Category: 617-55-0

Zhu, Sheng; Lin, Wen-qing; Zhang, Xiao-mei published the artcile< Process improvement on the synthesis of (S)-(+)-3-hydroxytetrahydrofuran>, SDS of cas: 617-55-0, the main research area is process improvement synthesis hydroxy THF preparation; tetrahydrofuranol preparation asym synthesis.

A method for the synthesis of the title compound [i.e., (S)-(+)-3-hydroxytetrahydrofuran] is reported here. Said target compound (overall yield 43.2%, 99.0% enantiomeric excess) was prepared by a synthetic sequence involving the esterification of L-malic acid, reduction and cyclization through intramol. dehydration. The product structure was determined by NMR.

Hecheng Huaxue published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Salvatore, Ralph N.; Chu, Feixia; Nagle, Advait S.; Kapxhiu, Elona A.; Cross, Richard M.; Jung, Kyung Woon published the artcile< Efficient Cs2CO3-promoted solution and solid phase synthesis of carbonates and carbamates in the presence of TBAI>, Product Details of C6H10O5, the main research area is carbamate carbonate preparation cesium carbonate tetrabutylammonium iodide; solid phase preparation carbamate carbonate; carbon dioxide reaction alc amine alkyl halide.

Novel solution and solid-phase methods for the synthesis of carbonates and carbamates were developed using cesium bases and TBAI via a three-component coupling. Cesium carbonate not only promoted successful carbonylations of alcs. and carbamations of amines, but also suppressed common side reactions traditionally seen using existing protocols. Various alcs. and amines were examined, using a wide array of alkyl halides, and the results demonstrated that this methodol. was highly chemoselective. In particular, use of either sterically demanding substrates or amino acid derivatives afforded the corresponding products exclusively, offering a wide variety of applications such as novel protecting groups and peptidomimetic syntheses.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Product Details of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Madry, Tomasz; Czapik, Agnieszka; Kwit, Marcin published the artcile< Optical Activity and Helicity Enhancement of Highly Sensitive Dinaphthylmethane-Based Stereodynamic Probes for Secondary Alcohols>, Quality Control of 617-55-0, the main research area is optical activity helicity enhancement dinaphthylmethane stereodynamic probe secondary alc.

The chirality transfer from CD-silent secondary alc. (inductor) to the stereodynamic bichromophoric di(1-naphthyl)methane probe (reporter) led to the generation of intense induced exciton-type Cotton effects in the UV/VIS absorption region. The di(1-naphthyl)methane probe exhibits extraordinarily high sensitivity to even small structural variations of the alc. skeleton, i.e., the probe is able to distinguish between an oxygen atom and a methylene group in a 3-hydroxytetrahydrofurane skeleton. Signs and amplitudes of the exciton couplets of 1Bb electronic transition might be correlated with the type of stereo differentiating parts of the mol., flanking the stereogenic center, however, not with the absolute configuration. The origin of the induced Cotton effects was established by means of exptl. and theor. methods. As a result, a mechanism of chirality transfer from permanent stereogenic center to the bichromophore is proposed.

ACS Omega published new progress about Bond angle, dihedral. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Quality Control of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lowe, Gordon; Potter, Barry V. L. published the artcile< Synthesis, absolute configuration, and circular dichroism of the enantiomers of fluorosuccinic acid>, Reference of 617-55-0, the main research area is malate ester stereospecific fluorination; fluorosuccinate configuration CD; succinate fluoro configuration CD; asym preparation fluorosuccinate.

D-labeling showed that fluorination of (2S)- and (2R)-MeO2CCH(OH)CH2CO2Me with Et2NSF3 (CHCl3, 0æŽ?ambient temperature) occurred stereospecifically with inversion of configuration to give (2R)- and (2S)-MeO2CCHFCH2CO2Me, resp., (I, II, resp.). The CD spectra of I and II and the corresponding acids, obtained by acid hydrolysis, were ‘anomalous’, showing that the previously determined (Harper, D. B., Blakeley, E. R.; 1971) absolute configuration of (+)-HO2CCHFCH2CO2H obtained from Pseudomonal is incorrect.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Circular dichroism. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Reference of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qiu, You-Chun; Zhang, Fu-Li; Zhang, Chun-Nian published the artcile< A practical and efficient procedure for reduction of carboxylic acids and their derivatives: use of KBH4-MgCl2>, Category: esters-buliding-blocks, the main research area is carboxylic acid ester anhydride imide reduction borohydride magnesium chloride.

The use of KBH4-MgCl2 to reduce carboxylic acids and their derivatives to the corresponding alcs. or the resp. reduced products is described. Me (S)-3,4-O-isopropylidene-3,4-dihydroxybutanoate used as a reference substrate was reduced with KBH4 and MgCl2 in 1:1 mol ratio to 80 % (S)-1,2-O-isopropylidene-1,2,4-butanetriol. KBH4-LiCl gave higher yields but LiCl is more expensive than MgCl2.

Tetrahedron Letters published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Mengyu; Sun, Deli; Gong, Hegui published the artcile< Ni-Catalyzed Reductive C-O Bond Arylation of Oxalates Derived from ä¼?Hydroxy Esters with Aryl Halides>, Electric Literature of 617-55-0, the main research area is synthesis aryl ester reductive cross coupling oxalate aryl halide; aryl ester preparation arylation aryl halide oxalate radical fragmentation; oxalate radical fragmentation reduction potential.

A Ni-catalyzed reductive cross-coupling of ä¼?hydroxycarbonyl compounds modified with oxalyl groups and aryl halides has been developed that furnishes ä¼?aryl esters under mild conditions and tolerates a variety of functionalized aryl halides bearing electron-withdrawing and -donating groups. This work highlights C-O bond fragmentation on secondary alkyl carbon centers that generates ä¼?carbonyl radicals.

Organic Letters published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Electric Literature of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sefkow, Michael; Koch, Andreas; Kleinpeter, Erich published the artcile< New results on the stereoselective alkylations of malic acid derivatives supported by molecular modeling>, Application In Synthesis of 617-55-0, the main research area is stereoselective alkylation malic acid derivative mol modeling.

The stereoselectivity of the alkylation of dialkyl malates is dependent on steric hindrance of both ester alkyl groups. It was found that the two alkyl groups have opposite effects on diastereoselectivity. Increased steric hindrance at the C(1) carboxy group increases the anti-selectivity, whereas increased steric hindrance at the C(4) carboxy group decreases it. The results are explained by comparing the structures of the enolates, which were obtained by mol. modeling. Alkylation at C(4′) of dioxolanones, derived from benzyl-substituted malic acids, with an addnl. stereogenic center on the side chain is dependent on the stereogenic centers of the ring acetal and of the side chain. Alkylation at low temperatures occurs only with cis-dioxolanones having an (R)-configured side-chain stereogenic center. The corresponding trans-dioxolanone and the cis-dioxolanone with a (S)-configured side-chain stereogenic center were recovered unchanged. A rationale is presented with models of monolithiated dioxolanones obtained by ab initio calculations

Helvetica Chimica Acta published new progress about Acetals, cyclic Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent) (of malic acid derivatives). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jia, Kaimin; Cao, Ruikai; Hua, Duy H.; Li, Ping published the artcile< Study of Class I and Class III Polyhydroxyalkanoate (PHA) Synthases with Substrates Containing a Modified Side Chain>, Category: esters-buliding-blocks, the main research area is polyhydroxyalkanoate PHA synthase substrate specificity preparation structure activity.

Polyhydroxyalkanoates (PHAs) are carbon and energy storage polymers produced by a variety of microbial organisms under nutrient-limited conditions. They have been considered as an environmentally friendly alternative to oil-based plastics due to their renewability, versatility, and biodegradability. PHA synthase (PhaC) plays a central role in PHA biosynthesis, in which its activity and substrate specificity are major factors in determining the productivity and properties of the produced polymers. However, the effects of modifying the substrate side chain are not well understood because of the difficulty to accessing the desired analogs. In this report, a series of 3-(R)-hydroxyacyl CoA (HACoA) analogs were synthesized and tested with class I synthases from Chromobacterium sp. USM2 (PhaCCs and A479S-PhaCCs) and Caulobacter crescentus (PhaCCc) as well as class III synthase from Allochromatium vinosum (PhaECAv). It was found that, while different PHA synthases displayed distinct preference with regard to the length of the alkyl side chains, they could withstand moderate side chain modifications such as terminal unsaturated bonds and the azide group. Specifically, the specific activity of PhaCCs toward propynyl analog (HHxyCoA) was only 5-fold less than that toward the classical substrate HBCoA. The catalytic efficiency (kcat/Km) of PhaECAv toward azide analog (HABCoA) was determined to be 2.86脳105 M-1 s-1, which was 6.2% of the value of HBCoA (4.62脳106 M-1 s-1) measured in the presence of bovine serum albumin (BSA). These side chain modifications may be employed to introduce new material functions to PHAs as well as to study PHA biogenesis via click-chem., in which the latter remains unknown and is important for metabolic engineering to produce PHAs economically.

Biomacromolecules published new progress about Enzyme inhibition kinetics. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Latxague, Laurent; Patwa, Amit; Amigues, Eric; Barthelemy, Philippe published the artcile< Glycosyl-nucleo-lipids as new bio-inspired amphiphiles>, Category: esters-buliding-blocks, the main research area is endothermic phase transition surface tension glycosyl nucleoside preparation click; glycolipid nucleoside amphiphile fluorocarbon azido thymidine preparation.

Four new Glycosyl-Nucleo-Lipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochem. studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity compared to the first generation of GNFs.

Molecules published new progress about 1,3-Dipolar cycloaddition reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sato, Hiromi; Matsuda, Noriko; Kikuchi, Masao published the artcile< Constituents of Viburnum awabuki>, Category: esters-buliding-blocks, the main research area is Viburnum composition; malate Viburnum; glycoside Viburnum.

Sixteen constituents, including L-4-Me 2-O-methylmalate and glycosides were isolated from V. awabuki.

Natural Medicines (Tokyo) published new progress about Glycosides Role: BSU (Biological Study, Unclassified), PEP (Physical, Engineering or Chemical Process), BIOL (Biological Study), PROC (Process). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics