Category: 71195-85-2

Bajj, Daniel N. F.; Tran, Michael V.; Tsai, Hsin-Yun; Kim, Hyungki; Paisley, Nathan R.; Algar, W. Russ; Hudson, Zachary M. published the artcile< Fluorescent Heterotelechelic Single-Chain Polymer Nanoparticles: Synthesis, Spectroscopy, and Cellular Imaging>, Quality Control of 71195-85-2, the main research area is fluorescent heterotelechelic single chain polymer nanoparticle synthesis cellular imaging.

The folding and collapse of individual polymer chains into single-chain polymer nanoparticles (SCPNs) is a versatile and emerging platform for biol. applications such as diagnostics, imaging, and therapy, where components for two or more of these functions can be combined onto a single polymer carrier. Here, we prepare heterotelechelic polymers with three sets of sep. addressable chem. handles at their α-terminus and ω-terminus, and along their backbone. As a model system, the α- and ω-termini are conjugated with a targeting ligand (folic acid or biotin) and therapeutic drug cargo (camptothecin), resp., and the backbone is grafted with pendant fluorescent dye mols., poly(ethylene glycol) oligomers, and benzene-1,3,5-tricarboxamide. These polymers fold in water to give fluorescent SCPNs, which are characterized with respect to their phys. and photophys. properties. The latter reveals a relationship between polymer folding, quantum yield, and resistance to photobleaching. The SCPNs are then shown to be useful for immunolabeling of SK-BR-3 breast cancer cells and exhibit little or no acute cytotoxicity. This work demonstrates that SCPNs can be used as a viable platform for bioconjugation and cell labeling, helps establish a set of design criteria for optimizing future biol. applications, and opens the door to the development of SCPNs for a broader range of theranostic applications.

ACS Applied Nano Materials published new progress about Biocompatible materials. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Quality Control of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bhattacharya, Koushik; Banerjee, Sovan Lal; Das, Subhayan; Samanta, Sarthik; Mandal, Mahitosh; Singha, Nikhil K. published the artcile< REDOX Responsive Fluorescence Active Glycopolymer Based Nanogel: A Potential Material for Targeted Anticancer Drug Delivery>, SDS of cas: 71195-85-2, the main research area is REDOX responsive fluorescence glycopolymer nanogel targeted anticancer drug delivery; REDOX responsive; anticancer activity; fluorescence active; glycopolymer; nanogel.

A well-defined glycopolymer based fluorescence active nanogel has been prepared via the combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and Diels-Alder (DA) “”click”” chem. To prepare the nanogel, initially, a functional AB block copolymer (BCP) poly(pentafluorophenyl acrylate)-b-poly(furfuryl methacrylate) (PPFPA-b-PFMA), having activated pentafluorophenyl ester group, was synthesized via RAFT polymerization The activated pentafluorophenyl functionality was replaced by the amine functionality of glucosamine to introduce the amphiphilic BCP poly[2-(acrylamido) glucopyranose]-b-poly(furfuryl methacrylate) (PAG-b-PFMA). Furthermore, the terminal acid (-COOH) functionality of the RAFT agent was modified by gelatin QDs (GQDs) to generate fluorescence active glycopolymer. An anticancer drug, Doxorubicin, was loaded in the micelle via the successive addition of the drug mol. and crosslinking using dithio-bismaleimidoethane (DTME), a REDOX responsive cross-linker. The anticancer activity of the drug loaded nanogel was observed over MBA-MD-231, human breast cancer cell line, and monitored via fluorescence spectroscopy and flow cytometric analyses (FACS). The cytotoxicity of the prepared glycopolymer based nanogel over the MBA-MD-231 cell line was assessed via MTT assay test, and it was observed that the synthesized nanogel was noncytotoxic in nature.

ACS Applied Bio Materials published new progress about Antitumor agents. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, SDS of cas: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiong, Shaobing; Hou, Zhangyu; Dong, Wei; Li, Danqin; Yang, Jianming; Bai, Ruirong; Wu, Yuning; Li, Dong; Wu, Hongbo; Ma, Zaifei; Xu, Jianhua; Liu, Xianjie; Bao, Qinye published the artcile< Additive-Induced Synergies of Defect Passivation and Energetic Modification toward Highly Efficient Perovskite Solar Cells>, Formula: C9H3F5O2, the main research area is FAMA additive synergy energy passivation perovskite solar cell.

Defect passivation via additive and energetic modification via interface engineering are two effective strategies for achieving high-performance perovskite solar cells (PSCs). Here, the synergies of pentafluorophenyl acrylate when used as additive, in which it not only passivates surface defect states but also simultaneously modifies the energetics at the perovskite/Spiro-OMeTAD interface to promote charge transport, are shown. The additive-induced synergy effect significantly suppresses both defect-assisted recombination and interface carrier recombination, resulting in a device efficiency of 22.42% and an open-circuit voltage of 1.193 V with excellent device stability. The two photovoltaic parameters are among the highest values for polycrystalline CsFormamidinium/Methylammonium (FAMA)/FAMA based n-i-p structural PSCs using low-cost silver electrodes reported to date. The findings provide a promising approach by choosing the dual functional additive to enhance efficiency and stability of PSCs.

Advanced Energy Materials published new progress about Electron transfer. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

De Vrieze, Jana; Louage, Benoit; Deswarte, Kim; Zhong, Zifu; De Coen, Ruben; Van Herck, Simon; Nuhn, Lutz; Kaas Frich, Camilla; Zelikin, Alexander N.; Lienenklaus, Stefan; Sanders, Niek N.; Lambrecht, Bart N.; David, Sunil A.; De Geest, Bruno G. published the artcile< Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists>, COA of Formula: C9H3F5O2, the main research area is spatial control small mol TLR7 TLR8 agonist amphiphile conjugate; immunomodulation; innate immunity; lipid amphiphiles; lymph nodes; polymers.

Uncontrolled systemic inflammatory immune triggering has hampered the clin. translation of several classes of small-mol. immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage of the inherent serum-protein-binding property of lipid motifs and their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid-polymer conjugates that suppress systemic inflammation but provoke potent lymph-node immune activation. This work provides a rational basis for the design of lipid-polymer amphiphiles for optimized lymphoid targeting.

Angewandte Chemie, International Edition published new progress about Amphiphiles. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, COA of Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ganda, Sylvia; Wong, Chin Ken; Stenzel, Martina H. published the artcile< Corona-Loading Strategies for Crystalline Particles Made by Living Crystallization-Driven Self-Assembly>, HPLC of Formula: 71195-85-2, the main research area is corona crystalline particle crystallization selfassembly.

Self-assembled block copolymer (BCP) nanoparticles offer exciting opportunities for drug delivery applications. A key feature of using BCP nanoparticles for drug delivery is their ability to accommodate therapeutic cargoes within their particle core. This has become widely established for BCP nanoparticles with an amorphous core. The same, however, cannot be achieved with BCP nanoparticles with a crystalline core. This is because the encapsulation of therapeutic cargoes in a crystalline particle core disrupts crystallinity and ultimately leads to particle disassembly. Herein, we present several strategies to incorporate therapeutics and other functional cargoes onto the surface of crystalline particles, as this helps to ensure that the crystallinity of the particle core is maintained and the particle morphol. is hence unaffected. As a platform to showcase our strategies, in this study, we used biodegradable and bioactive 2D glycoplatelets prepared by living crystallization-driven self-assembly (CDSA). Specifically, we show that we can incorporate either an anticancer drug, doxorubicin (DOX), or a fluorescent dye, Cyanine5 (Cy5), onto the surface of glycoplatelets by seeded growth of prefunctionalized polymers or via postmodification using polymers with reactive handles. We believe that the strategies presented herein are versatile and should thus be applicable to other CDSA systems. Overall, our findings present new opportunities for crystalline particles to be used in drug delivery application.

Macromolecules (Washington, DC, United States) published new progress about Acrylic polymers, polyester-, block Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kursun, Talya Tugana; Cimen, Dilek; Caykara, Tuncer published the artcile< Glycopolymer brushes with specific protein recognition property>, Synthetic Route of 71195-85-2, the main research area is glycopolymer brush protein recognition.

Here, the authors report the synthesis of glycopolymer brushes on the silicon substrate by interface-mediated reversible addition-fragmentation chain transfer (RAFT) polymerization of pentafluorophenyl acrylate as well as subsequent attachment of D-glucosamine to determine specific and nonspecific protein interactions. The root-mean-square roughness of the glycopolymer brushes is only �.1 nm, indicating unstable distribution of the collapsed glycopolymer chains on the surface. The water contact angle of glycopolymer brush was determined as �3� indicating a hydrophilic behavior. The results of fluorescence microscopy studies indicated that the glycopolymer brushes have specific interaction with fluorescence-labeled Con A and nonspecific interaction with fluorescence-labeled bovine serum albumin. The glycopolymer brushes tested here are hoped to enlarge to the knowledge of recognition phenomena at the surface of polymer brushes. �2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45238.

Journal of Applied Polymer Science published new progress about Bovine serum albumin Role: BSU (Biological Study, Unclassified), PEP (Physical, Engineering or Chemical Process), BIOL (Biological Study), PROC (Process). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Synthetic Route of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lim, Jaehoon; Borg, Lisa zur; Dolezel, Stefan; Schmid, Friederike; Char, Kookheon; Zentel, Rudolf published the artcile< Strategy for Good Dispersion of Well-Defined Tetrapods in Semiconducting Polymer Matrices>, SDS of cas: 71195-85-2, the main research area is strategy dispersion tetrapod semiconducting polymer matrixes; morphology; organic-inorganic hybrids; semiconducting polymers; tetrapods.

The morphol. or dispersion control in inorganic/organic hybrid systems is studied, which consist of monodisperse CdSe tetrapods (TPs) with grafted semiconducting block copolymers with excess polymers of the same type. Tetrapod arm-length and amount of polymer loading are varied in order to find the ideal morphol. for hybrid solar cells. Addnl., polymers without anchor groups are mixed with the TPs to study the effect of such anchor groups on the hybrid morphol. A numerical model is developed and Monte Carlo simulations to study the basis of compatibility or dispersibility of TPs in polymer matrixes are performed. The simulations show that bare TPs tend to form clusters in the matrix of excess polymers. The clustering is significantly reduced after grafting polymer chains to the TPs, which is confirmed exptl. Transmission electron microscopy reveals that the block copolymer-TP mixtures (“”hybrids””) show much better film qualities and TP distributions within the films when compared with the homopolymer-TP mixtures (“”blends””), representing massive aggregations and cracks in the films. This grafting-to approach for the modification of TPs significantly improves the dispersion of the TPs in matrixes of “”excess”” polymers up to the arm length of 100 nm.

Macromolecular Rapid Communications published new progress about Acrylic polymers, fluorine-containing, block, diblock Role: POF (Polymer in Formulation), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, SDS of cas: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wagner, Natalie; Kessler, Daniel; Theato, Patrick published the artcile< Reactive Coatings in Glass Capillaries: Preparation of Temperature- and Light-Responsive Surfaces and Accurate Determination of Wettability Switching>, Electric Literature of 71195-85-2, the main research area is capillary tube wettability wetting contact angle.

The inner walls of thin glass capillaries are coated with a reactive precursor coating that can be converted into different temperature- and light-responsive coatings. The switching range of wettability can be determined by measuring the meniscus height of water inside these capillaries at different temperatures and upon UV-light irradiation In comparison with the sessile drop measurement, very accurate equilibrium contact angles are obtained by this method.

Macromolecular Chemistry and Physics published new progress about Attenuated-total-reflectance IR spectra. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kubilis, Artur; Abdulkarim, Ali; Eissa, Ahmed M.; Cameron, Neil R. published the artcile< Giant Polymersome Protocells Dock with Virus Particle Mimics via Multivalent Glycan-Lectin Interactions>, HPLC of Formula: 71195-85-2, the main research area is giant polymersome virus particle glycan lectin.

Despite the low complexity of their components, several simple phys. systems, including microspheres, coacervate droplets and phospholipid membrane structures (liposomes), have been suggested as protocell models. These, however, lack key cellular characteristics, such as the ability to replicate or to dock with extracellular species. Here, we report a simple method for the de novo creation of synthetic cell mimics in the form of giant polymeric vesicles (polymersomes), which are capable of behavior approaching that of living cells. These polymersomes form by self-assembly, under electroformation conditions, of amphiphilic, glycosylated block copolymers in aqueous solution The glycosylated exterior of the resulting polymeric giant unilamellar vesicles (GUVs) allows their selective interaction with carbohydrate-binding receptor-functionalized particles, in a manner reminiscent of the cell-surface docking of virus particles. We believe that this is the first example of a simple protocell model displaying cell-like behavior through a native receptor-ligand interaction.

Scientific Reports published new progress about Amphipathicity. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Daikos, Olesya; Naumov, Sergej; Knolle, Wolfgang; Heymann, Katja; Scherzer, Tom published the artcile< Peculiarities of the photoinitiator-free photopolymerization of pentabrominated and pentafluorinated aromatic acrylates and methacrylates>, Electric Literature of 71195-85-2, the main research area is photopolymerization pentabrominated pentafluorinated aromatic acrylate methacrylate.

Pentabrominated and fluorinated aromatic (meth)acrylates as well as their non-halogenated counterparts have been studied with the aim to avoid conventional photoinitiators and to overcome some neg. consequences related to their use. Therefore, RTIR spectroscopy, laser flash photolysis and GC/MS were utilized. Even low concentrations (1 to 5 wt%) of brominated (meth)acrylates in the model varnish lead to initiation of a photopolymerization reaction under exposure to UV light with æµ?> 300 nm. This is due to the fact that excitation of the aryl moiety leads to the homolysis of bromine-Ph bonds with a high quantum yield of é–?.15-0.3. Both, bromine radicals released from either ortho, meta or para position as well as the corresponding tetrabromoaryl radicals, may initiate the polymerization of brominated aromatic (meth)acrylates. In contrast, fluorinated aromatic (meth)acrylates undergo æµ?cleavage of the carboxyl group (as in the case of non-halogenated aromatic (meth)acrylates), if excitation of the acrylic double bonds is done with UV-C light (æµ?< 280 nm). Radical formation occurs with a comparable quantum yield of 0.1-0.22 (fluorinated) and 0.16-0.36 (non-halogenated compounds), despite the different pathway of fragmentation. Thus, in all cases the efficiency of initiation is comparable to conventional photoinitiators. Quantum chem. calculations of orbitals involved and of the Gibbs free energy of transients and products support the suggested reaction pathway. Physical Chemistry Chemical Physics published new progress about Density functional theory, B3LYP. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics