Category: 93-92-5

Taritla, Sidhartha;Kumari, Madhuree;Kamat, Siya;Bhat, Sarita G.;Jayabaskaran, C. published 《Optimization of physicochemical parameters for production of cytotoxic secondary metabolites and apoptosis induction activities in the culture extract of a marine algal-derived endophytic fungus Aspergillus sp.》. The research results were published in《Frontiers in Pharmacology》 in 2021.Reference of 1-Phenylethyl acetate The article conveys some information:

The endophytic fungal community in the marine ecosystem has been demonstrated to be relevant source of novel and pharmacol. active secondary metabolites. The current study focused on the evaluation of cytotoxic and apoptosis induction potential in the culture extracts of endophytic fungi associated with Sargassum muticum, a marine brown alga. The cytotoxicity of the four marine endophytes, Aspergillus sp., Nigrospora sphaerica, Talaromyces purpureogenus, and Talaromyces stipitatus, was evaluated by the MTT assay on HeLa cells. Further, several physicochem. parameters, including growth curve, culture media, and organic solvents, were optimized for enhanced cytotoxic activity of the selected extract The Aspergillus sp. Et acetate extract (ASE) showed maximum cytotoxicity on multiple cancer cell lines. Chem. investigation of the metabolites by gas chromatog.-mass spectroscopy (GC-MS) showed the presence of several compounds, including quinoline, indole, 2,4-bis(1,1-dimethylethyl) phenol, and hexadecenoic acid, known to be cytotoxic in ASE. The ASE was then tested for cytotoxicity in vitro on a panel of six human cancer cell lines, namely, HeLa (cervical adenocarcinoma), MCF-7 (breast adenocarcinoma), Hep G2 (hepatocellular carcinoma), A-549 (lung carcinoma), A-431 (skin/epidermis carcinoma), and LN-229 (glioblastoma). HeLa cells were most vulnerable to ASE treatment with an IC₅₀ value of 24 ± 2 μg/mL. The mechanism of cytotoxicity exhibited by the ASE was further investigated on Hela cells. The results showed that the ASE was capable of inducing apoptosis in HeLa cells through production of reactive oxygen species, depolarization of mitochondrial membrane, and activation of the caspase-3 pathway, which shows a possible activation of the intrinsic apoptosis pathway. It also arrested the HeLa cells at the G2/M phase of the cell cycle, eventually leading to apoptosis. Through this study, we add to the knowledge about the marine algae associated with fungal endophytes and report its potential for purifying specific compounds responsible for cytotoxicity. And 1-Phenylethyl acetate (cas: 93-92-5) was used in the research process.

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Reference of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pham, Ly L.;Truong, Lisa;Ouedraogo, Gladys;Loisel-Joubert, Sophie;Martin, Matthew T.;Paul Friedman, Katie published 《Profiling 58 compounds including cosmetic-relevant chemicals using ToxRefDB and ToxCast》. The research results were published in《Food and Chemical Toxicology》 in 2019.Name: 1-Phenylethyl acetate The article conveys some information:

This work suggests that NAMs for bioactivity may inform a conservative point-of-departure estimate for diverse CRCs. For 17 of the 58 CRCs, high-throughput toxicokinetic data were used to calculate administered equivalent doses (AEDs) in mg/kg/day units for the in vitro bioactivity observed, and these AEDs served as conservative estimators of the systemic LELs observed in vivo. In terms of both target organ effects and study type, the median of the lowest effect level (LEL) doses in ToxRefDB for CRCs tended to be slightly higher than the median for the remaining 928 chems. with study data in ToxRefDB, though the ranges of LELs were similar. CRCs were diverse in use types as suggested by broad chem. use categories. To demonstrate NAMs for safety assessment, we surveyed in vitro bioactivity and in vivo systemic toxicity data in the US Environmental Protection Agency’s (EPA’s) Toxicity Forecaster (ToxCast) and Toxicity Reference databases (ToxRefDB), resp., for 58 chems. identified as CRCs, including cosmetic ingredients as well as trace contaminants. Safety assessment for cosmetic-relevant chems. (CRCs) in the European Union has been reshaped by restrictions on animal testing, and new approach methodologies (NAMs) for predicting toxicity are critical to ensure new cosmetic product safety. The experimental procedure involved many compounds, such as 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Name: 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 93-92-5In 2020, Zarini, Daniele;Sangion, Alessandro;Ferri, Emanuele;Caruso, Enrico;Zucchi, Sara;Orro, Alessandro;Papa, Ester published 《Are In Silico Approaches Applicable As a First Step for the Prediction of e-Liquid Toxicity in e-Cigarettes?》. 《Chemical Research in Toxicology》published the findings. The article contains the following contents:

Recent studies have raised concerns about e-cigarette liquid inhalation toxicity by reporting the presence of chems. with European Union CLP toxicity classification. In this scenario, the regulatory context is still developing and is not yet up to date with vaping current reality. Due to the paucity of toxicol. studies, robust data regarding which components in tent. In this study we applied computational methods for studied chems. as a useful tool for predicting the acute toxicity of chems. contained in e-liquids The purpose of t the potential health concerns associated with e-liquid ingredients, (b) to prioritize e-liquid ingredients by calculating the e-tox index, and (c) to estimate acute toxicity of e-liquid mixtures QSAR models were generated using QSARINS software to fill the acute toxicity data gap of 264 e-liquid ingredients. As a second step, the potential acute toxicity of e-liquids mixtures was evaluated. Our preliminary data suggest that a computational approa serve as a roadmap to enable regulatory bodies to better regulate e-liquid composition and to contribute to consumer health protection. To complete the study, the researchers used 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Related Products of 93-92-5 It may be prepared by acetylation of methyl phenyl carbinol; from 1-bromoethylbenzene and silver acetate in acetic acid; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Janta, Pannipa;Pinyo, Duangkamol;Yodta, Yamonporn;Vasasiri, Porames;Weidenbach, Meinolf;Pursch, Matthias;Yang, Xiuhan;Kulsing, Chadin published 《A multi-location peak parking approach for calculation of second dimensional retention indices for improved volatile compound identification with cryogen-free comprehensive heart-cut two-dimensional gas chromatography》 in 2021. The article was appeared in 《Analytical Methods》. They have made some progress in their research.Reference of 1-Phenylethyl acetate The article mentions the following:

Comprehensive heart-cut multidimensional gas chromatog. (CH/C MDGC) without a cryogenic trapping device was developed with an established approach for calculation of first and second dimensional retention indexes (1I and 2I) for improved compound identification. A first dimensional (1D) DB-1MS column (60 m) and a second dimensional (2D) DB-WAX column (60 m) were applied with a Deans switch (DS) using a constant H/C window of 0.2 min and a periodic multiple heartcut strategy comprising 225H/C throughout the CH/C. 1I was calculated based on comparison of the middle of the heartcut time with the alkane retention times on the 1D column. A multi-location peak parking approach using sixteen sets of automated injections of alkane references was also established with the least square curve fitting method for construction of the alkane isovolatility curves which were applied for 2I calculation The untargeted compound anal. of a perfume sample was then performed according to comparison with the libraries of mass spectra, 1I and 2I. The CH/C MDGC system with a 25 h anal. time showed a peak capacity (nc) of 9198 and 128 separated peaks with 71 compounds successfully identified according to MS, 1I and 2I library match under the established error approximation criteria. Furthermore, relationship between the anal. time and number of separated peaks was proposed based on the set of 84 identifiable compounds With the compensation of lower separation performance and greater I errors, the anal. time could be reduced by applying a 2.5 min H/C window with a total anal. time of 2 h and nc of 1134.1-Phenylethyl acetate (cas: 93-92-5) were involved in the experimental procedure.

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Reference of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from 1-bromoethylbenzene and silver acetate in acetic acid; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 1-Phenylethyl acetate《Insight into the Mechanism of the Acylation of Alcohols with Acid Anhydrides Catalyzed by Phosphoric Acid Derivatives》 was published in 2021. The authors were Hayashi, Hiroyuki;Yasukochi, Shotaro;Sakamoto, Tatsuhiro;Hatano, Manabu;Ishihara, Kazuaki, and the article was included in《Journal of Organic Chemistry》. The author mentioned the following in the article:

Insight into the mechanism of a safe, simple, and inexpensive phosphoric acid (H₃PO₄)-catalyzed acylation of alcs. with acid anhydrides is described. The corresponding in situ-generated diacylated mixed anhydrides, unlike traditionally proposed monoacylated mixed anhydrides, are proposed as the active species. In particular, the diacylated mixed anhydrides act as efficient catalytic acyl transfer reagents rather than as Bronsted acid catalysts simply activating acid anhydrides. Remarkably, highly efficient phosphoric acid (1-3 mol %)-catalyzed acylation of alcs. with acid anhydrides was achieved and a 23 g scale synthesis of an ester was demonstrated. Also, phosphoric acid catalyst was effective for synthetically useful esterification from carboxylic acids, alcs., and acid anhydride. Moreover, with regard to recent developments in chiral 1,1′-bi-2-naphthol (BINOL)-derived phosphoric acid diester catalysts toward asym. kinetic resolution of alcs. by acylation, some phosphate diesters were examined As a result, a ³¹P NMR study and a kinetics study strongly supported not only the acid-base cooperative mechanism as previously proposed by other researchers but also the mixed anhydride mechanism as presently proposed by us. To complete the study, the researchers used 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Reference of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Chengliang;Yan, Bin;Yin, Guibo;Chen, Junqing;Ji, Min published 《Fe(ClO₄)₃·H₂O-Catalyzed Ritter Reaction: A Convenient Synthesis of Amides from Esters and Nitriles》. The research results were published in《Synlett》 in 2018.Product Details of 93-92-5 The article conveys some information:

An efficient and inexpensive method was developed for the synthesis of N-substituted amides RC(O)NHR¹ [R = Me, cyclopropyl, Ph, etc.; R¹ = t-Bu, c-hexyl, Bn, etc.] via Fe(ClO₄)₃·H₂O-catalyzed Ritter reaction of nitriles with esters. Fe(ClO₄)₃·H₂O was an economically efficient catalyst for Ritter reaction under solvent-free conditions and provided the corresponding amides in high to excellent yields. And 1-Phenylethyl acetate (cas: 93-92-5) was used in the research process.

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Product Details of 93-92-5 It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meyer, Lars-Erik;Gummesson, Anja;Kragl, Udo;von Langermann, Jan published 《Development of Ionic Liquid-Water-Based Thermomorphic Solvent (TMS)-Systems for Biocatalytic Reactions》. The research results were published in《Biotechnology Journal》 in 2019.Reference of 1-Phenylethyl acetate The article conveys some information:

The applicability of ionic liquid-water-based thermomorphic solvent (TMS)-systems with an upper critical solution temperature for homogeneous biocatalysis is investigated. Cholinium- and imidazolium-based ionic liquids are used to facilitate a temperature-dependent phase change, which can be easily fine-tuned by adding salts or polar organic solvents. Within the TMS-system, a high enzymic activity and subsequent full conversion is achieved in the intermittent monophasic reaction system of the TMS-system. Therefore, the biocatalyst can be easily recycled after separating the phases at lower temperatures The experimental procedure involved many compounds, such as 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Reference of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schulze, Julia S.;Brand, Raoul D.;Hering, Joachim G. C.;Riegger, Luise M.;Schreiner, Peter R.;Smarsly, Bernd M. published 《DMAP Immobilized on Porous Silica Particles and Monoliths for the Esterification of Phenylethanol in Continuous Flow》. The research results were published in《ChemCatChem》 in 2022.Recommanded Product: 1-Phenylethyl acetate The article conveys some information:

We report the immobilization of 4-dimethylaminopyridine (DMAP), a versatile organocatalyst for sterically demanding esterifications, on mesoporous silica particles and macro-mesoporous silica monoliths, both possessing optimized properties for continuous flow synthesis. An alkyne-functionalized DMAP derivative was immobilized via click chem.; the materials were characterized by physisorption anal., diffuse reflectance IR Fourier transform spectroscopy (DRIFT) and elemental anal. While silica particles were functionalized in batch and packed into a packed-bed reactor, monoliths were cladded with a polyether ether ketone (PEEK) tube after sol-gel synthesis and functionalized in a circulating flow process. Samples with three different catalyst loadings were prepared, in order to study the impact of the catalyst amount on the mesopore space as well as the catalytic performance. In continuous flow experiments, complete conversion of 1-phenylethanol to phenylethylacetate was achieved with both materials and short contact times. Monoliths exhibited far lower pressures than packed bed reactors (7 bar at a flow rate of 1 mL min^-1) and reached turnover rates up to 9.3 × 10^-2 s^-1, which is almost twice as high as a comparable batch experiment The absence of diffusion limitations in monoliths made investigations on reaction kinetics with microkinetics-dominated experiments possible. This study demonstrates that all properties needed for a successful transfer of immobilized organocatalysts to sophisticated flow syntheses with complex organocatalysts can be met with functionalized meso-macroporous monoliths. The experimental procedure involved many compounds, such as 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Recommanded Product: 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Lijuan;Zhang, Ming;Zhang, Xiaoming;Xin, Hongchuan;Yang, Hengquan published 《Pickering Emulsion as an Efficient Platform for Enzymatic Reactions without Stirring》. The research results were published in《ACS Sustainable Chemistry & Engineering》 in 2016.COA of Formula: C10H12O2 The article conveys some information:

To address the current limitations of enzymic reactions, we develop a novel strategy to conduct stirring-free biphasic enzymic reactions. This strategy involves translation of a conventional biphasic enzymic reaction to a water-in-oil (W/O) Pickering emulsion system by adding a small amount of solid particle emulsifier. In such a system, enzymes, for example, a Candida Antarctica lipase B (CALB), are compartmentalized within millions of micron-sized water droplets, while organic substrates are dissolved in the oil phase (outside the droplets). It was demonstrated that CALB-catalyzed hydrolysis kinetic resolution of racemic esters in the stirring-free Pickering emulsion system gave favorable reaction efficiency and enantioselectivity as compared to those for the conventional biphasic system under stirring conditions, which was due to the large reaction interfacial area and the short mol. distances created by the Pickering emulsion droplets. The specific activity was found to depend on the water droplet size, highlighting the importance of the presence of droplets in the reaction system. Moreover, the convenient and effective recycling of CALB could be achieved through simple demulsification by centrifugation. After 27 reaction cycles, the ee values of ester and alc. were still as high as 87.5% and 99%, resp., which significantly exceed those of the conventional biphasic reaction. The high recyclability may be attributed to avoiding stirring that often causes damage to the three-dimensional structure of enzymes. This study compellingly demonstrates that a Pickering emulsion is an innovative platform to efficiently process enzymic reactions without need for stirring and immobilization. To complete the study, the researchers used 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. COA of Formula: C10H12O2 It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of 1-Phenylethyl acetate《Selective benzylic C-H monooxygenation mediated by iodine oxides》 was published in 2019. The authors were LaMartina, Kelsey B.;Kuck, Haley K.;Oglesbee, Linda S.;Odaini, Asma Al;Boaz, Nicholas C., and the article was included in《Beilstein Journal of Organic Chemistry》. The author mentioned the following in the article:

A method for the selective monooxdiation of secondary benzylic C-H bonds is described using an N-oxyl catalyst and a hypervalent iodine species as a terminal oxidant. Combinations of ammonium iodate and catalytic N-hydroxyphthalimide (NHPI) were shown to be effective in the selective oxidation of n-butylbenzene directly to 1-phenylbutyl acetate in high yield (86%). This method shows moderate substrate tolerance in the oxygenation of substrates containing secondary benzylic C-H bonds, yielding the corresponding benzylic acetates in good to moderate yield. Tertiary benzylic C-H bonds were shown to be unreactive under similar conditions, despite the weaker C-H bond. A preliminary mechanistic anal. suggests that this NHPI-iodate system is functioning by a radical-based mechanism where iodine generated in situ captures formed benzylic radicals. The benzylic iodide intermediate then solvolyzes to yield the product ester. The experimental procedure involved many compounds, such as 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Application In Synthesis of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from 1-bromoethylbenzene and silver acetate in acetic acid; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics