Category: esters-buliding-blocks

Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities was written by Fujioka, Hiroyoshi;Shou, Jingwen;Kojima, Ryosuke;Urano, Yasuteru;Ozeki, Yasuyuki;Kamiya, Mako. And the article was included in Journal of the American Chemical Society in 2020.HPLC of Formula: 4163-60-4 This article mentions the following:

Raman probes based on alkyne or nitrile tags hold promise for highly multiplexed imaging. However, sensing of enzyme activities with Raman probes is difficult because few mechanisms are available to modulate the vibrational response. Here we present a general strategy to prepare activatable Raman probes that show enhanced Raman signals due to electronic preresonance (EPR) upon reaction with enzymes under physiol. conditions. We identified a xanthene derivative bearing a nitrile group at position 9 (9CN-JCP) as a suitable scaffold dye, and synthesized four types of activatable Raman probes, which are targeted to different enzymes (three aminopeptidases and a glycosidase) and tuned to different vibrational frequencies by isotope editing of the nitrile group. We validated the activation of the Raman signals of these probes by the target enzymes and succeeded in simultaneous imaging of the four enzyme activities in live cells. Different cell lines showed different patterns of these enzyme activities. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4HPLC of Formula: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Contribution by Saccharomyces cerevisiae yeasts to fermentation and flavour compounds in wines from cv. Kalecik karasi grape was written by Nurgel, C.;Erten, H.;Canbas, A.;Cabaroglu, T.;Selli, S.. And the article was included in Journal of the Institute of Brewing in 2002.Electric Literature of C11H14O3 This article mentions the following:

The effect of indigenous and com. S. cerevisiae yeasts on fermentation and flavor compounds of wines was examined in pasteurized grape juice. The flavor compounds were analyzed and identified by GC-FID and GC-MS, resp. and in general, the amounts of these volatiles were increased by the use of both indigenous and com. yeasts. The levels of isoamyl alc., isoamyl acetate, Et octanoate and Et deconoate exceeded flavor thresholds. All grape juices were fermented to dryness. Selected yeasts produced higher ethanol concentrations compared to spontaneous fermentations In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Electric Literature of C11H14O3).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Electric Literature of C11H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Transition-Metal-Free Deaminative Vinylation of Alkylamines was written by Hu, Jiefeng;Cheng, Bo;Yang, Xianyu;Loh, Teck-Peng. And the article was included in Advanced Synthesis & Catalysis in 2019.Application of 185619-66-3 This article mentions the following:

An efficient metal-free system, that was capable of activating the C-N bonds of Katritzky pyridinium salts I [R = 3,3-difluorocyclobutyl, cyclohexyl, PhCH₂CH(CO₂Me), etc.] derived from diverse alkylamines for deaminative vinylation to produce various olefins RCH=CHAr [Ar = Ph, 2-thienyl, 4-FC₆H₄, etc.]. The key to the high reactivity was the utilization of pyridinium salt-activated alkylamines I with a base as a promoter. The transformation exhibited good functional group compatibility and included inexpensive primary amine feedstocks and amino acids. The proposed method could serve as a powerful synthetic method for late-stage modification of complex compounds Mechanistic experiments suggestes that free radical processes are involved in this system. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Application of 185619-66-3).

tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 185619-66-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aroma-Active Compounds in Robusta Coffee Pulp Puree-Evaluation of Physicochemical and Sensory Properties was written by Buck, Nina;Wohlt, Daria;Winter, Anne Ruth;Ortner, Eva. And the article was included in Molecules in 2021.Recommanded Product: 706-14-9 This article mentions the following:

Wet coffee processing generates a large amount of coffee pulp waste that is mostly disposed of in the processing units. To reduce this waste and the associated environmental burden, an alternative strategy would be to exploit the coffee pulp to produce a durable and stable consumable product. Accordingly, a puree produced from Robusta coffee pulp was investigated in relation to its physicochem. and sensory properties. After thermal and chem. stabilization, the obtained puree (pH 3.6) was found to exhibit a multimodal particle size distribution, shear-thinning behavior, and lower discoloration, as well as an antioxidant capacity of 87.9μmolTE/gDM. The flavor of the puree was examined by sensory evaluation and the corresponding analyses of aroma-active volatile compounds, as determined using aroma extract dilution analyses (AEDA) and gas chromatog.-mass spectrometry/olfactometry (GC-MS/O). The puree was characterized by dominant fruity (4.4), floral (3.4), citrusy (3.3) and hay-like (3.3) odor impressions. The aroma-active compounds were predominantly aldehydes, acids, and lactones, whereby (E)-β-damascenone, geraniol, 4-methylphenol, 3-hydroxy-4,5-dimethylfuran-2(5H)-one, and 4-hydroxy-3-methoxybenzaldehyde exhibited the highest flavor dilution (FD) factor (1024), thereby indicating their high impact on the overall aroma of the puree. This study demonstrates an approach to stabilize coffee pulp to produce a sweet, fruity puree with comparable phys. properties to other fruit purees and that can be used as a new and versatile flavoring ingredient for various food applications. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Recommanded Product: 706-14-9).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 706-14-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors was written by Matsumaru, Takanori;Inai, Makoto;Ishigami, Kana;Iwamatsu, Toshiki;Maita, Hiroshi;Otsuguro, Satoko;Nomura, Takao;Matsuda, Akira;Ichikawa, Satoshi;Sakaitani, Masahiro;Shuto, Satoshi;Maenaka, Katsumi;Kan, Toshiyuki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Application In Synthesis of Methyl 2-aminonicotinate This article mentions the following:

We accomplished divergent synthesis of potent kinase inhibitor BAY 61-3606 (1, I) and 27 derivatives via conjugation of imidazo[1,2-c]pyrimidine and indole ring compounds with aromatic (including pyridine) derivatives by means of palladium-catalyzed cross-coupling reaction. Spleen tyrosine kinase (Syk) and germinal center kinase (Gck, MAP4K2) inhibition assays showed that some of the synthesized compounds were selective Gck inhibitors. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Application In Synthesis of Methyl 2-aminonicotinate).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of Methyl 2-aminonicotinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Trifluoroethanol as a Unique Additive for the Chemoselective Electrooxidation of Enamines to Access Unsymmetrically Substituted NH-Pyrroles was written by Baidya, Mrinmay;Maiti, Debabrata;Roy, Lisa;De Sarkar, Suman. And the article was included in Angewandte Chemie, International Edition in 2022.Product Details of 33166-79-9 This article mentions the following:

An electrochem. method for the synthesis of unsym. substituted NH-pyrroles is described. The synthetic strategy comprises a challenging heterocoupling between two structurally diverse enamines via sequential chemoselective oxidation, addition and cyclization processes. A series of aryl- and alkyl-substituted enamines were effectively cross-coupled from an equimolar mixture to synthesize various unsym. pyrrole derivatives in up to 84% yield. The desired cross-coupling was achieved by tuning the oxidation potential of the enamines by utilizing a “magic effect” of the additive trifluoroethanol (TFE). Addnl., extensive computational studies revealed the unique role of TFE in promoting the heterocoupling process by regulating the activation energies of the reaction steps through H-bonding and C-H···π interactions. Importantly, the developed electrochem. protocol was found to be equally efficient for the homocoupling of enamines to form sym. pyrroles in up to 92% yield. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Product Details of 33166-79-9).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 33166-79-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A facile semi-synthetic approach towards halogen-substituted aminobenzoic acid analogues of platensimycin was written by Qiu, Lin;Tian, Kai;Pan, Jian;Jiang, Lin;Yang, Hu;Zhu, Xiangcheng;Shen, Ben;Duan, Yanwen;Huang, Yong. And the article was included in Tetrahedron in 2017.Safety of Methyl 3-amino-2-fluorobenzoate This article mentions the following:

Platensimycin (PTM), produced by several strains of Streptomyces platensis, is a promising drug lead for infectious diseases and diabetes. The recent pilot-scale production of PTM from S. platensis SB12026 has set the stage for the facile semi-synthesis of a focused library of PTM analogs. In this study, gram-quantity of platensic acid (PTMA) was prepared by the sulfuric acid-catalyzed ethanolysis of PTM, followed by a mild hydrolysis in aqueous lithium hydroxide. Three PTMA esters were also obtained in near quant. yields in a single step, suggesting a facile route to make PTMA aliphatic esters. 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU)-catalyzed coupling of PTMA and 33 aminobenzoates resulted in the synthesis of 28 substituted aminobenzoate analogs of PTM, among which 26 of them were reported for the first time. Several of the PTM analogs showed weak antibacterial activity against methicillin-resistant Staphylococcus aureus. Our study supported the potential utility to integrate natural product biosynthetic and semi-synthetic approaches for structure diversification. In the experiment, the researchers used many compounds, for example, Methyl 3-amino-2-fluorobenzoate (cas: 1195768-18-3Safety of Methyl 3-amino-2-fluorobenzoate).

Methyl 3-amino-2-fluorobenzoate (cas: 1195768-18-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of Methyl 3-amino-2-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Long-chain Phenols. Part 33. Synthesis of saturated anacardic acids, and alkenyl and alkynyl analogs was written by Tyman, John H. P.;Visani, Naina. And the article was included in Journal of Chemical Research, Synopses in 1997.Application In Synthesis of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:

C-alkylation of esters of 2-methoxy-6-methylbenzoic acid and of the 4-Me isomers affords a route to homologous compounds of the natural anacardic acid series and of the unnatural isoanacardic acids, resp. ω-Alkenyl and ω-alkynyl compounds suitable for synthesizing other natural phenolic lipids or for structure-activity studies are also accessible. Thus, alkylation of 2,6-HO(Me)C₆H₃CO₂Et with LiN(CHMe₂)₂ followed by alkyl halides gave 2,6-HO(RCH₂)C₆H₃CO₂Et [R = CH₂CH:CH₂, (CH₂)_mCH:CH₂, m = 2, 4, 8, 9, (CH₂)₆CCH, (CH₂)₆OH, (CH₂)₈CH:CH(CH₂)₇Me-(Z), (CH₂)₁₃Me]. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Application In Synthesis of Methyl 2-methoxy-4-methylbenzoate).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of Methyl 2-methoxy-4-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

High orientation structure in UHMWPE / BN composites continuously obtained by elongational flow field leading to superior thermal conductivity was written by He, Guangjian;Lin, Zhihao;Yin, Xiaochun;Feng, Yanhong. And the article was included in Journal of Applied Polymer Science in 2022.Formula: C73H108O12 This article mentions the following:

Ultra-high-mol.-weight polyethylene/boron nitride (BN) composites have been continuously prepared successfully by eccentric rotor extruder (ERE) based on elongational flow. Optical microscopy (OM), SEM (SEM), x-ray diffraction (XRD), thermal conductivity test, heat-dissipation test, and tensile test were performed to investigate the orientation structure, thermal conductivity, mech. properties, and insulation properties. The orientation factor and thermal conductivity of the composites prepared by ERE were 79.3 and 3.75 W·m^-1·K^-1, which were much higher than those of composites prepared with a torque mixer (14.7 and 2.73 W·m^-1·K^-1, resp.). OM and SEM showed that the BN sheets were in contact inside the composites and formed an efficient thermal conductivity network. Besides, the composites prepared by ERE had satisfactory mech. and insulation properties (>10¹³ Ω·cm). This study provides exptl. and theor. guidance for industrial preparation of polymer/layered-filler functional composites. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Formula: C73H108O12).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C73H108O12

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fabrication of highly efficient phenylphosphorylated chitosan bio-based flame retardants for flammable PLA biomaterial was written by Ma, Xiaobing;Wu, Ningjing;Liu, Pengbo;Cui, Hongli. And the article was included in Carbohydrate Polymers in 2022.Related Products of 6683-19-8 This article mentions the following:

Modified chitosan (CS)-based flame retardants exhibit promising prospects owing to their sustainability, biodegradability, and good charring properties. A series of novel modified-CS bio-based flame retardants (phenylphosphorylated CS (PhPCS) and phenylphosphoramidated CS (PhPNCS)) were prepared by the phosphorylation and phosphoramidation reactions of CS with phenylphosphoryl dichloride and tetraethylenepentamine, resp. Bio-based PhPCS and PhPNCS exhibited excellent flame retardancy efficiency for poly(lactic acid) (PLA). The limited oxygen index (LOI) values of the PLA/3 wt% PhPCS and PLA/3 wt% PhPNCS biocomposites increased to 29% and 27%, resp., and they both achieved a V-0 rating during the UL-94 vertical combustion test. However, the mech. properties of the PLA/PhPCS biocomposites decreased with increasing PhPCS content. The mech. strengths of the PLA/PhPNCS biocomposites were better than those of the PLA/PhPCS biocomposites owing to the reactive compatibilization of the interface between the amino and carboxyl end groups of the PhPNCS nanoparticles and PLA matrix, resp. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Related Products of 6683-19-8).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 6683-19-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics