Category: 94-02-0

Jamshaid, Sana; Devkota, Shreedhar; Lee, Yong Rok published the artcile< Catalyst- and Substituent-Controlled Regio- and Stereoselective Synthesis of Indolyl Acrylates by Lewis-Acid-Catalyzed Direct Functionalization of 3-Formylindoles with Diazo Esters>, Formula: C11H12O3, the main research area is hydroxy indolyl acrylate preparation diastereoselective regioselective; alkoxy oxoethoxy indolyl acrylate preparation diastereoselective regioselective; formylindole diazo ester addition reaction Lewis Acid catalyst.

A facile and efficient In(OTf)3- and BF3.OEt2-catalyzed direct transformation of 3-formylindoles I (R = Me, prop-2-en-1-yl, Ph, Bn, etc.; R1 = H, Me, Et, Ph; R2 = H, Ph, OBn; R3 = H, Me, Ph, naphthalen-2-yl, etc.; R4 = H, Me, Br, Cl, F; R5 = H, Me; R4R5 = -(CH2)3-, -CH=CH-CH=CH-) with diazo esters N2=CHC(O)OR6 (R6 = Et, allyl, Bn, cyclohexyl, etc.) has been developed for synthesizing diverse and functionalized indolyl acrylates II, III and IV. This one-pot protocol furnishes various (Z)-α-hydroxy-β-indolyl acrylates II, (E)-β-(2-alkoxy-2-oxoethoxy)-α-indolyl acrylates III, and (Z)-3-hydroxy-2-indolyl acrylates IV by a catalyst- and substituent-controlled, regio- and stereoselective cascade reaction. The protocol has several advantages, including low loading of the catalyst, mild reaction conditions, broad scope, and high functional group tolerance. The synthesized compounds II, III and IV can be further converted into diversely functionalized materials.

Organic Letters published new progress about C-H bond activation. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xueguo; Wang, Peigen; Zhu, Liangwei; Chen, Baohua published the artcile< Rhodium(III)-catalyzed chemodivergent annulations between phenyloxazoles and diazos via C-H activation>, Application of C11H12O3, the main research area is isocoumarin preparation regioselective chemoselective; isoquinolinone preparation regioselective chemoselective; diazo compound phenyloxazole carboxylic acid cyclization rhodium catalyst.

Acid-controlled, chemodivergent and redox-neutral annulations for the synthesis of isocoumarins I (R = t-Bu, 4-bromophenyl, cyclohexyl, thiophen-2-yl, etc.; R1 = Me, Et, Ph; R2 = Me, Et, t-Bu) and isoquinolinones II (R3 = t-Bu, heptyl, furan-2-yl, etc.) have been realized via Rh(III)-catalyzed C-H activation. Diazo compounds R1C(O)C(=N2)C(O)OR2 act as a carbene precursor, and coupling occurs in one-pot process, where adipic acid and trimethylacetic acid promote chemodivergent cyclizations.

Chinese Chemical Letters published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application of C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lucia; Lin, Shengjia; Santos, Emmanuel; Pralat, Jenna; Spotton, Kaylyn; Sharma, Abhishek published the artcile< Boron-Promoted Deprotonative Conjugate Addition: Geminal Diborons as Soft Pronucleophiles and Acyl Anion Equivalents>, Application In Synthesis of 94-02-0, the main research area is diboryl ketone preparation; geminal diboron alkene deprotonative conjugate addition.

The 1,4-addition of α,α-diboryl carbanions generated via deprotonation of the corresponding geminal diborons R1CH(Bpin)2 (R1 = prop-2-en-1-yl, thiophen-3-ylmethyl, cyclopropylmethyl, etc.) has been reported. The methodol. provided a general route to highly substituted and synthetically useful γ,γ-diboryl ketones R1C(Bpin)2CH(R3)C(O)R2 (R2 = C6H5, 4-ClC6H4, cyclohexyl, etc.; R3 = Me, Ph, Et, etc.). The development of geminal diborons as soft pronucleophiles also enabled their use as acyl anion equivalent via a one-pot tandem conjugate addition-oxidation sequence.

Journal of Organic Chemistry published new progress about Alkanes Role: RCT (Reactant), RACT (Reactant or Reagent) (diboryl). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application In Synthesis of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cai, Hongyun; Khanal, Hari Datta; Lee, Yong Rok published the artcile< Base-Promoted Direct Cascade Transformation of Chromones to Coumarins via Benzannulation and Transesterification>, Electric Literature of 94-02-0, the main research area is alkenyl chromone acetoacetate cesium carbonate promoter tandem benzannulation transesterification; acyl phenylcoumarin preparation.

A mild base-promoted reaction between 3-substituted chromones and β-keto esters for the easy access to various coumarins with structural diversity was described. This protocol provided highly functionalized 3-acyl-4-arylcoumarins in good-to-excellent yield via benzannulation and transesterification. A reaction mechanism containing Michael addition, 1,5-H shift and intramol. transesterification was proposed.

Asian Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Electric Literature of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Budama-Kilinc, Yasemin; Kecel-Gunduz, Serda; Ozdemir, Burak; Bicak, Bilge; Akman, Gizem; Arvas, Busra; Aydogan, Feray; Yolacan, Cigdem published the artcile< New nanodrug design for cancer therapy: Its synthesis, formulation, in vitro and in silico evaluations>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is antitumor cancer; DNA binding; anticancer; coumarin derivative; molecular docking; nanoparticle.

The aim of this study was to develop a novel nanosize drug candidate for cancer therapy. For this purpose, (S)-Me 2-[(7-hydroxy-2-oxo-4-phenyl-2H-chromen-8-yl)methyleneamino]-3-(1H-indol-3-yl)propanoate (ND3) was synthesized by the condensation reaction of 8-formyl-7-hydroxy-4-phenylcoumarin with L-tryptophan Me ester. Its controlled release formulation was prepared and characterized by different spectroscopic and imaging methods. The cytotoxic effects of ND3 and its controlled release formulation were evaluated against MCF-7 and A549 cancer cell lines, and it was found that both of them have a toxic effect on cancer cells. For drug design and process development, the mol. docking anal. technique helps to clarify the effects of some DNA-targeted anticancer drugs to determine the interaction mechanisms of these drugs on DNA in a shorter time and at a lower cost. By using the mol. docking anal. and DNA binding assays, the interaction between the synthesized compound and DNA was elucidated and non-binding interactions were also determined To predict the pharmacokinetics, and thereby accelerate drug discovery, the absorption, distribution, metabolism, excretion and toxicity values of the synthesized compound were determined by in silico methods.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Antitumor agents. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xing, Xiu; Liu, Yan; Shi, Ming-Liang; Li, Kun; Fan, Xin-Yue; Wu, Zhong-Liu; Wang, Na; Yu, Xiao-Qi published the artcile< Preparation of chiral aryl alcohols: a controllable enzymatic strategy via light-driven NAD(P)H regeneration>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is rhodamine B labeled UiO 67 immobilized enzyme catalyst preparation; alc preparation enantioselective; ketone reduction photochem enzyme catalyst.

Controllable and mild photoenzymic production of chiral alcs. RCH(OH)R1 [R = Ph, 4-pyridyl, 2-naphthyl, etc.; R1 = H, Me, CH2CO2Me, etc.] was realized by coupling a versatile photochem. NAD(P)H regeneration system with (R)- or (S)-selective ketoreductases. The efficiency of NAD(P)H regeneration was improved using a rhodium functionalized metal organic framework, namely Rh-UiO-67, to adjust and control electron transport and electron utilization. Furthermore, six different ketoreductases could be successfully immobilized on Rh-UiO-67 and combined with the light-driven NAD(P)H regeneration system to produce chiral aryl alcs. Various chiral alcs. with complementary (R)- and (S)-conformations could be constructed by this method with high yields (97%) and excellent stereoselectivity (>99% ee).

New Journal of Chemistry published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Binyu; Wen, Xiaolu; Chen, Hongbing; Hu, Lin published the artcile< N-Nosyl-O-bromoethyl hydroxylamine acts as a multifunctional formaldehyde, formaldimine, and 1,2-oxazetidine surrogate for C-C and C-O bond-forming reactions>, Application of C11H12O3, the main research area is aminomethyl ketone preparation; nosyl bromoethyl hydroxylamine benzoyl acetate bond formation; hydroxymethyl ketone preparation; hydroxy ketone nosyl bromoethyl hydroxylamine bond formation; carboxylate indanone hydroxymethyl preparation enantioselective chemoselective; alkoxyl indanone carboxylate preparation enantioselective chemoselective; indanone carboxylate bond formation Mannich chiral catalyst.

N-Nosyl-O-bromoethyl hydroxylamine, a bench stable solid, could function as a novel formaldehyde, formaldimine and 1,2-oxazetidine surrogate under DBU basic conditions were described. By merely using this simple reagent, a broad range of synthetically useful β-aminomethyl ketones I [R1 = Me, Ph, 2-furyl, etc.; R2 = Me, Et, allyl, Bn; R1R2 = (CH2)3, (CH2)4, (CH2)5, etc.; R3 = Ac, CO2Me, CO2Et, SO2Ph] and α-hydroxymethyl ketones II [R4 = Me, Et, allyl, Bn; Q = (CH2)n, n = 1,2], as well as chiral α-alkoxyl indanone carboxylates III [R5 = H, 4-MeO, 5-F, etc.; X = OCH2CH2] and α-aminomethyl indanone carboxylates III [X = CH2] could be divergently obtained via chemo- and stereoselective aldol, Mannich or umpolung C-O bond-forming reactions. The challenging catalytic asym. Mannich reaction of formaldimine equivalent was also realized with moderate enantioselectivities.

Organic Chemistry Frontiers published new progress about Bond formation. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application of C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Chunyu; Tian, Xianhai; Song, Lina; Liu, Yaowen; Hashmi, A. Stephen K. published the artcile< Tetra-substituted furans by a gold-catalysed tandem C(sp3)-H alkynylation/oxy-alkynylation reaction>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is THF preparation; ketone hypervalent iodine reagent tandem alkynylation oxyalkynylation.

A gold-catalyzed cascade C(sp3)-H alkynylation/oxy-alkynylation of acceptor-substituted carbonyl compounds with hypervalent iodine(III) reagents for the synthesis of tetra-substituted furans is described. This reaction involves two Au(I)/Au(III) catalytic cycles and proceeds through a C(sp3)-H alkynylation of a substituted ketone and a subsequent oxy-alkynylation of the generated 2-alkynyl ketone. This mild and simple method can tolerate a wide range of functionalities, offering distinct advantages over previous methods using PIDA as the external oxidant. Furthermore, a gram-scale synthesis is feasible and the synthesized furan product was readily transformed into other related compounds

Organic Chemistry Frontiers published new progress about Alkynylation. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fobi, Kwabena; Bunce, Richard A. published the artcile< Domino Nitro Reduction-Friedlander Heterocyclization for the Preparation of Quinolines>, Name: Ethyl 3-oxo-3-phenylpropanoate, the main research area is quinoline preparation; aminobenzaldehyde activated ketone domino nitro reduction Friedlander heterocyclization; Friedländer synthesis; dissolving metal reduction; domino reaction; heterocyclization; quinolin-2(1H)-ones; quinolines.

The Friedlander synthesis offers efficient access to substituted quinolines from 2-aminobenzaldehydes and activated ketones in the presence of a base. The disadvantage of this procedure lies in the fact that relatively few 2-aminobenzaldehyde derivatives are readily available. To overcome this problem, authors report a modification of this process involving the in situ reduction of 2-nitrobenzaldehydes with Fe/AcOH in the presence of active methylene compounds (AMCs) to produce substituted quinolines in high yields. The conditions are mild enough to tolerate a wide range of functionality in both reacting partners and promote reactions not only with Ph and benzyl ketones, but also with β-keto-esters, β-keto-nitriles, β-keto-sulfones and β-diketones. The reaction of 2-nitroarom. ketones with unsym. AMCs is less reliable, giving a competitive formation of substituted quinolin-2(1H)-ones from the cyclization of the Z Knoevenagel intermediate which appears to be favored when certain large groups are adjacent to the AMC ketone carbonyl.

Molecules published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Name: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kurt, Adnan; Koca, Murat published the artcile< Synthesis, characterization and thermal degradation kinetics of pyrazole derived methacrylate polymer, poly(1,3-diphenyl-1H-pyrazol-5-Yl methacrylate)>, Application In Synthesis of 94-02-0, the main research area is polydiphenyl pyrazol methacrylate preparation thermal degradation activation energy; Pyrazole derived polymer; activation energy; reaction mechanism; synthesis and characterization; thermal degradation kinetics.

Since the behavior and properties of macromol. pyrazole derived polymers differ from their small mols., such polymers are in the class of well-defined functional polymers due to the fact that the pyrazole ring contains two π-bonds as well as two hetero atoms in its structure, and this feature makes them important in the fields of scientific and technol. applications. In present study, therefore, we synthesized a new pyrazole derived methacrylate monomer, 1,3-diphenyl-1H-pyrazol-5-yl methacrylate, from the reaction of 1,3-diphenyl-5-pyrazolone with methacryloyl chloride in the presence of triethylamine. After that, its homopolymerization was carried out by free radical polymerization method at 60°C initiated with benzoyl peroxide. Spectral characterizations were achieved by 1H-NMR and FTIR spectroscopies. The kinetics of thermal degradation of the new polymer, poly(1,3-diphenyl-1H-pyrazol-5-yl methacrylate), poly(DPPMA), were investigated by thermogravimetric anal. (TGA) at different heating rates. The initial decomposition temperature of the polymer changed from 216.3°C to 243.5°C depending on the increasing heating rate. The thermal decomposition activation energies in a conversion range of 7-19% were 79.45 kJ/mol and 81.56 kJ/mol by the Flynn-Wall-Ozawa and Kissinger methods, resp. Thermodegrdn. mechanism of the poly(DPPMA) were investigated in detail by using different kinetic methods available in the literature such as Coats-Redfern, Tang, Madhusudanan and Van Krevelen. Among all these methods, the best result was obtained for Coats-Redfern method (E = 90.93 kJ/mol) at the optimum heating rate of 15°C/min for D1 mechanism that is a one-dimensional diffusion type deceleration mechanism.

Acta Chimica Slovenica published new progress about Activation energy. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application In Synthesis of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics