Category: esters-buliding-blocks

Kondratenko, N. V.; Matyushecheva, G. I.; Yagupol’skii, L. M. published the artcile< Halomethylbenzenes>, Application In Synthesis of 112-63-0, the main research area is halomethyl fluorobenzenes; fluorobenzenes halomethyl; inductive effect halomethyl substituents; conjugative effect halomethyl substituents.

19F NMR spectroscopy of m- and p-substituted fluorobenzenes was used to determine the inductive and conjugative effects of CH2X, CHX2, and CX3 groups (X = F, Cl, Br, I, SCF3). Almost no conjugative interaction was observed between these substituents and the aromatic nucleus. The inductive effect increased with increasing number of X in the substituent group, and was greatest for X = SCF3.

Zhurnal Organicheskoi Khimii published new progress about Conjugation (bond). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Poulsen, Thomas B.; Bell, Mark; Jorgensen, Karl Anker published the artcile< Organocatalytic asymmetric allylic carbon-carbon bond formation>, Synthetic Route of 112-63-0, the main research area is malononitrile cycloalkylidene enantioselective Michael addition nitroalkene cinchona alkaloid catalyst; allylic carbon bond formation asym organocatalytic.

Organocatalytic allylic C-C bond-forming addition of activated alkylidenes I [X = O, CH2, CH2CH2, R1 = H; X = CH2, R1 = 7-MeO, 6-MeO, 5,7-Me2, 6,7-(MeO)2] to alkyl and aryl nitroalkenes R2CH:CHNO2 (R2 = n-pentyl, cyclohexyl, Ph, 4-MeOC6H4, 2-naphthyl, 2-thienyl, etc.) has been achieved with high diastereo- and enantioselectivity. Chiral tertiary amine catalysts are used to give allyl intermediates which exhibit γ-selectivity in the C-C bond forming step. The reactions proceed with up to >99:1 syn:anti ratio for both the alkyl- and aryl nitroalkenes with up 96% and 98% ee, resp. The products II of this conjugate addition are transformed into a range of intermediates, such as optically active conjugated dienes and 1-substituted tetralones, which are difficult to access via alternative methods.

Organic & Biomolecular Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brouwer, T.; van Lin, R.; ten Kate, A. J. B.; Schuur, B.; Bargeman, G. published the artcile< Influence of Solvent and Acid Properties on the Relative Volatility and Separation Selectivity for Extractive Distillation of Close-Boiling Acids>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is selectivity extractive distillation mixture organic acid solvent volatility.

The increasing need for sustainable processes stimulates the production and recovery of renewable organic acids. The purification of these acids is often difficult because of similar acid volatilities but can be improved through extractive distillation Generic insights into solvent effects on the separation efficiency for close-boiling acids are however lacking. This study provides insights into the effect of acidity, the acidity difference between the acids, the hydrogen-bonding strength of the solvent, and the solvent-to-feed ratio on organic acid separation efficiency. For an acetic acid-formic acid (AA-FA) mixture, the addition of high-boiling organic acids increases the relative volatility of FA over AA significantly. The addition of a Lewis base reverses the relative volatility, which depends on the applied solvent-to-feed ratio and the Lewis base BF3 affinity. For several binary acid mixtures (such as AA-FA and monochloroacetic acid-dichloroacetic acid), where the acids have a relatively big difference in acidity (ΔpKa ≥ 1), the separation selectivity appears practically independent of the acid strength of the individual acids and increases with increasing BF3 affinity of the Lewis base. For acid mixtures with a lower ΔpKa, a lower separation selectivity is obtained, as observed for separation of the pivalic acid-butyric acid and valeric acid-2-Me butyric acid mixtures When one of the acids in the mixture contains a secondary ketone group (i.e., levulinic acid in a levulinic acid-octanoic acid mixture), the strongest acid based on pKa is not necessarily attracted most by the added Lewis base. This, at first sight, unexpected behavior is most likely the result of complex intra- and intermol. interactions and is quant. in line with COSMO-RS-based selectivity predictions.

Industrial & Engineering Chemistry Research published new progress about Acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ferreira de Lima, Nayana; de Andrade Picanco, Guaraciara; Costa, Tatiane Luiza; Vinaud, Marina Clare published the artcile< In vitro metabolic stress induced by nitazoxanide and flubendazole combination in Taenia crassiceps cysticerci>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Taenia crassiceps nitazoxanide flubendazole antiparasitic cysticercosis; Experimental cysticercosis; Flubendazole; Metabolism; Nitazoxanide.

Taenia crassiceps is often used as exptl. model for T. solium cysticercosis studies. Currently cysticercosis antiparasitic treatment is based on albendazole and praziquantel which may present side effects and parasitic resistance. The search for other antiparasitic drugs is necessary. Nitazoxanide (NTZ) and flubendazole (FLB) are broad spectrum antiparasitic drugs that present anti-cysticercosis effect. Metabolic analyses help to determine the impact of these drugs on parasites. The aim of this study was to determine the impact on the production and excretion of organic metabolites in T. crassiceps cysticerci after in vitro exposure to NTZ and FLB, isolated or in combination. T. crassiceps cysticerci were culture in RPMI medium and exposed to 10μg/mL of NTZ, 10μg/mL of FLB or 10μg/mL of NTZ +10μg/mL of FLB. 24 h after exposure, the parasites were chromatog. analyzed to determine the impact of these drugs on glycolysis, homolactic fermentation, tricarboxylic acid cycle, fatty acids oxidation and proteins catabolism. It was possible to determine that the drugs combination induced greater metabolic impact on cysticerci in comparison to the isolated drugs exposure. The drugs combination induced gluconeogenesis, metabolic acidosis, increase in tricarboxylic acid cycle and in proteins catabolism. While the NTZ isolated exposure induced metabolic acidosis and protein catabolism and the FLB isolate exposure induced gluconeogenesis and protein catabolism. These results show that the combination of drugs with different modes of action increase the antiparasitic effect and may be indicated as alternative cysticercosis treatments.

Experimental Parasitology published new progress about Cysticercosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Su, Huaigang; Zhao, Qin; Wang, Yanan; Zhao, Qilong; Cheng, Jang; Niu, Yongfang; Lou, Wenjing; Qi, Yanxing published the artcile< SnO nanoparticles on graphene oxide as an effective catalyst for synthesis of lubricating ester oils>, SDS of cas: 112-63-0, the main research area is tinoxide nanoparticle graphene oxide esterification lubricating ester oil.

In this paper, nanosized SnO was deposited on graphene oxide (GO) by adopting hydrothermal technique to fabricate a new composite material SnO@GO, which was characterized by TEM, BET, XPS, XRD and FE-SEM. The SnO@GO composite exhibits excellent catalytic performance for esterifying fatty acids and trimethylolpropane at stoichiometric ratio. The yield of resulting polyol esters could reach 99%. Addnl., the SnO@GO composition can be recycled for 6 cycles without obvious deactivation. The outstanding catalytic performance was attributed by the active Lewis acid of SnO and the increase of specifc surface area with the loading of SnO onto GO.

Catalysis Communications published new progress about Adsorption (isotherms). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hou, Wen; Wei, Bao; Liu, Hong Sheng published the artcile< The protective effect of Panax notoginseng mixture on hepatic ischemia/reperfusion injury in mice via regulating NR3C2, SRC, and GAPDH>, COA of Formula: C19H34O2, the main research area is Panax hepatic ischemia reperfusion injury NR3C2 SRC GAPDH; glyceraldehyde-3-phosphate dehydrogenase liver; hepatic ischemia/reperfusion injury; mineralocorticoid receptor; notoginseng mixture; tyrosine-protein kinase.

Panax notoginseng mixture (PNM) has the characteristics of multicomponent, multitarget, and multieffect, which can cope with the multidirectional and multidimensional complex pathol. process caused by hepatic ischemia/reperfusion injury (HIRI). Our animal experiments showed that PNM composed of notoginseng, dogwood, and white peony root could significantly reduce the level of aspartate transaminase and alanine aminotransferase in the blood of mice with HIRI, indicating that this preparation had a protective effect on HIRI in mice. Therefore, on this basis, the mol. mechanism of PNM intervention in HIRI was further explored by network pharmacol. First, target genes corresponding to active components and HIRI were obtained through databases such as TCMSP, Pharm Mapper, Swiss Target Prediction, GeneCards, and so on. All target genes were standardized by Uniprot database, and a total of 291 target genes with their intersection were obtained. Then, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and biol. processes (BPs) of 291 target genes were obtained through the online public platform of DAVID. A total of 177 KEGG pathways and 337 BPs were obtained by setting p < 0.01 and false discovery rate <0.05. The network mapping map of components and disease targets was drawn by Cytoscape, and the top 10 Hub target genes related to HIRI were obtained. At the same time, the String database was used to obtain the proteinaprotein interaction dataset, which was imported into Cytoscape, and the first 10 Hub target genes were obtained. The Hub target genes obtained by the above two methods were mol. docking with their corresponding small mol. compounds through DockThor online tool. The results showed that the docking of paeoniflorin with glyceraldehyde 3-phosphate dehydrogenase (GAPDH), paeoniflorin and loganin with SRC, ginsenoside Rb1 with NR3C2, ursolic acid and oleanolic acid with IL-6, paeoniflorin docking VEGFA, and MMP9. Finally, NR3C2, SRC, and GAPDH were identified as target genes in this study by referring to relevant literature reports. After verification by immunohistochem. experiments, compared with the sham group, the above three target genes were highly expressed in the HIRI group (p < 0.01). Compared with the HIRI group, the expression of three target genes in the PNM + HIRI group was significantly decreased (p < 0.01). The results showed that PNM could protect mouse HIRI by decreasing the expression of NR3C2, SRC, and GAPDH. Frontiers in Pharmacology published new progress about Adenosine A2A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Prathiba, S.; Vaishnavi, A.; Saranya, R.; Chandrasatheesh, C.; Jayapriya, J. published the artcile< Synthesis of hydroxyl ether based biolubricant from poultry waste and to evaluate the friction performance with titania nanoparticles>, Category: esters-buliding-blocks, the main research area is hydroxyl ether biolubricant poultry waste friction titania nanoparticle.

Low-cost chicken waste fat, with a high content of palmitic acid (saturated fatty acid) and oleic acid (unsaturated fatty acid) was used for biolubricant production The effects of different reaction parameters on the fat transesterification reaction using potassium hydroxide to form fatty acid Me esters were investigated. In this study, the Me esters from chicken waste fat were chem. modified to produce hydroxyl ethers (biolubricants) through epoxidation, followed by the ring-opening reaction of the epoxides with isoamyl alc. in the molar ratio of 3:1 (alc.:methyl esters) using the acid catalyst p-toluene sulfonic acid. The biolubricant obtained after the ring-opening of the Me epoxides exhibited higher oxidative stability (OS) (18 h) than that of the biodiesel (3.85 h). The viscosity index of the biolubricant was found to be 295.32. The tribol. performance of the biolubricant was enhanced by the addition of TiO2 (0.05% w/v). The biolubricant with 0.05% TiO2 led to a 25% reduction in friction coefficient and also enhanced the viscosity by 1.1-fold. Thus, TiO2 is suggested as a good antifriction property enhancer and viscosity modifier for the chicken waste lubricant. In summary, the chicken waste fat can be considered a feasible alternative to formulate biolubricants that match the physicochem. and low-temperature properties of com. hydraulic oils.

Chemical Engineering Research and Design published new progress about Alcohols Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Acemoglu, Murat; Allmendinger, Thomas; Calienni, John; Cercus, Jacques; Loiseleur, Olivier; Sedelmeier, Gottfried H.; Xu, David published the artcile< Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds>, Category: esters-buliding-blocks, the main research area is phenylacetic acid arylamino preparation; oxindole aryl preparation ring opening.

Various new N-aryl oxindoles I (R1 = Me, Et; R2 = 2-Cl-6-FC6H3, 2,3,6-F3C6H2, 2,6-Cl2-4-MeC6H2, etc.) were synthesized as intermediates for the preparation of pharmacol. active 2-(N-arylamino)phenylacetic acids II. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structures, in addition to Buchwald arylamination and Smiles rearrangement. Condensation of anilines with 2-oxo-cyclohexylidene-acetic acid derivatives and subsequent dehydrogenation is a new and viable method for the preparation of N-aryl oxindoles.

Tetrahedron published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Suryana, Shendi; Mutakin, Mutakin; Rosandi, Yudi; Hasanah, Aliya Nur published the artcile< Rational design of salmeterol xinafoate imprinted polymer through computational method: Functional monomer and crosslinker selection>, Category: esters-buliding-blocks, the main research area is salmeterol xinafoate imprinted polymer computational functional monomer crosslinker selection.

A mol. imprinted polymer (MIP) was computationally designed and synthesized for the selective extraction of salmeterol xinafoate (SLX) from human serum. In this study, semi-empirical PM3 calculations were used to find a suitable functional monomer (FM), the ratio of template (T) to FM, and types of crosslinkers. MIPs were synthesized with 2-hydroxyethyl methacrylate (HEMA) with T:FM mol ratios of 1:6 and 1:4 and ethylene glycol dimethacrylate (EGDMA) or trimethylolpropane trimethacrylate (TRIM) as a crosslinker. On the basis of computational and exptl. results, HEMA and TRIM in the mol ratio 1:6 of T-FM (MIP3) were found to be the best choices of FM and crosslinker, resp. These polymers were then used as a selective sorbent to develop a molecularly imprinted solid-phase extraction procedure followed by high performance liquid chromatog. with UV detection for the determination of SLX in serum. The extraction ability of MIP3 was excellent with a recovery of 92.17% ± 2.66% of SLX in spiked serum, and 91.15% ± 1.12% when SLX was spiked as a mixture with another analogous structure. By comparing the performance of the synthesized sorbent with a C-18 cartridge with a recovery of 79.11% ± 2.96%, it was determined that MIP had better performance over the latter. On the basis of these results, the imprinted receptor MIPs, especially MIP 3, can be applied for the direct extraction of SLX in clin. anal.

Polymers for Advanced Technologies published new progress about Adsorption. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bolscher, Jan G. M.; Brevoord, Judith; Nazmi, Kamran; Ju, Tongzhong; Veerman, Enno C. I.; van Wijk, Joanna A. E.; Cummings, Richard D.; van Die, Irma published the artcile< Solid-phase synthesis of a pentavalent GalNAc-containing glycopeptide (Tn antigen) representing the nephropathy-associated IgA hinge region>, Application In Synthesis of 112-63-0, the main research area is Tn antigen glycopeptide IgA nephropathy.

Incomplete or aberrant glycosylation leading to Tn antigen (GalNAcα1-Ser/Thr) expression on human glycoproteins is strongly associated with human pathol. conditions, including tumors, certain autoimmune diseases, such as the idiopathic IgA nephropathy, and may modulate immune homeostasis. In addition, the Tn antigen is highly expressed by certain pathogens and plays a role in host-pathogen interactions. To enable exptl. approaches to study interactions of the Tn antigen with the immune system and analyze anti-Tn antibody responses in infection or disorders, we generated a Tn-expressing resource that can be used for high-throughput screening. In consideration of IgA nephropathy in which the hinge region is incompletely glycosylated, we used this hinge sequence that encodes five potential glycosylation sites as the ideal template for the synthesis of a Tn antigen-expressing glycopeptide. Inclusion of an N-terminal biotin in the peptide enabled binding to streptavidin-coated ELISA plates as monitored using Helix pomatia agglutinin or anti-Tn monoclonal antibody. We also found that the biotinylated IgA-Tn peptide is a functional acceptor for β1-3-galactosylation using recombinant T-synthase (β1-3-galactosyltransferase). Besides its immunochem. functionality as a possible diagnostic tool for IgA nephropathy, the peptide is an excellent substrate for glycan elongation and represents a novel template applicable for glycan-antigen-associated diseases.

Carbohydrate Research published new progress about Agglutinins and Lectins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics