Category: esters-buliding-blocks

Photocatalyzed reductive fluoroalkylation of 2-acetoxyglycals towards the stereoselective synthesis of α-1-fluoroalkyl-C-glycosyl derivatives was written by Mora Flores, Erwin W.;Uhrig, Maria Laura;Postigo, Al. And the article was included in Organic & Biomolecular Chemistry in 2020.Recommanded Product: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate This article mentions the following:

A benign, efficient, regio- and stereoselective protocol for the syntheses of α-1-fluoroalkyl-C-glycosyl compounds bearing CF₃, C₄F₉, and C₆F₁₃ substituents on the anomeric carbon has been developed by a new methodol. starting from 2-acetoxyglycals for the first time. Remarkably, the reactions proceeded in only one step, through the visible light-photocatalyzed reductive fluoroalkylation of 2-acetoxyglycals by means of an Ir photocatalyst and employed com. available fluoroalkyl iodides n-C_nF_2n+1-I (n = 1, 4, 6) as a source of fluoroalkyl radicals. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Recommanded Product: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of different heat treatments on the Maillard reaction products, volatile compounds and glycation level of milk was written by Zhang, Yumeng;Yi, Shengnan;Lu, Jing;Pang, Xiaoyang;Xu, Xiaoxi;Lv, Jiaping;Zhang, Shuwen. And the article was included in International Dairy Journal in 2021.Computed Properties of C10H18O2 This article mentions the following:

In this study, the formation of Maillard reaction products and the Maillard reaction sites of milk proteins were studied under different heat treatment conditions. Fifteen samples heated at 75, 90, 105, 120 or 135°C for 5, 15 or 30 s were selected to investigate the effects of different heat treatment conditions on the Maillard reaction products volatile compounds and protein glycation degree. The contents of fluorescence intensity, furosine, lactulose, and 5-hydroxymethylfural were pos. associated with the heat temperature and treatment time. Compared with that of raw milk, the number of glycated proteins increased from 14 to 49 in the milk samples heated at 135°C for 5 s, and the number of binding sites increased from 47 to 166. These results advance current knowledge about the effect of different heat treatments on the degree of the Maillard reaction and the sensory quality and glycation level of milk. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Computed Properties of C10H18O2).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C10H18O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis was written by Smith, Elizabeth M.;Sorota, Steve;Kim, Hyunjin M.;McKittrick, Brian A.;Nechuta, Terry L.;Bennett, Chad;Knutson, Chad;Burnett, Duane A.;Kieselgof, Jane;Tan, Zheng;Rindgen, Diane;Bridal, Terry;Zhou, Xiaoping;Jia, Yu-Ping;Dong, Zoe;Mullins, Debbie;Zhang, Xiaoping;Priestley, Tony;Correll, Craig C.;Tulshian, Deen;Czarniecki, Michael;Greenlee, William J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Category: esters-buliding-blocks This article mentions the following:

A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca_V3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the potency, selectivity and DMPK properties of leads will be described. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Category: esters-buliding-blocks).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of aroma-active components in black teas produced by six Chinese tea cultivars in high-latitude region by GC-MS and GC-O analysis was written by Wang, Baoyi;Chen, Huimin;Qu, Fengfeng;Song, Yakang;Di, Taimei;Wang, Peiqiang;Zhang, Xinfu. And the article was included in European Food Research and Technology in 2022.Formula: C12H20O2 This article mentions the following:

In this study, gas chromatog.-mass spectrometry (GC-MS) and gas chromatog.-olfactometry (GC-O) anal. was performed to figure out the characteristic aroma compounds of high-latitude black teas and select the suitable cultivar for producing high-aroma black tea. Sensory evaluation revealed that Jinxuan presented an obviously floral aroma and got the highest score, followed by Longjing Changye, Zhongcha 302, Yingshuang, Baihaozao and Huangshan Quntizhong. Furthermore, a total of 135 volatiles were identified in all black teas and 12 components can be used to distinguish different latitude black teas by principal component anal. (PCA). Cluster anal. (CA) showed six samples were divided into two clusters and Jinxuan was classified sep. of cluster B. Based on GC-O anal., 41 volatile organic compounds (VOCs) were found to promote the aroma of high-latitude black teas. Among them, phenylethyl alc., geraniol, linalool, α-ionone, cis-3-hexenyl hexanoate and Me salicylate were the major contributors to the floral fragrance of black tea and accounted for a relative high proportion in Jinxuan, Longjing Changye and Baihaozao. In summary, Jinxuan and Longjing Changye were suitable for producing high-quality black tea in high-latitude area. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Formula: C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Formula: C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Single-Use Face Masks as a Potential Source of Synthetic Antioxidants to the Environment was written by Liu, Runzeng;Mabury, Scott A.. And the article was included in Environmental Science & Technology Letters in 2021.HPLC of Formula: 6683-19-8 This article mentions the following:

Single-use face masks are a powerful tool for reducing the spread of COVID-19. The usage of single-use face masks has increased enormously since the start of the COVID-19 pandemic, and pollution from the huge volume of discarded single-use face masks may become an environmental issue. This study focuses on synthetic antioxidants (AOs), including synthetic phenolic antioxidants (SPAs) and organophosphite antioxidants (OPAs), used in single-use 3-layer face masks. Both SPAs and OPAs were detected in single-use face masks, with total concentrations ranging 20.0-575μg/g (median of 175μg/g). The dominant congeners detected in the face masks were tris(2,4-di-tert-butylphenyl) phosphite (AO168, median of 83.2μg/g), tris(2,4-di-tert-butylphenyl) phosphate (AO168O, median of 72.9μg/g), and pentaerythritol tetrakis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate] (AO1010, median of 13.7μg/g). No significant concentration difference was observed between medical and nonmedical face masks. Among the 3 different layers of the face masks, the middle layers showed the highest AO concentrations On the basis of the median concentrations detected, we estimate that 1084 tons of AOs is used in face masks annually, suggesting that discarded face masks may be a source of AOs to the environment. This is the 1st study to report the occurrence of a wide range of AOs in face masks. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8HPLC of Formula: 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The spatiotemporal distribution and potential risk assessment of 19 phthalate acid esters in wastewater treatment plants in China was written by Sun, Shaojing;Shen, Jimin;Li, Bo;Geng, Jialu;Ma, Lixin;Qi, Hong;Zhang, Anping;Zhao, Zebin. And the article was included in Environmental Science and Pollution Research in 2021.Application of 84-61-7 This article mentions the following:

The spatiotemporal distribution of phthalate acid esters (phthalates, PAEs) in wastewater treatment plants (WWTPs) in China was studied. The concentration of PAEs in influent and effluent increased from 2009 to 2016, indicating that the exposure level of PAEs in China increased continuously. Although the concentration of PAEs in sewage sludge in China ranged from 33.3 to 298 ug/g, there was no obvious spatial distribution pattern. Among the 19 PAE homologues, DEHP, DnBP, and DIBP were the most abundant phthalates detected in wastewater and sludge. Ecol. risk assessment confirmed that there was a high chronic and acute risk of DIBP in effluent since 2015. Therefore, this study highlights the need for further studies on the exposure and toxicol. of DIBP. Dietary intake accounted for more than 98% of the total risk, indicating that the risk of sludge application in agricultural land was much higher than that in nonagricultural land. The results from this study will provide valuable information for the safe disposal of sludge and wastewater. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Application of 84-61-7).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 84-61-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and Biological Investigation of Coumarin Piperazine (Piperidine) Derivatives as Potential Multireceptor Atypical Antipsychotics was written by Chen, Yin;Wang, Songlin;Xu, Xiangqing;Liu, Xin;Yu, Minquan;Zhao, Song;Liu, Shicheng;Qiu, Yinli;Zhang, Tan;Liu, Bi-Feng;Zhang, Guisen. And the article was included in Journal of Medicinal Chemistry in 2013.Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

The discovery and synthesis of potential and novel antipsychotic coumarin derivatives, associated with potent dopamine D₂, D₃, and serotonin 5-HT_1A and 5-HT_2A receptor properties, are the focus of the present article. The most-promising derivative was 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl)butoxy)-4-methyl-8-chloro-2H-chromen-2-one (I). This derivative possesses unique pharmacol. features, including high affinity for dopamine D₂ and D₃ and serotonin 5-HT_1A and 5-HT_2A receptors. Moreover, it possesses low affinity for 5-HT_2C and H₁ receptors (to reduce the risk of obesity associated with chronic treatment) and hERG channels (to reduce the incidence of torsade de pointes). In animal models, compound I inhibited apomorphine-induced climbing behavior, MK-801-induced hyperactivity, and the conditioned avoidance response without observable catalepsy at the highest dose tested. Further, fewer preclin. adverse events were noted with I compared with risperidone in assays that measured prolactin secretion and weight gain. Acceptable pharmacokinetic properties were also noted with I. Taken together, I may constitute a novel class of drugs for the treatment of schizophrenia. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis base-catalyzed hydrosilylation was written by Chen, Xing;Zheng, Yongsheng;Shu, Chang;Yuan, Weicheng;Liu, Bo;Zhang, Xiaomei. And the article was included in Journal of Organic Chemistry in 2011.Quality Control of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-ones has been accomplished through chiral Lewis base-catalyzed hydrosilylation. The corresponding products were obtained in excellent yields (up to 99%) and enantioselectivities (up to 98%). The absolute configuration of product I has been determined as S by X-ray crystallog. anal. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Quality Control of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One-dimensional optoelectronic nanostructures derived from the aqueous self-assembly of π-conjugated oligopeptides was written by Diegelmann, Stephen R.;Gorham, Justin M.;Tovar, John D.. And the article was included in Journal of the American Chemical Society in 2008.COA of Formula: C7H8O2S This article mentions the following:

The aqueous self-assembly of oligopeptide-flanked π-conjugated mols. into discrete one-dimensional nanostructures is described. Unique to these mols. is the fact that the π-conjugated unit has been directly embedded within the peptide backbone by way of a synthetic amino acid with π-functionality that is compatible with standard Fmoc-based (Fmoc = 9-fluorenylmethoxycarbonyl) peptide synthesis. The peptide-based mol. design enforces intimate π-π communication within the aggregate after charge-screening and self-assembly, making these nanostructures attractive for optical or electronic applications in biol. environments. The synthesis and assembly are reported along with spectroscopic and morphol. characterization of the new nanomaterials. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9COA of Formula: C7H8O2S).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C7H8O2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Inhibition of human sperm motility and capacitation by ziram is mediated by decreasing tyrosine protein kinase was written by Wen, Zina;Lei, Zhen;Tian, Erpo;Wang, Yiyan;Zhong, Ying;Ge, Ren-shan. And the article was included in Ecotoxicology and Environmental Safety in 2021.Name: Dicyclohexyl phthalate This article mentions the following:

Many endocrine disruptors may interfere with sperm motility, hyperactivation, and capacitation, thereby leading to male infertility. In the current study, we screened 14 endocrine disruptors, including plant ingredients, cigarette ingredients, minerals, insecticides and fungicides, plastics, and plasticizers, to inhibit human sperm motility and forward motility. Only ziram, a dithiocarbamate fungicide, can effectively inhibit sperm motility, forward motility, hyperactivation, capacitation, and spontaneous acrosome reaction of normal human spermatozoa. Its half maximum inhibitory concentration (IC50) values were less than 4μM. Ziram also inhibited sperm motility and forward motility of asthenozoospermia spermatozoa and IC50 values were about 6-8μM. In addition, ziram inhibited normal sperm motility, calcium influx, reactive oxygen species, and mitochondrial membrane potential at 2.5 and/or 5μM, with IC50 values exceeding 100μM, although it did not affect sperm DNA fragmentation up to 5μM. Ziram-mediated inhibition of sperm motility and forward motility was irreversible. Forskolin, 8Br-cAMP, pentoxifylline, progesterone, vitamin E, and A23187 cannot prevent ziram-mediated inhibition of sperm motility and forward motility. Further studies have shown that ziram inhibited the level of tyrosine protein kinase with an IC50 value of about 10μM, without affecting p21-activated kinase 4, and it caused damage to the mitochondrial structure of normal spermatozoa at 2.5 and 5μM. In conclusion, ziram irreversibly inhibits human sperm motility, forward motility, and capacitation by reducing the level of tyrosine protein kinase and damaging the ultrastructure of mitochondria. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Name: Dicyclohexyl phthalate).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Dicyclohexyl phthalate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics