Category: 93476-46-1

On June 15, 2011, Zhang, Yuhong; Huang, Lehao; Xie, Yongju; Niu, Tianmin published a patent.Application In Synthesis of Ethyl indolizine-1-carboxylate The title of the patent was Process for preparation of indolizine Mannich base-like compound. And the patent contained the following:

A process for preparation of indolizine Mannich base deri. is disclosed. The claimed title compound is shown in structure I (R = cyano, methoxycarbonyl, or ethoxycarbonyl; R1 = Me, Et, tert-Bu, H, or Cl; R2 = Me, H, or Cl; R3 = Me, Ph, or H). The claimed compound is prepared with N,N-dimethylaniline II and indolizine III via condensation reaction in the presence of catalyst. The catalyst is selected from CuCl, CuBr, CuI, or Cu2O. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Application In Synthesis of Ethyl indolizine-1-carboxylate

The Article related to indolizine mannich base preparation dimethylaniline indolizine condensation cuprous catalysis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of Ethyl indolizine-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Huayou; Liu, Yong; Xu, Juan; Kan, Yuhe; Wang, Chao; Ji, Min published an article in 2014, the title of the article was Palladium catalyzed oxidative Suzuki coupling reaction of indolizine at the 3-position using oxygen gas as the only oxidant.Formula: C11H11NO2 And the article contains the following content:

A Pd(OAc)2/O2 catalytic system with or without ligands was developed for an oxidative Suzuki coupling reaction of indolizines at the 3-position through C-H activation. The unwanted dimerization of 2,3-unsubstituted indolizines was inhibited by the addition of picolinic acid as a ligand. 1,2-Disubstituted indolizines that do not easily dimerize were reacted smoothly with arylboronic acids under ligand-free conditions. Furthermore, broad group tolerance was observed for both indolizines and arylboronic acids. Mild conditions, a broad array of starting materials and the use of a green oxidant are the advantages of this method. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Formula: C11H11NO2

The Article related to boronic acid aryl regioselective oxidative suzuki coupling indolizine, indolizine aryl preparation green chem, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C11H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gu, Jian; Cai, Chun published an article in 2016, the title of the article was Synthesis of substituted indolizines via radical oxidative decarboxylative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids.Quality Control of Ethyl indolizine-1-carboxylate And the article contains the following content:

A copper mediated radical oxidative annulation of 2-(pyridin-2-yl)acetate derivatives I (R = CO2Me, CO2Et, CO2i-Pr, CO2t-Bu, CN) with α,β-unsaturated carboxylic acids R1CH=CHCOOH (R1 = H, C6H5, 4-ClC6H4, 2-thienyl, etc.) is developed. This study offers a new and expedient strategy for the synthesis of useful indolizines II in moderate to good yields and exhibits a broad substrate scope and good functional group tolerance. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Quality Control of Ethyl indolizine-1-carboxylate

The Article related to indolizine preparation, unsaturated carboxylic acid pyridine oxidative decarboxylative annulation copper catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of Ethyl indolizine-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 6, 2015, Hu, Huayou; Li, Guodong; Hu, Weiming; Liu, Yun; Wang, Xiang; Kan, Yuhe; Ji, Min published an article.Formula: C11H11NO2 The title of the article was Synthesis of Pyrrolo[2,1,5-cd]indolizines through Dehydrogenative Heck Annelation of Indolizines with Diaryl Acetylenes Using Dioxygen as an Oxidant. And the article contained the following:

A dehydrogenative Heck annelation reaction of indolizine with diaryl acetylene via dual C-H bond cleavage was developed. Oxygen gas was employed as a clean oxidant in this catalysis under base-free conditions. Diarylpyrrolo[2,1,5-cd]indolizines were synthesized with high atom economy. In addition, kinetic isotope experiments provided evidence for C-H bond metalation of the 5-position of the indolizine as the rate-limiting step. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Formula: C11H11NO2

The Article related to dehydrogenative heck annelation indolizine diaryl alkyne palladium catalyst, pyrroloindolizine diaryl preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C11H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Chunjie; Jia, Huali; Li, Zhiwei; Zhang, Hui; Zhao, Baoli published an article in 2016, the title of the article was Palladium-catalyzed C-3 desulfitative arylation of indolizines with sodium arylsulfinates and arylsulfonyl hydrazides.HPLC of Formula: 93476-46-1 And the article contains the following content:

Derivatized indolizines I (R = 4-CH3OC6H4, 4-FC6H4, 3-BrC6H4, 2-naphthyl, etc.) were efficiently prepared by direct C-3 arylation of indolizines using sodium arylsulfinates and arylsulfonyl hydrazides. Pd-catalyzed desulfitative C-3 arylation with sodium arylsulfinates was achieved with the assistance of peroxides, and the catalytic efficiency was promoted by N-containing ligands. Arylsulfonyl hydrazides were also successfully applied in Pd-catalyzed desulfitative C-3 arylation with indolizines, and the side homocoupling reactions can be restrained in the component solvent under milder conditions. Various derivatives were synthesized in good yields by both methods, offering expedient protocols for the synthesis of C-3 functionalized indolizine mols. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).HPLC of Formula: 93476-46-1

The Article related to indolizine preparation, sodium arylsulfinate arylsulfonyl hydrazide indolizine desulfitative arylation palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.HPLC of Formula: 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 5, 2009, Xia, Ji-Bao; You, Shu-Li published an article.Application of 93476-46-1 The title of the article was Synthesis of 3-Haloindolizines by Copper(II) Halide Mediated Direct Functionalization of Indolizines. And the article contained the following:

3-Haloindolizines were synthesized via Cu(II) halide mediated halogenation of indolizines. This C-H direct functionalization process occurred under mild conditions giving 3-haloindolizines in moderate to excellent yields, and the products obtained were tested under the Suzuki-Miyaura reaction providing 3-arylindolizines in high yields. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Application of 93476-46-1

The Article related to regioselective preparation haloindolizine cupric halide mediated halogenation indolizine, suzuki miyaura reaction haloindolizine, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 21, 2022, Zhang, Wen-Wen; Liu, Chen-Xu; Yang, Pusu; Zhang, Su-Zhen; Gu, Qing; You, Shu-Li published an article.Safety of Ethyl indolizine-1-carboxylate The title of the article was Rhodium-Catalyzed Atroposelective C-H/C-H Cross-Coupling Reaction between 1-Aryl Isoquinoline Derivatives and Indolizines. And the article contained the following:

Rhodium-catalyzed asym. oxidative C-H/C-H cross-coupling reaction between 1-aryl isoquinolines and indolizines was disclosed. With a matched pair of SCpRh complex and chiral carboxylic acid, enantioselective 2-fold C-H/C-H cross-coupling reactions between 1-aryl isoquinolines and indolizines provide a variety of axially chiral bi(hetero)aryls in excellent yields and enantioselectivity (up to 96% yield and 98% ee). Mechanistic studies suggest that both C-H cleavages are likely reversible. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Safety of Ethyl indolizine-1-carboxylate

The Article related to indolizine heterobiarene rhodium catalyst enantioselective cross coupling reaction, heterobiaryl indolizine preparation, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Acridines, Quinolizines, etc.) and other aspects.Safety of Ethyl indolizine-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 18, 2011, Huang, Lehao; Niu, Tianmin; Wu, Jun; Zhang, Yuhong published an article.HPLC of Formula: 93476-46-1 The title of the article was Copper-Catalyzed Oxidative Cross-Coupling of N,N-Dimethylanilines with Heteroarenes under Molecular Oxygen. And the article contained the following:

A direct cross-coupling reaction of heteroarenes with N,N-dimethylanilines in the presence of copper catalyst is reported in this paper. Oxygen and/or air are successfully used as the oxidant, which is of great importance to the industrialized economies. The reaction is compatible with a wide range of heterocycles, including indolizines, imidazoles, indoles, and aniline, to enable the formation of various alkylated heteroarenes, e.g., I under very mild reaction conditions. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).HPLC of Formula: 93476-46-1

The Article related to alkylated heteroarene preparation, dimethylaniline heteroarene oxidative cross coupling copper catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 1, 1999, Katritzky, Alan R.; Qiu, Guofang; Yang, Baozhen; He, Hai-Ying published an article.Product Details of 93476-46-1 The title of the article was Novel syntheses of indolizines and pyrrolo[2,1-a]isoquinolines via benzotriazole methodology. And the article contained the following:

Indolizines I (R = H, Et, R1 = CO2Et, cyano, CO2Me, R2 = H, CO2Me, CO2Et, Ph, R3 = H, Et, 4-MeC6H4) and pyrrolo[2,1-a]isoquinolines II (X = cyano, Y = H; X = Y = CO2Et) are synthesized by 1,3-dipolar cycloadditions of pyridinium benzotriazolylmethylides or isoquinolinium benzotriazolylmethylides with ethylenes R1CH:CHR2 and acetylenes R1CCR2. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Product Details of 93476-46-1

The Article related to indolizine preparation benzotriazole, pyrroloisoquinoline preparation benzotriazole, isoquinoline pyrrolo preparation, benzotriazole preparation indolizine pyrroloisoquinoline and other aspects.Product Details of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 6, 2013, Steeneck, Christoph; Kinzel, Olaf; Gege, Christian; Kleymann, Gerald; Hoffmann, Thomas published a patent.HPLC of Formula: 93476-46-1 The title of the patent was Preparation of pyrrolocarboxamides as modulators of orphan nuclear receptor RAR-related orphan receptor-gamma (RORγ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases. And the patent contained the following:

The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administrating these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolocarboxamide compounds I [R1 = H, alkyl, cycloalkyl, etc.; R2 = H, alkyl, haloalkyl, hydroxyalkyl; or NR1R2 = (un)substituted 3-8 membered ring containing carbon atoms and optionally containing 1-2 heteroatoms selected from O, S and N; R3 = (un)substituted pyridinone, 6-10 membered mono- or bicyclic aryl, 5-10 membered mono- or bicyclic heteroaryl containing 1-4 heteroatoms selected from N, O or S, etc.; R4 = SO2(CR8R8)yR7, SO2NR12R7, (CR8R8)xR10 or cycloalkyl, which is spirocyclic fused with cycloalkyl; R5 = H, alkyl, haloalkyl, etc.; R6 = H, alkyl, haloalkyl, halo; R7 = (un)substituted cycloalkyl, heterocycloalkyl; R8 = H, F, alkyl, haloalkyl, OH; R10 = (un)substituted cycloalkyl; R12 = H, alkyl, haloalkyl; x = 1-2; y = 0-2; with the proviso] and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof. Over six hundred compounds I were prepared E.g., a multi-step synthesis of II, starting from 1-cyclohexylethanol, was described. Exemplified compounds I were tested in RORγ GaI4 reporter gene assay (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).HPLC of Formula: 93476-46-1

The Article related to pyrrolocarboxamide preparation orphan nuclear receptor rar related gamma modulator, retinoid related orphan receptor gamma modulator pyrrolocarboxamide preparation antiinflammatory, autoimmune disease treatment pyrrolocarboxamide preparation ror gamma modulator and other aspects.HPLC of Formula: 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics