Category: 924-99-2

The author of 《Preparation of the key dolutegravir intermediate via MgBr2-promoted cyclization》 were Kong, Jiahui; Xia, Haijian; He, Renbao; Chen, Hao; Yu, Yongping. And the article was published in Molecules in 2021. Application of 924-99-2 The author mentioned the following in the article:

A novel approach for synthesizing the key dolutegravir intermediate is described via MgBr2-promoted intramol. cyclization. Condensation of com. available Me oxalyl chloride and Et 3-(N,N-dimethylamino)acrylate afforded the vinylogous amide in an excellent yield. Subsequent substitution by aminoacetaldehyde di-Me acetal and Me bromoacetate gave rise to the expected precursor for cyclization, which was promoted by MgBr2 to highly selectively convert into pyridinone diester. The key dolutegravir intermediate was finally prepared by the selective hydrolysis of the corresponding diester via LiOH.Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Application of 924-99-2) was used in this study.

Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Application of 924-99-2

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Zhang, Yan; Long, Zhiwu; Le, Yi; Liu, Li; Yan, Longjia published an article in Heterocycles. The title of the article was 《Microwave-assisted synthesis of phenylisoxazole derivatives via 1,3-dipolar cycloaddition》.Electric Literature of C7H13NO2 The author mentioned the following in the article:

In this paper, an efficient method was developed to prepare phenylisoxazoles via metal-free microwave-assisted 1,3-dipolar cycloaddition reaction. Thirty derivatives were synthesized under the optimal condition and identified by NMR and HRMS. The yield was good from 30% to 93%. In addition to this study using Ethyl 3-(dimethylamino)acrylate, there are many other studies that have used Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Electric Literature of C7H13NO2) was used in this study.

Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Electric Literature of C7H13NO2

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Ester – Wikipedia,
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Safety of Ethyl 3-(dimethylamino)acrylateOn November 5, 2021 ,《Visible-Light-Driven Multicomponent Cyclization by Trapping a 1,3-Vinylimine Ion Intermediate: A Direct Approach to Pyrimido[1,2-b]indazole Derivatives》 appeared in Organic Letters. The author of the article were Geng, Xiao; Xu, Zhaoliang; Cai, Yiwen; Wang, Lei. The article conveys some information:

Here a novel visible-light-driven three-component cyclization by trapping an 1,3-vinylimine ion intermediate for the direct synthesis of pyrimido[1,2-b]indazole derivatives from bromodifluoroacetic acid derivatives, enaminones, and 3-aminoindazoles under mild conditions was developed. Notably, the robust methodol. provided a valuable opportunity for the introduction of aliphatic substituents and enables good compatibility of complex bioactive mols. Furthermore, this was the first example of photoinduced multicomponent reaction by employing bromodifluoroacetic acid derivatives as a C1-synthon. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Safety of Ethyl 3-(dimethylamino)acrylate)

Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of Ethyl 3-(dimethylamino)acrylate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2020,Green Chemistry included an article by Hu, Deqing; Yang, Lu; Wan, Jie-Ping. Computed Properties of C7H13NO2. The article was titled 《Biaryl and atropisomeric biaryl aldehyde synthesis by one-step, metal-free benzannulation of aryl enals and propiolates》. The information in the text is summarized as follows:

A new method involving the benzannulation of aromatic enals ArCH=CHCHO (Ar = C6H5, 2-furyl, 1-naphthyl, etc.) and two alkyl propiolate mols. CHCC(O)2R (R = Me, Et, t-Bu) has been developed as a powerful route to biaryl aldehydes I simply via the promotion of di-Me amine. The benzannulation process in the absence of an oxidant additive tolerates successfully the formyl group in the enal component, leading to a straightforward one-step synthesis of biaryl and atropisomeric aldehydes I. An enamine activation based on the aza-Michael addition of di-Me amine to the propiolate and the amine elimination-based generation of cyclohexadiene intermediate constitute the major factors enabling the titled reactions. In the experimental materials used by the author, we found Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Computed Properties of C7H13NO2)

Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Computed Properties of C7H13NO2

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Ester – Wikipedia,
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Computed Properties of C7H13NO2On October 31, 2020 ,《Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity》 appeared in Bioorganic Chemistry. The author of the article were Song, Runzhe; Wang, Yue; Wang, Minghui; Gao, Ruixuan; Yang, Teng; Yang, Song; Yang, Cai-Guang; Jin, Yongsheng; Zou, Siyuan; Cai, Jianfeng; Fan, Renhua; He, Qiuqin. The article conveys some information:

The desfluoroquinolone-based hybrids with involvement of C-7 aminopyrimidine functional group were designed and synthesized. The biol. results showed majority of these hybrids still demonstrated potent anti-MRSA activity with MIC values between 0.38 and 1.5μg/mL, despite the lack of the typical C-6 fluorine atom. Particularly, the most active 1-cyclopropyl-7-((4-(3,4-dimethylphenoxy)pyrimidin-2-yl) amino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid exhibited activities at submicromolar concentrations against a panel of MRSA strains including vancomycin-intermediate strains, levofloxacin-resistant isolates, and linezolid-resistant isolates, etc. As expected, it also displayed highly selective toxicity toward bacterial cells and low hERG inhibition. Further resistance development study indicated MRSA is unlikely acquired resistance against 1-cyclopropyl-7-((4-(3,4-dimethylphenoxy)pyrimidin-2-yl)amino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. The docking study revealed that two hydrogen bonds were formed between the C-7 substituent and the surrounding DNA bases, which contributed to resistance by reducing the dependence on the magnesium-water bridge interactions with topoisomerase IV. These indicated a promising strategy for developing new antibiotic quinolones to combat multidrug resistance and cardiotoxicity was resulted. In the experimental materials used by the author, we found Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Computed Properties of C7H13NO2)

Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Computed Properties of C7H13NO2

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Cogent Chemistry included an article by Al-Taweel, Samir A.; Al-Trawneh, Salah A.; Al-Trawneh, Wal’a M.. Application In Synthesis of Ethyl 3-(dimethylamino)acrylate. The article was titled 《Palladium-catalyzed amination of 2-chlorothienopyridone with primary aromatic amines》. The information in the text is summarized as follows:

A series of Et 7-cyclopropyl-2-(arylamino)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates I (R1 = H; R2 = H, Me, F etc,) were prepared by coupling of Et 7-cyclopropyl-2-chloro-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate with primary aromatic amines via palladium-catalyzed amination using palladium acetate Pd(OAc)2 in the presence of cesium fluoride in good yields. 7-Cyclopropyl-2-(phenylamino)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid showed weak activity against E.aerogenas and S.aureus bacteria. The results came from multiple reactions, including the reaction of Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2Application In Synthesis of Ethyl 3-(dimethylamino)acrylate)

Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Application In Synthesis of Ethyl 3-(dimethylamino)acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics