Category: 924-99-2

Yoshii, Daichi published the artcileGold nanoparticles on OMS-2 for heterogeneously catalyzed aerobic oxidative α,β-dehydrogenation of β-heteroatom-substituted ketones, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(99), 14314-14317, database is CAplus and MEDLINE.

In the presence of Au nanoparticles supported on manganese oxide OMS-2 (Au/OMS-2), various kinds of β-heteroatom-substituted α,β-unsaturated ketones (heteroatom = N, O, S) can be synthesized through α,β-dehydrogenation of the corresponding saturated ketones using O₂ (in air) as the oxidant. The catalysis of Au/OMS-2 is truly heterogeneous, and the catalyst can be reused.

Chemical Communications (Cambridge, United Kingdom) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H12ClNO, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hansen, Camilla P. published the artcileCarbamoylcholine analogs as nicotinic acetylcholine receptor agonists-Structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC), Application In Synthesis of 924-99-2, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(1), 87-91, database is CAplus and MEDLINE.

Compounds based on the 3-(dimethylamino)butyl dimethylcarbamate (DMABC) scaffold were synthesized and pharmacol. characterized at the α₄β₂, α₃β₄, α₄β₄ and α₇ neuronal nicotinic acetylcholine receptors (nAChRs). The carbamate functionality and a small hydrophobic substituent in the C-3 position were found to be vital for the binding affinity to the nAChRs, whereas the carbamate nitrogen substituents were important for nAChR subtype selectivity. Finally, the compounds were found to be agonists at the α₃β₄ nAChR.

Bioorganic & Medicinal Chemistry Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application In Synthesis of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yu, Tongyan published the artcileFacile synthesis of penta-substituted pyrroles and pyrrole-fused piperidin-4-ones via four component reactions of 2,3-diketoesters, anilines and enaminones, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Organic Chemistry Frontiers (2021), 8(20), 5716-5721, database is CAplus.

Herein, a novel BF₃.Et₂O mediated four component reaction of 2,3-diketoesters RC(O)C((OH)₂)C(O)R¹ (R = Me, 2-phenylethenyl, naphthalen-2-yl, thiophen-2-yl, etc.; R¹ = OMe, OEt, (2-methylpropyl)oxidanyl, dimethylaminyl, OBn), anilines 4-R²C₆H₄NH₂ (R² = H, Me, Br, methoxycarbonyl, etc.) and enaminones R³C(O)CH=CHN(CH₃)₂ (R³ = OEt, Ph, furan-2-yl, etc.)/R⁴CH=CHC(O)CH=CHN(CH₃)₂ (R⁴ = Ph, 4-methoxyphenyl), providing highly functionalized pyrroles I and pyrrole-fused piperidin-4-ones II in moderate to good yields was presented. The key to success lies in the utilization of enaminone as the substrate and precise capture of the carbocation intermediate by anilines, allowing the amination to occur at the 5-position smoothly. This strategy is potentially applicable to diverse nucleophilic reagents. Moreover, an intramol. version of this strategy can be utilized to form fused heterocycles.

Organic Chemistry Frontiers published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C4H4N2O2, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yoshimura, Akira published the artcileHypervalent Iodine(III) Reagent Mediated Regioselective Cycloaddition of Aldoximes with Enaminones, SDS of cas: 924-99-2, the publication is European Journal of Organic Chemistry (2019), 2019(39), 6682-6689, database is CAplus.

An efficient oxidative cycloaddition of enaminones with nitrile oxides generated in situ from resp. aldoximes using hypervalent iodine reagent was developed for the synthesis of 3,4-disubstituted isoxazoles I [R = n-Pr, Ph, 1-naphthyl, etc.; R¹ = H, Me, Ph, etc.; R² = H, Me]. Reactions of various aldoximes with enaminones in the presence of [hydroxy(tosyloxy)iodo]benzene involved the regioselective cycloaddition reaction resulting in the formation of products I in moderate to good yields. Structures of several isoxazole products were confirmed by a single X-ray crystallog.

European Journal of Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C8H5IO, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Awadi, Nouria A. published the artcileEnaminones in a multicomponent synthesis of 4-aryldihydropyridines for potential applications in photoinduced intramolecular electron-transfer systems, Quality Control of 924-99-2, the publication is Beilstein Journal of Organic Chemistry (2012), 441-447, database is CAplus and MEDLINE.

An efficient three component reaction with enaminones, primary amines and aldehydes resulted in easy access to 1,4-dihydropyridines with different substituents at the 1-, 3-, 4- and 5-positions. Microwaves improved the reaction yield, reducing also considerably the reaction time and the amount of solvent used. Chiral primary amines gave chiral 1-substituted-1,4-dihydropyridines. The 4-(1-naphthyl) and 4-(phenanthren-9-yl)dihydropyridine derivatives exhibited an interesting photoluminescence behavior, which suggests their potential application as suitable photoinduced intramol. electron-transfer systems.

Beilstein Journal of Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Quality Control of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mao, Tian-Qi published the artcileStructural Modifications of Diarylpyrimidine-quinolone Hybrids as Potent HIV-1 NNRTIs with an Improved Drug Resistance Profile, HPLC of Formula: 924-99-2, the publication is Current Pharmaceutical Design (2016), 22(46), 6982-6987, database is CAplus and MEDLINE.

Earlier we reported the identification of diarylpyrimidine-quinolone hybrids as a new class of HIV-1 NNRTIs. A few of these hybrids displayed moderate inhibitory activity against wt HIV-1 replication at submicromolar level, however, all of them lacked inhibitory activity against the double mutant virus (K103N/Y181C), which is the most prevalent NNRTI resistant-associated double mutant observed in the clinic. In the present study, we designed and synthesized a new series of diarylpyrimidine-quinolone hybrids featuring a halogen group at C-6′ position of quinolone ring. The biol. results indicated that most of these hybrids could inhibit wt HIV-1 replication at nanomolar level ranging from 0.088 to 0.0096 μM. The most promising hybrid 5c displayed a significant EC50 value of 0.0096 μM against HIV-1 III_B and of 0.98 μM against K103N/Y181C. Further docking studies revealed that these hybrids could be well located in the hydrophobic NNIBP of HIV-1 RT despite the bulky and polar properties of a quinolone 3-carboxylic acid scaffold in the mols. These promising results suggested a high potential to further develop these hybrids as next-generation NNRTIs with improved antiviral efficacy and resistance profile.

Current Pharmaceutical Design published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, HPLC of Formula: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mao, Tian-Qi published the artcileAnti-HIV diarylpyrimidine-quinolone hybrids and their mode of action, HPLC of Formula: 924-99-2, the publication is Bioorganic & Medicinal Chemistry (2015), 23(13), 3860-3868, database is CAplus and MEDLINE.

A mol. hybridization approach is a powerful tool in the design of new mols. with improved affinity and efficacy. In this context, a series of diarylpyrimidine-quinolone hybrids were synthesized and evaluated against both wt HIV-1 and mutant viral strains. The most active hybrid 5a displayed an EC₅₀ value of 0.28±0.07 μM against HIV-1 III_B. A couple of enzyme-based assays clearly pinpoint a RT-targeted mechanism of action. Docking studies revealed that these hybrids could be well located in the NNIBP of HIV-1 RT despite the bulky and polar properties of a quinolone 3-carboxylic acid moiety in the mols.

Bioorganic & Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, HPLC of Formula: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Makhseed, Saad published the artcileStudies with 2-(arylhydrazono)aldehydes: Synthesis and chemical reactivity of mesoxalaldehyde 2-arylhydrazones and of ethyl 2-arylhydrazono-3-oxopropionates, SDS of cas: 924-99-2, the publication is Zeitschrift fuer Naturforschung, B: Chemical Sciences (2007), 62(4), 529-536, database is CAplus.

The coupling reaction of 3-(dimethylamino)acrolein and Et 3-(dimethylamino)acrylate with arenediazonium chlorides afforded the 2-(arylhydrazono)aldehydes RC₆H₄NHN:CR¹CHO [I, R = 4-Cl, H, 4-OMe, 3-Cl; R¹ = CHO, CO₂Et]. I [R = H, 4-Cl, R¹ = CHO] reacted with hydroxylamine hydrochloride to yield the oximes. The dioxime was obtained from reaction of I [R = 4-Cl, R¹ = CHO] with an excess of hydroxylamine hydrochloride. This dioxime afforded the 1,2,3-triazolecarbonitrile when treated with acetic anhydride, while α-hydrazonopropionitrile was obtained with acetic acid. I could be used for the synthesis of a variety of pyrazoles and arylazolopyrimidines via reaction with hydrazines, halo ketones and amino azoles, resp.

Zeitschrift fuer Naturforschung, B: Chemical Sciences published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Abu Shuheil, Mohammad Y. published the artcileHeterocycles [h]-fused onto 4-oxoquinoline-3-carboxylic acid, III. Facile synthesis and antitumor activity of model heterocycles [a]-fused onto pyrido[2,3-f]quinoxaline-3-carboxylic acids, HPLC of Formula: 924-99-2, the publication is Heterocycles (2007), 71(10), 2155-2172, database is CAplus.

Direct interaction between 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and each of (S)-proline, (2S,4R)-4-hydroxyproline, and (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in hot aqueous ethanolic NaHCO₃ yielded the corresponding optically pure N-(4-oxoquinolin-7-yl)-α-amino acids. The latter derivatives underwent reductive lactamization upon treatment with Na₂S₂O₄ in aqueous ethanol to afford moderate yields of the resp. pyrido[2,3-f]quinoxaline-3-carboxylic acid [fused]- to tetrahydropyrrolo[1,2-a]-, tetrahydrohydroxylpyrrolo[1,2-a]-and tetrahydroisoquinolino[2,3-a]heterocycles, e.g., I, resp. The antitumor activity against four human tumor cell lines showed that all those compounds displayed high levels of cytotoxicity as compared with Cisplatin. Interestingly, these compounds were more potent against breast carcinoma cell lines (MCF-7 and T-47D) than the lymphoid origin tumor cell lines (Jurkat and BHL-89). In particular, the (S)-proline derivative I exhibited preferential cytotoxicity to adherent cells (IC₅₀ = 0.5 μM), indicative of better potential in blocking the growth of solid tumors rather than the disseminated ones.

Heterocycles published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, HPLC of Formula: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gordeev, Mikhail F. published the artcileNovel oxazolidinone-quinolone hybrid antimicrobials, Computed Properties of 924-99-2, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(23), 4213-4216, database is CAplus and MEDLINE.

Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogs I and II [racemic and 3-(S)-isomer] display an improved potency vs. linezolid against gram-pos. and fastidious gram-neg. pathogens. The compounds are also active against linezolid- and ciprofloxacin-resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these new antimicrobials is consistent with a combination of protein synthesis and gyrase A/topoisomerase IV inhibition, with a structure-dependent degree of the contribution from each inhibitory mechanism.

Bioorganic & Medicinal Chemistry Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics