Category: esters-buliding-blocks

Synthesis of functionalized S-benzyl dithiocarbamates from diazo-compounds via multi-component reactions with carbon disulfide and secondary amines was written by Kumar, Nitin;Venkatesh, Rapelly;Kandasamy, Jeyakumar. And the article was included in Organic & Biomolecular Chemistry in 2022.Recommanded Product: 584-74-7 This article mentions the following:

Triflic acid promoted multi-component synthesis of functionalized S-benzyl dithiocarbamates R¹CH(C(O)R²)(SC(S)NR³R⁴) [R¹ = Ph, 2-fluorophenyl, 4-methylphenyl, etc.; R² = OEt, OMe, Oi-Pr, Ot-Bu, cyclohexyloxy; R³ = H, Et, Pr, hexyl; R⁴ = Et, Pr, Bu, hexyl, benzylmethyl; R³R⁴ = -(CH₂)₄-, -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-, -(CH₂)₂S(CH₂)₂-, -(CH₂)₂N(Me)(CH₂)₂-] from diazo compounds R¹C(=N₂)C(O)R², carbon disulfide and secondary amines R³R⁴NH is reported. The reactions proceeded at room temperature and gave the desired S-benzyl dithiocarbamates in good yields. Wide-substrate scope and easy operation are the important features of this methodol. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Recommanded Product: 584-74-7).

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 584-74-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Construction of Bridged Aza- and Oxa-[n.2.1] Skeletons via an Intramolecular Formal [3 + 2] Cycloaddition of Aziridines and Epoxides with Electron-deficient Alkenes was written by Xing, Siyang;Wang, Yuhan;Jin, Changkun;Shi, Shaochen;Zhang, Yihui;Liao, Ziya;Wang, Kui;Zhu, Bolin. And the article was included in Journal of Organic Chemistry in 2022.Quality Control of malonic acid dibutyl ester This article mentions the following:

An intramol. formal [3+2] cycloaddition of activated aziridines and epoxides with electron-deficient alkene I (X = N,O; R¹ = Me, Et, n-Pr, i-Pr, n-bu, Bn; R³ = H, F, Cl; R⁴ = H, OMe, CF₃; R⁵ = H, Me; R² = 4-Br₆H₄, 4-NO₂C₆H₄, C₆H₅) has been developed for the general and efficient construction of bridged aza- and oxa-[n.2.1] (n = 3,4) II skeletons. The strategy can be promoted by lithium iodide efficiently. In order to demonstrate its potential, the intramol. formal [3 + 2] cycloaddition was used to access the important intermediate of homoepiboxidine. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Quality Control of malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of malonic acid dibutyl ester

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bioactivity assessment of essential oils of Cymbopogon species using a network pharmacology approach was written by Bansal, Hina;Pravallika, Vusala Sri Sai;Srivastava, Gauri;Ganjewala, Deepak. And the article was included in Biologia Futura in 2022.Quality Control of (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate This article mentions the following:

Essential oils of Cymbopogon species have wide com. applications in fragrance, perfumery, and pharmaceuticals as they exhibit a horizon of bioactivities. Here, essential oils of C. flexuosus and C. martinii were analyzed to identify bioactive constituents and bioactivities using a network pharmacol. approach. Essential oils were isolated using hydro-distillation in a mini Clevenger apparatus Anal. of essential oils by GC-MS revealed 20 and 15 chem. constituents in C. flexuosus and C. martinii, resp. An ingredient-target protein-pathway network was constructed comprising 10 oil constituents (citral, geraniol, geranyl acetate, limonene, linalool, α-terpineol, borneol, a-pinene, myrcene, and n-decanol), 14 target proteins, 51 related pathways, and 108 connections. Analyses of the network showed geraniol, geranyl acetate, limonene, linalool, and citral as major active constituents. A core sub-network constructed from the ingredient-target protein-pathway network revealed bioactivities including anti-cancer, anti-inflammatory and neuroprotective. The protein association network pointed out the major target proteins viz., THRB, FXR, ALOX15, and TSHR and pathways like metabolic, and neuroactive ligand-receptor interaction pathways of essential oil constituents. The target proteins and pathways provided insights into the mechanism of action of bioactive constituents. Based on the results of the study, geraniol was correlated with neuroprotective, citral to chemo-preventive, and limonene to anti-inflammatory activities. Thus, the study offers a new way for the assessment of the bioactivities of Cymbopogon species essential oils leading to the development of new biomedicines. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Quality Control of (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Palladium-catalyzed arylation of diisopropyl malonate applied to the efficient synthesis of the selective MMP inhibitor 5-(4-phenoxyphenyl)-5-[4-(2-pyrimidinyl)-1-piperazinyl]barbituric acid was written by Hutchings, Stanley;Liu, Wen;Radinov, Roumen. And the article was included in Heterocycles in 2006.Electric Literature of C11H20O4 This article mentions the following:

An efficient synthesis of the highly selective MMP inhibitor 5-(4-phenoxyphenyl)-5-(4-pyrimidin-2-ylpiperazin-1-yl)barbituric acid is reported. The title compound was prepared in three steps and 72% overall yield from 4-bromophenyl Ph ether via an improved arylation of diisopropyl malonate. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Electric Literature of C11H20O4).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C11H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In Vitro and In Vivo Antiviral Studies of New Heteroannulated 1,2,3-Triazole Glycosides Targeting the Neuraminidase of Influenza A Viruses was written by Kutkat, Omnia;Kandeil, Ahmed;Moatasim, Yassmin;Elshaier, Yaseen A. M. M.;El-Sayed, Wael A.;Gaballah, Samir T.;El Taweel, Ahmed;Kamel, Mina Nabil;El Sayes, Mohamed;Ramadan, Mohammed A.;El-Shesheny, Rabeh;Abdel-Megeid, Farouk M. E.;Webby, Richard;Kayali, Ghazi;Ali, Mohamed A.. And the article was included in Pharmaceuticals in 2022.HPLC of Formula: 4163-60-4 This article mentions the following:

There is an urgent need to develop and synthesize new anti-influenza drugs with activity against different strains, resistance to mutations, and suitability for various populations. Herein, we tested in vitro and in vivo the antiviral activity of new 1,2,3-triazole glycosides incorporating benzimidazole, benzooxazole, or benzotriazole cores synthesized by using a click approach. The Cu-catalyzation strategy consisted of 1,3-dipolar cycloaddition of the azidoalkyl derivative of the resp. heterocyclic and different glycosyl acetylenes with five or six carbon sugar moieties. The antiviral activity of the synthesized glycosides against wild-type and neuraminidase inhibitor resistant strains of the avian influenza H5N1 and human influenza H1N1 viruses was high in vitro and in mice. Structure-activity relationship studies showed that varying the glycosyl moiety in the synthesized glycosides enhanced antiviral activity. The compound (2R,3R,4S,5R)-2-((1-(Benzo[d]thiazol-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (Compound 9c) had a 50% inhibitory concentration (IC50) = 2.280 μM and a ligand lipophilic efficiency (LLE) of 6.84. The compound (2R,3R,4S,5R)-2-((1-((1H-Benzo[d]imidazol-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate had IC50 = 2.75 μM and LLE = 7.3 after docking anal. with the H5N1 virus neuraminidase. Compound 9c achieved full protection from H1N1 infection and 80% protection from H5N1 in addition to a high binding energy with neuraminidase and was safe in vitro and in vivo. This compound is suitable for further clin. studies as a new neuraminidase inhibitor. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4HPLC of Formula: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Photodegradation pathways of typical phthalic acid esters Under UV, UV/TiO2, and UV-Vis/Bi2WO6 systems was written by Wang, Chunying;Zeng, Ting;Gu, Chuantao;Zhu, Sipin;Zhang, Qingqing;Luo, Xianping. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2019.Category: esters-buliding-blocks This article mentions the following:

Photolysis and photocatalysis of typical phthalic acid esters (di-Me phthalate, DMP; di-Et phthalate, DEP; di-Bu phthalate, DBP) were carried out in UV, UV/TiO₂, and UV-Vis/Bi2WO6 systems. All of the selected phthalic acid esters and their decomposition byproducts were subjected to qual. and quant. anal. through HPLC and GC-MS. The results of 300 min of photolysis and photodegradation reaction were that each system demonstrated different abilities to remove DMP, DEP, and DBP. The UV/TiO₂ system showed the strongest degradation ability on selected PAEs, with removal efficiencies of up to 93.03, 92.64, and 92.50% for DMP, DEP, and DBP in 90 min, resp. UV-Vis/Bi2WO6 had almost no ability to remove DMP and DEP. However, all of the systems had strong ability to degrade DBP. On the other hand, the different systems resulted in various byproducts and PAE degradation pathways. The UV system mainly attacked the carbon branch and produced o-hydroxybenzoates. No ring-opening byproducts were detected in the UV system. In the photocatalytic process, the hydroxyl radicals produced not only attacked the carbon branch but also the benzene ring. Therefore, hydroxylated compounds and ring-opening byproducts were detected by GC-MS in both the UV/TiO₂ and UV-Vis/Bi2WO6 photocatalytic systems. However, there were fewer products due to direct hole oxidation in the UV-Vis/Bi2WO6 system compared with the UV/TiO₂ system, which mainly reacted with the pollutants via hydroxyl radicals. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Category: esters-buliding-blocks).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Twin liquid crystals and segmented thermotropic polyesters containing azobenzene-effect of spacer length on LC properties was written by Nardele, Chinmay G.;Asha, S. K.. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2012.Recommanded Product: Dimethyl decanedioate This article mentions the following:

Systematic studies are reported for a homologous series of twin liquid crystalline (LC) mols. based on phenylazobenzene and naphthylazobenzene (PnP and NpnNp, n = number of spacer groups) as well as segmented copolyesters based on them. The twin series had the structure azobenzene-oligooxyethylene-azobenzene, where the ethyleneoxy length was varied from 2 to 6 units. The LC properties of the twin series depended on the chem. structure of the azo chromophore and also the length of the central oligooxyethylene segment. The PnP series exhibited smectic LC properties for n greater than three oligooxyethylene units. Conversely, NpnNp series exhibited spherulitic phases only for the shortest member Np2Np. One non-LC short spacer twin (P2P) and one LC long spacer twin (P6P) were incorporated as part of a main chain polyester composed of fully aliphatic segments of sebacate and di- or tetraethylene glycol (DEG/TEG) units by melt polycondensation. Non-LC P2P formed LC polymers even at low (5 mol%) incorporation in DEG-based copolymers, whereas the LC-P6P could do so only at 30 mol% incorporation. The LC properties of the twin mols. as well as copolymers were studied using differential scanning calorimetry, polarized light microscopy (PLM) along with variable temperature wide angle X-ray diffraction. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Recommanded Product: Dimethyl decanedioate).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: Dimethyl decanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Probing the contamination characteristics, mobility, and risk assessments of typical plastic additive-phthalate esters from a typical coastal aquaculture area, China was written by Zhang, Ze-Ming;Wang, Liu-Yong;Gu, Yan-Yu;Sun, Ai-Li;You, Jin-Jie;Shi, Xi-Zhi;Chen, Jiong. And the article was included in Journal of Hazardous Materials in 2021.Computed Properties of C20H26O4 This article mentions the following:

Contamination characteristics, equilibrium partitioning and risk assessment of phthalate esters (PAEs) were investigated in seawater, sediment and biol. samples collected from the Xiangshan Bay area during an annual investigation between Jan. and Nov. 2019. PAE concentrations detected in the mariculture environment in surface seawater, sediment, and biol. samples were 172-3365 ng/L, 190-2430μg/kg (dry weight [dw]), and 820-4926μg/kg (dw), resp. The dominant congeners in different media included di-Bu phthalate (DnBP), diisobutyl phthalate (DiBP), and di(2-ethylhexyl) phthalate (DEHP). The inner bay and the bay mouth were the gathering area of PAEs and heavily influenced by the mariculture activities, river inputs, and anthropogenic activities. The bioaccumulation of PAEs demonstrated benthic feeding fishes with relatively high trophic levels concentrated high levels of phthalates. The mobility of PAEs in sediment-seawater showed that the transfer tendency of low-mol. weight species was from the sediment to the water, which was in contrast with those of high-mol. weight PAEs. DEHP, DiBP and DnBP had various degrees of ecol. risks in the aquatic environment, whereas only the DiBP posed potential risks in sediments. The current assessment of carcinogenic and noncarcinogenic risks posed by fish consumption were within acceptable limits for humans. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Computed Properties of C20H26O4).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C20H26O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Palladium-catalyzed dearomative 1,4-difunctionalization of naphthalenes was written by Yang, Ping;Zheng, Chao;Nie, Yu-Han;You, Shu-Li. And the article was included in Chemical Science in 2020.Electric Literature of C9H10O3S This article mentions the following:

A highly diastereoselective dearomatization of naphthalenes via a Pd-catalyzed 1,4-difunctionalization reaction is described. In the presence of a com. available palladium precursor and ligand, intramol. dearomative Heck-type insertion provides π-allylpalladium intermediates which are readily captured by a series of nucleophiles in excellent yields (up to 99%). This reaction features mild conditions, broad substrate scope, and useful transformations of the products. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Electric Literature of C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Green and Efficient Esterification Method Using Dried Dowex H⁺/NaI Approach was written by Turhanen, Petri A.;Leppanen, Jukka;Vepsalainen, Jouko J.. And the article was included in ACS Omega in 2019.Name: Ethyl 2-hydroxybenzoate This article mentions the following:

The usefulness of dried Dowex H⁺ cation-exchange resin with or without sodium iodide (NaI) as a catalyst system for different kinds of esterifications using carboxylic acids and alcs. as starting materials has been systematically investigated. The Dowex H⁺/NaI approach is very effective, generally high yielding, energy-efficient, and nontoxic, and the Dowex H⁺ resin is reusable. Since the whole procedure from start to product isolation is also very simple, these features make the method environmentally friendly. The method is regioselective, and its potential for separation of valuable carboxylic acids like resin acids from mixtures containing other kinds of carboxylic acids has been demonstrated. Examples for green and straightforward esterification of highly important natural amino acids are also presented. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Name: Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: Ethyl 2-hydroxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics