Category: 6149-41-3

In 2007,Koenig, Andreas; Roegler, Carolin; Lange, Kathrin; Daiber, Andreas; Glusa, Erika; Lehmann, Jochen published 《NO donors. Investigations on structure-activity relationships of organic mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent vasodilator》.Bioorganic & Medicinal Chemistry Letters published the findings.Category: esters-buliding-blocks The information in the text is summarized as follows:

The vasoactive properties of 14 organic mononitrates were investigated in vitro using PGF2α-precontracted porcine pulmonary arteries. A surprisingly wide range of vasorelaxant potencies was observed (pD2: 3.36-7.50). Activities showed to be highly sensitive to the mol. structure and the substituents at the mol. carrier of the nitrate group. A correlation between lipophilicity and vasorelaxant potency could not be recognized. 2-Nitrooxyethylammoniumnitrate (1) was found to be slightly superior to the high potency trinitrate GTN. After reading the article, we found that the author used Methyl 3-hydroxypropanoate(cas: 6149-41-3Category: esters-buliding-blocks)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Unexpected Preference of the E. coli Translation System for the Ester Bond during Incorporation of Backbone-Elongated Substrates》 was written by Sando, Shinsuke; Abe, Kenji; Sato, Nobuhiko; Shibata, Toshihiro; Mizusawa, Keigo; Aoyama, Yasuhiro. Recommanded Product: Methyl 3-hydroxypropanoateThis research focused ontranslation ribosome tRNA protein oligopeptide hydroxypropionic acid stereochem. The article conveys some information:

There have been recent advances in the ribosomal synthesis of various mols. composed of nonnatural ribosomal substrates. However, the ribosome has strict limitations on substrates with elongated backbones. Here, we show an unexpected loophole in the E. coli translation system, based on a remarkable disparity in its selectivity for β-amino/hydroxy acids. We challenged β-hydroxypropionic acid (β-HPA), which is less nucleophilic than β-amino acids but free from protonation, to produce a new repertoire of ribosome-compatible but main-chain-elongated substrates. PAGE anal. and mass-coupled S-tag assays of amber suppression experiments using yeast suppressor tRNAPheCUA confirmed the actual incorporation of β-HPA into proteins/oligopeptides. We investigated the side-chain effects of β-HPA and found that the side chain at position α and R stereochem. of the β-substrate is preferred and even notably enhances the efficiency of incorporation as compared to the parent substrate. These results indicate that the E. coli translation machinery can utilize main-chain-elongated substrates if the pKa of the substrate is appropriately chosen. In the experimental materials used by the author, we found Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: Methyl 3-hydroxypropanoate)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2004,Khokhar, Shaista S.; Wirth, Thomas published 《Nucleophile-selective selenocyclizations》.European Journal of Organic Chemistry published the findings.HPLC of Formula: 6149-41-3 The information in the text is summarized as follows:

Electrophilic cyclizations are one of the major strategies for cyclofunctionalizations of alkenes. Selective selenocyclizations can be performed by adjusting various factors in such reactions. The nature of the electrophile, the counterion, solvents, and external additives coordinating to the electrophilic species are used to control the course of such cyclizations with high degrees of efficiency. Investigations reported here have been extended towards stereoselective reactions using chiral selenium electrophiles. For example, the stereoselective selenocyclization of chiral selenium electrophile I with α-(hydroxymethyl)-γ-(methylene)benzenebutanoic acid (II) gave furanone III. In the experimental materials used by the author, we found Methyl 3-hydroxypropanoate(cas: 6149-41-3HPLC of Formula: 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wan, Qiaoqiao; Wang, Xinyue; Zhao, Bei; Zhao, Guoming; Zhao, Guangzhen; Gao, Enyuan; Gong, Yuxiu; Yu, Haibin; Wang, Xing; Liu, Di; Tian, Yuanyu published an article in 2021. The article was titled 《Influence of calcination temperature on the cooperative catalysis of base sites and gold nanoparticles on hydrotalcite-supported gold materials for the base-free oxidative esterification of 1, 3-propanediol with methanol to methyl 3-hydroxypropionate》, and you may find the article in Reaction Kinetics, Mechanisms and Catalysis.Quality Control of Methyl 3-hydroxypropanoate The information in the text is summarized as follows:

Magnesium-aluminum hydrotalcite (HT) supported gold catalyst (1 wt% Au/HT) was prepared by the colloid-deposition method and characterized by inductively coupled plasma at. emission spectroscopy (ICP-AES), X-ray diffraction (XRD), nitrogen adsorption, transmission electron microscopy (TEM), XPS and Hammett indicator method. The effects of calcination temperature of catalyst and support on the catalytic performance of aerobic oxidative esterification of 1,3-propanediol with methanol to Me 3-hydroxypropionate (3-HPM) under base-free condition were studied. The results showed that the conversion of 1,3-propanediol and the selectivity of 3-HPM increased first and then decreased with the increase of calcination temperature of catalyst and support. The optimal calcination temperature of catalyst and support is 150°C. Under the optimum preparation conditions, the conversion of 1,3-propanediol and the selectivity to 3-HPM are 96.2% and 94.9%, resp. In addition, the 1 wt% Au/HT catalyst could be effectively recovered by calcining at 150°C in air atm., and the performance of the catalyst does not decrease significantly. The performance of the catalyst is higher than that reported previously. The structure of magnesium-aluminum hydrotalcite with appropriate d. and medium strength base sites and small metallic Au particles are favorable for the selective oxidative esterification of 1,3-propanediol to 3-HPM. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-hydroxypropanoate(cas: 6149-41-3Quality Control of Methyl 3-hydroxypropanoate)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2008,Tredwell, Matthew; Luft, Jennifer A. R.; Schuler, Marie; Tenza, Kenny; Houk, Kendall N.; Gouverneur, Veronique published 《Fluorine-directed diastereoselective iodocyclizations》.Angewandte Chemie, International Edition published the findings.Electric Literature of C4H8O3 The information in the text is summarized as follows:

β-Fluorinated lactones and tetrahydrofurans are synthesized by iodocyclization of various allylic fluorides. The fluorine substituent acts as a highly efficient syn-stereodirecting group for the ring closure. The exptl. results combined with theor. studies provide evidence in support of an inside fluoro effect to account for the sense and level of stereocontrol of these reactions. In the experiment, the researchers used Methyl 3-hydroxypropanoate(cas: 6149-41-3Electric Literature of C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2003,Hollowood, Christopher J.; Yamanoi, Shigeo; Ley, Steven V. published 《Use of π-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase β and HIV reverse transcriptase》.Organic & Biomolecular Chemistry published the findings.Computed Properties of C4H8O3 The information in the text is summarized as follows:

The total synthesis of taurospongin A (I) by two new approaches has been achieved where π-allyltricarbonyliron lactone complexes have been used to control highly stereoselective additions of the . In the experiment, the researchers used Methyl 3-hydroxypropanoate(cas: 6149-41-3Computed Properties of C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Methyl 3-hydroxypropanoateIn 2007 ,《Thermal decomposition of methyl β-hydroxyesters in m-xylene solution》 was published in International Journal of Chemical Kinetics. The article was written by Zapata, Edilma; Gaviria, Jair; Quijano, Jairo. The article contains the following contents:

The products and kinetics of the thermal decomposition of several methyl-β-hydroxyesters in m-xylene solution were studied. All β-hydroxyesters studied pyrolyze to form a mixture of Me acetate and the corresponding aldehyde or ketone and the decomposition follows first-order kinetics and appears to be homogeneous and unimol. The rate pyrolysis of methyl-3-hydroxypropanoate, methyl-3-hydroxybutanoate, and methyl-3-hydroxy-3-methylbutanoate was measured between 250 and 320°C. The relative rates of primary, secondary, and tertiary alcs. at 553 K are 1.0, 8.5 and 54.1, resp. The absence of large substituent effects indicates that little charge separation occurs during the breaking of carbon-carbon single bond. The activation entropy is compatible with a semipolar six-membered cyclic transition state postulated for other β-hydroxy compounds In addition to this study using Methyl 3-hydroxypropanoate, there are many other studies that have used Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: Methyl 3-hydroxypropanoate) was used in this study.

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Luo, Jingjie; Liu, Pengcheng; Yang, Wenhao; Niu, Hongyu; Li, Shaojie; Liang, Changhai published an article in Frontiers in Chemistry (Lausanne, Switzerland). The title of the article was 《Chemical kinetics and promoted Co-immobilization for efficient catalytic carbonylation of ethylene oxide into methyl 3-hydroxypropionate》.COA of Formula: C4H8O3 The author mentioned the following in the article:

The carbonylative transformation of ethylene oxide (EO) into Me 3- hydroxypropionate (3-HPM) is a key process for the production of 1,3- propanediol (1,3-PDO), which is currently viewed as one of the most promising monomers and intermediates in polyester and pharmaceuticals industry. In this work, a homogeneous reaction system using com. Co2(CO)8 was first studied for the carbonylation of EO to 3-HPM. The catalytic behavior was related to the electronic environment of N on aromatic rings of ligands, where N with rich electron d. induced a stronger coordination with Co center and higher EO transformation. A reaction order of 2.1 with respect to EO and 0.3 with respect to CO was unraveled based on the kinetics study. The 3-HPM yield reached 91.2% at only 40°C by Co2(CO)8 coordinated with 3-hydroxypyridine. However, Cocontaining colloid was formed during the reaction, causing the tough separation and impossible recycling of samples. Concerning the sustainable utilization, Co particles immobilized on pre-treated carbon nanotubes (Co/ CNT-C) were designed via an in situ reduced colloid method. It is remarkable that unlike conventional Co/CNT, Co/CNT-C was highly selective toward the transformation of EO to 3-HPM with a specific rate of 52.2 mmol · g-1 Co · h-1, displaying a similar at. efficiency to that of coordinated Co2(CO)8. After reaction, the supported Co/CNT-C catalyst could be easily separated from the liquid reaction mixture, leading to a convenient cyclic utilization. After reading the article, we found that the author used Methyl 3-hydroxypropanoate(cas: 6149-41-3COA of Formula: C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Luo, Jingjie; Liu, Pengcheng; Yang, Wenhao; Niu, Hongyu; Li, Shaojie; Liang, Changhai published an article in Frontiers in Chemistry (Lausanne, Switzerland). The title of the article was 《Chemical kinetics and promoted Co-immobilization for efficient catalytic carbonylation of ethylene oxide into methyl 3-hydroxypropionate》.COA of Formula: C4H8O3 The author mentioned the following in the article:

The carbonylative transformation of ethylene oxide (EO) into Me 3- hydroxypropionate (3-HPM) is a key process for the production of 1,3- propanediol (1,3-PDO), which is currently viewed as one of the most promising monomers and intermediates in polyester and pharmaceuticals industry. In this work, a homogeneous reaction system using com. Co2(CO)8 was first studied for the carbonylation of EO to 3-HPM. The catalytic behavior was related to the electronic environment of N on aromatic rings of ligands, where N with rich electron d. induced a stronger coordination with Co center and higher EO transformation. A reaction order of 2.1 with respect to EO and 0.3 with respect to CO was unraveled based on the kinetics study. The 3-HPM yield reached 91.2% at only 40°C by Co2(CO)8 coordinated with 3-hydroxypyridine. However, Cocontaining colloid was formed during the reaction, causing the tough separation and impossible recycling of samples. Concerning the sustainable utilization, Co particles immobilized on pre-treated carbon nanotubes (Co/ CNT-C) were designed via an in situ reduced colloid method. It is remarkable that unlike conventional Co/CNT, Co/CNT-C was highly selective toward the transformation of EO to 3-HPM with a specific rate of 52.2 mmol · g-1 Co · h-1, displaying a similar at. efficiency to that of coordinated Co2(CO)8. After reaction, the supported Co/CNT-C catalyst could be easily separated from the liquid reaction mixture, leading to a convenient cyclic utilization. After reading the article, we found that the author used Methyl 3-hydroxypropanoate(cas: 6149-41-3COA of Formula: C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2010,Jakobsche, Charles E.; Choudhary, Amit; Miller, Scott J.; Raines, Ronald T. published 《n → π* Interaction and n)(π Pauli Repulsion Are Antagonistic for Protein Stability》.Journal of the American Chemical Society published the findings.Recommanded Product: Methyl 3-hydroxypropanoate The information in the text is summarized as follows:

In many common protein secondary structures, such as α-, 310, and polyproline II helixes, an n → π* interaction places the adjacent backbone amide carbonyl groups in close proximity to each other. This interaction, which is reminiscent of the Burgi-Dunitz trajectory, involves delocalization of the lone pairs (n) of the oxygen (Oi-1) of a peptide bond over the antibonding orbital (π*) of Ci:Oi of the subsequent peptide bond. Such a proximal arrangement of the amide carbonyl groups should be opposed by the Pauli repulsion between the lone pairs (n) of Oi-1 and the bonding orbital (π) of Ci:Oi. We explored the conformational effects of this Pauli repulsion by employing common peptidomimetics, wherein the n → π* interaction is attenuated while the Pauli repulsion is retained. Our results indicate that this Pauli repulsion prevents the attainment of such proximal arrangement of the carbonyl groups in the absence of the n → π* interaction. This finding indicates that the poor mimicry of the amide bond by many peptidomimetics stems from their inability to partake in the n → π* interaction and emphasizes the quantum-mech. nature of the interaction between adjacent amide carbonyl groups in proteins.Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: Methyl 3-hydroxypropanoate) was used in this study.

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics