Category: 924-99-2

Wang, Weiqiang published the artcileSynthesis of ethyl N,N-dimethylaminoacrylate, Name: Ethyl 3-(dimethylamino)acrylate, the publication is Huagong Shengchan Yu Jishu (2008), 15(4), 29-31, database is CAplus.

Synthetic routes of Et N,N-dimethylaminoacrylate, imine complexation, high-pressure of carbon monoxide synthesis, aldol condensation, were compared with their advantages and disadvantages. The method of aldol condensation was started from Et formate and Et acetate, reacted with sodium or sodium hydride, to obtain sodium Et formylacetate, then reacted with dimethylamine hydrochloride to obtain the final product. The total yield was 60%. This process had many advantages, such as mild reaction conditions, simple procedure, high atom economy and less pollution, so it was suitable for industrial production

Huagong Shengchan Yu Jishu published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C15H14O3, Name: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Boehme, H. published the artcilePreparation, properties, and rearrangement of (β-alkoxycarbonylalkylidene)ammonium salts, Application of Ethyl 3-(dimethylamino)acrylate, the publication is Tetrahedron (1977), 33(8), 841-5, database is CAplus.

Methylation and protonation of β-alkoxycarbonyl enamines gave iminium salts which were characterized by 1H NMR spectroscopy. E.g., methylation with MeI and protonation with HCl of Me2NCH:CMeCO2Et gave (Me2N:CHCMe2CO2Et)+ (I) and (Me2N:CHCHMeCO2Et)+, resp. The reactions of the iminium salts with PhMgBr, MeMgBr, dimedone, and PhCOMe were studied; in some cases, secondary reactions involving amine elimination occurred. E.g., I with MeMgBr and PhCOMe gave Me2NCHMeCMe2CO2Et and PhCOCH:CHCMe2CO2Et, resp.

Tetrahedron published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Laurence, Christian published the artcileAn Enthalpic Scale of Hydrogen-Bond Basicity. 4. Carbon π Bases, Oxygen Bases, and Miscellaneous Second-Row, Third-Row, and Fourth-Row Bases and a Survey of the 4-Fluorophenol Affinity Scale, Formula: C7H13NO2, the publication is Journal of Organic Chemistry (2010), 75(12), 4105-4123, database is CAplus and MEDLINE.

The thermodn. of the O-H···B hydrogen bond (HB) has been determined in CCl₄ by FTIR spectrometry for a wide variety of carbon π bases, oxygen bases, and miscellaneous first- to fourth-row bases, using 4-fluorophenol as a reference hydrogen-bond donor (HBD). After inclusion of previously studied nitrogen, sulfur, and halogen bases, this 4-fluorophenol affinity scale contains 314 varied organic bases and ranges over 40 kJ mol^-1. The 4-fluorophenol affinity scale in CCl₄ is shown to be applicable to most HBDs in most media, provided a small family dependence is taken into account. The HB affinity orders are quant. established according to the at. acceptor site or to its bearing functional group. A comprehensive survey of the influence of substituents on these affinity orders is then achieved, considering electronic and steric effects, as well as effects of vinylogy or iminol. Iminol. is found to be more efficient than vinylogy for transmitting resonance effects. Steric effects are shown to be less important in HB affinity than in HB basicity since they mainly act on the HB entropy. The spatial proximity of two acceptor sites can favor complexation through three-center hydrogen bonds, leading to superhydrogen-bond bases on the affinity scale.

Journal of Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Khutorianskyi, Andrii published the artcileDifluoromethyl Nitrile Oxide (CF₂HCNO): A Neglected Chemical Reagent, Formula: C7H13NO2, the publication is European Journal of Organic Chemistry (2017), 2017(27), 3935-3940, database is CAplus.

The synthesis of CF₂H-isoxazoles I [R = CN, C(O)CH₃, CO₂Me, etc.] via [3+2]-cycloaddition of a novel chem. reagent – difluoromethyl nitrile oxide (CF₂HCNO) in-situ generated from difluoromethylacetaldehyde oximes with alkynes/enamines was reported. These products were promising cores for agrochem. A representative CHF₂-isoxazole was incorporated into the known fungicide Fluxapyroxad and the synthesized analog showed higher antifungal activity than the parent fungicide.

European Journal of Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sabatini, Stefano published the artcile8-Methyl-7-substituted-1,6-naphthyridine-3-carboxylic acids as new 6-desfluoroquinolone antibacterials, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Journal of Heterocyclic Chemistry (1999), 36(4), 953-957, database is CAplus.

1,6-Naphthyridine-8-methyl-7-substituted-3-carboxylic acids I (R = N-methylpiperazine, piperidine, 1,2,3,4-tetrahydroisoquinoline) were synthesized as new 6-desfluoroquinolone antibacterials in which the usual fluorine atom at C-6 position was replaced by an endocyclic nitrogen atom. The antibacterial activity of I proved less when compared to our previous 6-amino and 6-hydrogen counterparts. However, the presence of Me group at C-8 position provided good Gram-pos. antibacterial activity, with min. inhibitory concentration values on the same order of ciprofloxacin for the piperidinyl and tetrahydroisoquinolinyl derivatives

Journal of Heterocyclic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pasquini, Serena published the artcileInvestigations on the 4-quinolone-3-carboxylic acid motif. 2. synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo, Synthetic Route of 924-99-2, the publication is Journal of Medicinal Chemistry (2008), 51(16), 5075-5084, database is CAplus and MEDLINE.

Quinolone-3-carboxamides bearing at position 5, 6, 7, or 8 diverse substituents such as halides, alkyl, aryl, alkoxy, and aryloxy groups differing in their steric/electronic properties, were prepared The new compounds were tested in vitro for CB1 and CB2 receptor affinity in comparison with the reference compounds rimonabant and SR144528. The tested compounds exhibited CB2 affinity in the range from 55.9 to 0.8 nM and CB1 affinity in the range from >10 000 to 5.3 nM, with selectivity indeces [K_i(CB1)/K_i(CB2)] varying from >2666.6 to 1.23. On the basis of the structure-selectivity relationship developed, the presence of a substituent at C6/C8 or C7 well accounts for the high or low CB2 selectivity, resp. Compound I, characterized by high CB2 affinity and selectivity, showed analgesic activity in the formalin test of acute peripheral and inflammatory pain in mice as a result of selective CB2 agonistic activity.

Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Synthetic Route of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Schmitt, Etienne published the artcileFluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and Heterocycles, Synthetic Route of 924-99-2, the publication is Organic Letters (2017), 19(18), 4960-4963, database is CAplus and MEDLINE.

Fluoroalkyl amino reagents have been developed from com. available trifluoromethyl trifluorovinyl ether via a hydroamination reaction with diethylamine or dimethylamine. These reagents can be activated by treatment with a Lewis acid and subsequently used as a mono- or dielectrophile for the introduction of the fluoro(trifluoromethoxy)methyl group, either in Vilsmeier-type acylations of aromatic substrates or in the synthesis of fluorinated pyrazoles from CH-acidic substrates and of bis-fluorinated pyrazoles, all being important building blocks for medicinal and agricultural chem.

Organic Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Synthetic Route of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kirk, Ralph published the artcileNovel C-7 carbon substituted fourth generation fluoroquinolones targeting N. Gonorrhoeae infections, Related Products of esters-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(20), 127428, database is CAplus and MEDLINE.

Delafloxacin, a fourth-generation anionic fluoroquinolone (FQ) was approved in 2019 for community acquired bacterial pneumonia (CARP). It has broad spectrum activity and an improved class-related toxicity profile. However, it has recently failed a Phase 3 clin. trial for treatment of N. gonorrhoeae infections due to the lack of sufficient efficacy at the dose administered. Inspired by the microbiol. and safety profile of delafloxacin, we have developed and profiled the first reported delafloxacin carbon analog whereby a Nitrogen-for-Carbon swap has been successfully carried out at the C7 position. Not only have we shown that compounds with this modification maintain activity against N. gonorrhoeae (plus other gram-pos. and gram-neg. bacteria) but they also demonstrate a differentiated physicochem. profile. A zwitterionic derivative of delafloxacin was also profiled and demonstrated a superior microbiol. profile against gram-neg. strains, while maintaining favorable selected ADMET properties.

Bioorganic & Medicinal Chemistry Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Platts, Michelle Y. published the artcileA concise synthesis of HIV integrase inhibitors bearing the dipyridone acid motif, Formula: C7H13NO2, the publication is Tetrahedron Letters (2011), 52(4), 512-514, database is CAplus.

An efficient route to dipyridone acid HIV integrase inhibitors is developed. The key steps include a one-pot three-step formation of the core template (containing one point of structural diversity) followed by a regioselective benzylation and in situ deprotection to afford the title compounds

Tetrahedron Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Abadleh, Mohammed M. published the artcileFacile synthesis of model 2,4-diaryl-1,3,4-thiadiazino[5,6-h]fluoroquinolones, Synthetic Route of 924-99-2, the publication is Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences (2019), 74(6), 507-512, database is CAplus.

A Selected set of 2,4-diaryl-7-oxo-1,2,4-thiadiazino[5,6-h]quinoline-8-carboxylic acids I (Ar = C₆H₅, 4-MeC₆H₅, 4-FC₆H₅, etc.) has been prepared via reaction of the parent 7-chloro-8-nitro-10-cyclopropyl-6-fluoroquinolone with the appropriate N’-(aryl)benzothiohydrazides in presence of triethylamine. Structures of the new heterocyclics I are supported by spectral data and confirmed by single-crystal X-ray crystallog. for I (Ar = C₆H₅).

Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Synthetic Route of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics