Category: esters-buliding-blocks

Wang, Shengju; Jiang, Huajuan; Liu, Qianqian; Zhou, Yongfeng; Cheng, Yanfen; Zhou, Tao; Zhang, Jinming; He, Yao; Ren, Chaoxiang; Pei, Jin published the artcile< A comparative study on the traditional versus modern yellow rice wine processing methods using Taohong Siwu Decoction for pharmaceutical production>, Quality Control of 112-63-0, the main research area is metabolomics yellow rice wine processing method Taohong Siwu decoction; Catalpol; Ferulic acid; Hydroxysafflor yellow A; Metabolomics; Primary dysmenorrhea; Taohong Siwu decoction; Yellow rice wine processing method.

Taohong Siwu Decoction (THSWD) is based on the “”First Recipe of Gynecol””. It is widely used in various blood stasis and deficiency syndromes, mainly in gynecol. blood stasis, irregular menstruation, and dysmenorrhea. THSWD has great demand in traditional Chinese medicine (TCM), gynecol., orthopedics, and internal medicine. According to classical records, three medicinal materials, namely Rehmanniae radix, Angelica sinensis, and Carthamus tinctorius, used in THSWD need to be “”washed with yellow rice wine””. In the study of TCM prescriptions, the processing methods of medicinal materials not only needed to follow traditional records but also should consider modern tech. conditions. Many medicinal materials in the repertoire of classical prescriptions involve yellow rice wine processing. Determining the processing method for medicinal materials is a key and difficult problem in the research and development of classical prescriptions. With THSWD as the representative, this study analyzed differences between no processing method, the modern processing method of “”stir-frying the materials with yellow rice wine,”” and the traditional processing method of “”washing with yellow rice wine””. We focused on three aspects: composition, efficacy, and endogenous metabolism This study aimed to provide a reference for research on the processing methods of medicinal materials used in classical prescriptions. UPLC-Q-Orbitrap HRMS was used to quickly identify and classify the main chem. compounds of THSWD. A model of primary dysmenorrhea (PD) was established using estradiol benzoate combined with oxytocin. The latent period and writhing time; the levels of serum PGF2α, PGE2, ET-1, and β-EP; and the pathol. sections of the uterus were observed to determine their pharmacodynamic differences. GC-TOF/MS was used to analyze the differences in serum metabolites in rats. A total of 54 active compounds were identified, and the results showed that catalpol and rehmapicroside disappeared following yellow rice wine processing. Compared with materials processed by the traditional method, the relative contents of 15 components, such as 5-hydroxymethylfurfural and digitalis C, increased in materials processed by the modern method. However, the relative contents of 16 components, such as hydroxysafflor yellow A, verbascoside, and ferulic acid, decreased in the modern processing method. The modern and classic processing methods acted on PD through different metabolic pathways. THSWD obtained by classical processing methods mainly treated PD through anti-inflammatory and estrogen metabolism pathways, whereas THSWD obtained by modern processing methods mainly treated PD through anti-inflammatory metabolic pathways. The study revealed the differences in different yellow rice wine processing methods in terms of chem. composition of the THSWD obtained, as well as the mechanisms of action for the treatment of PD. This study provides a reference for the clin. application of THSWD and development of classical prescription preparations

Journal of Ethnopharmacology published new progress about Angelica sinensis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jimenez-Garcia, Sandra N.; Garcia-Mier, Lina; Ramirez-Gomez, Xochitl S.; Aguirre-Becerra, Humberto; Escobar-Ortiz, Alexandro; Contreras-Medina, Luis M.; Garcia-Trejo, Juan F.; Feregrino-Perez, Ana A. published the artcile< Pitahaya Peel: A By-Product with Great Phytochemical Potential, Biological Activity, and Functional Application>, Electric Literature of 112-63-0, the main research area is hypertension pitahaya peel byproduct betalain biol activity flavonoid antioxidant; Hylocerous spp.; biological activity; phenolic compounds.

Hylocereus spp. present two varieties of com. interest due to their color, organoleptic characteristics, and nutritional contribution, such as Hylocerous polyrhizus and Selenicerus undatus. The fruit recognized as dragon fruit or Pitahaya is an exotic fruit whose pulp is consumed, while the peel is discarded during the process. Studies indicate that the pulp has vitamin C and betalains, and seeds are rich in essential fatty acids, compounds that can contribute to the prevention of chronic non-communicable diseases (cancer, hypertension, and diabetes). In the present study, polyphenolic compounds, biol. activity, and fatty acids present in the peel of the two varieties of pitahaya peel were evaluated, showing as a result that the variety S. undatus had higher antioxidant activity with 51% related to the presence of flavonoids 357 mgRE/g sample and fatty acids (hexadecanoic acid and linoleate) with 0.310 and 0.248 mg AG/g sample, resp. On the other hand, H. polyrhizuun showed a significant difference in the inhibitory activity of amylase and glucosidase enzymes with 68% and 67%, resp. We conclude that pitahaya peel has potential health effects and demonstrate that methylated fatty acids could be precursors to betalain formation, as well as showing effects against senescence and as a biol. control against insects; in the same way, the peel can be reused as a byproduct for the extraction of important enzymes in the pharmaceutical and food industry.

Molecules published new progress about Alkanes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khodabakhshi, Elham; Kloeckner, Benjamin; Zentel, Rudolf; Michels, Jasper J.; Blom, Paul W. M. published the artcile< Suppression of electron trapping by quantum dot emitters using a grafted polystyrene shell>, Synthetic Route of 71195-85-2, the main research area is electron trapping quantum dot emitter grafted polystyrene shell.

A fundamental problem of adding chromophores to an organic host is that their smaller band gap leads to severe trapping of either electrons or holes, resulting in strongly unbalanced transport. We demonstrate that electron trapping by an inorganic quantum dot (QD) in a conjugated polymer host can be suppressed by functionalizing its shell with a thin insulating polystyrene layer. The polystyrene shell not only reduces trapping, but also suppresses detrapping of captured electrons, resulting in increased charging of the QDs with subsequent voltage scans, after initial charging, a red-emitting hybrid polymer:QD light-emitting diode is obtained with voltage independent electroluminescence spectrum and equal efficiency as the blue polymer host.

Materials Horizons published new progress about Band gap Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Synthetic Route of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Drusian, Luca; Nigro, Elisa Agnese; Mannella, Valeria; Pagliarini, Roberto; Pema, Monika; Costa, Ana S. H.; Benigni, Fabio; Larcher, Alessandro; Chiaravalli, Marco; Gaude, Edoardo; Montorsi, Francesco; Capitanio, Umberto; Musco, Giovanna; Frezza, Christian; Boletta, Alessandra published the artcile< mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma>, Related Products of 112-63-0, the main research area is renal cell carcinoma FH gene fumarate accumulation mTORC1; TCA cycle; cancer metabolism; cancer signaling; epithelial transformation; fumarate hydratase; metabolic reprogramming; papillary carcinoma; rapamycin; renal cancer; renal cysts.

Renal cell carcinomas (RCCs) are common cancers diagnosed in more than 350,000 people each year worldwide. Several pathways are de-regulated in RCCs, including mTORC1. However, how mTOR drives tumorigenesis in this context is unknown. The lack of faithful animal models has limited progress in understanding and targeting RCCs. Here, we generated a mouse model harboring the kidney-specific inactivation of Tsc1. These animals develop cysts that evolve into papillae, cystadenomas, and papillary carcinomas. Global profiling confirmed several metabolic derangements previously attributed to mTORC1. Notably, Tsc1 inactivation results in the accumulation of fumarate and in mTOR-dependent downregulation of the TCA cycle enzyme fumarate hydratase (FH). The re-expression of FH in cellular systems lacking Tsc1 partially rescued renal epithelial transformation. Importantly, the mTORC1-FH axis is likely conserved in human RCC specimens. We reveal a role of mTORC1 in renal tumorigenesis, which depends on the oncometabolite fumarate.

Cell Reports published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Dongdong; Liang, Jianwen; Robertson, Stuart J.; Chen, Yingtong; Wang, Naiguang; Shao, Minhua; Shi, Zhicong published the artcile< Heterogeneous Bimetallic Organic Coordination Polymer-Derived Co/Fe@NC Bifunctional Catalysts for Rechargeable Li-O2 Batteries>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is bimetallic organic polymer bifunctional catalyst lithium oxide battery; Li−O2 battery; MOCPs; bifunctional catalyst; dual metal sites; nitrogen-doped carbon.

The Li-O2 battery has attracted substantial attention due to its high theor. energy d. In particular, high-efficiency oxygen catalysts are very important for the design of practical Li-O2 batteries. Herein, we have synthesized heterogeneous crystalline-coated partially crystalline bimetallic organic coordination polymers (PC@C-BMOCPs), which are further pyrolyzed to obtain Co- and Fe-based nanoparticles embedded within rodlike N-doped carbon (Co/Fe@NC) as a bifunctional oxygen reduction reaction/oxygen evolution reaction (ORR/OER) catalyst used in the Li-O2 battery. Owing to excellent ORR/OER catalytic ability, the Co/Fe@NC bifunctional catalyst exhibits an efficient reversible reaction between O2 and Li2O2. Addnl., a large number of mesoporous channels are present in the core-shell Co/Fe@NC nanoparticles. These channels not only promote the diffusion of Li+ and O2, but also create ample room to store insoluble discharge product Li2O2. The Li-O2 batteries utilizing the bifunctional Co/Fe@NC oxygen electrode exhibit a large capacity of 17,326 mAh g-1, a long cycling life of more than 250 cycles, and excellent reversibility. This work provides a universally applicable strategy for designing nonnoble metal ORR/OER catalysts with excellent electrochem. performance for metal-air batteries.

ACS Applied Materials & Interfaces published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Linhan; Zhou, Ting; Zhong, Linyu; Zhou, Qian; Gu, Gang; Hu, Mengjun; Chen, Fengping; Lin, Sheng published the artcile< Bioremediation of quinclorac injury on tobacco by a rhizosphere bacterium>, HPLC of Formula: 112-63-0, the main research area is rhizosphere bacterium tobacco quinclorac injury bioremediation; Bioremediation; Herbicide; Klebsiella variicola; Plant growth-promoting bacterium; Tobacco.

The presence of herbicides residues in soil represents a serious problem for agriculture. Quinclorac is a common herbicide applied in rice field, but its residue can cause abnormal growth in successive crop of tobacco in Southern China. Remediation by microorganisms is considered to be an environmentally friendly method to remove such pollutants injury. The aims of this study were to obtain quinclorac remediation isolates and to investigate the possible mechanism(s) of remediation. Six bacterial isolates were obtained from rhizosphere of rice-tobacco rotation fields, and were found to be capable of degrading quinclorac on a mineral salt medium (MSM), with degradation efficiency ranging from 2.1 to 23.7%. Among these isolates, J5 had the highest degradation efficiency, and was identified as Klebsiella variicola based on phylogenetic anal. and a metabolic profile generating by Biolog GEN III system. Bioremediation of quinclorac injury was confirmed using pot assays with tobacco, in which J5 reversed the detrimental effect of quinclorac on leaf area, leaf number, and plant height. The J5 isolate also seemed to promote plant growth, in terms of tobacco seedling growth and seed germination, which were 2.2 times and 1.6 times higher compared to untreated control, resp. The mechanisms of plant growth promoting (PGP) traits were found to involve nitrogen-fixing, indole-3-acetic acid (IAA) production, and phosphate solubilization ability. In addition, proteomic anal. and relative quant. PCR revealed an elevated level of 4-hydroxyphenylacetate 3-monooxygenase (HPMO) in quinclorac-treated J5, suggesting that this enzyme may play an important role in quinclorac remediation. This study showed that the J5 isolate could be exploited to not only assist in soil remediation due to quinclorac residue issues but also promote tobacco growth.

World Journal of Microbiology & Biotechnology published new progress about Germination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thiel, Cora S.; Vahlensieck, Christian; Bradley, Timothy; Tauber, Svantje; Lehmann, Martin; Ullrich, Oliver published the artcile< Metabolic Dynamics in Short- and Long-Term Microgravity in Human Primary Macrophages>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is metabolomics microgravity hypergravity metabolite amino acids glucose ketoleucine rhamnose; immune cells; metabolomics; microgravity; sounding rocket; spaceflight.

Microgravity acts on cellular systems on several levels. Cells of the immune system especially react rapidly to changes in gravity. In this study, we performed a correlative metabolomics anal. on short-term and long-term microgravity effects on primary human macrophages. We could detect an increased amino acid concentration after five minutes of altered gravity, that was inverted after 11 days of microgravity. The amino acids that reacted the most to changes in gravity were tightly clustered. The observed effects indicated protein degradation processes in microgravity. Further, glucogenic and ketogenic amino acids were further degraded to Glucose and Ketoleucine. The latter is robustly accumulated in short-term and long-term microgravity but not in hypergravity. We detected highly dynamic and also robust adaptative metabolic changes in altered gravity. Metabolomic studies could contribute significantly to the understanding of gravity-induced integrative effects in human cells.

International Journal of Molecular Sciences published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Xiao; Huang, Pei Qiang; Ruan, Yuan Ping; Lee, Albert W. M.; Chan, Wing Hong published the artcile< A new asymmetric synthesis of (R)-3-methylpyrrolidine alkaloids starting from (S)-malic acid>, Formula: C6H10O5, the main research area is methylpyrrolidine alkaloid asym synthesis malate; pyrrolidine methyl alkaloid asym synthesis; leptothoracine synthesis.

Diastereoselective methylation of di-Me (S)-malate followed by two three-step reductive dehydroxylation procedures afforded di-Me (R)-2-methylsuccinate in 80.2% and 84.7% ee resp., the later was further transformed into the natural enantiomers of ant venom alkaloids (R)-leptothoracine (I) and (R)-3-methyl-N-(2-phenylethyl)pyrrolidine and (3R,2’S)-3-methyl-N-(2-methylbutyl)pyrrolidine.

Heterocycles published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation) (pyrrolidine). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondo, Toru published the artcile< Glioblastoma-initiating cell heterogeneity generated by the cell-of-origin, genetic/epigenetic mutation and microenvironment>, SDS of cas: 112-63-0, the main research area is review glioblastoma cell heterogeneity mutation microenvironment; Dihydroorotate dehydrogenase (DHODH); GBM-initiating cells (GICs); Glioblastoma (GBM); Heterogeneity; Temozolomide (TMZ).

A review. Glioblastoma (GBM) and other malignant tumors consist of heterogeneous cancer cells, including GBM-initiating cells (GICs). This heterogeneity is likely to arise from the following: different sets of genetic mutations and epigenetic modifications, which GICs gain in the transformation process; differences in cells of origin, such as stem cells, precursor cells or differentiated cells; and the cancer microenvironment, in which GICs communicate with neural cells, endothelial cells and immune cells. Furthermore, considering that various types of GICs can be generated at different time points of the transformation process, GBM very likely consists of heterogeneous GICs and their progeny. Because cancer cell heterogeneity is responsible for therapy resistance, it is crucial to develop methods of reducing such heterogeneity. Here, I summarize how GIC heterogeneity is generated in the transformation process and present how cell heterogeneity in cancer can be addressed based on recent findings.

Seminars in Cancer Biology published new progress about Genetics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wender, Paul A.; Staveness, Daryl published the artcile< Improved Protein Kinase C Affinity through Final Step Diversification of a Simplified Salicylate-Derived Bryostatin Analog Scaffold>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is protein kinase salicylate bryostatin analog scaffold.

Bryostatin 1, in clin. trials or preclin. development for cancer, Alzheimer’s disease, and a first-of-its-kind strategy for HIV/AIDS eradication, is neither readily available nor optimally suited for clin. use. In preceding work, we disclosed a new class of simplified bryostatin analogs designed for ease of access and tunable activity. Here we describe a final step diversification strategy that provides, in only 25 synthetic steps, simplified and tunable analogs with bryostatin-like PKC modulatory activities.

Organic Letters published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics