisoprenoidic and monoterpenic volatiles made up ∼42% of the total level of the volatiles observed in the glycosidase enzyme-released fraction. The other volatiles were C₆ alcs. (6%) and benzenoid compounds (51%). The dominating monoterpene alcs. were the cis and trans isomers of 3,7-dimethyl-1,6-octadiene-3,8-diol (8-hydroxylinalool). The C₁₃-norisoprenoid pattern was composed by 3-hydroxy-β-damascone, 3-oxo-α-ionol, vomifoliol, 4-oxo-β-ionol, 3-oxo-7,8-dihydro-α-ionol, 4-oxo-7,8-dihydro-β-ionol, grasshopper ketone, and 7,8-dihydrovomifoliol. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Application In Synthesis of Ethyl 2-hydroxy-3-phenylpropanoate).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of Ethyl 2-hydroxy-3-phenylpropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalytic hydroconversion of Yiwu lignite over solid superacid and solid superbase was written by Liu, Zhong-Qiu;Wei, Xian-Yong;Liu, Fang-Jing;Liu, Guang-Hui;Zong, Zhi-Min. And the article was included in Fuel in 2019.Recommanded Product: Ethyl 2-hydroxybenzoate This article mentions the following:

Trifluoromethanesulfonic acid supported on attapulgite powder (TFMSA/AP) and Mg₂Si/γ-Al₂O₃ were facilely prepared by impregnating TFMSA onto AP and Mg₂Si onto γ-Al₂O₃. The extraction residue from Yiwu lignite (YL_ER) was subjected to non-catalytic hydroconversion (NCHC) and catalytic hydroconversion (CHC) over TFMSA/AP and Mg₂Si/γ-Al₂O₃, resp. Detailed mol. compositions of the soluble portions from the NCHC (SP_NCHC) and CHC over TFMSA/AP (SP_CHC-A) and Mg₂Si/γ-Al₂O₃ (SP_CHC-B) were characterized with a gas chromatograph/mass spectrometer. As a result, the yields of SP_CHC-A and SP_CHC-B are 19.6% and 17.5%, resp., which are much higher than that of SP_NCHC (1.04%), suggesting that both TFMSA/AP and Mg₂Si/γ-Al₂O₃ show excellent activity for the CHC of YL_ER. Arenes and arenols are predominant in SP_CHC-A and SP_CHC-B, resp., while large amounts of alkanoates were detected in SP_NCHC. The results indicate that TFMSA/AP effectively catalyzes the cleavage of C_ar-C_alk and C_alk-O bridged bonds (BBs) in YL_ER, while Mg₂Si/γ-Al₂O₃ significantly promotes the cleavage of C-O BBs in YL_ER. Di(1-naphthyl)methane, 1-methylnaphthalene, oxydibenzene, and benzyloxybenzene were used as coal-related model compounds (CRMCs) for the CHC to further explore the catalysis of TFMSA/AP and Mg₂Si/γ-Al₂O₃. The results show that TFMSA/AP not only releases mobile H⁺ but also heterolytically splits H₂ to form an immobile H^– and a mobile H⁺, leading to the cleavage of C_alk-C_ar and C_alk-O BBs in the CRMCs. In contrast, Mg₂Si/γ-Al₂O₃ facilitates heterolytically splitting H₂ to an immobile H⁺ and a mobile H^–, resulting in the cleavage of C-O BBs in the CRMCs. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Recommanded Product: Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Ethyl 2-hydroxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function was written by Kwiatkowski, Nicholas;Jelluma, Nannette;Filippakopoulos, Panagis;Soundararajan, Meera;Manak, Michael S.;Kwon, Mijung;Choi, Hwan Geun;Sim, Taebo;Deveraux, Quinn L.;Rottmann, Sabine;Pellman, David;Shah, Jagesh V.;Kops, Geert J. P. L.;Knapp, Stefan;Gray, Nathanael S.. And the article was included in Nature Chemical Biology in 2010.Recommanded Product: Methyl 3-(cyclopentylamino)propanoate This article mentions the following:

Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. As Mps1 function has been implicated in numerous phases of the cell cycle, the development of a potent, selective small-mol. inhibitor of Mps1 should facilitate dissection of Mps1-related biol. We describe the cellular effects and Mps1 cocrystal structures of new, selective small-mol. inhibitors of Mps1. Consistent with RNAi studies, chem. inhibition of Mps1 leads to defects in Mad1 and Mad2 establishment at unattached kinetochores, decreased Aurora B kinase activity, premature mitotic exit and gross aneuploidy, without any evidence of centrosome duplication defects. However, in U2OS cells having extra centrosomes (an abnormality found in some cancers), Mps1 inhibition increases the frequency of multipolar mitoses. Lastly, Mps1 inhibitor treatment resulted in a decrease in cancer cell viability. In the experiment, the researchers used many compounds, for example, Methyl 3-(cyclopentylamino)propanoate (cas: 754125-43-4Recommanded Product: Methyl 3-(cyclopentylamino)propanoate).

Methyl 3-(cyclopentylamino)propanoate (cas: 754125-43-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-(cyclopentylamino)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The freezing temperature of organic substances was written by Serwy, H.. And the article was included in Bulletin des Societes Chimiques Belges in 1933.Application of 1190-39-2 This article mentions the following:

A tabulation of precise measurements of phys. properties of pure substances. Cl(CH₂)₃Cl, m. -99.5°, b. 120.4°; Cl(CH₂)₅Cl, m. -72.8°; b. 182.3°; d₄ 1.11622, d₄¹⁵ 1.10158, d₄³⁰ 1.08692; viscosity 1928 at 15°, 1481 at 30°; ns at 15° n He red 1.45858, n_α 1.45903, n He yellow 1.46161, n He green 1.46675, nβ 1.46801, n He blue 1.47189, n_γ 1.47681; Br(CH₂)₃Br, m. -34.2°, b. 167.34°; d₄ 2.01618, 1.98927 and 1.96238; viscosities 2241 and 1746; ns 1.52121, 1.52174, 1.52546, 1.53252, 1.53416, 1.53932 and 1.54464; Br(CH₂)₅Br, m. -39.5°, b. 222.3°, b₁₂ 99°; d₄ 1.72952, 1.70876 and 1.68788; viscosities 3888 and 2818; ns 1.50908, 1.50960, 1.51311, 1.51970, 1.52131, 1.52634 and 1.53072; NC(CH₂)₃CN, m. -29.45°, b₂₂ 160.4°, d₄ 1.00293, 0.99112 and 0.97930; viscosities 8104 and 5226; ns 1.43426, 1.43461, 1.43699, 1.44137, 1.44242, 1.44573 and 1.45048; NC(CH₂)₅CN, m. -31.4°, b_14.6 177.8°; d₄ 0.96181, 0.95070 and 0.93961; viscosities 9080 and 5501; ns 1.44010, 1.44044, 1.44278, 1.44721, 1.44816, 1.45167 and 1.45721; HO₂CCH₂CO₂H, m. 134.8-.9°; HO₂C(CH₂)₃CO₂H, m. 98.0-.1°; HO₂C(CH₂)₄CO₂H, m. 153.0.1°; HO₂C(CH₂)₅CO₂H, m. 105.7-.8°; EtO₂C(CH₂)₃CO₂Et, m. -23.80°, b. 233.68°, b₁₃ 117.6°; d₄ 1.04202, 1.02704 and 1.01210; viscosities 3260 and 2311; ns 1.42294, 1.42333, 1.42570, 1.42982, 1.43086, 1.43382 and 1.43820; EtO₂C(CH₂)₄CO₂Et m. -19.9°, b₁₃ 131°; d₄ 1.02589, 1.01165 and 0.99744; viscosities 3871 and 2648; ns 1.42673, 1.42708, 1.42924, 1.43362, 1.43463, 1.43783 and 1.44335; PrO₂CCH₂CO₂Pr, m. about -95°, b. 229.2°, b₁₃ 113°; d₄ 1.02929, 1.01453, 0.99977; viscosities 3161 and 2236; ns 1.41967, 1.42010, 1.42243, 1.42660, 1.42768, 1.43092 and 1.43569; PrO₂C(CH₂)₃CO₂Pr, m. -45.5°, b. 264.9°, b₁₃ 142.4°; d₄ 1.00766, 0.99385, 0.98001; viscosities 4437 and 3033; ns 1.42723, 1.42760, 1.42999, 1.43420, 1.43521, 1.43848 and 1.44144; PrO₂C(CH₂)₅CO₂Pr, m. -34°, b₁₃ 165.8°; d₄ 0.98676, 0.97371, 0.97074; viscosities 5017 and 4019; ns 1.43224, 1.43247, 1.43485, 1.43914, 1.44015, 1.44312 and 1.44890; BuO₂CCH₂CO₂Bu, m. -83°, b. 251.5°, b₁₃ 137.4°; d₄ 0.99930, 0.98560 and 0.97191; viscosities 3873 and 2682; ns, 1.42520, 1.42664, 1.42792, 1.43218, 1.43324, 1.43658 and 1.44133; BuO₂C(CH₂)₃CO₂Bu, m. -50.6°, b. 292.8°, b₁₃ 162.9°; d₄ 0.98534, 0.97227 and 0.95922; viscosities 5424 and 3659; ns 1.43147, 1.43189, 1.43426, 1.43845, 1.43955, 1.44279 and 1.44443; BuO₂C(CH₂)₅CO₂Bu, m. -30.5°, b_13.6 188.6°; d₄ 0.97509, 0.96295 and 0.95084; viscosities 8214 and 5262; ns 1.43460, 1.43673, 1.43910, 1.44344, 1.44445, 1.44771 and 1.45283; AmO₂CCO₂Am, m. -9°, b_14.8 154.1°; d₄ 0.98404, 0.97059 and 0.95718; viscosities 4983 and 3330; ns 1.42789, 1.42825, 1.43063, 1.43507, 1.43606, 1.43934 and 1.44496; AmO₂CCH₂CO₂Am, m. -60.0°, b_13.4 162.4°; d₄ 0.97853, 0.96550 and 0.95254; viscosities 5297 and 3562; ns 1.43041, 1.43080, 1.43316, 1.43748, 1.43847, 1.44180, 1.44293; AmO₂C(CH₂)₃CO₂Am, m. -35.1°, b_13.6 186.8°; d₄ 0.97607, 0.96367 and 0.95133; viscosities 8375 and 5308; ns 1.43597, 1.43631, 1.43868, 1.44313, 1.44411, 1.44740 and 1.45293; AmO₂C(CH₂)₅CO₂Am, m. -28.9°, b_17.4 213.4-3.5°; d₄ 0.95879, 0.94671 and 0.93471; viscosities 9428 and 5911. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Application of 1190-39-2).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 1190-39-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A new procedure for the synthesis of barbituric acid was written by Dick, J.;Drugarin, C.. And the article was included in Acad. Rep. Populare Romine, Baza Cercetari Stiint. Timisoara, Studii. Cercetari Stiinte Chim. in 1961.Related Products of 1190-39-2 This article mentions the following:

A mixture of 120 g. butanol, 50 g. malonic acid, and 3.7 g. H₂SO₄ is refluxed two hours to yield 72.5% pure dibutyl malonate (I), n²⁰_D 1.4255, d₂₀ 1.0005. I (15 g.) and 6 g. urea in 50 g. butanol is added to 50 g. butanol containing 2 g. Na; the mixture is refluxed two hrs., cooled to 70° 80 g. H₂O and 10 g. HCl added, and the mixture further cooled to 40° and filtered to yield 73% barbituric acid (II). In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Related Products of 1190-39-2).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 1190-39-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics