Category: esters-buliding-blocks

Gidik, Betul published the artcile< Antioxidant, Antimicrobial Activities and Fatty Acid Compositions of Wild Berberis spp. by Different Techniques Combined with Chemometrics (PCA and HCA)>, Product Details of C19H34O2, the main research area is berberis medicinal plant ferric reducing antioxidant phenolic flavonoid content; HCA; PCA; bioactivity; industrial crops; medicinal plants; wild fruits.

Interest in medicinal plants and fruits has increased in recent years due to people beginning to consume natural foods. This study aims to investigate the total phenolic flavonoid content, antioxidant activity, condensed tannin content, oil content, and fatty acid compositions of five local breeds of Berberis spp. from Bayburt, Turkey, and their antioxidant and antimicrobial activities. The fatty acid composition of samples was performed with gas chromatog.-mass spectrometry (GC-MS), and the total fatty acid content of samples was between 6.12% and 8.60%. The main fatty acids in Berberis spp. samples were α-linolenic acid (32.85-37.88%) and linoleic acid (30.98-34.28%) followed by oleic acid (12.85-19.56%). Two antioxidant assays produced similar results, demonstrating that extracts of wild B. vulgaris L. had the highest ferric reducing antioxidant power (FRAP) (621.02μmol FeSO4.7H2O/g) and 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) (0.10 SC50 mg/mL) values. According to principal component anal. (PCA), four components were determined In addition, two main groups were determined according to hierarchical cluster anal. (HCA), and wild and culture of B. vulgaris L. were in different subgroups. This is the first original report about the fatty acid composition and oil content of Berberis spp. grown in Bayburt, Turkey. The obtained results indicate that B. integerrima Bunge and B. vulgaris, which have especially remarkable fatty acid content, antioxidant, and antimicrobial activity, could be potential sources for these properties in different areas of use.

Molecules published new progress about Antimalarials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Bin; Wang, Yanling; Liang, Lei published the artcile< Preparation and performance of supercritical carbon dioxide thickener>, Application of C18H26O6, the main research area is supercritical carbon dioxide thickener preparation; core damage; greenhouse effect; molecular simulation; supercritical carbon dioxide; thickener.

The low sand-carrying problem caused by the low viscosity of supercritical carbon dioxide (SC-CO2) limits the development of supercritical CO2 fracturing technol. In this study, a mol. simulation method was used to design a fluorine-free solvent-free SC-CO2 thickener 1,3,5,7-tetramethylcyclotetrasiloxane (HBD). Simulations and experiments mutually confirm that HBD-1 and HBD-2 have excellent solubility in SC-CO2. The apparent viscosity of SC-CO2 after thickening was evaluated with a self-designed and assembled capillary viscometer. The results show that when the concentration of HBD-2 is 5 weight% (305.15 K, 10 MPa), the viscosity of SC-CO2 increases to 4.48 mPa. Combined with the capillary viscometer and core displacement device, the low damage of SC-CO2 fracturing fluid to the formation was studied. This work solves the pollution problems of fluoropolymers and co-solvents to organisms and the environment and provides new ideas for the mol. design and research of SC-CO2 thickeners.

Polymers (Basel, Switzerland) published new progress about Cloud point. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Application of C18H26O6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhi-Wen; Liu, Yan-Qiu; Zhu, Yu-Chao; Wu, Jie-Ying published the artcile< 4-(4-Nitrostyryl)-N,N-diphenylaniline>, Formula: C19H34O2, the main research area is crystal structure Nitrostyryldiphenylaniline; mol structure hydrogen bond Nitrostyryldiphenylaniline.

In the triarylamine group of the title compound, C26H20N2O2, the N atom adopts an approx. trigonal-planar geometry, lying 0.046 (5) Å from the plane P defined by its three neighboring C atoms; the benzene and two terminal Ph rings are twisted by 37.4(1), 31.4(1) and 47.8(1)°, resp. from plane P. In the trans-stilbene fragment, the two benzene rings form a dihedral angle of 31.3 (1)°. In the crystal, weak intermol. C-H···O interactions link the mols. into ribbons in [100]. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Fang-Fang; Ma, Jian-Fang; Song, Shu-Yan; Yang, Jin; Liu, Ying-Ying; Su, Zhong-Min published the artcile< Influence of Neutral Ligands on the Structures of Silver(I) Sulfonates>, Electric Literature of 112-63-0, the main research area is silver sulfonate pyrazine picoline hexamethylenetetramine complex preparation structure; crystal structure silver sulfonate pyrazine picoline hexamethylenetetramine complex.

This article represents a systematical examination of the structures of Ag(I) sulfonates incorporating neutral ligands. To survey the influence of the properties of neutral ligands on the structures of Ag(I) sulfonates, three kinds of sulfonate anions (L1 = 1-naphthalenesulfonate, L2 = p-toluenesulfonate, and L3 = 1,3,6,8-pyrenetetrasulfonate) and three kinds of neutral ligands (pyrazine, Pyr, a divergent bidentate ligand; hexamethylenetetramine, hmt, a divergent tetradentate ligand; and β-picoline, Pic, a monodentate ligand) were selected for study, and five novel Ag(I) sulfonates containing neutral ligands were synthesized: [Ag(L1)(Pyr)]·H2O (1), Ag(L2)(Pyr) (2), Ag4(L3)(Pyr)4(H2O)2 (3), [Ag(L1)(hmt)]·H2O (4), and Ag(L1)(Pic)2 (5). The crystal structures were determined by single-crystal x-ray diffraction, and these compounds show a variety of structures with different dimensionalities. Also, the luminescent properties of compounds 2, 4 and 5 are also discussed.

Inorganic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nasrin, Suaad; Islam, Mohammad Nazmul; Tayab, Mohammed Abu; Nasrin, Mst. Samima; Siddique, Abu Bakar Md.; Emran, Talha Bin; Reza, A. S. M. Ali published the artcile< Chemical profiles and pharmacological insights of Anisomeles indica Kuntze: An experimental chemico-biological interaction>, Reference of 112-63-0, the main research area is Anisomeles human blood diarrhea phytochem antidepressive antidiarrheal thrombolytic antiinflammatory; Anisomeles indica; Anti-depression; Anti-inflammatory; Antidiarrheal; MeOH-AI; Thrombolytic.

Anisomeles indica (L.) Kuntze is an ethnomedicinally important plant that has long been used in traditional medicine to treat a variety of ailments, including dyspepsia, abdominal pain, colic, allergies, inflammation, and rheumatic arthritis. However, the scientific framework underlying these medicinal properties is not well known. This study aimed to investigate the antidepressive, antidiarrheal, thrombolytic, and anti-inflammatory potential of a methanol extract of A. indica (MeOH-AI). The potential bioactive compounds in the MeOH-AI were identified using gas chromatog.-mass spectrometry (GC-MS), and antidepressant activities were evaluated using the tail suspension test (TST) and forced swim test (FST). Antidiarrheal effects were also assayed in castor oil-induced diarrhea and gastrointestinal motility studies. The anti-inflammatory activities were explored by examining the effects on protein inhibition and denaturation in heat- and hypotonic solution-induced hemolysis assays. The thrombolytic activity was evaluated using the clot lysis test in human blood. BIOVIA and Schrodinger Maestro (v11.1) were applied for docking anal. to determine binding interactions, and the absorption, distribution, metabolisms, excretion/toxicity (ADME/T) properties of bioactive compounds were explored using a web-based method. The GC-MS anal. of MeOH-AI revealed the presence of several bioactive compounds MeOH-AI administration resulted in significant (p < 0.01) reductions in the immobility times for both the FST and TST compared with those in the control group. MeOH-AI also induced significant (p < 0.01) reductions in castor oil-induced diarrhea severity and gastrointestinal motility in a mouse model. In addition, the in vitro anti-inflammatory and thrombolytic activity studies produced remarkable responses. The binding assay showed that 4-dehydroxy-N-(4,5-methylenedioxy-2-nitrobenzylidene) tyramine interacts favorably with monoamine oxidase and serotonin and M3 muscarinic acetylcholine receptors, displaying good pharmacokinetic properties, which may mediate the effects of MeOH-AI on depression and diarrhea. Overall, the research findings indicated that MeOH-AI has significant antidepressant, antidiarrheal, and anti-inflammatory effects and may represent an alternative source of novel therapeutic factors. Biomedicine & Pharmacotherapy published new progress about 5-HT3 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Campolo, Michela; Casili, Giovanna; Lanza, Marika; Filippone, Alessia; Paterniti, Irene; Cuzzocrea, Salvatore; Esposito, Emanuela published the artcile< Multiple mechanisms of dimethyl fumarate in amyloid β-induced neurotoxicity in human neuronal cells>, Electric Literature of 112-63-0, the main research area is dimethyl fumarate neuroprotectant neurotoxicity Alzheimer disease; Alzheimer’s disease; Nf-kB; Nrf2; dimethyl fumarate; oxidative stress; tau hyper-phosphorylation.

Alzheimer disease (AD) is characterized by a complex heterogeneity of pathol. changes, and any therapeutic approach categorically requires a multi-targeted way. It has been demonstrated that together with the hallmarks of the disease such as neurofibrillary tangles and senile plaques, oxidative and inflammatory stress covered an important role. Di-Me fumarate (DMF) is an orally bioavailable Me ester of fumaric acid and activator of Nrf2 with potential neuroprotective and immunomodulating activities. Therefore, the aim of the present work was to evaluate the potential beneficial effects of DMF, compared with its active metabolite monomethyl fumarate (MMF) (both at 30μM) in an in vitro Alzheimer’s model using SH-SY5Y human neuroblastoma cell lines stimulated with amyloid-beta (Aβ). Moreover, the effect of DMF, compared with MMF, was evaluate by an ex vivo model using organotypic hippocampal slice cultures stimulated with Aβ1-42 (1μg/mL), to better understand its action in a pathol. setting. In both models, DMF pre-treatment (30μM) preserved cellular viability from Aβ stimulation, reducing tau hyper-phosphorylation, much more efficiently then MMF (30μM). Moreover, DMF was able to induce an activation of manganese superoxide dismutase (MnSOD) and heme-oxygenase-1 (HO-1), decreasing the severity of oxidative stress. Our results showed important multi-protective effects of DMF pre-treatment from Aβ stimulation both in in vitro and ex vivo models, highlighting an Nrf2/NF-κB-dependent mechanism, which could provide a valuable support to the therapies for neurodegenerative diseases today.

Journal of Cellular and Molecular Medicine published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jin, Tianyun; Shen, Tao; Zhou, Mingxing; Li, Ailing; Feng, Da; Zheng, Bolun; Gong, Jie; Sun, Jiawei; Li, Lingyu; Xiang, Lan published the artcile< Chemical constituents from Portulaca oleracea and their bioactivities>, Formula: C6H10O5, the main research area is Portulaca organic acid antiinflammation.

In the present study, we aimed to intensively study the chem. constituents, especially organic acids from a medicinal plant Portulaca oleracea L., and screen their anti-inflammatory and quinone reductase (QR, a phase II detoxyfication enzyme) inductive activity. A total of 20 compounds were isolated and identified based on spectroscopic methods, as succinic acid (1), mono-Me succinate (2), L-malic acid (3), L-1-Me malate (4), L-4-Me malate (5), L-dimethyl malate (6), L-6-Et citrate (7), L-1-Me citrate (8), L-1,5-dimethyl citrate (9), 4-hydroxy-5-methylfuran-3-carboxylic acid (10), 5-hydroxymethyl-furoic acid (11), stearic acid (12), L-pyroglutamic acid (13), cyclo-(tyrosine-leucine) (14), L-isoleucine (15), (-)-dehydrovomifoliol (16), (-)-epiloliolide (17), 3,4-dihydroxyphenylethanol (18), succinimide (19), and uracil (20). Among them, 14 compounds (2, 4-8, 10, 11, 13-18) were isolated from P. oleracea for the first time. Compound 18 (12.5 μM) exhibited potent anti-inflammatory effect in lipopolysaccharide (LPS)-induced macrophage cells (RAW264.7) by reducing NO production, and it also increased QR activity in Hepa lclc7 cells. Compound 16 (50 μM) showed weak QR inductive activity. None of other compounds showed anti-inflammatory or QR inductive activities.

Journal of Chinese Pharmaceutical Sciences published new progress about Portulaca oleracea. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Scherschinski, Lea; Prem, Markus; Kremenetskaia, Irina; Tinhofer, Ingeborg; Vajkoczy, Peter; Karbe, Anna-Gila; Onken, Julia Sophie published the artcile< Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma>, Related Products of 112-63-0, the main research area is glioblastoma receptor tyrosine kinase temozolomide radiation; R428; RTK-AXL; glioblastoma multiforme; post-translational receptor modification; radiation; temozolomide; tyrosine kinase inhibitor (TKI).

The receptor tyrosine kinase AXL (RTK-AXL) is implicated in therapy resistance and tumor progression in glioblastoma multiforme (GBM). Here, we investigated therapy-induced receptor modifications and how endogenous RTK-AXL expression and RTK-AXL inhibition contribute to therapy resistance in GBM. GBM cell lines U118MG and SF126 were exposed to temozolomide (TMZ) and radiation (RTX). Receptor modifications in response to therapy were investigated on protein and mRNA levels. TMZ-resistant and RTK-AXL overexpressing cell lines were exposed to increasing doses of TMZ and RTX, with and without RTK-AXL tyrosine kinase inhibitor (TKI). Colorimetric microtiter (MTT) assay and colony formation assay (CFA) were used to assess cell viability. Results showed that the RTK-AXL shedding product, C-terminal AXL (CT-AXL), rises in response to repeated TMZ doses and under hypoxia, acts as a surrogate marker for radio-resistance. Endogenous RTX-AXL overexpression leads to therapy resistance, whereas combination therapy of TZM and RTX with TKI R428 significantly increases therapeutic effects. This data proves the role of RTK-AXL in acquired and intrinsic therapy resistance. By demonstrating that therapy resistance may be overcome by combining AXL TKI with standard treatments, we have provided a rationale for future study designs investigating AXL TKIs in GBM.

International Journal of Molecular Sciences published new progress about Animal cell line (SF126). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia-Gallego, Sandra; Andren, Oliver C. J.; Malkoch, Michael published the artcile< Accelerated Chemoselective Reactions to Sequence-Controlled Heterolayered Dendrimers>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is sequence controlled heterolayered dendrimer synthesis chemoselective reaction.

Chemoselective reactions are a highly desirable approach to generate well-defined functional macromols. Their extraordinary efficiency and selectivity enable the development of flawless structures, such as dendrimers, with unprecedented structure-to-property capacity but with typically tedious synthetic protocols. Here we demonstrate the potency of chemoselective reactions to accomplish sequence-controlled heterolayered dendrimers. An accurate accelerated design of bis-MPA monomers with orthogonally complementary moieties and a wisely selected chem. toolbox generated highly complex monodisperse dendrimers through simplified protocols. The versatility of the strategy was proved by obtaining different dendritic families with different properties after altering the order of addition of the monomers. Moreover, we evaluated the feasibility of the one-pot approach toward these heterolayered dendrimers as proof-of-concept.

Journal of the American Chemical Society published new progress about 1,3-Dipolar cycloaddition reaction (CuAAC). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Borah, Ruli; Sarma, Jadab C. published the artcile< Behavior of α-carbethoxy radical generated from the ester of N-hydroxy-2-thiopyridone>, Application of C19H34O2, the main research area is carbethoxy radical reaction mechanism; photolysis ester hydroxythiopyridone; Barton ester photolysis.

Studies on the behavior of α-carbethoxy radical generated from the ester of N-hydroxy-2-thiopyridone is described.

Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry published new progress about Homolytic addition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics