Category: 6290-49-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6290-49-9, name is Methyl 2-methoxyacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Methyl 2-methoxyacetate

Intermediate 16; 5-(Methoxy)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone To a three-neck 500 mL round-bottomed flask, equipped with mechanical stirring, were added toluene (100 mL) and metallic sodium (5.75 g; 0.25 moles). A mixture of methyl methoxyacetate (25 mL; 0.25 moles) and ethyl formate (20 mL; 0.25 moles) was added dropwise to the system using an addition funnel. An external water bath was used to keep the system below 30 C. throughout the addition. The system was stirred at room temperature for 16 h. The liquid phase was then decanted and the remaining gummy solid was treated with thiourea (19 g; 0.25 moles) and ethanol (50 mL). The system was heated to reflux for 4 h and cooled to room temperature. The light pink solid was collected by filtration and dissolved in 125 mL of water. The solution was acidified (pH 4-5) with concentrated HCl. The solid precipitated was collected by filtration, washed with water and dried under high vacuum Intermediate 16 (22 g; 56% yield) was obtained. MS: (M+H)-=159.

The synthetic route of 6290-49-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Johnson, Neil W.; Bryan, Deborah L.; US2008/182852; (2008); A1;,
Ester – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6290-49-9, name is Methyl 2-methoxyacetate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H8O3

A 10 L three-necked round bottom flask equipped with a mechanic stirrer and thermometer was charged with a solution of tert-butyl acetate (1612, 13.9 mol) in dry THF (14 L) and cooled to -70 C under N2. A solution of LiHMDS (13.9 L, 13.9 mol) in THF was added at -70 C and the mixture was allowed to stir at -70 C for 1 hour. A solution of 3b (723 g, 6.95 mol) in THF (1 L) was added to the reaction and stirred at -70 C for 0.5 hours. The reaction was quenched by the addition of water (10 L) and the mixture was extracted with EtOAc. The combined the organic phase was washed with brine, dried over Na2SO4 and concentrated in vacuo to provide 3c as oil. ?H NMR (400 MHz, CDC13) oe 4.09 (s, 2H), 3.43 (s, 2H), 3.42 (s, 2H),1.47 (s, 9H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6290-49-9.

Reference:
Patent; MERCK SHARP & DOHME CORP.; GRAHAM, Thomas H.; LIU, Wensheng; YU, Tao; ZHANG, Yonglian; WADDELL, Sherman T.; WAI, John S.; COLEMAN, Paul J.; SANDERS, John M.; EMBREY, Mark W.; WALJI, Abbas; FERGUSON, Ronald Dale II; MARCO, Christina Ng Di; STEELE, Thomas; HU, Lihong; PENG, Xuanjia; WO2015/89847; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 6290-49-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6290-49-9, name is Methyl 2-methoxyacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a 1000 ml four-necked flask, 102 g (0.98 mol) of methyl methoxyacetate and 75 g (1.25 mol) of methyl formate were added, and the temperature was lowered to 10 C. with stirring.60 g (1.11 mol) of sodium methoxide was added in portions, and the temperature was controlled to not exceed 30 C.After the addition of sodium methoxide, the reaction was stirred at 25 C for 2h, and the temperature was raised to 36 C for 4h.At the end of the reaction, the temperature was lowered and suction filtered. The solid product content was 98.0%, and the yield was 92.0%.

The synthetic route of Methyl 2-methoxyacetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Kuai Da Agrochemical Co., Ltd.; Lin Longlong; Wu Feng; Cao Weidong; Xia Xiaofeng; (4 pag.)CN110759829; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 6290-49-9, These common heterocyclic compound, 6290-49-9, name is Methyl 2-methoxyacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of methyl methoxyacetate (52 g, 500 mmol), hydrazine hydrate (30 mL) washeated to reflux for 8 h. Excess hydrazine and water were removed under vacuum. The residuewas extracted with n-butanol, dried with NaaSC^. Excess w-butanol was removed to yield 45g ofhydrazide.

The synthetic route of 6290-49-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AXYS PHARMACEUTICALS; WO2004/108661; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics