Category: esters-buliding-blocks

Clark, J. Stephen; Fessard, Thomas C.; Wilson, Claire published the artcile< A Concise and Stereoselective Synthesis of the A-Ring Fragment of the Gambieric Acids>, Formula: C6H10O5, the main research area is asym synthesis gambieric acid ring fragment rearrangement oxonium ylide.

The A-ring fragment I of the gambieric acids has been prepared by a short and efficient route. The key 3(2H)-furanone intermediate has been obtained by [2,3] rearrangement of an allylic oxonium ylide generated from intramol. reaction of a crotyl ether with a copper carbenoid. A single stereogenic center has been set by using a chiral pool starting material and the other three have been established by using highly diastereoselective substrate-controlled transformations.

Organic Letters published new progress about Rearrangement ([2,3]-rearrangement). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Can; Sadeghzadeh, Seyed Mohsen published the artcile< CdSnO3/SnD NPs as a Nanocatalyst for Carbonylation of o-Phenylenediamine with CO2>, Computed Properties of 112-63-0, the main research area is phenylenediamine carbonylation cadmium stannate nanocatalyst preparation property.

In order to carbonize o-phenylenediamine with CO2, an effective approach was used with UV light irradiation by Sn(IV) doping DFNS (SnD) supported CdSnO3 as a catalyst (CdSnO3/SnD). In this catalyst, SnD with the ratios of Si/Sn in the range of 6 to 50 were obtained using the Direct Hydrothermal Synthesis (DHS), and the nanoparticles of CdSnO3 on the surfaces of SnD were reduced in situ. Scanning Electron Microscope, X-ray Diffraction, Fourier Transform IR Spectroscopy, X-ray Energy Dispersive Spectroscopy, and Transmission Electron Microscopy were utilized for characterizing CdSnO3/SnD. It was found that CdSnO3/SnD nanostructures could be used for synthesizing o-phenylenediamines due to their effective and novel catalytic behavior through the reaction between o-phenylenediamines and CO2.

Catalysis Letters published new progress about Carbonylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takahagi, Hiroki; Fujibe, Satoshi; Iwasawa, Nobuharu published the artcile< Guest-Induced Dynamic Self-Assembly of Two Diastereomeric Cage-Like Boronic Esters>, Product Details of C19H34O2, the main research area is boronic ester cage guest induced diastereoselective self assembly; crystal structure benzenetriboronate ester cage diastereomer preparation; mol structure benzenetriboronate ester cage diastereomer.

Reaction of racemic tetrol (I) with 1,3,5-benzenetriboronic acid (II) in MeOH gave 90% yield of a solid consisting of a single, highly sym. 3:2 complex of tetrol I and triboronic acid II (homo-[3+2]) which contained no MeOH. Crystals of homo-[3+2]·PhMe grown in PhMe-pentane were analyzed by x-ray crystallog. The complex had the expected cage-like structure with 1 mol. of PhMe in the internal space, suggesting π-π interactions with the Ph rings of the triboronic acid groups. The 3 tetrol units in homo-[3+2] were derived from the same enantiomer of tetrol I, indicating that diastereoselective self-assembly occurred during formation of this structure. Several guest mols. (C6H6, PhMe, cumene, o-, m-, and p-xylene) were examined as templates for cyclic boronic esters; C6H6, PhMe and p-xylene gave only (homo-[3+2]), whereas cumene afforded complex mixtures When 13 equiv o- or m-xylene were used as guest mols., a diastereomeric isomer (hetero-[3+2]) was formed containing 1 mol. of xylene guest compound that could be displaced by CHCl3. The structure of (hetero-[3+2])·CHCl3 was determined by x-ray crystallog. A similar diastereoselectivity was observed by using dicyanobenzenes as guests. E.g., only 0.33 equiv o-C6H4(CN)2 induced the selective formation of hetero-[3+2]. Thus, 2 diastereomeric host mols. were constructed by guest-induced self-assembly with recognition of the substitution pattern of disubstituted benzenes. When I and II were mixed in presence of 2 xylenes in MeOH, completely selective inclusion of o- or m-xylene over p-xylene was achieved during the precipitation process, and o-xylene was included preferentially over m-xylene.

Chemistry – A European Journal published new progress about Cage compounds Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jagadeesh, Rajenahally V.; Wienhoefer, Gerrit; Westerhaus, Felix A.; Surkus, Annette-Enrica; Pohl, Marga-Martina; Junge, Henrik; Junge, Kathrin; Beller, Matthias published the artcile< Efficient and highly selective iron-catalyzed reduction of nitroarenes>, COA of Formula: C19H34O2, the main research area is iron phenanthroline carbon pyrolysis nitroarene reduction supported catalyst; aniline preparation chemoselective.

Pyrolysis of iron-phenanthroline complexes supported on carbon leads to highly selective catalysts for the reduction of structurally diverse nitroarenes to anilines in 90-99% yields. Excellent chemoselectivity for the nitro group reduction is demonstrated.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takada, Akiomi; Hashimoto, Yoshimitsu; Takikawa, Hiroshi; Hikita, Katsuyoshi; Suzuki, Keisuke published the artcile< Total Synthesis and Absolute Stereochemistry of Seragakinone A>, Synthetic Route of 112-63-0, the main research area is enantioselective synthesis seragakinone A cyclization rearrangement; seragakinone A mol structure absolute configuration.

The first asym. total synthesis of (-)seragakinone A (I) is reported. Noteworthy features of the synthesis include the benzoin-forming reaction which worked well to effect two sep. cyclization, the pinacol-type rearrangement and determination of the absolute configuration of the natural product.

Angewandte Chemie, International Edition published new progress about Absolute configuration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gu, Yiyu; Lu, Xiaoqing; Ma, Xiaodong; Zhang, Haojian; Ji, Yuanyuan; Ding, Wanjing; Shen, Li published the artcile< Design, synthesis and biological evaluation of (quinolinyl-3-pyridinyl) benzenesulfonamide-based hydroxamic acids as PI3K and HDAC dual targeting inhibitors>, Reference of 112-63-0, the main research area is quinolinylpyridinylbenzenesulfonamide hydroxamic acid PI 3K HDAC targeting inhibitor.

Polypharmacol. has emerged as a promising approach to drug discovery, especially antitumor drug. This study reports the design, synthesis, and biol. evaluation of novel phosphatidylinositol 3-kinases (PI3Ks) and histone deacetylases (HDACs) dual inhibitors on the basis of GSK2126458 under clin. evaluation and vorinostat approved. Among these hybrid mols., GYB-4 and GYB-5 possessed potent inhibition against both PI3Kα (1.0 and 1.3 nmol/L, resp.) and HDAC1 (4.2 and 4.8 nmol/L, resp.). Antiproliferative assays with HCT116, PC3 and A2780 cell lines subsequently were performed. The structure-activity relationship study will guide to optimization of dual PI3K and HDAC inhibitors.

Youji Huaxue published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dong, Haiying; Zhang, Jing; Rong, Hua; Zhang, Xiaojie; Dong, Miaoxian published the artcile< Paeoniflorin and Plycyrrhetinic Acid Synergistically Alleviate MPP+/MPTP-Induced Oxidative Stress through Nrf2-Dependent Glutathione Biosynthesis Mechanisms>, Reference of 112-63-0, the main research area is paeoniflorin glycyrrhetinic acid antioxidant antiparkinsonian oxidative stress Parkinsons disease; neuroprotectant Nrf2 glutathione biosynthesis paeoniflorin glycyrrhetinic acid; Paeoniflorin; Parkinson’s disease; glycyrrhetinic acid; oxidative stress; synergism.

Recently, combination therapy has proven to be an effective strategy for treating polygenic/multifactorial/complex disorder such as Parkinson’s disease (PD). Here, we hypothesized that dual up-regulation of glutamate cysteine ligase (GCL) catalytic subunit (GCLc) and GCL modifier subunit (GCLm) via nuclear factor E2-related factor (Nrf2) contribute to the antioxidant effect of paeoniflorin (PF) synergistically with glycyrrhetinic acid (GA) (henceforth called PF/GA) in the context of MPP+/MPTP neurotoxicity. Expectedly, CompuSyn synergism/antagonism anal. showed that PF/GA exerts synergistic neuroprotection. Moreover, the antioxidant effect of PF was significantly enhanced by the combined administration of GA, although GA alone did not confer the effect. Mechanistically, PF triggered extracellular signal-regulated kinase (ERK1/2) phosphorylation, resulting in Nrf2 nuclear translocation from cytoplasmic pool via de novo synthesis in MPP+-challenged SH-SY5Y cells. Concomitantly, GA activates Akt which in turn induces nuclear accumulation of Nrf2. Especially, PF/GA up-regulated glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase modifier subunit (Gclm) are formed via two sep. pathways. Furthermore, these results were confirmed through pathway blockade assays using PD98059 (ERK1/2 inhibitor), LY294002 (phosphatidylinositol-3-kinase inhibitor), and shRNA-induced Nrf2 knockdown. Addnl., using a mouse MPTP-induced model of PD, we demonstrated that PF/GA synergistically ameliorates both motor deficits and oxidative stress in the ventral midbrain. In parallel, PF/GA also up-regulated both GCLc and GCLm expression at levels of transcription and translation. Conversely, antiparkinsonism and antioxidant effects of PF/GA were not observed in Nrf2-knockout MPTP-mice. Collectively, these results show that ERK1/2 and Akt activation contribute to the synergistic antioxidant effect of PF/GA. Hence, PF/GA regimen warrants further preclin. and possible clin. study for PD.

ACS Chemical Neuroscience published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Chengwei; Prichard, Mark N.; Korba, Brent E.; Drach, John C.; Zemlicka, Jiri published the artcile< Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine>, Related Products of 112-63-0, the main research area is fluorinated methylenecyclopropane analog nucleoside preparation antiviral; fluoromethyl hydroxymethyl cyclopropylidene adenine guanine preparation antiviral structure.

Synthesis and antiviral activity of the title fluoromethylenecyclopropane analogs 15a, 15b, 16a, and 16b is described. Methylenecyclopropane carboxylate was first transformed to 2,2-bis-hydroxymethylmethylenecyclopropane. Selective monoacetylation followed by introduction of fluorine gave 2-acetoxymethyl-2-fluoromethylmethylenecyclopropane as the key intermediate. The synthesis of analogs 15a, 15b, 16a, and 16b then followed alkylation-elimination procedure as described previously for other methylenecyclopropane analogs. The adenine Z-isomer 15a was found to be a potent inhibitor of Epstein-Barr virus (EBV) in vitro with EC50/CC50 (μM) 0.5/55.7. Compounds 15b, 16a, and 16b were also active but at higher concentrations, EC50/CC50 (μM) 3.2-7.5/53.6-64.1. Analog 15a inhibited hepatitis C virus by virtue of its cytotoxicity and it moderately inhibited replication of the Towne strain of human cytomegalovirus (HCMV). The E-isomer 16a was a substrate for adenosine deaminase, whereas the Z-isomer 15a was not deaminated.

Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Bin; Chansaenpak, Kantapat; Wu, Hongmiao; Zhu, Lin; Wang, Mengzhe; Li, Zibo; Lu, Hongjian published the artcile< Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process>, Reference of 112-63-0, the main research area is oxazolidindione oxazinanone radiofluorinated oxazolidinone preparation; olefin acrylamide cyclization fluorination cascade silver radical.

The intramol. fluorocyclization of unsaturated carbamates is described here using a hypervalent iodine reagent in the presence of a silver catalyst. Both (hetero)aryl-substituted olefins and acrylamides can be utilized as effective substrates. Preliminary mechanistic investigations suggest that the reaction proceeds via a cyclization/1,2-(hetero)aryl migration/fluorination cascade involving an unusual radical process. Furthermore, starting from no-carrier-added [18F]TBAF, a simple one-pot, two-step cascade method was developed for the generation of 18F-labeled heterocycles with high radiochem. purity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Yaohong; Qian, Yihua; Su, Wei; Chen, Xi published the artcile< Application of molecular probe to investigate surface structure of metal passivator on copper>, Formula: C19H34O2, the main research area is copper sulfide surface structure metal passivator investigative.

Copper sulfide (Cu2S) contaminant is semi-conductive. Its formation and migration to insulating paper and oil caused insulation breakdown. Addition of benzotriazole derivatives as metal passivator slows down the corrosion process, as the metal passivator produces a protective layer on the copper surface, which prevents the reaction between corrosive sulfur and copper. But the surface structure of this impermeable film is still unknown. Herein we reported our investigation on the orientation of metal-passivator complex on copper surface by means of mol. probe. Ageing exptl. study with different steric and electronic groups in benzotriazole skeleton indicated that the second position of the mol. was sensitive to steric effect, suggesting end-on orientation preferable. Subsequently, SEM-EDX revealed the relative amount of copper sulfide on copper surface. Moreover, FTIR represented the characteristic wavenumber of C=O, C=N moiety and benzene skeleton of passivator-copper complex. XPS anal. delivered the organic elemental composition of the protective layer.

IEEE Transactions on Dielectrics and Electrical Insulation published new progress about Corrosion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics