Category: 6149-41-3

In 2017,Khan, Ajmal; Khan, Sardaraz; Khan, Ijaz; Zhao, Can; Mao, Yuxue; Chen, Yan; Zhang, Yong Jian published 《Enantioselective Construction of Tertiary C-O Bond via Allylic Substitution of Vinylethylene Carbonates with Water and Alcohols》.Journal of the American Chemical Society published the findings.Category: esters-buliding-blocks The information in the text is summarized as follows:

An efficient method for the enantioselective construction of tertiary C-O bond via asym. allylic substitution of racemic vinylethylene carbonates with water and alcs. has been developed. Under the cooperative catalysis system of an in situ generated chiral palladium complex and boron reagent in mild conditions, the process allowed rapid access to valuable tertiary alcs. and ethers in high yields with complete regioselectivities and high enantioselectivities. This protocol represented the first example of direct enantioselective formation of a tertiary C-O bond with water as an oxygen donor. The synthetic utilities of the process have been demonstrated by the elaboration of the products into key intermediates of biol. relevant agents, and chiral tertiary cyclic ethers could also be provided through the sequential reactions of the allylic etherification and ring-closing metathesis. In the experimental materials used by the author, we found Methyl 3-hydroxypropanoate(cas: 6149-41-3Category: esters-buliding-blocks)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 6149-41-3In 2019 ,《Synthesis of the Sex Pheromone of the Oleander Scale (Aspidiotus nerii)》 was published in Journal of Organic Chemistry. The article was written by Castaneda, Mary Montano; Bargues, Javier Marzo; Primo, Jaime; Fuertes, Ismael Navarro. The article contains the following contents:

A total synthesis of the oleander scale [Aspidiotus nerii (Bouche)] sex pheromone (I), the unique sesquiterpenoid containing a cyclobutane moiety of this class of compounds, has been developed. In order to implement this sex pheromone as a new environmentally friendly tool to manage this pest, a more cost-effective, multigram synthesis was required. This new synthetic route, having a Blaise reaction, iron-catalyzed carbon-carbon coupling, and [2 + 2] photocycloaddition reactions as key steps, provides a general access to 4-alkyl lactones as well as a robust access to the target sex pheromone. Starting from readily available compounds as 3-hydroxypropanenitrile, Et bromoacetate, and 2-acetylbutyrolactone, the synthetic sequence afforded the A. nerii sex pheromone with min. intermediate purification and good overall yield in nine linear steps. In the experimental materials used by the author, we found Methyl 3-hydroxypropanoate(cas: 6149-41-3Product Details of 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2002,Ladame, Sylvain; Willson, Michele; Perie, Jacques published 《A convenient synthesis of dibenzyl α,α-difluoromethyl-β-ketophosphonates》.European Journal of Organic Chemistry published the findings.Formula: C4H8O3 The information in the text is summarized as follows:

The first synthesis of dibenzyl α,α-difluoro-β-ketophosphonates has been accomplished by an original fluorination reaction, namely addition of the F+ ion to the enolate form of the corresponding dibenzyl β-ketophosphonate. After an easy cleavage of the benzyloxy protecting groups on the phosphorus atom, α-fluoro-β-ketophosphonic acids were subsequently obtained as stable carboxyphosphate mimics. This approach enables α,α-difluoro-β-ketophosphonate moieties to be introduced into multiply functionalized mols., thus making the previously described di-Et phosphonate route no longer relevant. Moreover, study of their stability under neutral and basic conditions showed the importance of the keto-enol equilibrium in the decomposition pathway of these mols. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-hydroxypropanoate(cas: 6149-41-3Formula: C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2015,Butler, Christopher R.; Brodney, Michael A.; Beck, Elizabeth M.; Barreiro, Gabriela; Nolan, Charles E.; Pan, Feng; Vajdos, Felix; Parris, Kevin; Varghese, Alison H.; Helal, Christopher J.; Lira, Ricardo; Doran, Shawn D.; Riddell, David R.; Buzon, Leanne M.; Dutra, Jason K.; Martinez-Alsina, Luis A.; Ogilvie, Kevin; Murray, John C.; Young, Joseph M.; Atchison, Kevin; Robshaw, Ashley; Gonzales, Cathleen; Wang, Jinlong; Zhang, Yong; O’Neill, Brian T. published 《Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design》.Journal of Medicinal Chemistry published the findings.Related Products of 6149-41-3 The information in the text is summarized as follows:

The identification of centrally efficacious β-secretase (BACE1) inhibitors for the treatment of Alzheimer’s disease (AD) has historically been thwarted by an inability to maintain alignment of potency, brain availability, and desired absorption, distribution, metabolism, and excretion (ADME) properties. In this paper, the authors describe a series of truncated, fused thioamidines that are efficiently selective in garnering BACE1 activity without simultaneously inhibiting the closely related cathepsin D or neg. impacting brain penetration and ADME alignment, as exemplified by I. Upon oral administration, these inhibitors exhibit robust brain availability and are efficacious in lowering central Amyloid β (Aβ) levels in mouse and dog. In addition, chronic treatment in aged PS1/APP mice effects a decrease in the number and size of Aβ-derived plaques. Most importantly, evaluation of I in a 2-wk exploratory toxicol. study revealed no accumulation of autofluorescent material in retinal pigment epithelium or histol. findings in the eye, issues observed with earlier BACE1 inhibitors. The experimental process involved the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3Related Products of 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Zong, Zezhou; Zhang, Qi; Qiu, Shu-Hai; Wang, Qian; Zhao, Chengxi; Zhao, Cai-Xin; Tian, He; Qu, Da-Hui published an article in Angewandte Chemie, International Edition. The title of the article was 《Dynamic Timing Control over Multicolor Molecular Emission by Temporal Chemical Locking》.Product Details of 6149-41-3 The author mentioned the following in the article:

Dynamic control over mol. emission, especially in a time-dependent manner, holds great promise for the development of smart luminescent materials. Here we report a series of dynamic multicolor fluorescent systems based on the time-encoded locking and unlocking of individual vibrational emissive units. The intramol. cyclization reaction driven by adding chem. fuel acts as a chem. lock to decrease the conformational freedom of the emissive units, thus varying the fluorescence wavelength, while the resulting chem. locked state can be automatically unlocked by the hydrolysis reaction with water mols. The dynamic mol. system can be driven by adding chem. fuels for multiple times. The emission wavelength and lifetime of the locking states can be readily controlled by elaborating the mol. structures, indicating this strategy as a robust and versatile way to modulate multi-color mol. emission in a time-encoded manner. In the experimental materials used by the author, we found Methyl 3-hydroxypropanoate(cas: 6149-41-3Product Details of 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2017,Zhao, Chenfei; Sojdak, Christopher A.; Myint, Wazo; Seidel, Daniel published 《Reductive Etherification via Anion-Binding Catalysis》.Journal of the American Chemical Society published the findings.Computed Properties of C4H8O3 The information in the text is summarized as follows:

In the presence of bis[4-cyano-3,5-bis(trifluoromethyl)phenyl]thiourea as an anion-binding catalyst, aldehydes and ketones underwent chemoselective reductive etherification reactions with alcs. mediated by HCl and (HSiMe2)2O in CH2Cl2 to yield unsym. dialkyl ethers; the reaction tolerated chloro and bromo, nitro, cyano, and ester moieties, and formed little if any of the sym. ether derived from aldehyde or ketone reductive homocoupling. The results came from multiple reactions, including the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3Computed Properties of C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 6149-41-3In 2004 ,《Theoretical study of the thermolysis reaction of methyl β-hydroxycarboxylates in the gas phase》 was published in Journal of Physical Organic Chemistry. The article was written by Sanchez, Claudia; Quijano, Jairo; Notario, Rafael. The article contains the following contents:

Theor. studies on the thermolysis in the gas phase of three Me β-hydroxycarboxylates RR’C(OH)CH2COOCH3, Me 3-hydroxypropanoate (primary alc., I), Me 3-hydroxybutanoate (secondary alc., II) and Me 3-hydroxy-3-methylbutanoate (tertiary alc., III), were carried out using ab initio theor. methods at the MP2/6-31G(d) and MP2/6-311+G(d,p) levels of theory. The pathways describe a mechanism via a six-membered cyclic transition state, with the formation of an aldehyde or a ketone and an enol intermediate, followed by the tautomerization of this intermediate to Me acetate. The progress of the reactions was followed by means of the Wiberg bond indexes. The results indicate that the transition states are late, and the proton transfer is the more advanced process. The kinetic parameters calculated for the reactions studied agree well with the available exptl. results. A theor. study on the kinetic deuterium isotope primary and α- and β-secondary effects was also carried out. In the experiment, the researchers used many compounds, for example, Methyl 3-hydroxypropanoate(cas: 6149-41-3HPLC of Formula: 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2016,Tsuji, Hiroaki; Yamamoto, Hisashi published 《Hydroxy-Directed Amidation of Carboxylic Acid Esters Using a Tantalum Alkoxide Catalyst》.Journal of the American Chemical Society published the findings.Application of 6149-41-3 The information in the text is summarized as follows:

We describe herein a new strategy for the chemoselective synthesis of amides by using a metal-catalyzed hydroxy-directed reaction. A hydroxy group located at the β-position of an ester group promoted the activation of a carbonyl group with a tantalum alkoxide catalyst followed by amidation reactions, leading to a wide variety of β-hydroxyamides with excellent chemoselectivity. The chemoselective amidation strategy can be extended to the catalytic synthesis of dipeptide derivatives, which remains challenging research subjects in modern organic synthesis. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-hydroxypropanoate(cas: 6149-41-3Application of 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Methyl 3-hydroxypropanoateIn 2021 ,《Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Yasuno, Takumi; Ohe, Tomoyuki; Kataoka, Hiroki; Hashimoto, Kosho; Ishikawa, Yumiko; Furukawa, Keigo; Tateishi, Yasuhiro; Kobayashi, Toi; Takahashi, Kyoko; Nakamura, Shigeo; Mashino, Tadahiko. The article conveys some information:

In the present study, we newly synthesized three types of novel fullerene derivatives: pyridinium-type derivatives, piperidinium-type derivatives, and proline-type derivatives Among the assessed compounds, some were found to inhibit both HIV reverse transcriptase and HIV protease (HIV-PR), with IC50 values in the low micromolar range being observed Regarding HIV-PR inhibition activity, proline-type derivatives, bearing an alkyl chain between the hydroxylmethylcarbonyl (HMC) moiety and pyrrolidine ring, were more potent than other derivatives This result might indicate that connecting HMC moieties with proline-type fullerene derivatives through properly sized alkyl chain leads to improved HIV-PR inhibitory activity. After reading the article, we found that the author used Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: Methyl 3-hydroxypropanoate)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2004,Parkkari, Teija; Savinainen, Juha R.; Rauhala, Anu L.; Tolonen, Tiina L.; Nevalainen, Tapio; Laitinen, Jarmo T.; Gynther, Jukka; Jarvinen, Tomi published 《Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives》.Bioorganic & Medicinal Chemistry Letters published the findings.SDS of cas: 6149-41-3 The information in the text is summarized as follows:

Novel derivatives of arachidonyl alc. were synthesized and evaluated for their CB1 receptor activity by [35S]GTPγS assay using rat cerebellar membranes. The results came from multiple reactions, including the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3SDS of cas: 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics