Category: esters-buliding-blocks

Song, Sirong; Ma, Dongbin; Xu, Lixia; Wang, Qiong; Liu, Lanxiang; Tong, Xiaoguang; Yan, Hua published the artcile< Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence>, Electric Literature of 112-63-0, the main research area is glioma stem cell quiescence telomere damage LIPUS singlet oxygen; Cancer; Cell biology; Medical device; Stem cells research.

Cancer stem cells, quiescent and drug resistant, have become a therapeutic target. Unlike high-intensity focused ultrasound directly killing tumor, low-intensity pulsed ultrasound (LIPUS), a new noninvasive phys. device, promotes pluripotent stem cell differentiation and is primarily applied in tissue engineering but rarely in oncotherapy. We explored the effect and mechanism of LIPUS on glioma stem cell (GSC) expulsion from quiescence. Here, we observed that LIPUS led to attenuated expression of GSC biomarkers, promoted GSC escape from G0 quiescence, and significantly weakened the Wnt and Hh pathways. Of note, LIPUS transferred sonomech. energy into cytochrome c and B5 proteins, which converted oxygen mols. into singlet oxygen, triggering telomere crisis. The in vivo and in vitro results confirmed that LIPUS enhanced the GSC sensitivity to temozolomide. These results demonstrated that LIPUS “”waked up”” GSCs to improve their sensitivity to chemotherapy, and importantly, we confirmed the direct targeted proteins of LIPUS in GSCs.

iScience published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anjali, Kaiprathu; Vijayan, Arya; Venkatesha, Naragalu J.; Sakthivel, Ayyamperumal published the artcile< Niobium based macromolecule preparation and its potential application in biomass derived levulinic acid esterification>, Electric Literature of 112-63-0, the main research area is preparation niobium carboxyphenylporphyrin complex levulinate esterification; levulinate esterification niobium carboxyphenylporphyrin complex catalyst; niobium macromol biomass levulinate esterification.

Niobium incorporated meso-tetra-(4-carboxyphenyl)-porphyrin (Nb-TCPP) was prepared for the first time and grafted through the axial position by the surface amine groups present on functionalized SBA-15 (SBA-AM). The synthesized TCPP ligand, Nb-TCPP complex, and the grafted Nb-TCPP-SBA-AM complex were thoroughly characterized by various anal. and spectroscopic techniques such as FTIR, UV-visible, DR UV-visible, CHN, 1H NMR, powder XRD, and N2 sorption studies. The catalytic activity of the homogeneous (Nb-TCPP) and the heterogenized (Nb-TCPP-SBA-AM) complex were explored for the esterification of levulinic acid. The studies revealed that Nb-TCPP and Nb-TCPP-SBA-AM showed comparatively good catalytic activity (74-80% conversion) for the esterification of levulinic acid using methanol under mild reaction conditions with the formation of Me levulinate and α-angelica lactone as the major products.

Inorganic Chemistry Communications published new progress about Esterification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sadd, Matthew; Agostini, Marco; Xiong, Shizhao; Matic, Aleksandar published the artcile< Polysulfide Speciation and Migration in Catholyte Lithium-Sulfur Cells>, Application of C19H34O2, the main research area is polysulfide speciation migration lithium sulfur battery catholyte; catholyte; lithium−sulfur (Li−S) battery; operando Raman spectroscopy; polysulfides; radical species.

Semi-liquid catholyte Lithium-Sulfur (Li-S) cells have shown to be a promising path to realize high energy d. energy storage devices. In general, Li-S cells rely on the conversion of elemental sulfur to soluble polysulfide species. In the case of catholyte cells, the active material is added through polysulfide species dissolved in the electrolyte. Herein, we use operando Raman spectroscopy to track the speciation and migration of polysulfides in the catholyte to shed light on the processes taking place. Combined with ex-situ surface and electrochem. anal. we show that the migration of polysulfides is central in order to maximize the performance in terms of capacity (active material utilization) as well as interphase stability on the Li-metal anode during cycling. More specifically we show that using a catholyte where the polysulfides have the dual roles of active material and conducting species, e. g. no traditional Li-salt (such as LiTFSI) is present, results in a higher mobility and faster migration of polysulfides. We also reveal how the formation of long chain polysulfides in the catholyte is delayed during charge as a result of rapid formation and migration of shorter chain species, beneficial for reaching higher capacities. However, the depletion of ionic species during the last stage of charge, due to the conversion to and precipitation of elemental sulfur on the cathode support, results in polarization of the cell before full conversion can be achieved.

ChemPhysChem published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Proto, Maria Chiara; Fiore, Donatella; Piscopo, Chiara; Laezza, Chiara; Bifulco, Maurizio; Gazzerro, Patrizia published the artcile< Modified adenosines sensitize glioblastoma cells to temozolomide by affecting DNA methyltransferases>, Category: esters-buliding-blocks, the main research area is glioblastoma adenosine temozolomide resistance DNA methyltransferase protein expression; DNA methyltransferases; Fbxw7; MGMT; N6-benzyladenosine; N6-isopentenyladenosine; chemoresistance; glioblastoma; temozolomide.

Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor, and due to its unique features, its management is certainly one of the most challenging ones among all cancers. N6-isopentenyladenosine (IPA) and its analog N6-benzyladenosine (N6-BA) are modified nucleosides endowed with potent antitumor activity on different types of human cancers, including GBM. Corroborating our previous finding, we demonstrated that IPA and N6-BA affect GBM cell line proliferation by modulating the expression of the F-box WD repeat domain-containing-7 (FBXW7), a tumor suppressor with a crucial role in the turnover of many proteins, such as SREBPs and Mcl1, involved in malignant progression and chemoresistance. Luciferase assay revealed that IPA-mediated upregulation of FBXW7 translates in transcriptional inactivation of its oncogenic substrates (Myc, NFkB, or HIF-1α). Moreover, downregulating MGMT expression, IPA strongly enhances the killing effect of temozolomide (TMZ), producing a favorable sensitizing effect starting from a concentration range much lower than TMZ EC50. Through DNA methyltransferase (DNMT) activity assay, anal. of the global DNA methylation, and the histone modification profiles, we demonstrated that the modified adenosines behave similar to 5-AZA-dC, known DNMT inhibitor. Overall, our results provide new perspectives for the first time, suggesting the modified adenosines as epigenetic tools able to improve chemo- and radiotherapy efficacy in glioblastoma and potentially other cancers.

Frontiers in Pharmacology published new progress about Acetylated histone H3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Roslan, Nurul Asmawati; Zainal Abidin, Sumaiya; Abdullah, Norhayati; Osazuwa, Osarieme Uyi; Abdul Rasid, Ruwaida; Yunus, Nursofia Mohd published the artcile< Esterification reaction of free fatty acid in used cooking oil using sulfonated hypercrosslinked exchange resin as catalyst>, Formula: C19H34O2, the main research area is fatty acid cooking oil esterification sulfonated hypercrosslinked exchange resin; esterification kinetics physicochem property.

The production of valuable fatty acid alkyl ester (FAAE) com. known as biodiesel from used cooking oil (UCO) as feedstock has recently gained global interest. To carry out this production process, an esterification reaction is necessary to minimize the amount of free fatty acid (FFA) in the UCO. The purpose of this research work is to evaluate the performance of the newly snythesized sulfonated hypercrosslinked exchange resin (SHER) for the esterification reaction. The catalyst was first synthesized and characterized using various physicochem. analyses (i.e. FTIR, surface morphol., N2 physisorption anal. and TGA and further subjected to the esterification reaction to determine the reaction kinetics. The esterification reaction was conducted at various catalyst loading (1-8 wt%), reaction temperatures (40-60°C), and methanol to oil molar ratios (6:1-24:1). From the characterization study, SHER was found to have high decomposition temperature (up to 398°C) and sp. surface area (836 m2 g-1). Addnl., SHER had the capability to accommodate high number of active sites which could benefit the esterification reaction. The highest FFA conversion of 97% was achieved at 5 wt% catalyst loading, 60°C of reaction temperature and 12:1 methanol to oil mole ratio in 2 h reaction time. Analyses of the spent catalyst revealed the presence of impurities residue on the SHER’s surface following the esterification reaction, and the catalyst pore remained evident even after several reusability cycles.

Chemical Engineering Research and Design published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hayashi, H.; Nakanishi, K.; Brandon, C.; Marmur, J. published the artcile< Structure and synthesis of dihydroxypentyluracil from bacteriophage SP-15 deoxyribonucleic acid>, Name: (S)-Dimethyl 2-hydroxysuccinate, the main research area is bacteriophage dihydroxypentyluracil; ribonucleic acid bacteriophage SP15.

(S)-(+)-5-(4′,5′-Dihydroxypentyl)uracil, a base which replaces thymine in bacteriophage SP-15 DNA was prepared starting from (S)-(-)-malic acid establishing the 4′ configuration as being (S). The optical purity (100%) of a synthetic intermediate PhCH:CH(CH2)2CH(OMTPA)CH2OMTPA [MTPA = (+)-MeOCH(CF3)CO] was checked by NMR.

Journal of the American Chemical Society published new progress about DNA Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Name: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yi, Chae S.; Zeczycki, Tonya N.; Guzei, Ilia A. published the artcile< Highly Cooperative Tetrametallic Ruthenium-μ-Oxo-μ-Hydroxo Catalyst for the Alcohol Oxidation Reaction>, Formula: C19H34O2, the main research area is ruthenium oxo hydroxo phosphine cluster preparation alc oxidation catalyst; crystal structure ruthenium hydroxo phosphine tetranuclear dinuclear cluster; alc oxidation transfer dehydrogenation catalyzed ruthenium tetranuclear cluster.

The tetrametallic Ru-oxo-hydroxo-hydride complex {[(PCy3)(CO)RuH]4(μ4-O)(μ3-OH)(μ2-OH)} (1) was synthesized in two steps from monomeric (PCy3)(CO)RuHCl (2). The tetrameric 1 is a highly effective catalyst for the transfer dehydrogenation of alcs. Complex 1 showed a different catalytic activity pattern toward primary and secondary benzyl alcs., as indicated by the Hammett correlation for the oxidation reaction of p-X-C6H4CH2OH (ρ = -0.45) and p-X-C6H4CH(OH)CH3 (ρ = +0.22) (X = OMe, CH3, H, Cl, CF3). Both a sigmoidal curve from the plot of initial rate vs. [PhCH(OH)CH3] (K0.5 = 0.34M; Hill coefficient, n = 4.2 ± 0.1) and the phosphine inhibition kinetics revealed the highly cooperative nature of the complex for the oxidation of secondary alcs. The crystal structure of the intermediate (PCy3)2(CO)RuH(μ-OH)(μ-H)(PCy3)(CO)RuH (3) is also reported.

Organometallics published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Yingnan; Zhang, Ke; Gao, Suyu; Wang, Guihua; Huang, Jian; Wang, Jinhui; Chen, Lixia published the artcile< Discovery of potent c-MET inhibitors with new scaffold having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine headgroups>, SDS of cas: 112-63-0, the main research area is quinazoline pyridine tetrahydro pyridothienopyrimidine headgroup cellular MET; MET inhibitor; cancer therapy; pyridine; quinazoline; tetrahydro-pyridothienopyrimidine.

Cellular mesenchymal-epithelial transition factor (c-MET) is closely linked to human malignancies, which makes it an important target for treatment of cancer. In this study, a series of 3-methoxy-N-phenylbenzamide derivatives, N-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl) benzamide derivatives and N1-(3-fluoro-4-methoxyphenyl)-N3-(4-fluorophenyl) malonamide derivatives were designed and synthesized, some of them were identified as c-MET inhibitors. Among these compounds with new scaffolds having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine head groups, compound 11c, 11i, 13b, 13h exhibited both potent inhibitory activities against c-MET and high anticancer activity against tested cancer cell lines in vitro. In addition, kinase selectivity assay further demonstrated that both 13b and 13h are potent and selective c-MET inhibitors. Mol. docking supported that they bound well to c-MET and VEGFR2, which demonstrates that they are potential c-MET RTK inhibitors for cancer therapy.

Molecules published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zifeng; Su, Hai; Sun, Pengfei; Bai, Panxing; Yang, Jixing; Li, Mengjie; Deng, Yunfeng; Liu, Yang; Geng, Yanhou; Xu, Yunhua published the artcile< A nitroaromatic cathode with an ultrahigh energy density based on six-electron reaction per nitro group for lithium batteries>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nitroarom cathode energy density electron reaction lithium battery; Li-organic battery; high energy density; nitroaromatic compound; organic electrode material; six-electron reduction.

Organic electrode materials have emerged as promising alternatives to conventional inorganic materials because of their structural diversity and environmental friendliness feature. However, their low energy densities, limited by the single-electron reaction per active group, have plagued the practical applications. Here, we report a nitroarom. cathode that performs a six-electron reaction per nitro group, drastically improving the specific capacity and energy d. compared with the organic electrodes based on single-electron reactions. Based on such a reaction mechanism, the organic cathode of 1,5-dinitronaphthalene demonstrates an ultrahigh specific capacity of 1,338 mAh·g-1 and energy d. of 3,273 Wh·kg-1, which surpass all existing organic cathodes. The reaction path was verified as a conversion from nitro to amino groups. Our findings open up a pathway, in terms of battery chem., for ultrahigh-energy-d. Li-organic batteries.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Haiwei; Yan, Rongwei; Cai, Chang; Chen, Xingfan; Zhao, Fenghua; Fan, Liangliang; Xu, Chunbao Charles; Yang, Weiran published the artcile< Hydrothermal liquefaction of Cd-enriched Amaranthus hypochondriacus L. in ethanol-water co-solvent: Focus on low-N bio-oil and heavy metal/metal-like distribution>, Electric Literature of 112-63-0, the main research area is hydrothermal liquefaction cadmium amaranthus hypochondriacus; ethanol water nitrogen bio oil heavy metal.

The high nitrogen content in bio-oil from protein-rich biomass will cause the possible pollution problems by NOX emissions during combustion. In this study, Cd-enriched Amaranthus hypochondriacus L. (AHL) was treated by hydrothermal liquefaction (HTL) in ethanol-water co-solvent aiming to reduce the nitrogen content of the bio-oil. Besides, aqueous phase recycling (APR) was applied to achieve a higher bio-oil yield. HTL in ethanol-water co-solvent with APR three times resulted in the maximum bio-oil yield (47.26%) and greatly reduced the nitrogenous compounds content of bio-oil. During the APR process, the increase of total nitrogen (TN) content in the aqueous phase indicated that organic-N in the organic phase transformed into NH+4 to the aqueous phase. Acetic acid (13.87-22.37 mg/mL) was dominated in the aqueous phase, leading to a low pH value (6.27-5.29), which could serve as the possible catalyst for the HTL process during APR that can be the reason for the higher bio-oil yield. After the HTL process, Cr, Cu, Cd and Pb remained mostly in bio-char while As was present largely in the aqueous phase. Thus, this study demonstrated that the APR for HTL process in ethanol-water co-solvent can be a hopeful method to dispose the high-protein biomass for improved bio-oil yield and quality.

Fuel published new progress about Alcohols Role: TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics