Category: esters-buliding-blocks

Kim, Juyeon; Byun, Jaewon; Han, Jeehoon published the artcile< Process integration and economics of gamma-valerolactone using a cellulose-derived ethyl levulinate intermediate and ethanol solvent>, Category: esters-buliding-blocks, the main research area is ethyl levulinate gamma valerolactone preparation.

This study combines two catalytic conversion strategies, cellulose to Et levulinate and subsequently to gamma-valerolactone, into an integrated process. The effect of integrating the cellulose-to-Et levulinate and Et levulinate-to-gamma-valerolactone processes on a com. scale is investigated to improve energy efficiency and economics by performing a process simulation study. The conversion strategies show a low energy efficiency of 6.8% using excess ethanol solvent to achieve high yields of Et levulinate and gamma-valerolactone; however, in the integrated process, 0.4% of the ethanol and 30.8% of the cellulose-to-Et levulinate heat requirements are supplied by the Et levulinate-to-gamma-valerolactone process. The min. selling price for the integrated process is estimated to be $5.63/kg gamma-valerolactone, which makes it an economically feasible option for gamma-valerolactone production Finally, we conducted a sensitivity anal. of key parameters (cellulose price, steam price, and ethanol price) highly depending on the min. selling price of gamma-valerolactone.

Energy (Oxford, United Kingdom) published new progress about Heat exchangers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Banaras, Saira; Javaid, Arshad; Khan, Iqra Haider published the artcile< Bioassays guided fractionation of Ageratum conyzoides extract for the identification of natural antifungal compounds against Macrophomina phaseolina>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is octadecanal heptadecanol chloroform extract Ageratum antifungal agent Macrophomina.

Macrophomina phaseolina (Tassi) Goid. is a soil-borne fungal pathogen causing diseases in more than 500 plant species. The present study aimed to identify possible antifungal constituents in different parts of billygoat-weed (Ageratum conyzoides L.) through bioassays guided fractionation for the control of M. phaseolina. Extracts of different parts of the weed were made in methanol and antifungal bioassays were conducted using 1, 2, 3, 4 and 5% concentrations of the extract Stem extract caused the highest inhibition in fungal biomass (20-83%) followed by leaf extract (16-67%). Methanolic stem extract was partitioned using four organic solvents namely n-hexane, chloroform, Et acetate and n-butanol. Bioassays carried out with different concentrations (3.125, 6.25, 12.5, 25, 50, 100 and 200 mg mL-1) of the sub-fractions of stem extract revealed the highest antifungal potential of chloroform sub-fraction with 56-93% reduction in the fungal biomass followed by n-butanol, Et acetate and n-hexane sub-fractions causing 24-76%, 7-75% and 5-70% reduction in fungal biomass over control, resp. Chloroform sub-fraction with the highest antifungal potential was analyzed by GC-MS. Out of 10 compounds identified in this sub-fraction, 2H-1-benzopyran, 7-dimethoxy-2,2-dimethyl- (27.58%) was the most abundant followed by hexadecanoic acid, Me ester (18.85%); 11-octadecenoic acid, Me ester (15.28%) and 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) ester (10.88%), which could be responsible for antifungal activity.

International Journal of Agriculture and Biology published new progress about Ageratum conyzoides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Jinsong; Chen, Ying; Yang, Chao; Liu, Ting; Wang, Mingping; Xu, Haojie; Zhang, Ling; Zheng, Canhui; Song, Yunlong; Zhu, Ju published the artcile< Structure-based optimization leads to the discovery of NSC765844, a highly potent, less toxic and orally efficacious dual PI3K/mTOR inhibitor>, SDS of cas: 112-63-0, the main research area is dual PI3K mTOR inhibitor preparation cancer NSC 765844; Anticancer; Dual inhibitors; Mammalian target of rapamycin (mTOR); Phosphoinositide 3-kinase (PI3K).

The phosphoinositide 3-kinase (PI3K) family is one of the most frequently activated enzymes in a wide range of human cancers; thus, inhibition of PI3K represents a promising strategy for cancer therapy. Herein, a series of benzylamine substituted arylsulfonamides were designed and synthesized as dual PI3K/mTOR inhibitors using a strategy integrating focused library design and virtual screening, resulting in the discovery of 13b (NSC765844). The compound 13b exhibits highly potent enzyme inhibition with IC50s of 1.3, 1.8, 1.5, 3.8 and 3.8 nM for PI3Kα, β, γ, δ, and mTOR, resp. 13b was further evaluated in NCI by an in vitro cytotoxic screening program. Broad-spectrum antitumor activities with mean GI50 value of 18.6 nM against approx. 60 human tumor cell lines were found. 13b displayed favorable physicochem. properties and superior pharmacokinetic profiles for animal studies. It significantly inhibited tumor growth when administered orally in an A549 non-small-cell lung carcinoma xenograft and BEL7404 human hepatocellular carcinoma xenograft models. On the basis of its excellent in vivo efficacy and superior pharmacokinetic profiles, 13b has been selected for further preclin. investigation as a promising anticancer drug candidate.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Hui-Li; Xie, Ming-Sheng; Qu, Gui-Rong; Guo, Hai-Ming published the artcile< Organocatalytic Enantioselective Allylic Etherification of Morita-Baylis-Hillman Carbonates and Silanols>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is organocatalytic enantioselective allylic etherification MBH carbonate silanol; siloxy alkenylcarbonate preparation; crystal structure siloxyalkenylcarbonate; mol structure siloxyalkenylcarbonate.

The organocatalytic asym. allylic etherification reaction of Morita-Baylis-Hillman carbonates and silanols is reported for the 1st time. With modified cinchona alkaloid (DHQD)2PYR as the catalyst, aromatic, heterocyclic, or aliphatic Morita-Baylis-Hillman carbonates (25 examples) worked well with triphenylsilanol, affording the corresponding products in moderate to good yields (up to 98%), high regioselectivities (>20:1), and good enantioselectivities (up to 92%). When dimethylphenylsilanol was used as the nucleophile, the product was obtained in 60% yield and 87% ee.

Journal of Organic Chemistry published new progress about Carbonates Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hoffman, Robert V.; Kim, Hwa Ok published the artcile< The preparation of 2-hydrazinyl esters in high optical purity from 2-sulfonyloxy esters>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydrazine ester enantiospecific; sulfonyloxy hydrazine ester enantiospecific.

Chiral 2-triflyloxy esters, prepared from chiral 2-hydroxy esters, react enantiospecifically with BocNHNH2 to produce optically pure 2-hydrazinyl ester derivatives in high yields. The reaction of 2-nosyloxy esters with BocNHNH2 gives 2-(Boc-hydrazinyl) esters, thus providing an efficient (albeit slow) method for the conversion of esters to 2-hydrazinyl ester derivatives

Tetrahedron Letters published new progress about Carboxylic esters Role: SPN (Synthetic Preparation), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Molle, Edgar; Frech, Stefan; Grueger, Tilman; Theato, Patrick published the artcile< Electrochemically-initiated polymerization of reactive monomers via 4-fluorobenzenediazonium salts>, Safety of Perfluorophenyl acrylate, the main research area is electrochem polymerization reactive monomer fluorobenzenediazonium salt.

The straightforward electrochem.-initiated radical polymerization of three reactive monomers, i.e. 2,6-difluorophenyl acrylate (DFPA), pentafluorophenyl acrylate (PFPA), and glycidyl methacrylate (GMA), using a simple com. available electrochem. setup for the generation of initiating radical species from 4-fluorobenzenediazonium tetrafluoroborate upon electrochem. cathodic reduction is reported. The use of a fluorine-labeled initiator allowed for the determination of number-average molar masses Mn of fluorine-containing polymers by 19F NMR spectroscopy in addition to size-exclusion chromatog. The obtained polymers were thereafter successfully subjected to post-polymerization modifications in order to emphasize the applicability of this polymerization method in regard to highly reactive monomers.

Polymer Chemistry published new progress about Acrylic polymers, fluorine-containing Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Safety of Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Yune Sung; Kim, Jeong Soo; Sun, Genlin; Cheong, Won Jo published the artcile< Development of a New Solid Phase Extraction Cartridge Filled with Organic Monolith Particles for Extraction of di-Alkyl Phthalates>, Electric Literature of 3290-92-4, the main research area is dialkyl phthalate monolith particle phase extraction.

In this study, a new soft organic monolith was prepared by polymerization of Me methacrylate (MMA) and trimethylpropane trimetharylate (TPTM) to provide good affinity toward the analytes (di-alkyl phthalates) in SPE.

Bulletin of the Korean Chemical Society published new progress about Monolithic materials. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Electric Literature of 3290-92-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Rui; Wang, Sihui; Liu, Qing; Xie, Kaili; Xu, Yongsong; Shi, Jinli; Wang, Zhimin; Gong, Muxin published the artcile< Liquiritin enhancing intestinal absorption of paeoniflorin in in situ single-pass intestinal perfusion and in vitro Caco-2 cell monolayer absorption models>, Application In Synthesis of 112-63-0, the main research area is colorectal adenocarcinoma paeoniflorin liquiritin intestinal absorption pharmacokinetics.

In this study, we aimed to determine the interaction of paeoniflorin and liquiritin during intestinal absorption. Interaction between paeoniflorin and liquiritin (100 μM) was studied using in situ single-pass intestinal perfusion (SPIP) model use the whole small intestine and in vitro Caco-2 cell monolayer bidirectional transport model. In situ SPIP research demonstrated that liquiritin significantly increased the Ka, Papp, absorption rate, and cumulative amount of paeoniflorin up to 7.97, 8.98, 7.07, and 10.71 folds, resp., even higher than that of verapamil, a specific P-gp inhibitor, and control. Furthermore, 18 β-glycyrrhetinic acid (18 β-GA) markedly increased the Ka, Papp, absorption rate, and cumulative amount of paeoniflorin up to 3.30, 3.27, 3.42, and 4.04 folds, resp. Bidirectional transport studies indicated that liquiritin and paeoniflorin could prompt the absorption of each other by increasing the Papp (AP-BL) of paeoniflorin and liquiritin from (3.83 ± 0.51) x 10-7 to (5.60 ± 0.51) x 10-7 cm/s and (3.86 ± 0.34) x 10-7 to (8.26 ± 0.51) x 10-7 cm/s, resp. The 18 β-GA significantly prompted the Papp (AP-BL) of paeoniflorin to (5.54 ± 0.92) x 10-7 cm/s. Liquiritin and paeoniflorin increased the absorption of each other. This could provide essential reference to predict the oral bioavailability, the pharmacokinetics, and the clin. application of coadministration of liquiritin-and paeoniflorin-containing SGT and other herbal formulas.

Pharmacognosy Magazine published new progress about Colorectal adenocarcinoma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fernandes, Keysson V.; Cavalcanti, Elisa D. C.; Cipolatti, Eliane P.; Aguieiras, Erika C. G.; Pinto, Martina C. C.; Tavares, Fernanda A.; da Silva, Priscila R.; Fernandez-Lafuente, Roberto; Arana-Pena, Sara; Pinto, Jose Carlos; Assuncao, Charles L. B.; da Silva, Jose Andre C.; Freire, Denise M. G. published the artcile< Enzymatic synthesis of biolubricants from by-product of soybean oil processing catalyzed by different biocatalysts of Candida rugosa lipase>, COA of Formula: C19H34O2, the main research area is lipase synthesis biolubricant soybean oil distillate.

The present work studied the synthesis of biolubricants from byproducts of soybean oil processing using the lipase from Candida rugosa (CRL) both in free and immobilized forms, as biocatalysts. Soybean fatty acid distillate (SFAD) was used for first time as source of free fatty acids (FFA) to produce biolubricants via their enzymic esterification with neopentyl glycol (NPG) and trimethylolpropane (TMP) alcs. in a solvent-free medium. The immobilization of CRL was performed via interfacial activation using a com. hydrophobic support (Accurel) and a home-made core-shell matrix of poly(Me methacrylate) (PMMA). Conversions of about 80% were obtained using lyophilized CRL after 30 or 180 min using NPG and TMP, resp. When CRL-PMMA/PMMA was used to catalyze the synthesis of NPG esters, 90% conversion was achieved after only 6 h, while CRL-Accurel were more active using TMP. The biocatalysts maintained the reaction conversion during eight batches of 24 h. The lubricant properties of the products were also characterized, showing that it can be an environmentally friendly alternative for petrol lubricants.

Catalysis Today published new progress about Enzymic esterification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Pengyun; Ma, Songqi; Wang, Binbo; Xu, Xiwei; Feng, Hongzhi; Yu, Zhen; Yu, Tao; Liu, Yanlin; Zhu, Jin published the artcile< Degradable benzyl cyclic acetal epoxy monomers with low viscosity: Synthesis, structure-property relationships, application in recyclable carbon fiber composite>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is benzyl cyclic acetal epoxy carbon fiber composite degradable thermoset; thermal optical mech property vacuum assisted resin transfer molding.

Degradable thermosets can address the recycle issue of conventional thermosets and downstream materials like carbon fiber composites. Significant advances have been achieved on their recyclability even on high performance, but their processability was neglected. Herein, for the first time, from the processing point of view, degradable epoxy monomers with low viscosity were designed. Et or Me group was incorporated into the benzyl cyclic acetal structure to obtain three acetal epoxy monomers by the acetalization between p-hydroxybenzaldehyde analogs and triols to achieve diols, followed by reacting with epichlorohydrin. Two benzyl cyclic acetal epoxy monomers with Et group are liquid The viscosity and structure-property relationship of epoxy monomers were systematically investigated from experiments to simulate computation. The cured epoxies possessed favorable thermal properties, mech. properties and controllable degradability. Furthermore, the epoxy monomer with suitable viscosity was used to prepare carbon fiber composites with excellent performance via vacuum assisted resin transfer molding (VARTM) process. Meanwhile, the non-destructive recovery of carbon fiber was realized by taking advantage of the degradability of the acetal epoxy matrix.

Composites Science and Technology published new progress about Biodegradability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics