Category: 898787-14-9

Highly Enantioselective Addition of Dialkylzinc to Trifluoroacetophenones, Catalyzed by 1,2-Diamines. Synthesis of Key Fragments of Inhibitors of the Enzyme 11β-HSD1 and Kinetic Analysis of the Process was written by Genov, Miroslav;Martinez-Ilarduya, Jesus M.;Calvillo-Barahona, Mercedes;Espinet, Pablo. And the article was included in Organometallics in 2010.Recommanded Product: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate The following contents are mentioned in the article:

Chiral diamines derived from (R,R)- or (S,S)-1,2-diphenylethylenediamine and (S)- or (R)-2,2′-bis(bromomethyl)-1,1′-binaphthalene perform very well as catalysts in the enantioselective addition of ZnEt₂ and ZnMe₂ to trifluoroacetophenones, avoiding reduction products, in contrast to the poor results with amino alcs. Excellent yields (up to 99%) and high enantioselectivity (up to 92%) are achieved with the best ligands. A kinetic study at low temperature (-37°) shows that the reduction reaction rate on ligandless ZnEt₂ is negligible (2 orders of magnitude slower) compared to the rate of addition reaction on [ZnR₂(N-N)]. Using this new procedure, reported fragments of inhibitors of enzyme 11β-HSD1 that are active against obesity and type 2 diabetes mellitus, as well as new unreported modified fragments of these bioactive mols., were produced efficiently and enantioselectively. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Recommanded Product: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One-Pot Successive Turbo Grignard Reactions for the Facile Synthesis of α-Aryl-α-Trifluoromethyl Alcohols was written by Kani, Ryunosuke;Inuzuka, Toshiyasu;Kubota, Yasuhiro;Funabiki, Kazumasa. And the article was included in European Journal of Organic Chemistry in 2020.SDS of cas: 898787-14-9 The following contents are mentioned in the article:

A novel straightforward one-pot methodol. for two successive turbo Grignard reagent (iPrMgCl·LiCl) reactions, was developed for a facile synthesis of α-aryl-α-trifluoromethyl alcs., motifs of value in pharmaceutical chem. The method displayed broad functional group tolerance, including reducible groups. Dual roles of iPrMgCl·LiCl were exploited in the tandem reaction with com. available iodoarenes or iodoheteroarenes and 2,2,2-trifluoroethyl trifluoroacetate. The process encompasses three successive reactions in a one-pot process: the iPrMgCl·LiCl-mediated iodine/magnesium-exchange reaction of iodoarenes or iodoheteroarenes; nucleophilic addition of various generated aryl or heteroarylmagnesium reagents to 2,2,2-trifluoroethyl trifluoroacetate; and the reduction of in-situ generated aryl trifluoromethyl ketones with iPrMgCl·LiCl, to produce the corresponding α-aryl or α-heteroaryl-α-trifluoromethyl alcs. bearing various substituents, including reducible functional groups in good to excellent yields. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9SDS of cas: 898787-14-9).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 898787-14-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics