Category: esters-buliding-blocks

DNA base pair-specific ligands. I. Synthesis of distamycin A and its analogs with different numbers of N-methyl-and N-propylpyrrole residues was written by Grokhovskii, S. L.;Zhuze, A. L.;Gottikh, B. P.. And the article was included in Bioorganicheskaya Khimiya in 1975.Reference of 5930-92-7 This article mentions the following:

Distamycin A (I, R = Me) and its structural analogs I (R = Pr), II (R = Me, Pr), and III (R = Me, Pr) were obtained from Et 4-nitropyrrole-2-carboxylate by alkylation, saponification, chlorination, treatment with H2NCH2CH2CN, and hydrogenation. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Reference of 5930-92-7).

Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Reference of 5930-92-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of quaternary carbon-centered benzoindolizidinones via novel photoredox-catalyzed alkene aminoarylation: facile access to tylophorine and analogues was written by Zhang, Chao;Wang, Yi;Song, Yugang;Gao, Hongying;Sun, Yonghui;Sun, Xiuyun;Yang, Yiqing;He, Ming;Yang, Zimo;Zhan, Lingpeng;Yu, Zhi-Xiang;Rao, Yu. And the article was included in CCS Chemistry in 2019.Computed Properties of C6H12O2 This article mentions the following:

Photoredox-catalyzed aminoarylation and thioamination of unactivated alkenes was developed, providing novel synthetic routes to access synthetically challenging quaternary carbon-centered benzoindolizidinones and trifluoromethylthiolated piperidines using readily available starting materials. Notably, these transformations were enabled by merging amidyl radical generation from N-alkyl benzamides with oxidant incorporation. D. functional theory calculations were performed to understand the reaction mechanism and to rationalize the regioselectivities. Moreover, the newly developed catalytic aminoarylation provided a convenient synthetic route for natural product tylophorine and its gem-di-Me analogs with greatly improved drug-like properties such as enhanced solubility and stability. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Computed Properties of C6H12O2).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C6H12O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalytic, Cascade Ring-Opening Benzannulations of 2,3-Dihydrofuran O,O- and N,O-Acetals was written by Aponte-Guzman, Joel;Phun, Lien H.;Cavitt, Marchello A.;Taylor, J. Evans Jr.;Davy, Jack C.;France, Stefan. And the article was included in Chemistry – A European Journal in 2016.Application In Synthesis of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

An Al(OTf)₃-catalyzed intramol. cascade ring-opening benzannulation of 2,3-dihydrofuran O,O- and N,O-acetals was described. The cascade sequence involved the dihydrofuran ring-opening by acetal hydrolysis, an intramol. Prins-type cyclization, and aromatization to generate an array of benzo-fused (hetero)aromatic systems in up to 95 % yield. This method represented the first example of dihydrofuran acetal usage in benzannulation reactions. The approach provided excellent regiocontrol based on the choice of alkenes used to form the requisite dihydrofuran acetals. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Application In Synthesis of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Evaluation of chemicals of environmental concern in crumb rubber and water leachates from several types of synthetic turf football pitches was written by Celeiro, Maria;Armada, Daniel;Ratola, Nuno;Dagnac, Thierry;de Boer, Jacob;Llompart, Maria. And the article was included in Chemosphere in 2021.Electric Literature of C20H26O4 This article mentions the following:

Nowadays concern exists about the safety for both football players and the environment of recycled tire rubber used as infill in synthetic turf football pitches. In this study 40 target compounds, including polycyclic aromatic hydrocarbons (PAHs), plasticizers, antioxidants and vulcanization agents were determined in 50 synthetic football pitches of diverse characteristics to estimate environmental risks. This is the first study of crumb rubber sport facilities in Portugal. Analyses were performed by ultrasound-assisted extraction followed by gas chromatog.-tandem mass spectrometry (UAE-GC-MS/MS). To evaluate the transfer of the target chems. from the crumb rubber to the runoff water, water leachates collected from several football pitches were analyzed by solid-phase microextraction (SPME-GC-MS/MS). In addition, lab-scale runoff simulation experiments were performed to assess whether a persistent inflow of the target compounds from the football pitches into the runoff water wcould exist. Results revealed the presence of most of the target PAHs in crumb rubber at total concentrations up to 57μg g-1, next to a high number of plasticizers and vulcanization agents. Runoff water collected from the football pitches contained up to 13 PAHs as well as other chems. of environmental concern. In addition, continuous leaching of chems. from the crumb rubber to the surrounding water was demonstrated. The transfer of target chems. into the runoff water poses a potential risk for the aquatic environment. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Electric Literature of C20H26O4).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C20H26O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease was written by Harrison, Justin R.;Sarkar, Sandipan;Hampton, Shahienaz;Riley, Jennifer;Stojanovski, Laste;Sahlberg, Christer;Appelqvist, Pia;Erath, Jessey;Mathan, Vinodhini;Rodriguez, Ana;Kaiser, Marcel;Pacanowska, Dolores Gonzalez;Read, Kevin D.;Johansson, Nils Gunnar;Gilbert, Ian H.. And the article was included in Journal of Medicinal Chemistry in 2020.Product Details of 14667-47-1 This article mentions the following:

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments. In this work, we describe the optimization of a hit compound resulting from the phenotypic screen of a library of compounds against T. cruzi. The compound series was optimized to the level where it had satisfactory pharmacokinetics to allow an efficacy study in a mouse model of Chagas disease. We were able to demonstrate efficacy in this model, although further work is required to improve the potency and selectivity of this series. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Product Details of 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and antibacterial profiles of targeted triclosan derivatives was written by Howse, Gemma L.;Bovill, Richard A.;Stephens, Peter J.;Osborn, Helen M. I.. And the article was included in European Journal of Medicinal Chemistry in 2019.HPLC of Formula: 4163-60-4 This article mentions the following:

There is an ongoing urgent need for new targeted antibacterial compounds with novel mechanisms of action for the treatment of infections caused by bacteria that are resistant to currently available materials. Herein we report the synthesis and characterization of four α-D-glycopyranosides, e.g. I, and three β-D-glycopyranosides of the broad antibacterial agent triclosan, in generally good synthetic yields, and with excellent purity. Each triclosan glycoside was analyzed to determine its ability to inhibit the growth of a wide range of Gram-neg. and Gram-pos. organisms, including many of clin. significance. All of the triclosan glycosides that were synthesized demonstrated antibacterial activity against many of the organisms that were examined Two Bacillus strains could be identified from various strains of Bacillus and Staphylococcus after inoculation onto nutrient agar Number 2 with 0.25 μg/mL triclosan-α-D-glucopyranoside I. This glucoside may, therefore, be of use for the isolation and identification of the food-poisoning organism Bacillus cereus. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4HPLC of Formula: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characteristics of dust-phase phthalates in dormitory, classroom, and home and non-dietary exposure in Beijing, China was written by Qu, Meinan;Wang, Lixin;Liu, Fang;Zhao, Yi;Shi, Xiangzhao;Li, Sijia. And the article was included in Environmental Science and Pollution Research in 2021.Related Products of 84-61-7 This article mentions the following:

The phthalate concentrations in dust from undergraduate dormitories, classrooms, and homes in Beijing, China, were measured in Apr. 2017. We analyzed the characteristics of phthalates in dust from three environments. In addition, we estimated the daily intake of phthalates via three pathways using Monte Carlo simulations. The detection frequency of eight phthalates in dust ranges from 74.5 to 100%. Di (2-ethylhexyl) phthalate (DEHP), di-Bu phthalate (DnBP), and di-iso-Bu phthalate (DiBP) are the most abundant phthalates. The median proportion of DEHP in dust is the highest, ranging from 67.1 to 72.9%. The PMF results indicated that two, four, and three types of phthalate sources exist in home, dormitory, and classroom, resp. The differences in the phthalate concentrations between sunny and shaded rooms and urban and suburban classrooms are insignificant, whereas that between male and female dormitories is significant. The total daily intake of DEHP, DnBP, and DiBP ranges from 97.3 to 336 ng/ (kg·day). The oral intake for DEHP in classrooms and the dermal intake of DnBP and DiBP in homes are the highest. The carcinogenic risk of DEHP to university students is the highest in classrooms and the total carcinogenic risk of the three environments is 4.70 x 10^-6. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Related Products of 84-61-7).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 84-61-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and biological activities of amino acids functionalized α-GalCer analogues was written by Ma, Weiwei;Bi, Jingjing;Zhao, Chuanfang;Zhang, Zhiguo;Liu, Tongxin;Zhang, Guisheng. And the article was included in Bioorganic & Medicinal Chemistry in 2020.SDS of cas: 4163-60-4 This article mentions the following:

Invariant natural killer T-cells (iNKT-cells) are promising targets for manipulating the immune system, which can rapidly release a large amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipid antigens presented by CD1d. In this paper, we wish to report a novel series of α-GalCer analogs which were synthesized by incorporation of L-amino acid Me esters in the C-6′ position of glycolipid. The evaluation of these synthetic analogs for their capacities to stimulate iNKT-cells into producing Th1 and Th2 cytokines both in vitro and in vivo indicated that they were potent CD1d ligands and could stimulate murine spleen cells into a higher release of the Th1 cytokine IFN-γ in vitro. In vivo, Gly-α-GalCer (I) and Lys-α-GalCer (II) showed more Th1-biased responses than α-GalCer, especially II showed the highest selectivity for IFN-γ production (IFN-γ/IL-4 = 5.32) compared with I (IFN-γ/IL-4 = 2.5) in vivo. These novel α-GalCer analogs might be used as efficient X-ray crystallog. probes to reveal the relationship between glycolipids and CD1d proteins in α-GalCer/CD1d complexes and pave the way for developing new potent immunostimulating agents. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4SDS of cas: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.SDS of cas: 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Optical constants of organic insulators in the UV range extracted from reflection electron energy loss spectra was written by Yuryevna Ridzel, Olga;Kalbe, Henryk;Astasauskas, Vytautas;Kuksa, Pavel;Bellissimo, Alessandra;Werner, Wolfgang S. M.. And the article was included in Surface and Interface Analysis in 2022.Synthetic Route of C73H108O12 This article mentions the following:

Reflection electron energy loss spectroscopy (REELS) spectra were measured for seven insulating organic compounds (DNA, Irganox 1010, Kapton, polyethylene [PE], poly(Me methacrylate) [PMMA], polystyrene [PS] and polytetrafluoroethylene [PTFE]). Optical constants and energy band gaps were extracted from the measured REELS spectra after elimination of multiple electron scattering via a deconvolution and fitting the normalized single scattering energy loss spectra to Drude and Drude-Lindhard model dielec. functions, constrained by the Kramers-Kronig sum and f-sum rules. Satisfactory agreement is found for those optical constants for which literature data exists. For PTFE, the observed features in the optical data correspond to its electronic structure. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Synthetic Route of C73H108O12).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C73H108O12

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of lactic acid bacteria for improving the quality of reduced-salt dry fermented sausage: Texture, color, and flavor profiles was written by Hu, Yingying;Li, Yongjie;Li, Xiang-ao;Zhang, Hongwei;Chen, Qian;Kong, Baohua. And the article was included in LWT–Food Science and Technology in 2022.Application of 105-87-3 This article mentions the following:

The traditional dry sausage is highly appreciated in China because of its unique quality characteristics, but it contains high salt content. Hence, this study aimed to evaluate the effects of lactic acid bacteria (LAB) comprising Lactobacillus sakei (LS), Lactobacillus curvatus (LC), Lactobacillus plantarum (LP), and Weissella hellenica (WH) on the quality attributes of the reduced-salt dry fermented sausages. The results indicated that the LP sausage showed higher (P < 0.05) shear force value compared to the other sausages, while the LP, LC, and WH sausages had higher (P < 0.05) lightness values than the control sausages. Seventy-six volatile compounds were detected, and nine compounds were identified as the key differential volatile compounds among the sausages based on partial least squares discriminant anal. Clustering anal. of electronic nose results corresponded well to the volatile compound results. The sensory evaluation confirmed that the inoculation with LC and LP had a pos. impact on the aroma, color, and hardness attributes of the reduced-salt sausages. Besides, partial least squares regression anal. further indicated that L. curvatus and L. plantarum could be used as the potential starter cultures to manufacture reduced-salt dry fermented sausage having improved texture, color, and flavor. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Application of 105-87-3).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 105-87-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics