Category: 71195-85-2

Vanderburgh, Joseph; Hill, Jordan L.; Gupta, Mukesh K.; Kwakwa, Kristin A.; Wang, Sean K.; Moyer, Kathleen; Bedingfield, Sean K.; Merkel, Alyssa R.; d’Arcy, Richard; Guelcher, Scott A.; Rhoades, Julie A.; Duvall, Craig L. published the artcile< Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction>, COA of Formula: C9H3F5O2, the main research area is bone metastasis targeting nanoparticle alendronate; bisphosphonate; bone metastasis; bone targeting; hedgehog pathway; pharmacokinetics; polymer nanoparticles; tumor delivery.

Breast cancer patients are at high risk for bone metastasis. Metastatic bone disease is a major clin. problem that leads to a reduction in mobility, increased risk of pathol. fracture, severe bone pain, and other skeletal-related events. The transcription factor Gli2 drives expression of parathyroid hormone-related protein (PTHrP), which activates osteoclast-mediated bone destruction, and previous studies showed that Gli2 genetic repression in bone-metastatic tumor cells significantly reduces tumor-induced bone destruction. Small mol. inhibitors of Gli2 have been identified; however, the lipophilicity and poor pharmacokinetic profile of these compounds have precluded their success in vivo. In this study, we designed a bone-targeted nanoparticle (BTNP) comprising an amphiphilic diblock copolymer of poly[(propylene sulfide)-block-(alendronate acrylamide-co-N,N-dimethylacrylamide)] [PPS-b-P(Aln-co-DMA)] to encapsulate and preferentially deliver a small mol. Gli2 inhibitor, GANT58, to bone-associated tumors. The mol. % of the bisphosphonate Aln in the hydrophilic polymer block was varied in order to optimize BTNP targeting to tumor-associated bone by a combination of nonspecific tumor accumulation (presumably through the enhanced permeation and retention effect) and active bone binding. Although 100% functionalization with Aln created BTNPs with strong bone binding, these BTNPs had highly neg. zeta-potential, resulting in shorter circulation time, greater liver uptake, and less distribution to metastatic tumors in bone. However, 10 mol % of Aln in the hydrophilic block generated a formulation with a favorable balance of systemic pharmacokinetics and bone binding, providing the highest bone/liver biodistribution ratio among formulations tested. In an intracardiac tumor cell injection model of breast cancer bone metastasis, treatment with the lead candidate GANT58-BTNP formulation decreased tumor-associated bone lesion area 3-fold and increased bone volume fraction in the tibiae of the mice 2.5-fold. Aln conferred bone targeting to the GANT58-BTNPs, which increased GANT58 concentration in the tumor-associated bone relative to untargeted NPs, and also provided benefit through the direct antiresorptive therapeutic function of Aln. The dual benefit of the Aln in the BTNPs was supported by the observations that drug-free Aln-containing BTNPs improved bone volume fraction in bone-tumor-bearing mice, while GANT58-BTNPs created better therapeutic outcomes than both unloaded BTNPs and GANT58-loaded untargeted NPs. These findings suggest GANT58-BTNPs have potential to potently inhibit tumor-driven osteoclast activation and resultant bone destruction in patients with bone-associated tumor metastases.

ACS Nano published new progress about Bone neoplasm, metastasis. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, COA of Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eisenreich, Fabian; Meijer, E. W.; Palmans, Anja R. published the artcile< Amphiphilic Polymeric Nanoparticles for Photoredox Catalysis in Water>, Application of C9H3F5O2, the main research area is phenothiazine amphiphilic polymeric nanoparticle photoredox catalysis; enzyme mimics; green chemistry; nanoparticles; photoredox catalysis; supramolecular chemistry.

Photoredox catalysis has recently emerged as a powerful synthesis tool in organic and polymer chem. In contrast to the great achievements realized in organic solvents, performing photocatalytic processes efficiently in aqueous media encounters several challenges. Here, it is presented how amphiphilic single-chain polymeric nanoparticles (SCPNs) can be utilized as small reactors to conduct light-driven chem. reactions in water. By incorporating a phenothiazine (PTH) catalyst into the polymeric scaffold, metal-free reduction and C-C cross-coupling reactions can be carried out upon exposure to UV light under ambient conditions. The versatility of this approach is underlined by a large substrate scope, tolerance towards oxygen, and excellent recyclability. This approach thereby contributes to a sustainable and green way of implementing photoredox catalysis.

Chemistry – A European Journal published new progress about Amphiphiles. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Application of C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wijker, Stefan; Deng, Linlin; Eisenreich, Fabian; Voets, Ilja K.; Palmans, Anja R. A. published the artcile< En Route to Stabilized Compact Conformations of Single-Chain Polymeric Nanoparticles in Complex Media>, Product Details of C9H3F5O2, the main research area is conformation chain polymeric nanoparticle complex media.

Precise control over the folding pathways of polypeptides using a combination of noncovalent and covalent interactions has evolved into a wide range of functional proteins with a perfectly defined 3D conformation. Inspired hereby, we develop a series of amphiphilic copolymers designed to form compact, stable, and structured single-chain polymeric nanoparticles (SCPNs) of defined size, even in competitive conditions. The SCPNs are formed through a combination of noncovalent interactions (hydrophobic and hydrogen-bonding interactions) and covalent intramol. crosslinking using a light-induced [2 + 2] cycloaddition By comparing different self-assembly pathways of the nanoparticles, we show that, like for proteins in nature, the order of events matters. When covalent crosslinks are formed prior to the folding via hydrophobic and supramol. interactions, larger particles with less structured interiors are formed. In contrast, when the copolymers first fold via hydrophobic and hydrogen-bonding interactions into compact conformations, followed by covalent crosslinks, good control over the size of the SCPNs and microstructure of the hydrophobic interior is achieved. Such a structured SCPN can stabilize the solvatochromic dye benzene-1,3,5-tricarboxamide-Nile Red via mol. recognition for short periods of time in complex media, while showing slow exchange dynamics with the surrounding complex media at longer time scales. The SCPNs show good biocompatibility with cells and can carry cargo into the lysosomal compartments of the cells. Our study highlights the importance of control over the folding pathway in the design of stable SCPNs, which is an important step forward in their application as noncovalent drug or catalyst carriers in biol. settings.

Macromolecules (Washington, DC, United States) published new progress about [2+2] Cycloaddition reaction. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Product Details of C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Shiyu; Zhu, Lijuan; Wang, Donghui; Li, Cong; Chen, Yuanyuan; Chen, Xiaowei; Liu, Jie; Huang, Wei; Ling, Yao; Huang, Weiguo published the artcile< Rigidity-Tuned Full-Color Emission: Uncommon Luminescence Change from Polymer Free-Volume Variations>, Category: esters-buliding-blocks, the main research area is triazatruxene fluorophore morphol mech property density functional theory; anti-rigidochromism; charge-transfer complexes; free-volume-based data-encryption; full color; nonconjugated polymer rigidity detection.

Probing the rigidity change of microenvironments via tracking embedded mol. fluorophore emissions represents a robust approach to monitor various polymer microstructural evolutions and biomol. events with a high spatiotemporal resolution However, reported fluorophores exclusively blueshift their emissions (termed as “”rigidochromism””) or merely alter intensities upon rigidification, suffering from inferior sensitivities, low-contrast outputs, and attenuated biocompatibilities. Here, phenanthridine-fused triazatruxene fluorophores (PTFs) with pronounced bathochromic emission (up to 135 nm) toward rigidifying media at a low loading of 5 ppm without sacrificing the quantum yields and lifetime are developed. PTFs effectively interact with polymeric matrixes through polar-π interactions and form charge-transfer complexes, resulting to a remarkable fluorescent color change from blue to red-orange over matrix rigidifying. Such a unique anti-rigidochromism enables a highly sensitive rigidity detection (i.e., a subtle polymer mol.-weight change (as low as 1000 Da vs up to 10 kDa for conventional probes) can result to obvious emission color changes). PTFs are able to noninvasively detect polymerization kinetics and in situ optically report polymer degradations The broadly (nearly full-spectrum) tunable emission and the efficient coupling between anti-rigidochromism and polymer hierarchical structures/topologies render fluorescence with controlled wavelength and chirality, leading to an unprecedented free-volume-based data encryption and anti-counterfeiting technol. with a superhigh security level.

Advanced Materials (Weinheim, Germany) published new progress about Binding energy. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ulrich, Sebastian; Osypova, Alina; Panzarasa, Guido; Rossi, Rene M.; Bruns, Nico; Boesel, Luciano F. published the artcile< Pyranine-Modified Amphiphilic Polymer Conetworks as Fluorescent Ratiometric pH Sensors>, Electric Literature of 71195-85-2, the main research area is pyranine amphiphilic polymer fluorescent pH sensor; amphiphilic polymers conetworks; fluorescent dyes; nanophase separation; optical pH sensors; pyranine.

The fluorescent dye 8-hydroxypyrene-1,3,6-trisulfonate (pyranine) combines high photostability with ratiometric pH detection in the physiol. range, making it a prime candidate for optical sensors in biomedical applications, such as pH-based chronic wound monitoring. However, pyranine’s high water solubility and the difficulty of covalent attachment pose severe limitations in terms of leaching from sensor matrixes. Herein, pyranine-modified nanophase-separated amphiphilic polymer conetworks (APCNs) are reported as fluorescent ratiometric pH sensors. The thin, freestanding APCN membranes composed of one hydrophilic and one hydrophobic polymer provide an optically transparent, flexible, and stable ideal matrix that enables contact between dye and aqueous environment. An active ester-based conjugation approach results in a highly homogeneous and stable pyranine modification of the APCN’s hydrophilic phase. This concept effectively solves the leaching challenge for pyranine without compromising its functionality, which is demonstrated by ratiometric pH detection in the range of pH 5-9.

Macromolecular Rapid Communications published new progress about Acid-base indicators. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Li Qun; Chen, Jiu Cun; Qian, Shan Shan; Zhang, Ao Kai; Fu, Guo Dong; Li, Chang Ming; Kang, En-Tang published the artcile< PEGylated Metalloporphyrin Nanoparticles as a Promising Catalyst for the Heterogeneous Oxidation of Cyclohexene in Water>, Related Products of 71195-85-2, the main research area is PEGylated metalloporphyrin nanoparticle self assembly cyclohexene oxidation catalyst.

Amphiphilic poly[poly(ethylene glycol) Me ether methacrylate]-b-poly(azidopropyl acrylamide) (PPEGMEMA-b-PAzPA) block copolymers are synthesized via a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and a reactive ester-amine reaction. The azido-functionalized PPEGMEMA-b-PAzPA block copolymers can self-assemble into polymeric micelles in an aqueous medium and encapsulate hydrophobic alkynyl-containing manganese(III)porphyrin (MnP) within the core domain. The subsequent in situ copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) leads to the formation of PEGylated-MnP nanoparticles (PEG-MnP NPs). The as-synthesized PEG-MnP NPs are explored as a heterogeneous catalyst for oxidation of cyclohexene in water. The effect of various parameters, such as precursor oxidants, substrate to catalyst loading ratio, and presence of a cocatalyst, is investigated to optimize the oxidation conditions. The catalytic activity of PEG-MnP NPs in water is also compared with that of dissolved MnP in organic solvent.

Macromolecular Chemistry and Physics published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Related Products of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tahir, Muhammad Nawaz; Eberhardt, Marc; Theato, Patrick; Faiss, Simon; Janshoff, Andreas; Gorelik, Tatiana; Kolb, Ute; Tremel, Wolfgang published the artcile< Reactive polymers: a versatile toolbox for the immobilization of functional molecules on TiO2 nanoparticles>, Name: Perfluorophenyl acrylate, the main research area is dye functionalized polypentafluorophenylacrylate immobilization titanium oxide nanoparticle.

TiO2 nanoparticles were functionalized with reactive poly(pentafluorophenylacrylate) ligands that incorporate chelating dopamine anchor groups, a modifying unit to allow the binding of functional mols. such as fluorescent dyes, and groups to tailor the solubility of the inorganic nanocrystals in different solvents.

Angewandte Chemie, International Edition published new progress about Fluorescence. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Name: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Durie, Karson; Yatvin, Jeremy; Kovaliov, Marina; Crane, Grant H.; Horn, Jessica; Averick, Saadyah; Locklin, Jason published the artcile< SuFEx Postpolymerization Modification Kinetics and Reactivity in Polymer Brushes>, Safety of Perfluorophenyl acrylate, the main research area is SuFEx postpolymn kinetic reactivity polymer brushe.

Since its introduction in 2014, the sulfur(VI) fluoride exchange (SuFEx) reaction has emerged as a promising new reaction in the field of polymer chem., in both polymerization of diverse polymer backbones and postpolymn. modification (PPM). Previously, we successfully reported the use of SuFEx chem. as a method for surface derivatization through the PPM of sulfonyl fluoride containing polymer brushes. However, with the diversity of conditions, substrate scope, and catalyst selection afforded by this reaction, it is advantageous to expand the use of SuFEx for PPM on polymer brushes to discern the advantages and limitations of this reaction in surface conjugation. In this work, we used three different polymer brush systems-alkyl sulfonyl fluorides, aromatic sulfonyl fluorides, and aromatic fluorosulfonates-and each was reacted with three different silyl ether derivatives (aryl, alkyl, and benzyl). Each of these reactions was subjected to different catalysts, and herein, we present rates, conditions, and side products for PPM of polymer brushes using SuFEx chem. In addition, we explored the use of TBDMS brushes and their reaction with fluorosulfonate derivatives, where surprisingly no surface reaction occurs. With these studies, we are able to better understand the rates and limitations of this click reaction in the context of surface derivatization.

Macromolecules (Washington, DC, United States) published new progress about Click chemistry. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Safety of Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Durie, Karson; Yatvin, Jeremy; Kovaliov, Marina; Crane, Grant H.; Horn, Jessica; Averick, Saadyah; Locklin, Jason published the artcile< SuFEx Postpolymerization Modification Kinetics and Reactivity in Polymer Brushes>, Safety of Perfluorophenyl acrylate, the main research area is SuFEx postpolymn kinetic reactivity polymer brushe.

Since its introduction in 2014, the sulfur(VI) fluoride exchange (SuFEx) reaction has emerged as a promising new reaction in the field of polymer chem., in both polymerization of diverse polymer backbones and postpolymn. modification (PPM). Previously, we successfully reported the use of SuFEx chem. as a method for surface derivatization through the PPM of sulfonyl fluoride containing polymer brushes. However, with the diversity of conditions, substrate scope, and catalyst selection afforded by this reaction, it is advantageous to expand the use of SuFEx for PPM on polymer brushes to discern the advantages and limitations of this reaction in surface conjugation. In this work, we used three different polymer brush systems-alkyl sulfonyl fluorides, aromatic sulfonyl fluorides, and aromatic fluorosulfonates-and each was reacted with three different silyl ether derivatives (aryl, alkyl, and benzyl). Each of these reactions was subjected to different catalysts, and herein, we present rates, conditions, and side products for PPM of polymer brushes using SuFEx chem. In addition, we explored the use of TBDMS brushes and their reaction with fluorosulfonate derivatives, where surprisingly no surface reaction occurs. With these studies, we are able to better understand the rates and limitations of this click reaction in the context of surface derivatization.

Macromolecules (Washington, DC, United States) published new progress about Click chemistry. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Safety of Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jochum, Florian D.; Theato, Patrick published the artcile< Thermo- and light responsive micellation of azobenzene containing block copolymers>, Reference of 71195-85-2, the main research area is reversible micellization azobenzene containing block polyoxyethylene polyisopropylacrylamide copolymer.

In this communication, the synthesis and characterization of thermo- and light-responsive block copolymers is reported. PEO-b-PNIPAM polymers with azobenzene moieties were prepared and analyzed by turbidimetry, fluorescence, NMR and DLS measurements. A temperature controlled reversible formation as well as a light induced disruption and reformation of micellar structures in water was found.

Chemical Communications (Cambridge, United Kingdom) published new progress about Hydrodynamic radius. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics