Category: 71195-85-2

Durie, Karson; Yatvin, Jeremy; McNitt, Christopher D.; Reese, R. Alexander; Jung, Calvin; Popik, Vladimir V.; Locklin, Jason published the artcile< Multifunctional Surface Manipulation Using Orthogonal Click Chemistry>, COA of Formula: C9H3F5O2, the main research area is reactive surface morphol polypentafluorophenyl acrylate brush click aminolysis.

Polymer brushes are excellent substrates for the covalent immobilization of a wide variety of mols. due to their unique physicochem. properties and high functional group d. By using reactive microcapillary printing, poly(pentafluorophenyl acrylate) brushes with rapid kinetic rates toward aminolysis can be partially patterned with other click functionalities such as strained cyclooctyne derivatives and sulfonyl fluorides. This trireactive surface can then react locally and selectively in a one pot reaction via three orthogonal chemistries at room temperature: activated ester aminolysis, strain promoted azide-alkyne cycloaddition, and sulfur(VI) fluoride exchange, all of which are tolerant of ambient moisture and oxygen. Furthermore, we demonstrate that these reactions can also be used to create areas of morphol. distinct surface features on the nanoscale, by inducing buckling instabilities in the films and the grafting of nanoparticles. This approach is modular, and allows for the development of highly complex surface motifs patterned with different chem. and morphol.

Langmuir published new progress about 1,3-Dipolar cycloaddition reaction. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, COA of Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Shaojian; Das, Anindita; Theato, Patrick published the artcile< CO2-Responsive graft copolymers: synthesis and characterization>, Recommanded Product: Perfluorophenyl acrylate, the main research area is carbon dioxide responsive amphiphilic acrylic graft copolymer; active ester grafting amphiphilic copolymer self assembly.

A facile and versatile approach for preparing CO2-responsive graft copolymers via a grafting-to strategy that combines controlled radical polymerization with post-polymerization modification has been demonstrated. A well-defined poly(N,N-dimethylacrylamide-co-pentafluorophenyl acrylate) (P(DMA-co-PFPA)) was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization bearing reactive pentafluorophenyl esters as grafting sites on a hydrophilic backbone. Then, amino end-functionalized poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) known for its CO2 responsiveness and hydrophobic poly(Me methacrylate) (PMMA) were prepared via atom transfer radical polymerization (ATRP) as side blocks, resp. The post-polymerization modification via active-ester amine chem. resulted in CO2-responsive graft copolymers with either homo-side chains or discrete multi-functional hetero side chains. The grafting-to strategy utilizing active-ester amine chem. appeared to be a facile and efficient method to fabricate graft copolymers. Both prepared CO2-responsive graft copolymers – due to their amphiphilic nature – could self-assemble into vesicles in aqueous solution and displayed CO2-responsive expansion owing to the protonation of tertiary amine groups of PDEAEMA side chains under CO2 stimulation.

Polymer Chemistry published new progress about Acrylic polymers, fluorine-containing Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ludwanowski, Simon; Skarsetz, Oliver; Creusen, Guido; Hoenders, Daniel; Straub, Paula; Walther, Andreas published the artcile< Wavelength-Gated Adaptation of Hydrogel Properties via Photo-Dynamic Multivalency in Associative Star Polymers>, Quality Control of 71195-85-2, the main research area is hydrogel photo multivalency associative star polymer; Arylazopyrazole; Hydrogels; Photoresponsive Systems; Photoswitch; Wavelength-Gated Engineering.

Responsive materials, such as switchable hydrogels, have been largely engineered for maximum changes between two states. In contrast, adaptive systems target distinct functional plateaus between these maxima. Here, we demonstrate how the photostationary state (PSS) of an E/Z-arylazopyrazole photoswitch can be tuned by the incident wavelength across a wide color spectrum, and how this behavior can be exploited to engineer the photo-dynamic mech. properties of hydrogels based on multivalent photoswitchable interactions. We show that these hydrogels adapt to the wavelength-dependent PSS and the number of arylazopyrazole units by programmable relationships. Hence, our material design enables the facile adjustment of the mech. properties without laborious synthetic efforts. The concept goes beyond the classical switching from state A to B, and demonstrates pathways for a truly wavelength-gated adaptation of hydrogel properties potentially useful to engineer cell fate or in soft robotics.

Angewandte Chemie, International Edition published new progress about Branched polymers, star-branched Role: PRP (Properties). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Quality Control of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ding, Lan; Zhou, Shixin; Li, Dahua; Wu, Chengfeng; Xing, Yuzhi; Song, Bo published the artcile< A facile method to incorporate tetraphenylethylene into polymeric amphiphiles: High emissive nanoparticles for cell-imaging>, Reference of 71195-85-2, the main research area is amphiphile polymer nanoparticle fluorescent probe cell imaging.

Encapsulating fluorogens into polymeric nanoparticles is proven an effective method to shield the fluorogens from the outer environment and improve the biocompatibility as well. Conventionally, the fluorogens are firstly conjugated to the monomers and then polymerized into macromols., where tedious mol. design and synthesis was unavoidable. Herein, we present a facile method to prepare the fluorogen-functionalized polymer, and then use the polymer as build blocks to fabricate nano-probes aiming at cell-imaging. Unlike the conventional ways, we prepared a homopolymer with active esters on the repeating units and used the polymer as matrix to graft fluorogens and hydrophilic groups. Note that the fluorogen and hydrophilic groups selected in our study were tetraphenylethylene (TPE) and polyethylene glycol (PEG), resp. The resulting amphiphilic random copolymer self-assembled into spherical nanoparticles with size around 225 nm in aqueous solution With comparable amount of TPE moieties, the polymeric nanoparticles demonstrated much stronger emission than the nanoparticles formed by small mols. of TPE derivatives The polymeric nanoparticles showed very good stability and biocompatibility, and were employed to label Hela cells and gave high-contrast fluorescent images. We anticipate that the methodol. presented in this study might be developed into a general avenue to encapsulating fluorogens into nanoparticles.

Dyes and Pigments published new progress about Amphiphiles. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Meina; Wang, Xingyou; Miao, Dengyun; Wang, Caiyun; Deng, Wei published the artcile< Synthesis of well-defined heteroglycopolymers via combining sequential click reactions and PPM: the effects of linker and heterogeneity on Con A binding>, Category: esters-buliding-blocks, the main research area is heteroglycopolymer sequential click reaction post polymerization modification.

Heteroglycopolymers displaying different sugar motifs have been increasingly used as tools to investigate the inherent heterogeneity in carbohydrate-protein binding to date. Herein a library of well-defined homo and hetero-glycopolymers consisting of different sugar units in the side chain were generated by reacting poly(pentafluorophenyl acrylate) (pPFPA) with difunctionalized sugar amines via post-polymerization modification, in which one class of sugar motifs is linked by the flexible thiol ether bond while the same or different sugar motifs are connected by the rigid triazole ring in the side chain. A series of difunctionalized sugar amines were synthesized by implementing sequential CuAAC and thiol-ene click reactions, which could serve as a facile methodol. for achieving heterogeneous sugar synthetic blocks with functional control. Isothermal titration calorimetry (ITC) measurements of the obtained glycopolymers with Con A as the model receptor indicated that heterogeneous glycopolymers bearing binding units D-mannose and non-binding sugar motifs in the side chains show higher affinities to Con A as compared to monoglycopolymer. More surprisingly, heterogeneous glycopolymers in which α-D-mannose is linked by the flexible thiol ether bond in the side chain showed higher binding affinity to Con A in comparison with the heterogeneous glycopolymer in which α-D-mannose is linked by the rigid triazole ring since the flexible linker could provide more spaces on the polymer.

Polymer Chemistry published new progress about Click chemistry. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yiliu; Pauloehrl, Thomas; Presolski, Stanislav I.; Albertazzi, Lorenzo; Palmans, Anja R. A.; Meijer, E. W. published the artcile< Modular Synthetic Platform for the Construction of Functional Single-Chain Polymeric Nanoparticles: From Aqueous Catalysis to Photosensitization>, Electric Literature of 71195-85-2, the main research area is single chain polymer nanoparticle photosensitization photodynamic therapy.

Single-chain polymeric nanoparticles (SCPNs) are intriguing systems for multiple applications. In order to arrive at a controlled, but random, positioning of the different side groups to the polymer backbone, alternative synthetic routes have to be developed. Here, a general postpolymn. modification strategy of poly(pentafluorophenyl acrylate) (pPFPA) is presented as a versatile method to rapidly access functional SCPNs. We first show that the sequential addition of a benzene-1,3,5-tricarboxamide-based amine, acting as the supramol. recognition motif, and water-soluble polyetheramine (Jeffamine) to pPFPA affords random copolymers that fold in water into SCPNs. The scope of the modular platform is illustrated by preparing two types of functional SCPNs. First, we prepared SCPNs designed for bio-orthogonal catalysis by attaching pendant mono(benzimidazoylmethyl)-bis(pyridylmethyl) (Bimpy), phenanthroline (Phen), or 2,2′-bipyridine (BiPy), ligands capable of binding either Cu(I) or Pd(II). The Bimpy- and Phen-containing SCPNs ligated to Cu(I) significantly accelerate azide-alkyne cycloaddition reactions while Bipy-containing SCPNs ligated to Pd(II) efficiently catalyze depropargylation reactions. In all cases, reactions proceeded efficiently in phosphate buffer at a physiol. pH and at low substrate concentrations Next, the potential of SCPNs for photodynamic therapy was evaluated. Introducing porphyrins in SCPNs leads to novel photosensitizers that can produce singlet oxygen (1O2) upon photoirradiation Addnl., by attaching both porphyrins and prodrug models, attached via 1O2-cleavable amino-acrylate linker, to the SCPNs, we show that irradiation of the SCPNs results in a cascade reaction of 1O2 generation followed by cleavage of the amino-acrylate linkers, releasing the drug model. The modular synthesis strategy reported here provides rapid and controlled access to SCPNs with tunable amounts of active units that fulfill different functions.

Journal of the American Chemical Society published new progress about Pharmaceutical nanoparticles. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hao, Qiubo; Wang, Zhixiong; Zhao, Wei; Wen, Liewei; Wang, Wenhui; Lu, Siyu; Xing, Da; Zhan, Meixiao; Hu, Xianglong published the artcile< Dual-Responsive Polyprodrug Nanoparticles with Cascade-Enhanced Magnetic Resonance Signals for Deep-Penetration Drug Release in Tumor Therapy>, Category: esters-buliding-blocks, the main research area is cell penetrating hyperbranched polymer prodrug amphiphile magnetic resonance antitumor; cascade degradation; magnetic resonance imaging; polyprodrug; reduction-responsive drug release; tumor deep penetration.

Smart transformable nanocarriers are promising to treat deep-seated diseases but require adaptable diagnostic/imaging potency to reflect the morphol. change and therapeutic feedback, yet their design and synthesis remains challenging. Herein, stimuli-responsive polyprodrug nanoparticles (SPNs) are formulated from the co-assembly of neg. charged corona and pos. charged polyprodrug cores, exhibiting high loading content of camptothecin (CPT, ~28.6 wt %) tethered via disulfide linkages in the core. SPNs are sequentially sensitive to tumor acidic condition and elevated reductive milieu in the cytosol for deep-penetration drug delivery. Upon accumulation at acidic tumor sites, SPNs dissociate to release smaller pos. charged polyprodrug nanoparticles, which efficiently enter deep-seated tumor cells to trigger high-dosage parent CPT release in the reductive cytosolic milieu. Meanwhile, the polyprodrug cores of SPNs labeled with DTPA(Gd), a magnetic resonance imaging contrast agent, can trace the cascade degradation and biodistribution of SPNs as well as the resulting intracellular CPT release. The longitudinal relaxivity of SPNs increases stepwise in the above two processes. The size-switchable polyprodrug nanoparticles exhibit remarkable tumor penetration and noteworthy tumor inhibition in vitro and in vivo, which are promising for endogenously activated precision diagnostics and therapy.

ACS Applied Materials & Interfaces published new progress about Antitumor agents. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hou, Zhanyao; Nau, Werner M.; Hoogenboom, Richard published the artcile< Reversible covalent locking of a supramolecular hydrogel via UV-controlled anthracene dimerization>, Recommanded Product: Perfluorophenyl acrylate, the main research area is supramol hydrogel UV irradiation anthracene dimerization.

Supramol. hydrogels gained significant attention as shear-thinning, self-healing materials. However, the introduction of non-covalent crosslinks inherently decreases the strength and stability of the hydrogel. In this work, we developed a novel supramol. hydrogel that undergoes a reversible transformation to the corresponding covalently crosslinked hydrogel upon UV-irradiation The supramol. hydrogel was developed based on the ternary host-guest interaction of two anthracene moieties and one large macrocyclic host. Anthracene functionalized poly(N-acryloylmorpholine)s were synthesized by post-polymerization modification of a copolymer consisting of N-acryloylmorpholine and an activated ester comonomer, whereby two different polymers were prepared having either neutral anthracene side-chains or carrying a pos. charge next to the anthracene to enhance the interaction with the host. The binding affinity of the anthracene side chains with and without an addnl. cationic charge were studied with two macrocyclic hosts, namely cucurbit[8]uril and γ-cyclodextrin (γ-CD) by UV-Vis titration revealing a markedly stronger binding in the presence of the cationic charge due to addnl. ion-dipole one of the macrocyclic hosts, cucurbit[8]uril. Subsequently, the effect of the binding affinity on the hydrogelation was investigated, indicating that the stronger binding affinity facilitated the hydrogel formation at lower concentration Finally, the reversible transformation of the supramol. hydrogel to a chem. hydrogel by anthracene dimerization was studied by the UV irradiation of the hydrogel at 365 nm for covalent crosslinking or at 254 nm for decrosslinking. It could be demonstrated that the dynamic nature of the hydrogel, that is responsible for the shear-thinning behavior, was indeed lost upon UV-irradiation indicative of the formation of a covalently crosslinked hydrogel. The capabilities of the formed supramol. hydrogel that is easily processable and able to reversibly convert to a chem. hydrogel, provides potential applications in applying mech. robust covalently crosslinked hydrogels in complex shapes and difficult to reach locations making use of the dynamic nature of the supramol. crosslinks.

Polymer Chemistry published new progress about Hydrogels. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Shaojian; Schattling, Philipp; Theato, Patrick published the artcile< Thermo- and CO2-responsive linear polymers and hydrogels as CO2 capturing materials>, Recommanded Product: Perfluorophenyl acrylate, the main research area is carbon dioxide responsive polymer hydrogel preparation critical solution concentration.

A series of poly(N-cyclopropyl acrylamide-co-L-Arginine Me ester acrylamide)s (P(CPAM-co-AME)s) with varying arginine content, and corresponding hydrogels (P(CPAM-co-AME) gels) for the CO2 capture were prepared via post-polymerization modification of reactive poly(pentafluorophenyl acrylate) with com. available amines. The resulting polymers are reversibly responsive to temperature and CO2. P(CPAM-co-AME)s can capture CO2 in water and exhibit CO2-switchable LCSTs. The LCSTs transition of P(CPAM-co-AME)s are unusual and decrease after bubbling CO2 through the solution This unusual phenomenon also happens in corresponding hydrogels. P(CPAM-co-AME) gels exhibit a CO2-switchable change in volume after treatment with CO2, i.e., the P(CPAM-co-AME) gels can undergo reversible shrinking and swelling cycles upon alternating treatment with CO2 and Ar, resp. Therefore, P(CPAM-co-AME)s and corresponding gels are suggested as potential polymers for CO2 capture.

Science of Advanced Materials published new progress about Hydrogels. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eissa, Ahmed M.; Abdulkarim, Ali; Sharples, Gary J.; Cameron, Neil R. published the artcile< Glycosylated Nanoparticles as Efficient Antimicrobial Delivery Agents>, Category: esters-buliding-blocks, the main research area is nanoparticle antibiotic glycosylation polybutyl acrylate.

Synthetic polymer nanoparticles that can be tailored through multivalent ligand display on the surface, while at the same time allowing encapsulation of desired bioactive mols., are especially useful in providing a versatile and robust platform in the design of specific delivery vehicles for various purposes. Glycosylated nanoparticles (glyco-NPs) of a poly(Bu acrylate) (pBA) core and poly(N-2-(β-D-glucosyloxy)ethyl acrylamide) (p(NβGlcEAM)) or poly(N-2-(β-D-galactosyloxy)ethyl acrylamide) (p(NβGalEAM)) corona were prepared via nanopptn. in aqueous solutions of preformed amphiphilic glycopolymers. Well-defined block copolymers of poly(pentafluorophenyl acrylate) (pPFPA) and pBA were first prepared by RAFT polymerization followed by postpolymn. functionalization with aminoethyl glycosides to yield p(NβGlcEAM-b-BA) and p(NβGalEAM-b-BA), which were then used to form glyco-NPs (glucosylated and galactosylated NPs, Glc-NPs and Gal-NPs, resp.). The glyco-NPs were characterized by dynamic light scattering (DLS) and TEM. Encapsulation and release of ampicillin, leading to nanoparticles that we have termed “”glyconanobiotics””, were studied. The ampicillin-loaded glyco-NPs were found to induce aggregation of Staphylococcus aureus and Escherichia coli and resulted in antibacterial activity approaching that of ampicillin itself. This glyconanobiotics strategy represents a potential new approach for the delivery of antibiotics close to the surface of bacteria by promoting bacterial aggregation. Defined release in the proximity of the bacterial envelope may thus enhance antibacterial efficiency and potentially reduce the quantities of agent required for potency.

Biomacromolecules published new progress about Antibacterial agents. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics